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Search results 1 to 100 out of 170 for Cd226

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Categories

Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
Gene
10666 | CD226
Type: gene
Organism: human
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Gene
307199 | Cd226
Type: gene
Organism: rat
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Gene
609196 | CD226
Type: gene
Organism: dog, domestic
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Gene
468577 | CD226
Type: gene
Organism: chimpanzee
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Gene
615496 | CD226
Type: gene
Organism: cattle
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Gene
772097 | CD226
Type: gene
Organism: chicken
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Gene
791164 | cd226
Type: gene
Organism: zebrafish
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Gene
703878 | CD226
Type: gene
Organism: macaque, rhesus
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Protein Coding Gene
MGI:3039602 | Cd226
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Domain
IPR042842 | CD226
Type: Family
Description: CD226, also known as DNAM-1, is a nectin receptor that contains two extracellular Ig-like domains (CD226-D1 and CD226-D2), and is widely expressed in monocytes, platelets, T cells, and most of the resting NK cells. The interactions between CD226and its nectin/Necl family ligands, CD155 (also known as Necl-5) and CD112 (nectin-2), play important roles in modulating NK cell adhesion and cytotoxicity, facilitating immunological synapse formation and promoting cytokine secretion during inflammation [, , ].
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Publication
30591568 | J:322383
First Author: Wang H
Year: 2019
Journal: Proc Natl Acad Sci U S A
Title: Binding mode of the side-by-side two-IgV molecule CD226/DNAM-1 to its ligand CD155/Necl-5.
Volume: 116
Issue: 3
Pages: 988-996
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Publication
33451863 | J:309279
 
First Author: Wang N
Year: 2021
Journal: Mol Immunol
Title: CD226 deficiency attenuates the homeostasis and suppressive capacity of Tr1 cells.
Volume: 132
Pages: 192-198
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Publication
26910838 | J:309235
First Author: Zhang Y
Year: 2016
Journal: Oncotarget
Title: CD226 reduces endothelial cell glucose uptake under hyperglycemic conditions with inflammation in type 2 diabetes mellitus.
Volume: 7
Issue: 11
Pages: 12010-23
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Publication
34823548 | J:333681
First Author: Ma J
Year: 2021
Journal: J Transl Med
Title: CD226 knockout alleviates high-fat diet induced obesity by suppressing proinflammatory macrophage phenotype.
Volume: 19
Issue: 1
Pages: 477
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Publication
35846105 | J:353328
 
First Author: Xie Y
Year: 2022
Journal: Mediators Inflamm
Title: CD226 Deficiency Alleviates Murine Allergic Rhinitis by Suppressing Group 2 Innate Lymphoid Cell Responses.
Volume: 2022
Pages: 1756395
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Protein
Q8K4F0
Organism: Mus musculus/domesticus
Length: 333  
Fragment?: false
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Protein
Q80UQ6
Organism: Mus musculus/domesticus
Length: 133  
Fragment?: false
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Protein
A0A494BBC0
Organism: Mus musculus/domesticus
Length: 119  
Fragment?: true
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Protein
A0A494BB66
Organism: Mus musculus/domesticus
Length: 154  
Fragment?: false
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Publication
36989896 | J:342898
 
First Author: Xie Y
Year: 2023
Journal: Int Immunopharmacol
Title: Ablation of CD226 on CD4(+) T cells modulates asthma progress associated with altered IL-10 response and gut microbiota.
Volume: 118
Pages: 110051
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Publication
19380793 | J:147715
First Author: Fang L
Year: 2009
Journal: J Immunol
Title: Expression of CD226 antagonizes apoptotic cell death in murine thymocytes.
Volume: 182
Issue: 9
Pages: 5453-60
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Publication
38325579 | J:346403
     
First Author: Qiao W
Year: 2024
Journal: J Invest Dermatol
Title: Costimulatory Molecule CD226 Regulates Atopic Dermatitis in a Mouse Model.
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Publication
32248623 | J:301797
First Author: Zhang J
Year: 2020
Journal: FASEB J
Title: Deficiency of platelet adhesion molecule CD226 causes megakaryocyte development and platelet hyperactivity.
Volume: 34
Issue: 5
Pages: 6871-6887
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Publication
31802539 | J:296058
First Author: Mu Y
Year: 2020
Journal: J Leukoc Biol
Title: CD226 deficiency on regulatory T cells aggravates renal fibrosis via up-regulation of Th2 cytokines through miR-340.
Volume: 107
Issue: 4
Pages: 573-587
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Publication
32983109 | J:305659
 
First Author: Wang N
Year: 2020
Journal: Front Immunol
Title: CD226 Attenuates Treg Proliferation via Akt and Erk Signaling in an EAE Model.
Volume: 11
Pages: 1883
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Publication
18793698 | J:145795
First Author: Zhang T
Year: 2009
Journal: Neuroscience
Title: Localization of CD226 in the mouse hippocampus and cerebellum during adulthood and postnatal development.
Volume: 158
Issue: 2
Pages: 766-75
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Publication
37864795 | J:342876
First Author: Ma J
Year: 2023
Journal: Cell Rep
Title: CD226 maintains regulatory T cell phenotype stability and metabolism by the mTOR/Myc pathway under inflammatory conditions.
Volume: 42
Issue: 10
Pages: 113306
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Publication
16034094 | J:107289
First Author: Dardalhon V
Year: 2005
Journal: J Immunol
Title: CD226 is specifically expressed on the surface of Th1 cells and regulates their expansion and effector functions.
Volume: 175
Issue: 3
Pages: 1558-65
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Publication
33013915 | J:308231
 
First Author: Shapiro MR
Year: 2020
Journal: Front Immunol
Title: CD226 Deletion Reduces Type 1 Diabetes in the NOD Mouse by Impairing Thymocyte Development and Peripheral T Cell Activation.
Volume: 11
Pages: 2180
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Protein
Q8K4E2
Organism: Mus musculus/domesticus
Length: 129  
Fragment?: false
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Publication
15039383 | -
First Author: Tahara-Hanaoka S
Year: 2004
Journal: Int Immunol
Title: Functional characterization of DNAM-1 (CD226) interaction with its ligands PVR (CD155) and nectin-2 (PRR-2/CD112).
Volume: 16
Issue: 4
Pages: 533-8
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Publication
31253644 | -
First Author: Deuss FA
Year: 2019
Journal: J Biol Chem
Title: Structural basis for the recognition of nectin-like protein-5 by the human-activating immune receptor, DNAM-1.
Volume: 294
Issue: 33
Pages: 12534-12546
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Publication
30504141 | J:268672
First Author: Du X
Year: 2018
Journal: Proc Natl Acad Sci U S A
Title: CD226 regulates natural killer cell antitumor responses via phosphorylation-mediated inactivation of transcription factor FOXO1.
Volume: 115
Issue: 50
Pages: E11731-E11740
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Publication
27503073 | J:236730
First Author: Lenac Rovis T
Year: 2016
Journal: J Exp Med
Title: Inflammatory monocytes and NK cells play a crucial role in DNAM-1-dependent control of cytomegalovirus infection.
Volume: 213
Issue: 9
Pages: 1835-50
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Publication
19029379 | J:165704
First Author: Iguchi-Manaka A
Year: 2008
Journal: J Exp Med
Title: Accelerated tumor growth in mice deficient in DNAM-1 receptor.
Volume: 205
Issue: 13
Pages: 2959-64
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Publication
20937876 | J:165511
First Author: Nabekura T
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: Critical role of DNAX accessory molecule-1 (DNAM-1) in the development of acute graft-versus-host disease in mice.
Volume: 107
Issue: 43
Pages: 18593-8
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Publication
26675069 | J:234675
 
First Author: Vo AV
Year: 2016
Journal: Mol Immunol
Title: Expression of DNAM-1 (CD226) on inflammatory monocytes.
Volume: 69
Pages: 70-6
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Publication
24658051 | J:209990
First Author: Chan CJ
Year: 2014
Journal: Nat Immunol
Title: The receptors CD96 and CD226 oppose each other in the regulation of natural killer cell functions.
Volume: 15
Issue: 5
Pages: 431-8
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Publication
29991650 | J:284464
 
First Author: Gaud G
Year: 2018
Journal: Sci Signal
Title: The costimulatory molecule CD226 signals through VAV1 to amplify TCR signals and promote IL-17 production by CD4+ T cells.
Volume: 11
Issue: 538
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Publication
33053331 | J:305975
First Author: Weulersse M
Year: 2020
Journal: Immunity
Title: Eomes-Dependent Loss of the Co-activating Receptor CD226 Restrains CD8+ T Cell Anti-tumor Functions and Limits the Efficacy of Cancer Immunotherapy.
Volume: 53
Issue: 4
Pages: 824-839.e10
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Publication
31919790 | J:295726
First Author: Wang N
Year: 2019
Journal: Immunol Res
Title: CD226 attenuates Treg suppressive capacity via CTLA-4 and TIGIT during EAE.
Volume: 67
Issue: 6
Pages: 486-496
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Publication
24337740 | J:207326
First Author: Ramsbottom KM
Year: 2014
Journal: J Immunol
Title: Cutting edge: DNAX accessory molecule 1-deficient CD8+ T cells display immunological synapse defects that impair antitumor immunity.
Volume: 192
Issue: 2
Pages: 553-7
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Publication
19029380 | J:159749
First Author: Gilfillan S
Year: 2008
Journal: J Exp Med
Title: DNAM-1 promotes activation of cytotoxic lymphocytes by nonprofessional antigen-presenting cells and tumors.
Volume: 205
Issue: 13
Pages: 2965-73
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Publication
28561023 | J:250346
 
First Author: Wagner AK
Year: 2017
Journal: Nat Commun
Title: Expression of CD226 is associated to but not required for NK cell education.
Volume: 8
Pages: 15627
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Publication
26689152 | J:246247
First Author: Georgiev H
Year: 2016
Journal: Eur J Immunol
Title: CD155/CD226-interaction impacts on the generation of innate CD8(+) thymocytes by regulating iNKT-cell differentiation.
Volume: 46
Issue: 4
Pages: 993-1003
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Publication
34672321 | J:347615
First Author: Nakamura-Shinya Y
Year: 2022
Journal: Int Immunol
Title: DNAM-1 promotes inflammation-driven tumor development via enhancing IFN-γ production.
Volume: 34
Issue: 3
Pages: 149-157
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Publication
30315271 | J:268098
First Author: Takenaka E
Year: 2018
Journal: Sci Rep
Title: Selective DNAM-1 expression on small peritoneal macrophages contributes to CD4+ T cell costimulation.
Volume: 8
Issue: 1
Pages: 15180
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Protein Coding Gene
MGP_CAROLIEiJ_G0022460 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_AJ_G0024584 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0024582 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_3039602 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0023823 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0024450 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0024535 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0025078 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0023886 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_SPRETEiJ_G0023376 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
10647817 | J:79315
First Author: Tian F
Year: 1999
Journal: DNA Seq
Title: Isolation of cDNAs encoding gibbon and monkey platelet and T cell activation antigen 1 (PTA1).
Volume: 10
Issue: 3
Pages: 155-61
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Protein Coding Gene
MGP_129S1SvImJ_G0024617 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0024555 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0024351 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0025030 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0024321 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0024417 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0024447 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0023569 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0019188 | -
Type: protein_coding_gene
Organism: Mus pahari
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Publication
9268302 | J:79321
First Author: Sherrington PD
Year: 1997
Journal: J Biol Chem
Title: TLiSA1 (PTA1) activation antigen implicated in T cell differentiation and platelet activation is a member of the immunoglobulin superfamily exhibiting distinctive regulation of expression.
Volume: 272
Issue: 35
Pages: 21735-44
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GXD Expression
GXD Expression
     
Probe: MGI:3775758
Assay Type: RT-PCR
Annotation Date: 2008-04-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603915
Stage: TS15
Assay Id: MGI:3775789
Age: embryonic day 9.5
Specimen Label: 7
Detected: true
Specimen Num: 8
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GXD Expression
GXD Expression
     
Probe: MGI:3775758
Assay Type: RT-PCR
Annotation Date: 2008-04-02
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1603915
Stage: TS15
Assay Id: MGI:3775789
Age: embryonic day 9.5
Specimen Label: 8
Detected: false
Specimen Num: 9
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Publication
23430112 | J:196691
First Author: Koyama M
Year: 2013
Journal: Blood
Title: Promoting regulation via the inhibition of DNAM-1 after transplantation.
Volume: 121
Issue: 17
Pages: 3511-20
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Protein
Q8K4E3
Organism: Mus musculus/domesticus
Length: 220  
Fragment?: false
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Protein
Q8K4E4
Organism: Mus musculus/domesticus
Length: 187  
Fragment?: false
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Protein
Q5DW69
Organism: Mus musculus/domesticus
Length: 333  
Fragment?: false
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Publication
26552706 | J:229022
First Author: Zhang Z
Year: 2015
Journal: J Exp Med
Title: DNAM-1 controls NK cell activation via an ITT-like motif.
Volume: 212
Issue: 12
Pages: 2165-82
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Publication
26840537 | J:248886
First Author: Kraus AK
Year: 2016
Journal: PLoS One
Title: The Role of T Cell Costimulation via DNAM-1 in Kidney Transplantation.
Volume: 11
Issue: 2
Pages: e0147951
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Publication
16636013 | J:109134
First Author: Shirakawa J
Year: 2006
Journal: Int Immunol
Title: LFA-1-dependent lipid raft recruitment of DNAM-1 (CD226) in CD4+ T cell.
Volume: 18
Issue: 6
Pages: 951-7
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Publication
20008292 | J:159408
First Author: Chan CJ
Year: 2010
Journal: J Immunol
Title: DNAM-1/CD155 interactions promote cytokine and NK cell-mediated suppression of poorly immunogenic melanoma metastases.
Volume: 184
Issue: 2
Pages: 902-11
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Publication
27551152 | J:237036
First Author: Kim KW
Year: 2016
Journal: J Exp Med
Title: MHC II+ resident peritoneal and pleural macrophages rely on IRF4 for development from circulating monocytes.
Volume: 213
Issue: 10
Pages: 1951-9
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Publication
34011606 | J:316956
 
First Author: Sato K
Year: 2021
Journal: Proc Natl Acad Sci U S A
Title: DNAM-1 regulates Foxp3 expression in regulatory T cells by interfering with TIGIT under inflammatory conditions.
Volume: 118
Issue: 21
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Publication
21416464 | J:175415
First Author: Levin SD
Year: 2011
Journal: Eur J Immunol
Title: Vstm3 is a member of the CD28 family and an important modulator of T-cell function.
Volume: 41
Issue: 4
Pages: 902-15
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Publication
25465800 | J:217453
First Author: Johnston RJ
Year: 2014
Journal: Cancer Cell
Title: The immunoreceptor TIGIT regulates antitumor and antiviral CD8(+) T cell effector function.
Volume: 26
Issue: 6
Pages: 923-937
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Publication
31729776 | J:293421
First Author: Chen S
Year: 2020
Journal: J Leukoc Biol
Title: Concomitant deletion of SLAM-family receptors, NKG2D and DNAM-1 reveals gene redundancy of NK cell activating receptors in NK cell development and education.
Volume: 107
Issue: 4
Pages: 561-572
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Publication
15752754 | J:97476
First Author: Tahara-Hanaoka S
Year: 2005
Journal: Biochem Biophys Res Commun
Title: Identification and characterization of murine DNAM-1 (CD226) and its poliovirus receptor family ligands.
Volume: 329
Issue: 3
Pages: 996-1000
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Publication
16249389 | J:129311
First Author: Tahara-Hanaoka S
Year: 2006
Journal: Blood
Title: Tumor rejection by the poliovirus receptor family ligands of the DNAM-1 (CD226) receptor.
Volume: 107
Issue: 4
Pages: 1491-6
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Publication
24440149 | J:209371
First Author: Nabekura T
Year: 2014
Journal: Immunity
Title: Costimulatory molecule DNAM-1 is essential for optimal differentiation of memory natural killer cells during mouse cytomegalovirus infection.
Volume: 40
Issue: 2
Pages: 225-34
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Publication
31810881 | J:288506
First Author: Nabekura T
Year: 2020
Journal: Immunity
Title: Type 1 Innate Lymphoid Cells Protect Mice from Acute Liver Injury via Interferon-γ Secretion for Upregulating Bcl-xL Expression in Hepatocytes.
Volume: 52
Issue: 1
Pages: 96-108.e9
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Publication
25818301 | J:228168
First Author: Martinet L
Year: 2015
Journal: Cell Rep
Title: DNAM-1 expression marks an alternative program of NK cell maturation.
Volume: 11
Issue: 1
Pages: 85-97
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Publication
26787820 | J:236840
First Author: Blake SJ
Year: 2016
Journal: Cancer Discov
Title: Suppression of Metastases Using a New Lymphocyte Checkpoint Target for Cancer Immunotherapy.
Volume: 6
Issue: 4
Pages: 446-59
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Publication
30894377 | J:274776
First Author: Mittal D
Year: 2019
Journal: Cancer Immunol Res
Title: CD96 Is an Immune Checkpoint That Regulates CD8+ T-cell Antitumor Function.
Volume: 7
Issue: 4
Pages: 559-571
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Publication
17551791 | J:132045
First Author: Chatterjee B
Year: 2007
Journal: Mamm Genome
Title: Nt mutation causing laterality defects associated with deletion of rotatin.
Volume: 18
Issue: 5
Pages: 310-5
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Publication
27034402 | J:299406
First Author: Smith LE
Year: 2016
Journal: J Leukoc Biol
Title: Sensitivity of dendritic cells to NK-mediated lysis depends on the inflammatory environment and is modulated by CD54/CD226-driven interactions.
Volume: 100
Issue: 4
Pages: 781-789
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Publication
19648922 | J:151768
First Author: Dong Z
Year: 2009
Journal: Nat Immunol
Title: Essential function for SAP family adaptors in the surveillance of hematopoietic cells by natural killer cells.
Volume: 10
Issue: 9
Pages: 973-80
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UniProt Feature
UniProt Feature
Begin: 19
Description: CD226 antigen
Type: chain
End: 333
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Publication
- | J:82809
     
First Author: European Mouse Mutant Archive
Year: 2003
Journal: Unpublished
Title: Information obtained from the European Mouse Mutant Archive (EMMA)
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Publication
- | J:238766
     
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
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Publication
- | J:136110
     
First Author: Velocigene
Year: 2008
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals)
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Publication
- | J:155845
     
First Author: Wellcome Trust Sanger Institute
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute
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Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

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