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Search results 1 to 100 out of 137 for Cd226

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0.021s
Type Details Score
Gene
Type: gene
Organism: Homo sapiens
Gene
Type: gene
Organism: Rattus norvegicus
Gene
Type: gene
Organism: Danio rerio
Protein Domain
Type: Family
Description: CD226, also known as DNAM-1, is a nectin receptor that contains two extracellular Ig-like domains (CD226-D1 and CD226-D2), and is widely expressed in monocytes, platelets, T cells, and most of the resting NK cells. The interactions between CD226 and its nectin/Necl family ligands, CD155 (also known as Necl-5) and CD112 (nectin-2), play important roles in modulating NK cell adhesion and cytotoxicity, facilitating immunological synapse formation and promoting cytokine secretion during inflammation [, , ].
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Publication
First Author: Chan CJ
Year: 2014
Journal: Nat Immunol
Title: The receptors CD96 and CD226 oppose each other in the regulation of natural killer cell functions.
Volume: 15
Issue: 5
Pages: 431-8
Publication  
First Author: Wang N
Year: 2021
Journal: Mol Immunol
Title: CD226 deficiency attenuates the homeostasis and suppressive capacity of Tr1 cells.
Volume: 132
Pages: 192-198
Publication
First Author: Zhang Y
Year: 2016
Journal: Oncotarget
Title: CD226 reduces endothelial cell glucose uptake under hyperglycemic conditions with inflammation in type 2 diabetes mellitus.
Volume: 7
Issue: 11
Pages: 12010-23
Protein
Organism: Mus musculus
Length: 154  
Fragment?: false
Protein
Organism: Mus musculus
Length: 119  
Fragment?: true
Protein
Organism: Mus musculus
Length: 333  
Fragment?: false
Protein
Organism: Mus musculus
Length: 133  
Fragment?: false
Publication
First Author: Fang L
Year: 2009
Journal: J Immunol
Title: Expression of CD226 antagonizes apoptotic cell death in murine thymocytes.
Volume: 182
Issue: 9
Pages: 5453-60
Publication
First Author: Zhang J
Year: 2020
Journal: FASEB J
Title: Deficiency of platelet adhesion molecule CD226 causes megakaryocyte development and platelet hyperactivity.
Volume: 34
Issue: 5
Pages: 6871-6887
Publication  
First Author: Wang N
Year: 2020
Journal: Front Immunol
Title: CD226 Attenuates Treg Proliferation via Akt and Erk Signaling in an EAE Model.
Volume: 11
Pages: 1883
Publication
First Author: Zhang T
Year: 2009
Journal: Neuroscience
Title: Localization of CD226 in the mouse hippocampus and cerebellum during adulthood and postnatal development.
Volume: 158
Issue: 2
Pages: 766-75
Publication
First Author: Mu Y
Year: 2020
Journal: J Leukoc Biol
Title: CD226 deficiency on regulatory T cells aggravates renal fibrosis via up-regulation of Th2 cytokines through miR-340.
Volume: 107
Issue: 4
Pages: 573-587
Publication
First Author: Dardalhon V
Year: 2005
Journal: J Immunol
Title: CD226 is specifically expressed on the surface of Th1 cells and regulates their expansion and effector functions.
Volume: 175
Issue: 3
Pages: 1558-65
Publication  
First Author: Shapiro MR
Year: 2020
Journal: Front Immunol
Title: CD226 Deletion Reduces Type 1 Diabetes in the NOD Mouse by Impairing Thymocyte Development and Peripheral T Cell Activation.
Volume: 11
Pages: 2180
Protein
Organism: Mus musculus
Length: 129  
Fragment?: false
Publication
First Author: Tahara-Hanaoka S
Year: 2004
Journal: Int Immunol
Title: Functional characterization of DNAM-1 (CD226) interaction with its ligands PVR (CD155) and nectin-2 (PRR-2/CD112).
Volume: 16
Issue: 4
Pages: 533-8
Publication
First Author: Wang H
Year: 2019
Journal: Proc Natl Acad Sci U S A
Title: Binding mode of the side-by-side two-IgV molecule CD226/DNAM-1 to its ligand CD155/Necl-5.
Volume: 116
Issue: 3
Pages: 988-996
Publication
First Author: Deuss FA
Year: 2019
Journal: J Biol Chem
Title: Structural basis for the recognition of nectin-like protein-5 by the human-activating immune receptor, DNAM-1.
Volume: 294
Issue: 33
Pages: 12534-12546
Publication
First Author: Du X
Year: 2018
Journal: Proc Natl Acad Sci U S A
Title: CD226 regulates natural killer cell antitumor responses via phosphorylation-mediated inactivation of transcription factor FOXO1.
Volume: 115
Issue: 50
Pages: E11731-E11740
Publication  
First Author: Vo AV
Year: 2016
Journal: Mol Immunol
Title: Expression of DNAM-1 (CD226) on inflammatory monocytes.
Volume: 69
Pages: 70-6
Publication
First Author: Lenac Rovis T
Year: 2016
Journal: J Exp Med
Title: Inflammatory monocytes and NK cells play a crucial role in DNAM-1-dependent control of cytomegalovirus infection.
Volume: 213
Issue: 9
Pages: 1835-50
Publication
First Author: Iguchi-Manaka A
Year: 2008
Journal: J Exp Med
Title: Accelerated tumor growth in mice deficient in DNAM-1 receptor.
Volume: 205
Issue: 13
Pages: 2959-64
Publication
First Author: Nabekura T
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: Critical role of DNAX accessory molecule-1 (DNAM-1) in the development of acute graft-versus-host disease in mice.
Volume: 107
Issue: 43
Pages: 18593-8
Publication  
First Author: Gaud G
Year: 2018
Journal: Sci Signal
Title: The costimulatory molecule CD226 signals through VAV1 to amplify TCR signals and promote IL-17 production by CD4+ T cells.
Volume: 11
Issue: 538
Publication
First Author: Wang N
Year: 2019
Journal: Immunol Res
Title: CD226 attenuates Treg suppressive capacity via CTLA-4 and TIGIT during EAE.
Volume: 67
Issue: 6
Pages: 486-496
Publication
First Author: Gilfillan S
Year: 2008
Journal: J Exp Med
Title: DNAM-1 promotes activation of cytotoxic lymphocytes by nonprofessional antigen-presenting cells and tumors.
Volume: 205
Issue: 13
Pages: 2965-73
Publication
First Author: Ramsbottom KM
Year: 2014
Journal: J Immunol
Title: Cutting edge: DNAX accessory molecule 1-deficient CD8+ T cells display immunological synapse defects that impair antitumor immunity.
Volume: 192
Issue: 2
Pages: 553-7
Publication
First Author: Georgiev H
Year: 2016
Journal: Eur J Immunol
Title: CD155/CD226-interaction impacts on the generation of innate CD8(+) thymocytes by regulating iNKT-cell differentiation.
Volume: 46
Issue: 4
Pages: 993-1003
Publication  
First Author: Wagner AK
Year: 2017
Journal: Nat Commun
Title: Expression of CD226 is associated to but not required for NK cell education.
Volume: 8
Pages: 15627
Publication
First Author: Li XY
Year: 2018
Journal: J Clin Invest
Title: CD155 loss enhances tumor suppression via combined host and tumor-intrinsic mechanisms.
Volume: 128
Issue: 6
Pages: 2613-2625
Publication
First Author: Takenaka E
Year: 2018
Journal: Sci Rep
Title: Selective DNAM-1 expression on small peritoneal macrophages contributes to CD4+ T cell costimulation.
Volume: 8
Issue: 1
Pages: 15180
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Sherrington PD
Year: 1997
Journal: J Biol Chem
Title: TLiSA1 (PTA1) activation antigen implicated in T cell differentiation and platelet activation is a member of the immunoglobulin superfamily exhibiting distinctive regulation of expression.
Volume: 272
Issue: 35
Pages: 21735-44
Publication
First Author: Tian F
Year: 1999
Journal: DNA Seq
Title: Isolation of cDNAs encoding gibbon and monkey platelet and T cell activation antigen 1 (PTA1).
Volume: 10
Issue: 3
Pages: 155-61
GXD Expression      
Probe: MGI:3775758
Assay Type: RT-PCR
Annotation Date: 2008-04-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603915
Stage: TS15
Assay Id: MGI:3775789
Age: embryonic day 9.5
Detected: true
Specimen Num: 8
GXD Expression      
Probe: MGI:3775758
Assay Type: RT-PCR
Annotation Date: 2008-04-02
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1603915
Stage: TS15
Assay Id: MGI:3775789
Age: embryonic day 9.5
Detected: false
Specimen Num: 9
Publication
First Author: Koyama M
Year: 2013
Journal: Blood
Title: Promoting regulation via the inhibition of DNAM-1 after transplantation.
Volume: 121
Issue: 17
Pages: 3511-20
Protein
Organism: Mus musculus
Length: 187  
Fragment?: false
Protein
Organism: Mus musculus
Length: 333  
Fragment?: false
Protein
Organism: Mus musculus
Length: 220  
Fragment?: false
Publication
First Author: Zhang Z
Year: 2015
Journal: J Exp Med
Title: DNAM-1 controls NK cell activation via an ITT-like motif.
Volume: 212
Issue: 12
Pages: 2165-82
Publication
First Author: Kraus AK
Year: 2016
Journal: PLoS One
Title: The Role of T Cell Costimulation via DNAM-1 in Kidney Transplantation.
Volume: 11
Issue: 2
Pages: e0147951
Publication
First Author: Shirakawa J
Year: 2006
Journal: Int Immunol
Title: LFA-1-dependent lipid raft recruitment of DNAM-1 (CD226) in CD4+ T cell.
Volume: 18
Issue: 6
Pages: 951-7
Publication
First Author: Chan CJ
Year: 2010
Journal: J Immunol
Title: DNAM-1/CD155 interactions promote cytokine and NK cell-mediated suppression of poorly immunogenic melanoma metastases.
Volume: 184
Issue: 2
Pages: 902-11
Publication
First Author: Kim KW
Year: 2016
Journal: J Exp Med
Title: MHC II+ resident peritoneal and pleural macrophages rely on IRF4 for development from circulating monocytes.
Volume: 213
Issue: 10
Pages: 1951-9
Publication
First Author: Johnston RJ
Year: 2014
Journal: Cancer Cell
Title: The immunoreceptor TIGIT regulates antitumor and antiviral CD8(+) T cell effector function.
Volume: 26
Issue: 6
Pages: 923-937
Publication
First Author: Levin SD
Year: 2011
Journal: Eur J Immunol
Title: Vstm3 is a member of the CD28 family and an important modulator of T-cell function.
Volume: 41
Issue: 4
Pages: 902-15
Publication
First Author: Chen S
Year: 2020
Journal: J Leukoc Biol
Title: Concomitant deletion of SLAM-family receptors, NKG2D and DNAM-1 reveals gene redundancy of NK cell activating receptors in NK cell development and education.
Volume: 107
Issue: 4
Pages: 561-572
Publication
First Author: Tahara-Hanaoka S
Year: 2005
Journal: Biochem Biophys Res Commun
Title: Identification and characterization of murine DNAM-1 (CD226) and its poliovirus receptor family ligands.
Volume: 329
Issue: 3
Pages: 996-1000
Publication
First Author: Tahara-Hanaoka S
Year: 2006
Journal: Blood
Title: Tumor rejection by the poliovirus receptor family ligands of the DNAM-1 (CD226) receptor.
Volume: 107
Issue: 4
Pages: 1491-6
Publication
First Author: Nabekura T
Year: 2014
Journal: Immunity
Title: Costimulatory molecule DNAM-1 is essential for optimal differentiation of memory natural killer cells during mouse cytomegalovirus infection.
Volume: 40
Issue: 2
Pages: 225-34
Publication
First Author: Nabekura T
Year: 2020
Journal: Immunity
Title: Type 1 Innate Lymphoid Cells Protect Mice from Acute Liver Injury via Interferon-γ Secretion for Upregulating Bcl-xL Expression in Hepatocytes.
Volume: 52
Issue: 1
Pages: 96-108.e9
Publication
First Author: Martinet L
Year: 2015
Journal: Cell Rep
Title: DNAM-1 expression marks an alternative program of NK cell maturation.
Volume: 11
Issue: 1
Pages: 85-97
Publication
First Author: Blake SJ
Year: 2016
Journal: Cancer Discov
Title: Suppression of Metastases Using a New Lymphocyte Checkpoint Target for Cancer Immunotherapy.
Volume: 6
Issue: 4
Pages: 446-59
Publication
First Author: Mittal D
Year: 2019
Journal: Cancer Immunol Res
Title: CD96 Is an Immune Checkpoint That Regulates CD8+ T-cell Antitumor Function.
Volume: 7
Issue: 4
Pages: 559-571
Publication
First Author: Chatterjee B
Year: 2007
Journal: Mamm Genome
Title: Nt mutation causing laterality defects associated with deletion of rotatin.
Volume: 18
Issue: 5
Pages: 310-5
Publication
First Author: Smith LE
Year: 2016
Journal: J Leukoc Biol
Title: Sensitivity of dendritic cells to NK-mediated lysis depends on the inflammatory environment and is modulated by CD54/CD226-driven interactions.
Volume: 100
Issue: 4
Pages: 781-789
Publication
First Author: Dong Z
Year: 2009
Journal: Nat Immunol
Title: Essential function for SAP family adaptors in the surveillance of hematopoietic cells by natural killer cells.
Volume: 10
Issue: 9
Pages: 973-80
UniProt Feature
Begin: 19
Description: CD226 antigen
Type: chain
End: 333
Publication      
First Author: European Mouse Mutant Archive
Year: 2003
Journal: Unpublished
Title: Information obtained from the European Mouse Mutant Archive (EMMA)
Publication      
First Author: Velocigene
Year: 2008
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals)
Publication      
First Author: Wellcome Trust Sanger Institute
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute
Publication      
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
Publication
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
Publication
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
Publication      
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
Publication
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
Publication
First Author: Gaudet P
Year: 2011
Journal: Brief Bioinform
Title: Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.
Volume: 12
Issue: 5
Pages: 449-62
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2000
Title: Gene Ontology Annotation by electronic association of SwissProt Keywords with GO terms
Publication      
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
Publication      
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations