| Type |
Details |
Score |
| Gene |
| Type: |
gene |
| Organism: |
human |
|
•
•
•
•
•
|
| Gene |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
chimpanzee |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Tchilian EZ |
| Year: |
1994 |
| Journal: |
Blood |
| Title: |
Molecular cloning of two isoforms of the murine homolog of the myeloid CD33 antigen. |
| Volume: |
83 |
| Issue: |
11 |
| Pages: |
3188-98 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Griciuc A |
| Year: |
2013 |
| Journal: |
Neuron |
| Title: |
Alzheimer's disease risk gene CD33 inhibits microglial uptake of amyloid beta. |
| Volume: |
78 |
| Issue: |
4 |
| Pages: |
631-43 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Brinkman-Van der Linden EC |
| Year: |
2003 |
| Journal: |
Mol Cell Biol |
| Title: |
CD33/Siglec-3 binding specificity, expression pattern, and consequences of gene deletion in mice. |
| Volume: |
23 |
| Issue: |
12 |
| Pages: |
4199-206 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Duan S |
| Year: |
2019 |
| Journal: |
J Clin Invest |
| Title: |
CD33 recruitment inhibits IgE-mediated anaphylaxis and desensitizes mast cells to allergen. |
| Volume: |
129 |
| Issue: |
3 |
| Pages: |
1387-1401 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Griciuc A |
| Year: |
2019 |
| Journal: |
Neuron |
| Title: |
TREM2 Acts Downstream of CD33 in Modulating Microglial Pathology in Alzheimer's Disease. |
| Volume: |
103 |
| Issue: |
5 |
| Pages: |
820-835.e7 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Griciuc A |
| Year: |
2020 |
| Journal: |
Hum Mol Genet |
| Title: |
Gene therapy for Alzheimer's disease targeting CD33 reduces amyloid beta accumulation and neuroinflammation. |
| Volume: |
29 |
| Issue: |
17 |
| Pages: |
2920-2935 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Gnoth K |
| Year: |
2022 |
| Journal: |
Biomolecules |
| Title: |
Evidence for Enhanced Efficacy of Passive Immunotherapy against Beta-Amyloid in CD33-Negative 5xFAD Mice. |
| Volume: |
12 |
| Issue: |
3 |
|
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
Mus caroli |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
Mus pahari |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
Mus spretus |
|
•
•
•
•
•
|
| GXD Expression |
|
| Assay Type: |
In situ reporter (knock in) |
| Annotation Date: |
2021-04-16 |
| Strength: |
Present |
| Sex: |
Male |
| Emaps: |
EMAPS:1876728 |
| Pattern: |
Not Specified |
| Stage: |
TS28 |
| Assay Id: |
MGI:6693248 |
| Age: |
postnatal adult |
| Image: |
JAX_1799893 |
|
| Specimen Label: |
JAX_1799893 |
| Detected: |
true |
| Specimen Num: |
7 |
|
•
•
•
•
•
|
| GXD Expression |
|
| Assay Type: |
In situ reporter (knock in) |
| Annotation Date: |
2021-04-16 |
| Strength: |
Present |
| Sex: |
Male |
| Emaps: |
EMAPS:1737328 |
| Pattern: |
Not Specified |
| Stage: |
TS28 |
| Assay Id: |
MGI:6693248 |
| Age: |
postnatal adult |
| Image: |
JAX_1799894 |
| Note: |
kidney |
| Specimen Label: |
JAX_1799894 |
| Detected: |
true |
| Specimen Num: |
8 |
|
•
•
•
•
•
|
| GXD Expression |
|
| Assay Type: |
In situ reporter (knock in) |
| Annotation Date: |
2021-04-16 |
| Strength: |
Present |
| Sex: |
Female |
| Emaps: |
EMAPS:3267828 |
| Pattern: |
Not Specified |
| Stage: |
TS28 |
| Assay Id: |
MGI:6693248 |
| Age: |
postnatal adult |
| Image: |
JAX_1799888 |
|
| Specimen Label: |
JAX_1799888 |
| Detected: |
true |
| Specimen Num: |
2 |
|
•
•
•
•
•
|
| GXD Expression |
|
| Assay Type: |
In situ reporter (knock in) |
| Annotation Date: |
2021-04-16 |
| Strength: |
Present |
| Sex: |
Female |
| Emaps: |
EMAPS:1754028 |
| Pattern: |
Not Specified |
| Stage: |
TS28 |
| Assay Id: |
MGI:6693248 |
| Age: |
postnatal adult |
| Image: |
JAX_1799887 |
|
| Specimen Label: |
JAX_1799887 |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
|
| Assay Type: |
In situ reporter (knock in) |
| Annotation Date: |
2021-04-16 |
| Strength: |
Present |
| Sex: |
Female |
| Emaps: |
EMAPS:1757728 |
| Pattern: |
Not Specified |
| Stage: |
TS28 |
| Assay Id: |
MGI:6693248 |
| Age: |
postnatal adult |
| Image: |
JAX_1799889 |
|
| Specimen Label: |
JAX_1799889 |
| Detected: |
true |
| Specimen Num: |
3 |
|
•
•
•
•
•
|
| GXD Expression |
|
| Assay Type: |
In situ reporter (knock in) |
| Annotation Date: |
2021-04-16 |
| Strength: |
Present |
| Sex: |
Female |
| Emaps: |
EMAPS:2991528 |
| Pattern: |
Not Specified |
| Stage: |
TS28 |
| Assay Id: |
MGI:6693248 |
| Age: |
postnatal adult |
| Image: |
JAX_1799890 |
|
| Specimen Label: |
JAX_1799890 |
| Detected: |
true |
| Specimen Num: |
4 |
|
•
•
•
•
•
|
| GXD Expression |
|
| Assay Type: |
In situ reporter (knock in) |
| Annotation Date: |
2021-04-16 |
| Strength: |
Present |
| Sex: |
Female |
| Emaps: |
EMAPS:1689428 |
| Pattern: |
Not Specified |
| Stage: |
TS28 |
| Assay Id: |
MGI:6693248 |
| Age: |
postnatal adult |
| Image: |
JAX_1799891 |
|
| Specimen Label: |
JAX_1799891 |
| Detected: |
true |
| Specimen Num: |
5 |
|
•
•
•
•
•
|
| GXD Expression |
|
| Assay Type: |
In situ reporter (knock in) |
| Annotation Date: |
2021-04-16 |
| Strength: |
Present |
| Sex: |
Male |
| Emaps: |
EMAPS:1881228 |
| Pattern: |
Not Specified |
| Stage: |
TS28 |
| Assay Id: |
MGI:6693248 |
| Age: |
postnatal adult |
| Image: |
JAX_1799892 |
|
| Specimen Label: |
JAX_1799892 |
| Detected: |
true |
| Specimen Num: |
6 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Yu Z |
| Year: |
2001 |
| Journal: |
Biochem J |
| Title: |
mSiglec-E, a novel mouse CD33-related siglec (sialic acid-binding immunoglobulin-like lectin) that recruits Src homology 2 (SH2)-domain-containing protein tyrosine phosphatases SHP-1 and SHP-2. |
| Volume: |
353 |
| Issue: |
Pt 3 |
| Pages: |
483-92 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Claude J |
| Year: |
2013 |
| Journal: |
J Neurosci |
| Title: |
Microglial CD33-related Siglec-E inhibits neurotoxicity by preventing the phagocytosis-associated oxidative burst. |
| Volume: |
33 |
| Issue: |
46 |
| Pages: |
18270-6 |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
cattle |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wang X |
| Year: |
2022 |
| Journal: |
Cell Metab |
| Title: |
CD24-Siglec axis is an innate immune checkpoint against metaflammation and metabolic disorder. |
| Volume: |
34 |
| Issue: |
8 |
| Pages: |
1088-1103.e6 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
O'Connell RM |
| Year: |
2010 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
MicroRNAs enriched in hematopoietic stem cells differentially regulate long-term hematopoietic output. |
| Volume: |
107 |
| Issue: |
32 |
| Pages: |
14235-40 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Stubbs L |
| Year: |
1996 |
| Journal: |
Genomics |
| Title: |
Detailed comparative map of human chromosome 19q and related regions of the mouse genome. |
| Volume: |
35 |
| Issue: |
3 |
| Pages: |
499-508 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Sundberg JP |
| Year: |
2017 |
| Journal: |
PLoS One |
| Title: |
Systematic screening for skin, hair, and nail abnormalities in a large-scale knockout mouse program. |
| Volume: |
12 |
| Issue: |
7 |
| Pages: |
e0180682 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Dickinson ME |
| Year: |
2016 |
| Journal: |
Nature |
| Title: |
High-throughput discovery of novel developmental phenotypes. |
| Volume: |
537 |
| Issue: |
7621 |
| Pages: |
508-514 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
The Jackson Laboratory |
| Year: |
2012 |
| Journal: |
MGI Direct Data Submission |
| Title: |
Alleles produced for the KOMP project by The Jackson Laboratory |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Shanghai Model Organisms Center |
| Year: |
2017 |
| Journal: |
MGI Direct Data Submission |
| Title: |
Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Velocigene |
| Year: |
2008 |
| Journal: |
MGI Direct Data Submission |
| Title: |
Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals) |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2005 |
|
| Title: |
Mouse Synonym Curation |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC) |
| Year: |
2014 |
| Journal: |
Database Release |
| Title: |
Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Koscielny G |
| Year: |
2014 |
| Journal: |
Nucleic Acids Res |
| Title: |
The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. |
| Volume: |
42 |
| Issue: |
Database issue |
| Pages: |
D802-9 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Adams DJ |
| Year: |
2024 |
| Journal: |
Nature |
| Title: |
Genetic determinants of micronucleus formation in vivo. |
| Volume: |
627 |
| Issue: |
8002 |
| Pages: |
130-136 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
GemPharmatech |
| Year: |
2020 |
|
| Title: |
GemPharmatech Website. |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
UniProt-GOA |
| Year: |
2012 |
|
| Title: |
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Carninci P |
| Year: |
2005 |
| Journal: |
Science |
| Title: |
The transcriptional landscape of the mammalian genome. |
| Volume: |
309 |
| Issue: |
5740 |
| Pages: |
1559-63 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Okazaki Y |
| Year: |
2002 |
| Journal: |
Nature |
| Title: |
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. |
| Volume: |
420 |
| Issue: |
6915 |
| Pages: |
563-73 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
The Gene Ontology Consortium |
| Year: |
2010 |
|
| Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Diez-Roux G |
| Year: |
2011 |
| Journal: |
PLoS Biol |
| Title: |
A high-resolution anatomical atlas of the transcriptome in the mouse embryo. |
| Volume: |
9 |
| Issue: |
1 |
| Pages: |
e1000582 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
MGI Genome Annotation Group and UniGene Staff |
| Year: |
2015 |
| Journal: |
Database Download |
| Title: |
MGI-UniGene Interconnection Effort |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
| Year: |
2010 |
|
| Title: |
Annotation inferences using phylogenetic trees |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Allen Institute for Brain Science |
| Year: |
2004 |
| Journal: |
Allen Institute |
| Title: |
Allen Brain Atlas: mouse riboprobes |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics |
| Year: |
2010 |
| Journal: |
Database Release |
| Title: |
Protein Ontology Association Load. |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2009 |
| Journal: |
Database Download |
| Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
| Year: |
2000 |
| Journal: |
Database Release |
| Title: |
Entrez Gene Load |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2009 |
| Journal: |
Database Download |
| Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
| Year: |
2010 |
| Journal: |
Database Download |
| Title: |
Consensus CDS project |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Group |
| Year: |
2003 |
| Journal: |
Database Procedure |
| Title: |
Automatic Encodes (AutoE) Reference |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Bairoch A |
| Year: |
1999 |
| Journal: |
Database Release |
| Title: |
SWISS-PROT Annotated protein sequence database |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2005 |
|
| Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2005 |
|
| Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
|
|
|
|
•
•
•
•
•
|
| Allele |
| Name: |
CD33 molecule; endonuclease-mediated mutation 3, Shanghai Model Organisms Center |
| Allele Type: |
Endonuclease-mediated |
| Attribute String: |
Humanized sequence, Inserted expressed sequence |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
cattle |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
dog, domestic |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
frog, African clawed |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ulyanova T |
| Year: |
1999 |
| Journal: |
Eur J Immunol |
| Title: |
The sialoadhesin CD33 is a myeloid-specific inhibitory receptor. |
| Volume: |
29 |
| Issue: |
11 |
| Pages: |
3440-9 |
|
•
•
•
•
•
|
| Allele |
| Name: |
CD33 molecule; endonuclease-mediated mutation 1, Shanghai Model Organisms Center |
| Allele Type: |
Endonuclease-mediated |
| Attribute String: |
Conditional ready, No functional change |
|
•
•
•
•
•
|
| UniProt Feature |
| Begin: |
17 |
| Description: |
Myeloid cell surface antigen CD33 |
| Type: |
chain |
| End: |
403 |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
coisogenic, mutant strain, endonuclease-mediated mutation |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Bhattacherjee A |
| Year: |
2019 |
| Journal: |
Commun Biol |
| Title: |
Repression of phagocytosis by human CD33 is not conserved with mouse CD33. |
| Volume: |
2 |
|
| Pages: |
450 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Bhattacherjee A |
| Year: |
2021 |
| Journal: |
Mol Neurodegener |
| Title: |
The CD33 short isoform is a gain-of-function variant that enhances Aβ(1-42) phagocytosis in microglia. |
| Volume: |
16 |
| Issue: |
1 |
| Pages: |
19 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Eskandari-Sedighi G |
| Year: |
2024 |
| Journal: |
Mol Neurodegener |
| Title: |
Alzheimer's disease associated isoforms of human CD33 distinctively modulate microglial cell responses in 5XFAD mice. |
| Volume: |
19 |
| Issue: |
1 |
| Pages: |
42 |
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| Publication |
| First Author: |
Kim MY |
| Year: |
2018 |
| Journal: |
Cell |
| Title: |
Genetic Inactivation of CD33 in Hematopoietic Stem Cells to Enable CAR T Cell Immunotherapy for Acute Myeloid Leukemia. |
| Volume: |
173 |
| Issue: |
6 |
| Pages: |
1439-1453.e19 |
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| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
403
 |
| Fragment?: |
false |
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•
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| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
334
 |
| Fragment?: |
false |
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| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
240
 |
| Fragment?: |
true |
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| Strain |
| Attribute String: |
coisogenic, mutant strain, endonuclease-mediated mutation |
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| Allele |
| Name: |
CD33 molecule; wild type |
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| Allele |
| Name: |
CD33 molecule; targeted mutation 1, Ajit Varki |
| Allele Type: |
Targeted |
| Attribute String: |
Null/knockout |
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•
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•
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| Allele |
| Name: |
CD33 molecule; targeted mutation 1, Velocigene |
| Allele Type: |
Targeted |
| Attribute String: |
Null/knockout, Reporter |
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•
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| Allele |
| Name: |
CD33 molecule; targeted mutation 1.1, Velocigene |
| Allele Type: |
Targeted |
| Attribute String: |
Null/knockout, Reporter |
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•
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| Allele |
| Name: |
CD33 molecule; endonuclease-mediated mutation 1, Yang Liu |
| Allele Type: |
Endonuclease-mediated |
| Attribute String: |
Null/knockout |
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•
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| Allele |
| Name: |
CD33 molecule; endonuclease-mediated mutation 2, Yang Liu |
| Allele Type: |
Endonuclease-mediated |
| Attribute String: |
Null/knockout |
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| Strain |
| Attribute String: |
targeted mutation, mutant strain, congenic |
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•
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| Strain |
| Attribute String: |
mutant strain, targeted mutation |
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| Strain |
| Attribute String: |
mutant strain, targeted mutation |
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|
| Strain |
| Attribute String: |
mutant strain, coisogenic, targeted mutation |
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| Allele |
| Name: |
CD33 molecule; endonuclease-mediated mutation 1, GemPharmatech Co., Ltd |
| Allele Type: |
Endonuclease-mediated |
| Attribute String: |
Conditional ready, No functional change |
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•
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| Allele |
| Name: |
CD33 molecule; endonuclease-mediated mutation 2, GemPharmatech Co., Ltd |
| Allele Type: |
Endonuclease-mediated |
| Attribute String: |
Null/knockout |
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