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Search results 1 to 100 out of 110 for Cd46

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0.023s
Type Details Score
Gene
Type: gene
Organism: Homo sapiens
Gene
Type: gene
Organism: Rattus norvegicus
Protein Domain
Type: Family
Description: This entry represents a group of membrane cofactor proteins (also known as CD46 or TLX). Human CD46 acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue []. Rat CD46 may be involved in the fusion of the spermatozoa with the oocyte during fertilization [].
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Publication
First Author: Lyzogubov V
Year: 2014
Journal: Am J Pathol
Title: Complement regulatory protein CD46 protects against choroidal neovascularization in mice.
Volume: 184
Issue: 9
Pages: 2537-48
Publication
First Author: Inoue N
Year: 2003
Journal: Mol Cell Biol
Title: Disruption of mouse CD46 causes an accelerated spontaneous acrosome reaction in sperm.
Volume: 23
Issue: 7
Pages: 2614-22
Publication
First Author: Johansson L
Year: 2005
Journal: J Immunol
Title: Human-like immune responses in CD46 transgenic mice.
Volume: 175
Issue: 1
Pages: 433-40
Publication
First Author: Astier A
Year: 2000
Journal: J Immunol
Title: Cutting edge: CD46, a new costimulatory molecule for T cells, that induces p120CBL and LAT phosphorylation.
Volume: 164
Issue: 12
Pages: 6091-5
Publication
First Author: Mizuno M
Year: 2004
Journal: Biol Reprod
Title: Rat membrane cofactor protein (MCP; CD46) is expressed only in the acrosome of developing and mature spermatozoa and mediates binding to immobilized activated C3.
Volume: 71
Issue: 4
Pages: 1374-83
Publication
First Author: Lyzogubov VV
Year: 2016
Journal: Am J Pathol
Title: The Complement Regulatory Protein CD46 Deficient Mouse Spontaneously Develops Dry-Type Age-Related Macular Degeneration-Like Phenotype.
Volume: 186
Issue: 8
Pages: 2088-2104
Publication
First Author: Evlashev A
Year: 2000
Journal: J Virol
Title: Productive measles virus brain infection and apoptosis in CD46 transgenic mice.
Volume: 74
Issue: 3
Pages: 1373-82
Publication  
First Author: Nomura M
Year: 2000
Journal: Biochem J
Title: Identification and characterization of a silencer regulatory element in the 3'-flanking region of the murine CD46 gene.
Volume: 351 Pt 2
Pages: 353-65
Gene
Type: gene
Organism: Homo sapiens
Protein
Organism: Mus musculus
Length: 365  
Fragment?: false
Protein
Organism: Mus musculus
Length: 365  
Fragment?: false
Protein
Organism: Mus musculus
Length: 300  
Fragment?: false
Publication
First Author: Kemper C
Year: 2001
Journal: Clin Exp Immunol
Title: Membrane cofactor protein (MCP; CD46) expression in transgenic mice.
Volume: 124
Issue: 2
Pages: 180-9
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication  
First Author: Tsujimura A
Year: 1998
Journal: Biochem J
Title: Molecular cloning of a murine homologue of membrane cofactor protein (CD46): preferential expression in testicular germ cells.
Volume: 330 ( Pt 1)
Pages: 163-8
Publication
First Author: Nomura M
Year: 1999
Journal: Immunogenetics
Title: Membrane and secretory forms of mouse membrane cofactor protein (CD46) generated from a single gene through alternative splicing.
Volume: 50
Issue: 5-6
Pages: 245-54
Publication
First Author: Liszewski MK
Year: 2000
Journal: J Biol Chem
Title: Dissecting sites important for complement regulatory activity in membrane cofactor protein (MCP; CD46).
Volume: 275
Issue: 48
Pages: 37692-701
GXD Expression      
Probe: MGI:5473668
Assay Type: Northern blot
Annotation Date: 2013-04-10
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1876728
Stage: TS28
Assay Id: MGI:5473710
Age: postnatal adult
Detected: false
Specimen Num: 2
GXD Expression      
Probe: MGI:5473668
Assay Type: Northern blot
Annotation Date: 2013-04-10
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3568928
Stage: TS28
Assay Id: MGI:5473710
Age: embryonic day 10.5
Detected: false
Specimen Num: 4
GXD Expression      
Probe: MGI:5473681
Assay Type: RT-PCR
Annotation Date: 2013-04-10
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3568928
Stage: TS28
Assay Id: MGI:5473711
Age: embryonic day 10.5
Detected: false
Specimen Num: 3
GXD Expression      
Probe: MGI:5473668
Assay Type: Northern blot
Annotation Date: 2013-04-10
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1603917
Stage: TS17
Assay Id: MGI:5473710
Age: embryonic day 10.5
Detected: false
Specimen Num: 3
GXD Expression      
Probe: MGI:5473668
Assay Type: Northern blot
Annotation Date: 2013-04-10
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1797228
Stage: TS28
Assay Id: MGI:5473710
Age: postnatal adult
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:5473681
Assay Type: RT-PCR
Annotation Date: 2013-04-10
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1797228
Stage: TS28
Assay Id: MGI:5473711
Age: postnatal adult
Detected: true
Specimen Num: 5
Publication
First Author: Turnberg D
Year: 2003
Journal: Mol Immunol
Title: The regulation of the complement system: insights from genetically-engineered mice.
Volume: 40
Issue: 2-4
Pages: 145-53
Publication  
First Author: Lu M
Year: 2021
Journal: Proc Natl Acad Sci U S A
Title: A safe and highly efficacious measles virus-based vaccine expressing SARS-CoV-2 stabilized prefusion spike.
Volume: 118
Issue: 12
Publication
First Author: Delano MJ
Year: 2011
Journal: J Immunol
Title: Sepsis induces early alterations in innate immunity that impact mortality to secondary infection.
Volume: 186
Issue: 1
Pages: 195-202
Publication
First Author: Miwa T
Year: 1998
Journal: Immunogenetics
Title: Molecular cloning of rat and mouse membrane cofactor protein (MCP, CD46): preferential expression in testis and close linkage between the mouse Mcp and Cr2 genes on distal chromosome 1.
Volume: 48
Issue: 6
Pages: 363-71
Publication
First Author: Mao D
Year: 2003
Journal: Immunity
Title: Negligible role of antibodies and C5 in pregnancy loss associated exclusively with C3-dependent mechanisms through complement alternative pathway.
Volume: 19
Issue: 6
Pages: 813-22
Publication
First Author: Chen Y
Year: 2005
Journal: J Immunol
Title: Several genes contribute to the production of autoreactive B and T cells in the murine lupus susceptibility locus Sle1c.
Volume: 175
Issue: 2
Pages: 1080-9
Publication  
First Author: Collin GB
Year: 2020
Journal: Cells
Title: Mouse Models of Inherited Retinal Degeneration with Photoreceptor Cell Loss.
Volume: 9
Issue: 4
Publication
First Author: Johansson L
Year: 2003
Journal: Science
Title: CD46 in meningococcal disease.
Volume: 301
Issue: 5631
Pages: 373-5
Publication          
First Author: MGD Nomenclature Committee
Year: 1995
Publication      
First Author: MGI and IMPC
Year: 2018
Journal: Database Release
Title: MGI Load of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC)
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Rat to Mouse ISO GO annotation transfer
Publication
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
Publication      
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
Publication
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
Publication
First Author: Gaudet P
Year: 2011
Journal: Brief Bioinform
Title: Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.
Volume: 12
Issue: 5
Pages: 449-62
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2000
Title: Gene Ontology Annotation by electronic association of SwissProt Keywords with GO terms
Publication      
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
Publication      
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
Publication      
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
Publication      
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
Publication      
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
Publication      
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
Publication
First Author: Grumelli S
Year: 2011
Journal: PLoS One
Title: CD46 protects against chronic obstructive pulmonary disease.
Volume: 6
Issue: 5
Pages: e18785
Publication
First Author: Blixenkrone-Møller M
Year: 1998
Journal: Virology
Title: Role of CD46 in measles virus infection in CD46 transgenic mice.
Volume: 249
Issue: 2
Pages: 238-48
Publication
First Author: Matsui H
Year: 2009
Journal: Infect Immun
Title: CD46 transgenic mouse model of necrotizing fasciitis caused by Streptococcus pyogenes infection.
Volume: 77
Issue: 11
Pages: 4806-14
Publication
First Author: Thorley BR
Year: 1997
Journal: Eur J Immunol
Title: Transgenic expression of a CD46 (membrane cofactor protein) minigene: studies of xenotransplantation and measles virus infection.
Volume: 27
Issue: 3
Pages: 726-34
Allele
Name: CD46 antigen, complement regulatory protein; targeted mutation 1, John P Atkinson
Allele Type: Targeted
Attribute String: Null/knockout
Publication categories: ProxyCollection
Publication  
First Author: Feng Y
Year: 2020
Journal: J Virol
Title: Human Desmoglein-2 and Human CD46 Mediate Human Adenovirus Type 55 Infection, but Human Desmoglein-2 Plays the Major Roles.
Volume: 94
Issue: 17
Allele      
Name: CD46 antigen, complement regulatory protein; wild type
ProxyCollection
Allele
Name: transgene insertion 2, Frank Grosveld
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
Publication categories: ProxyCollection
Publication
First Author: Reynaud JM
Year: 2014
Journal: J Virol
Title: Human herpesvirus 6A infection in CD46 transgenic mice: viral persistence in the brain and increased production of proinflammatory chemokines via Toll-like receptor 9.
Volume: 88
Issue: 10
Pages: 5421-36
Allele
Name: CD46 antigen, complement regulatory protein; endonuclease-mediated mutation 1, Harwell
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
Publication categories: ProxyCollection
Transgene
Type: transgene
Organism: Mus musculus
Strain
Attribute String: congenic, mutant strain, targeted mutation
Genotype
Symbol: Cd46/Cd46
Background: B6.129-Cd46
Zygosity: hm
Has Mutant Allele: true
Publication
First Author: Oldstone MB
Year: 1999
Journal: Cell
Title: Measles virus infection in a transgenic model: virus-induced immunosuppression and central nervous system disease.
Volume: 98
Issue: 5
Pages: 629-40
Allele
Name: CD46 antigen, complement regulatory protein; targeted mutation 1, Research Institute for Microbial Diseases, Osaka University
Allele Type: Targeted
Attribute String: Null/knockout
Publication categories: ProxyCollection
Genotype
Symbol: Cd46/Cd46
Background: involves: 129S2/SvPas * C57BL/6
Zygosity: hm
Has Mutant Allele: true
Publication
First Author: Wang H
Year: 2019
Journal: J Clin Invest
Title: In vivo hematopoietic stem cell gene therapy ameliorates murine thalassemia intermedia.
Volume: 129
Issue: 2
Pages: 598-615
Publication
First Author: Duncan AW
Year: 2010
Journal: Nature
Title: The ploidy conveyor of mature hepatocytes as a source of genetic variation.
Volume: 467
Issue: 7316
Pages: 707-10
Publication
First Author: Yannoutsos N
Year: 1996
Journal: Genes Cells
Title: A membrane cofactor protein transgenic mouse model for the study of discordant xenograft rejection.
Volume: 1
Issue: 4
Pages: 409-19
Publication
First Author: Oldstone MB
Year: 2005
Journal: J Exp Med
Title: A role for dual viral hits in causation of subacute sclerosing panencephalitis.
Volume: 202
Issue: 9
Pages: 1185-90
Publication
First Author: Li C
Year: 2018
Journal: Blood
Title: Reactivation of γ-globin in adult β-YAC mice after ex vivo and in vivo hematopoietic stem cell genome editing.
Volume: 131
Issue: 26
Pages: 2915-2928
Allele
Name: transgene insertion 373, Universitatsspital Zurich, Biologisches Zentrallaboratorium
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
Publication categories: ProxyCollection
Publication
First Author: Mrkic B
Year: 1998
Journal: J Virol
Title: Measles virus spread and pathogenesis in genetically modified mice.
Volume: 72
Issue: 9
Pages: 7420-7
Publication  
First Author: Larocca RA
Year: 2016
Journal: Sci Immunol
Title: Adenovirus serotype 5 vaccine vectors trigger IL-27-dependent inhibitory CD4+ T cell responses that impair CD8+ T cell function.
Volume: 1
Issue: 5
Genotype
Symbol: Tg(CD46)373Zbz/Tg(CD46)373Zbz
Background: involves: C3H/He * C57BL/6
Zygosity: hm
Has Mutant Allele: true
Publication
First Author: Hörner C
Year: 2020
Journal: Proc Natl Acad Sci U S A
Title: A highly immunogenic and effective measles virus-based Th1-biased COVID-19 vaccine.
Volume: 117
Issue: 51
Pages: 32657-32666
Genotype
Symbol: Ifnar1/Ifnar1 Tg(CD46)373Zbz/Tg(CD46)373Zbz
Background: involves: 129S2/SvPas * C3H/He * C57BL/6
Zygosity: cx
Has Mutant Allele: true