Type |
Details |
Score |
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
dog, domestic |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chimpanzee |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
cattle |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
frog, western clawed |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
199
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Cruz-Adalia A |
Year: |
2010 |
Journal: |
Circulation |
Title: |
CD69 limits the severity of cardiomyopathy after autoimmune myocarditis. |
Volume: |
122 |
Issue: |
14 |
Pages: |
1396-404 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lamana A |
Year: |
2006 |
Journal: |
Eur J Immunol |
Title: |
The role of CD69 in acute neutrophil-mediated inflammation. |
Volume: |
36 |
Issue: |
10 |
Pages: |
2632-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lamana A |
Year: |
2011 |
Journal: |
J Invest Dermatol |
Title: |
CD69 modulates sphingosine-1-phosphate-induced migration of skin dendritic cells. |
Volume: |
131 |
Issue: |
7 |
Pages: |
1503-12 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sancho D |
Year: |
2006 |
Journal: |
J Leukoc Biol |
Title: |
CD69 targeting differentially affects the course of collagen-induced arthritis. |
Volume: |
80 |
Issue: |
6 |
Pages: |
1233-41 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hasegawa A |
Year: |
2013 |
Journal: |
PLoS One |
Title: |
Crucial role for CD69 in the pathogenesis of dextran sulphate sodium-induced colitis. |
Volume: |
8 |
Issue: |
6 |
Pages: |
e65494 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mita Y |
Year: |
2018 |
Journal: |
Int Immunol |
Title: |
Crucial role of CD69 in anti-tumor immunity through regulating the exhaustion of tumor-infiltrating T cells. |
Volume: |
30 |
Issue: |
12 |
Pages: |
559-567 |
|
•
•
•
•
•
|
Publication |
First Author: |
Blanco-DomÃnguez R |
Year: |
2022 |
Journal: |
J Clin Invest |
Title: |
CD69 expression on regulatory T cells protects from immune damage after myocardial infarction. |
Volume: |
132 |
Issue: |
21 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Notario L |
Year: |
2016 |
Journal: |
J Virol |
Title: |
CD69 Deficiency Enhances the Host Response to Vaccinia Virus Infection through Altered NK Cell Homeostasis. |
Volume: |
90 |
Issue: |
14 |
Pages: |
6464-74 |
|
•
•
•
•
•
|
Publication |
First Author: |
Miki-Hosokawa T |
Year: |
2009 |
Journal: |
J Immunol |
Title: |
CD69 controls the pathogenesis of allergic airway inflammation. |
Volume: |
183 |
Issue: |
12 |
Pages: |
8203-15 |
|
•
•
•
•
•
|
Publication |
First Author: |
Alari-Pahissa E |
Year: |
2012 |
Journal: |
PLoS One |
Title: |
CD69 does not affect the extent of T cell priming. |
Volume: |
7 |
Issue: |
10 |
Pages: |
e48593 |
|
•
•
•
•
•
|
Publication |
First Author: |
Cortés JR |
Year: |
2014 |
Journal: |
J Autoimmun |
Title: |
Maintenance of immune tolerance by Foxp3+ regulatory T cells requires CD69 expression. |
Volume: |
55 |
|
Pages: |
51-62 |
|
•
•
•
•
•
|
Publication |
First Author: |
de la Fuente H |
Year: |
2014 |
Journal: |
Mol Cell Biol |
Title: |
The leukocyte activation receptor CD69 controls T cell differentiation through its interaction with galectin-1. |
Volume: |
34 |
Issue: |
13 |
Pages: |
2479-87 |
|
•
•
•
•
•
|
Publication |
First Author: |
Shinoda K |
Year: |
2012 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Type II membrane protein CD69 regulates the formation of resting T-helper memory. |
Volume: |
109 |
Issue: |
19 |
Pages: |
7409-14 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ziegler SF |
Year: |
1993 |
Journal: |
Eur J Immunol |
Title: |
Molecular characterization of the early activation antigen CD69: a type II membrane glycoprotein related to a family of natural killer cell activation antigens. |
Volume: |
23 |
Issue: |
7 |
Pages: |
1643-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Feng C |
Year: |
2002 |
Journal: |
Int Immunol |
Title: |
A potential role for CD69 in thymocyte emigration. |
Volume: |
14 |
Issue: |
6 |
Pages: |
535-44 |
|
•
•
•
•
•
|
Publication |
First Author: |
Liappas G |
Year: |
2016 |
Journal: |
J Am Soc Nephrol |
Title: |
Immune-Regulatory Molecule CD69 Controls Peritoneal Fibrosis. |
Volume: |
27 |
Issue: |
12 |
Pages: |
3561-3576 |
|
•
•
•
•
•
|
Publication |
First Author: |
Testi R |
Year: |
1994 |
Journal: |
Immunol Today |
Title: |
The CD69 receptor: a multipurpose cell-surface trigger for hematopoietic cells. |
Volume: |
15 |
Issue: |
10 |
Pages: |
479-83 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sancho D |
Year: |
2003 |
Journal: |
J Clin Invest |
Title: |
CD69 downregulates autoimmune reactivity through active transforming growth factor-beta production in collagen-induced arthritis. |
Volume: |
112 |
Issue: |
6 |
Pages: |
872-82 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kimura MY |
Year: |
2018 |
Journal: |
Nat Commun |
Title: |
CD69 prevents PLZFhi innate precursors from prematurely exiting the thymus and aborting NKT2 cell differentiation. |
Volume: |
9 |
Issue: |
1 |
Pages: |
3749 |
|
•
•
•
•
•
|
Publication |
First Author: |
Nakayama T |
Year: |
2002 |
Journal: |
J Immunol |
Title: |
The generation of mature, single-positive thymocytes in vivo is dysregulated by CD69 blockade or overexpression. |
Volume: |
168 |
Issue: |
1 |
Pages: |
87-94 |
|
•
•
•
•
•
|
Publication |
First Author: |
Cambiaggi C |
Year: |
1992 |
Journal: |
Immunogenetics |
Title: |
Constitutive expression of CD69 in interspecies T-cell hybrids and locus assignment to human chromosome 12. |
Volume: |
36 |
Issue: |
2 |
Pages: |
117-20 |
|
•
•
•
•
•
|
Publication |
First Author: |
Nakai S |
Year: |
2023 |
Journal: |
J Invest Dermatol |
Title: |
CD69 Is Indispensable for Development of Functional Local Immune Memory in Murine Contact Hypersensitivity. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Radulovic K |
Year: |
2013 |
Journal: |
PLoS One |
Title: |
The early activation marker CD69 regulates the expression of chemokines and CD4 T cell accumulation in intestine. |
Volume: |
8 |
Issue: |
6 |
Pages: |
e65413 |
|
•
•
•
•
•
|
Publication |
First Author: |
MartÃn P |
Year: |
2011 |
Journal: |
Sci Signal |
Title: |
CD69: an unexpected regulator of TH17 cell-driven inflammatory responses. |
Volume: |
4 |
Issue: |
165 |
Pages: |
pe14 |
|
•
•
•
•
•
|
Publication |
First Author: |
Murata K |
Year: |
2003 |
Journal: |
Int Immunol |
Title: |
CD69-null mice protected from arthritis induced with anti-type II collagen antibodies. |
Volume: |
15 |
Issue: |
8 |
Pages: |
987-92 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lauzurica P |
Year: |
2000 |
Journal: |
Blood |
Title: |
Phenotypic and functional characteristics of hematopoietic cell lineages in CD69-deficient mice. |
Volume: |
95 |
Issue: |
7 |
Pages: |
2312-20 |
|
•
•
•
•
•
|
Publication |
First Author: |
Shiow LR |
Year: |
2006 |
Journal: |
Nature |
Title: |
CD69 acts downstream of interferon-alpha/beta to inhibit S1P1 and lymphocyte egress from lymphoid organs. |
Volume: |
440 |
Issue: |
7083 |
Pages: |
540-4 |
|
•
•
•
•
•
|
Publication |
First Author: |
Brändle D |
Year: |
1994 |
Journal: |
Eur J Immunol |
Title: |
Regulation of RAG-1 and CD69 expression in the thymus during positive and negative selection. |
Volume: |
24 |
Issue: |
1 |
Pages: |
145-51 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bankovich AJ |
Year: |
2010 |
Journal: |
J Biol Chem |
Title: |
CD69 suppresses sphingosine 1-phosophate receptor-1 (S1P1) function through interaction with membrane helix 4. |
Volume: |
285 |
Issue: |
29 |
Pages: |
22328-37 |
|
•
•
•
•
•
|
Publication |
First Author: |
Radulovic K |
Year: |
2012 |
Journal: |
J Immunol |
Title: |
CD69 regulates type I IFN-induced tolerogenic signals to mucosal CD4 T cells that attenuate their colitogenic potential. |
Volume: |
188 |
Issue: |
4 |
Pages: |
2001-13 |
|
•
•
•
•
•
|
Publication |
First Author: |
Marzio R |
Year: |
1997 |
Journal: |
J Leukoc Biol |
Title: |
Expression and function of the early activation antigen CD69 in murine macrophages. |
Volume: |
62 |
Issue: |
3 |
Pages: |
349-55 |
|
•
•
•
•
•
|
Publication |
First Author: |
Siggs OM |
Year: |
2014 |
Journal: |
Immunology |
Title: |
A ZAP-70 kinase domain variant prevents thymocyte-positive selection despite signalling CD69 induction. |
Volume: |
141 |
Issue: |
4 |
Pages: |
587-95 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sánchez-DÃaz R |
Year: |
2017 |
Journal: |
Mol Cell Biol |
Title: |
Thymus-Derived Regulatory T Cell Development Is Regulated by C-Type Lectin-Mediated BIC/MicroRNA 155 Expression. |
Volume: |
37 |
Issue: |
9 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Miyamoto Y |
Year: |
2016 |
Journal: |
Nat Commun |
Title: |
VCAM1 acts in parallel with CD69 and is required for the initiation of oligodendrocyte myelination. |
Volume: |
7 |
|
Pages: |
13478 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gómez M |
Year: |
2009 |
Journal: |
Cardiovasc Res |
Title: |
Atherosclerosis development in apolipoprotein E-null mice deficient for CD69. |
Volume: |
81 |
Issue: |
1 |
Pages: |
197-205 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ziegler SF |
Year: |
1994 |
Journal: |
J Immunol |
Title: |
The mouse CD69 gene. Structure, expression, and mapping to the NK gene complex. |
Volume: |
152 |
Issue: |
3 |
Pages: |
1228-36 |
|
•
•
•
•
•
|
Publication |
First Author: |
Llera AS |
Year: |
2001 |
Journal: |
J Biol Chem |
Title: |
Crystal structure of the C-type lectin-like domain from the human hematopoietic cell receptor CD69. |
Volume: |
276 |
Issue: |
10 |
Pages: |
7312-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yim D |
Year: |
2002 |
Journal: |
Immunogenetics |
Title: |
Molecular cloning, expression pattern and chromosomal mapping of pig CD69. |
Volume: |
54 |
Issue: |
4 |
Pages: |
276-81 |
|
•
•
•
•
•
|
Publication |
First Author: |
Takamura S |
Year: |
2016 |
Journal: |
J Exp Med |
Title: |
Specific niches for lung-resident memory CD8+ T cells at the site of tissue regeneration enable CD69-independent maintenance. |
Volume: |
213 |
Issue: |
13 |
Pages: |
3057-3073 |
|
•
•
•
•
•
|
Publication |
First Author: |
Swan DJ |
Year: |
2012 |
Journal: |
PLoS One |
Title: |
Post-transplant immunosuppression: regulation of the efflux of allospecific effector T cells from lymphoid tissues. |
Volume: |
7 |
Issue: |
9 |
Pages: |
e45548 |
|
•
•
•
•
•
|
Publication |
First Author: |
López-Cabrera M |
Year: |
1993 |
Journal: |
J Exp Med |
Title: |
Molecular cloning, expression, and chromosomal localization of the human earliest lymphocyte activation antigen AIM/CD69, a new member of the C-type animal lectin superfamily of signal-transmitting receptors. |
Volume: |
178 |
Issue: |
2 |
Pages: |
537-47 |
|
•
•
•
•
•
|
Publication |
First Author: |
Padigel UM |
Year: |
2006 |
Journal: |
Infect Immun |
Title: |
Eosinophils can function as antigen-presenting cells to induce primary and secondary immune responses to Strongyloides stercoralis. |
Volume: |
74 |
Issue: |
6 |
Pages: |
3232-8 |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus caroli |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus pahari |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus spretus |
|
•
•
•
•
•
|
Publication |
First Author: |
Yokoyama WM |
Year: |
1988 |
Journal: |
J Immunol |
Title: |
Characterization of a cell surface-expressed disulfide-linked dimer involved in murine T cell activation. |
Volume: |
141 |
Issue: |
2 |
Pages: |
369-76 |
|
•
•
•
•
•
|
Publication |
First Author: |
Grigorova IL |
Year: |
2010 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Lymph node cortical sinus organization and relationship to lymphocyte egress dynamics and antigen exposure. |
Volume: |
107 |
Issue: |
47 |
Pages: |
20447-52 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lee YT |
Year: |
2011 |
Journal: |
J Virol |
Title: |
Environmental and antigen receptor-derived signals support sustained surveillance of the lungs by pathogen-specific cytotoxic T lymphocytes. |
Volume: |
85 |
Issue: |
9 |
Pages: |
4085-94 |
|
•
•
•
•
•
|
Publication |
First Author: |
Fang M |
Year: |
2011 |
Journal: |
Immunity |
Title: |
CD94 is essential for NK cell-mediated resistance to a lethal viral disease. |
Volume: |
34 |
Issue: |
4 |
Pages: |
579-89 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kimura H |
Year: |
2017 |
Journal: |
J Immunol |
Title: |
Orchestrating Role of Apoptosis Inhibitor of Macrophage in the Resolution of Acute Lung Injury. |
Volume: |
199 |
Issue: |
11 |
Pages: |
3870-3882 |
|
•
•
•
•
•
|
Publication |
First Author: |
Patel SN |
Year: |
2007 |
Journal: |
J Immunol |
Title: |
Disruption of CD36 impairs cytokine response to Plasmodium falciparum glycosylphosphatidylinositol and confers susceptibility to severe and fatal malaria in vivo. |
Volume: |
178 |
Issue: |
6 |
Pages: |
3954-61 |
|
•
•
•
•
•
|
Publication |
First Author: |
Han Y |
Year: |
2009 |
Journal: |
J Immunol |
Title: |
CD69+ CD4+ CD25- T cells, a new subset of regulatory T cells, suppress T cell proliferation through membrane-bound TGF-beta 1. |
Volume: |
182 |
Issue: |
1 |
Pages: |
111-20 |
|
•
•
•
•
•
|
Publication |
First Author: |
Laidlaw BJ |
Year: |
2019 |
Journal: |
J Exp Med |
Title: |
Sphingosine-1-phosphate receptor 2 restrains egress of γδ T cells from the skin. |
Volume: |
216 |
Issue: |
7 |
Pages: |
1487-1496 |
|
•
•
•
•
•
|
Publication |
First Author: |
Park SL |
Year: |
2019 |
Journal: |
Nature |
Title: |
Tissue-resident memory CD8+ T cells promote melanoma-immune equilibrium in skin. |
Volume: |
565 |
Issue: |
7739 |
Pages: |
366-371 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kamanaka M |
Year: |
2006 |
Journal: |
Immunity |
Title: |
Expression of interleukin-10 in intestinal lymphocytes detected by an interleukin-10 reporter knockin tiger mouse. |
Volume: |
25 |
Issue: |
6 |
Pages: |
941-52 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ramos-Perez WD |
Year: |
2015 |
Journal: |
Nat Immunol |
Title: |
A map of the distribution of sphingosine 1-phosphate in the spleen. |
Volume: |
16 |
Issue: |
12 |
Pages: |
1245-52 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gyetko MR |
Year: |
1999 |
Journal: |
J Lab Clin Med |
Title: |
Urokinase is required for T lymphocyte proliferation and activation in vitro. |
Volume: |
133 |
Issue: |
3 |
Pages: |
274-88 |
|
•
•
•
•
•
|
Allele |
Name: |
CD69 antigen; targeted mutation 1, Francisco Sanchez-Madrid |
Allele Type: |
Targeted |
Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
Publication |
First Author: |
Fang V |
Year: |
2017 |
Journal: |
Nat Immunol |
Title: |
Gradients of the signaling lipid S1P in lymph nodes position natural killer cells and regulate their interferon-γ response. |
Volume: |
18 |
Issue: |
1 |
Pages: |
15-25 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ishikawa S |
Year: |
2004 |
Journal: |
Int Immunol |
Title: |
Involvement of FcRgamma in signal transduction of osteoclast-associated receptor (OSCAR). |
Volume: |
16 |
Issue: |
7 |
Pages: |
1019-25 |
|
•
•
•
•
•
|
Publication |
First Author: |
Aprahamian T |
Year: |
2009 |
Journal: |
J Immunol |
Title: |
The peroxisome proliferator-activated receptor gamma agonist rosiglitazone ameliorates murine lupus by induction of adiponectin. |
Volume: |
182 |
Issue: |
1 |
Pages: |
340-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Stegmann KA |
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