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Search results 1 to 100 out of 4567 for Cdc42

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Type Details Score
Protein Domain
Type: Family
Description: Cdc42 is an essential GTPase that belongs to the Rho family of Ras-like GTPases. These proteins act as molecular switches by responding to exogenous and/or endogenous signals and relaying those signals to activate downstream components of a biological pathway. Cdc42 transduces signals to the actin cytoskeleton to initiate and maintain polarized growth and to mitogen-activated protein morphogenesis. In Saccharomyces cerevisiae, Cdc42 plays an important role in multiple actin-dependent morphogenetic events such as bud emergence, mating-projection formation, and pseudohyphal growth []. In mammalian cells, Cdc42 regulates a variety of actin-dependent events and induces the JNK/SAPK protein kinase cascade, which leads to the activation of transcription factors within the nucleus []. Cdc42 mediates these processes through interactions with a myriad of downstream effectors, whose number and regulation we are just starting to understand. In addition, Cdc42 has been implicated in a number of human diseases through interactions with its regulators and downstream effectors [].
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: chicken
Gene
Type: gene
Organism: zebrafish
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: frog, western clawed
Gene
Type: gene
Organism: dog, domestic
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: chimpanzee
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Publication
First Author: Tetley GJN
Year: 2017
Journal: J Biol Chem
Title: A dock and coalesce mechanism driven by hydrophobic interactions governs Cdc42 binding with its effector protein ACK.
Volume: 292
Issue: 27
Pages: 11361-11373
Publication
First Author: Johnson DI
Year: 1999
Journal: Microbiol Mol Biol Rev
Title: Cdc42: An essential Rho-type GTPase controlling eukaryotic cell polarity.
Volume: 63
Issue: 1
Pages: 54-105
Publication
First Author: Bi E
Year: 2000
Journal: Mol Biol Cell
Title: Identification of novel, evolutionarily conserved Cdc42p-interacting proteins and of redundant pathways linking Cdc24p and Cdc42p to actin polarization in yeast.
Volume: 11
Issue: 2
Pages: 773-93
Publication
First Author: Hirsch DS
Year: 2001
Journal: J Biol Chem
Title: A new family of Cdc42 effector proteins, CEPs, function in fibroblast and epithelial cell shape changes.
Volume: 276
Issue: 2
Pages: 875-83
GXD Expression
Probe: MGI:6379644
Assay Type: Immunohistochemistry
Annotation Date: 2019-12-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3799115
Pattern: Regionally restricted
Stage: TS15
Assay Id: MGI:6379665
Age: embryonic day 9.5
Image: 11 Cdc42 WT
Note: Expression localized mainly at anterior migratory front of cardiac neural crest cells (CNCC). Expression accumulates at edge of cells in stream of CNCC migrating along outflow tract, but not in CNCC within pharyngeal arches.
Specimen Label: 11 Cdc42 WT
Detected: true
Specimen Num: 1
GXD Expression
Probe: MGI:6379644
Assay Type: Immunohistochemistry
Annotation Date: 2019-12-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3799115
Pattern: Regionally restricted
Stage: TS15
Assay Id: MGI:6379665
Age: embryonic day 9.5
Image: 11 Cdc42 Ednra-/-
Note: Expression fails to localize at leading edges of migrating cardiac neural crest cells (CNCC).
Specimen Label: 11 Cdc42 Ednra-/-
Detected: true
Specimen Num: 2
Publication
First Author: Joberty G
Year: 1999
Journal: Mol Cell Biol
Title: The Borgs, a new family of Cdc42 and TC10 GTPase-interacting proteins.
Volume: 19
Issue: 10
Pages: 6585-97
Protein
Organism: Mus musculus/domesticus
Length: 191  
Fragment?: false
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: human
Publication
First Author: Reddy-Alla S
Year: 2010
Journal: Eur J Neurosci
Title: PH-domain-driven targeting of collybistin but not Cdc42 activation is required for synaptic gephyrin clustering.
Volume: 31
Issue: 7
Pages: 1173-84
Publication
First Author: Schnack C
Year: 2008
Journal: Neuroscience
Title: Protein array analysis of oligomerization-induced changes in alpha-synuclein protein-protein interactions points to an interference with Cdc42 effector proteins.
Volume: 154
Issue: 4
Pages: 1450-7
GO Term
Publication
First Author: Lee K
Year: 2013
Journal: Infect Immun
Title: Cdc42 promotes host defenses against fatal infection.
Volume: 81
Issue: 8
Pages: 2714-23
Publication
First Author: Allen WE
Year: 1998
Journal: J Cell Biol
Title: A role for Cdc42 in macrophage chemotaxis.
Volume: 141
Issue: 5
Pages: 1147-57
Publication
First Author: Nalbant P
Year: 2004
Journal: Science
Title: Activation of endogenous Cdc42 visualized in living cells.
Volume: 305
Issue: 5690
Pages: 1615-9
Publication
First Author: Aizawa R
Year: 2019
Journal: Biochem Biophys Res Commun
Title: Cdc42 regulates cranial suture morphogenesis and ossification.
Volume: 512
Issue: 2
Pages: 145-149
Publication
First Author: Yang L
Year: 2007
Journal: Blood
Title: Cdc42 critically regulates the balance between myelopoiesis and erythropoiesis.
Volume: 110
Issue: 12
Pages: 3853-61
Publication
First Author: Suzuki W
Year: 2015
Journal: Endocrinology
Title: Cdc42 is critical for cartilage development during endochondral ossification.
Volume: 156
Issue: 1
Pages: 314-22
Publication
First Author: Chen L
Year: 2006
Journal: Proc Natl Acad Sci U S A
Title: Cdc42 deficiency causes Sonic hedgehog-independent holoprosencephaly.
Volume: 103
Issue: 44
Pages: 16520-5
Publication
First Author: Sakamori R
Year: 2014
Journal: Cancer Res
Title: CDC42 inhibition suppresses progression of incipient intestinal tumors.
Volume: 74
Issue: 19
Pages: 5480-92
GXD Expression    
Probe: MGI:6169436
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689419
Pattern: Not Specified
Stage: TS19
Assay Id: MGI:6189932
Age: embryonic day 11.5
Specimen Label: Table S2 - E11.5 - Cdc42
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:6169436
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689421
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:6189932
Age: embryonic day 13.5
Specimen Label: Table S2 - E13.5 - Cdc42
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:6169436
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689424
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:6189932
Age: embryonic day 15.5
Specimen Label: Table S2 - E15.5 - Cdc42
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:6169436
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689426
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:6189932
Age: embryonic day 18.5
Specimen Label: Table S2 - E18.5 - Cdc42
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:6169436
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6189932
Age: postnatal day 4
Specimen Label: Table S2 - P4 - Cdc42
Detected: true
Specimen Num: 5
GXD Expression    
Probe: MGI:6169436
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6189932
Age: postnatal day 14
Specimen Label: Table S2 - P14 - Cdc42
Detected: true
Specimen Num: 6
GXD Expression    
Probe: MGI:6169436
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6189932
Age: postnatal day 28
Specimen Label: Table S2 - P28 - Cdc42
Detected: true
Specimen Num: 7
Publication
First Author: Mohammadi S
Year: 2013
Journal: J Cell Biol
Title: Cdc42 interacts with the exocyst complex to promote phagocytosis.
Volume: 200
Issue: 1
Pages: 81-93
Publication
First Author: Luckashenak N
Year: 2013
Journal: J Immunol
Title: Rho-family GTPase Cdc42 controls migration of Langerhans cells in vivo.
Volume: 190
Issue: 1
Pages: 27-35
Publication
First Author: Nagahama R
Year: 2016
Journal: Biochem Biophys Res Commun
Title: Rho GTPase protein Cdc42 is critical for postnatal cartilage development.
Volume: 470
Issue: 4
Pages: 813-7
Publication  
First Author: Yoshida Y
Year: 2021
Journal: Dev Biol
Title: Cdc42 has important roles in postnatal angiogenesis and vasculature formation.
Volume: 477
Pages: 64-69
Publication
First Author: Choi SY
Year: 2013
Journal: J Am Soc Nephrol
Title: Cdc42 deficiency causes ciliary abnormalities and cystic kidneys.
Volume: 24
Issue: 9
Pages: 1435-50
Publication
First Author: Han JS
Year: 2000
Journal: Exp Mol Med
Title: Molecular cloning and sequencing of rat Cdc42 GTPase cDNA.
Volume: 32
Issue: 3
Pages: 115-9
Publication
First Author: Mori Y
Year: 2021
Journal: Cell Rep
Title: Cdc42 is required for male germline niche development in mice.
Volume: 36
Issue: 7
Pages: 109550
Publication
First Author: Gong TW
Year: 1997
Journal: Biochim Biophys Acta
Title: Complete cDNAs for CDC42 from chicken cochlea and mouse liver.
Volume: 1352
Issue: 3
Pages: 282-92
Publication
First Author: Guo F
Year: 2009
Journal: Blood
Title: Rho GTPase Cdc42 is essential for B-lymphocyte development and activation.
Volume: 114
Issue: 14
Pages: 2909-16
Publication
First Author: Ito TK
Year: 2014
Journal: PLoS One
Title: A crucial role for CDC42 in senescence-associated inflammation and atherosclerosis.
Volume: 9
Issue: 7
Pages: e102186
Publication
First Author: Roney KE
Year: 2011
Journal: PLoS One
Title: Plexin-B2 negatively regulates macrophage motility, Rac, and Cdc42 activation.
Volume: 6
Issue: 9
Pages: e24795
Publication
First Author: Maillet M
Year: 2009
Journal: J Clin Invest
Title: Cdc42 is an antihypertrophic molecular switch in the mouse heart.
Volume: 119
Issue: 10
Pages: 3079-88
Publication
First Author: Garvalov BK
Year: 2007
Journal: J Neurosci
Title: Cdc42 regulates cofilin during the establishment of neuronal polarity.
Volume: 27
Issue: 48
Pages: 13117-29
Publication  
First Author: Heynen SR
Year: 2011
Journal: Mol Vis
Title: Retinal degeneration modulates intracellular localization of CDC42 in photoreceptors.
Volume: 17
Pages: 2934-46
Publication
First Author: Wang JB
Year: 2005
Journal: J Biol Chem
Title: Cdc42 and Ras cooperate to mediate cellular transformation by intersectin-L.
Volume: 280
Issue: 24
Pages: 22883-91
Publication
First Author: Wu X
Year: 2006
Journal: Genes Dev
Title: Cdc42 controls progenitor cell differentiation and beta-catenin turnover in skin.
Volume: 20
Issue: 5
Pages: 571-85
Publication
First Author: Zheng J
Year: 2018
Journal: J Dent Res
Title: Epithelial Cdc42 Deletion Induced Enamel Organ Defects and Cystogenesis.
Volume: 97
Issue: 12
Pages: 1346-1354
Publication
First Author: Nishikimi A
Year: 2005
Journal: FEBS Lett
Title: Zizimin2: a novel, DOCK180-related Cdc42 guanine nucleotide exchange factor expressed predominantly in lymphocytes.
Volume: 579
Issue: 5
Pages: 1039-46
Publication  
First Author: Laviña B
Year: 2018
Journal: Development
Title: Defective endothelial cell migration in the absence of Cdc42 leads to capillary-venous malformations.
Volume: 145
Issue: 13
Publication
First Author: Shitara A
Year: 2019
Journal: Mol Biol Cell
Title: Cdc42 negatively regulates endocytosis during apical membrane maintenance in live animals.
Volume: 30
Issue: 3
Pages: 324-332
Publication
First Author: Tokizane K
Year: 2017
Journal: Glia
Title: Phospholipid localization implies microglial morphology and function via Cdc42 in vitro.
Volume: 65
Issue: 5
Pages: 740-755
Publication
First Author: Shen Y
Year: 2008
Journal: Dev Cell
Title: Nudel binds Cdc42GAP to modulate Cdc42 activity at the leading edge of migrating cells.
Volume: 14
Issue: 3
Pages: 342-53
Publication
First Author: Heinrich A
Year: 2021
Journal: Cell Rep
Title: Cdc42 activity in Sertoli cells is essential for maintenance of spermatogenesis.
Volume: 37
Issue: 4
Pages: 109885
Publication
First Author: Jin D
Year: 2015
Journal: Biochem J
Title: Functional cross-talk between Cdc42 and two downstream targets, Par6B and PAK4.
Volume: 467
Issue: 2
Pages: 293-302
Publication  
First Author: Oshima-Nakayama M
Year: 2016
Journal: Bone Rep
Title: Cdc42 is crucial for facial and palatal formation during craniofacial development.
Volume: 5
Pages: 1-6
Publication
First Author: Mizukawa B
Year: 2017
Journal: Blood
Title: The cell polarity determinant CDC42 controls division symmetry to block leukemia cell differentiation.
Volume: 130
Issue: 11
Pages: 1336-1346
Publication
First Author: Wirth A
Year: 2013
Journal: Biochem J
Title: Dual lipidation of the brain-specific Cdc42 isoform regulates its functional properties.
Volume: 456
Issue: 3
Pages: 311-22
Publication
First Author: Kholmanskikh SS
Year: 2006
Journal: Nat Neurosci
Title: Calcium-dependent interaction of Lis1 with IQGAP1 and Cdc42 promotes neuronal motility.
Volume: 9
Issue: 1
Pages: 50-7
Publication  
First Author: Ma Y
Year: 2021
Journal: Development
Title: Ror2-mediated non-canonical Wnt signaling regulates Cdc42 and cell proliferation during tooth root development.
Volume: 148
Issue: 2
Publication
First Author: Bruurs LJ
Year: 2015
Journal: J Cell Biol
Title: ATP8B1-mediated spatial organization of Cdc42 signaling maintains singularity during enterocyte polarization.
Volume: 210
Issue: 7
Pages: 1055-63
Publication
First Author: Blattner SM
Year: 2013
Journal: Kidney Int
Title: Divergent functions of the Rho GTPases Rac1 and Cdc42 in podocyte injury.
Volume: 84
Issue: 5
Pages: 920-30
Publication  
First Author: Sakamoto I
Year: 2018
Journal: Exp Neurol
Title: Roles of Cdc42 and Rac in Bergmann glia during cerebellar corticogenesis.
Volume: 302
Pages: 57-67
Publication
First Author: Szczur K
Year: 2009
Journal: Blood
Title: The small Rho GTPase Cdc42 regulates neutrophil polarity via CD11b integrin signaling.
Volume: 114
Issue: 20
Pages: 4527-37
Publication
First Author: Kumar S
Year: 2012
Journal: Blood
Title: Cdc42 regulates neutrophil migration via crosstalk between WASp, CD11b, and microtubules.
Volume: 120
Issue: 17
Pages: 3563-74
Publication
First Author: Fantin A
Year: 2015
Journal: Cell Rep
Title: NRP1 Regulates CDC42 Activation to Promote Filopodia Formation in Endothelial Tip Cells.
Volume: 11
Issue: 10
Pages: 1577-90
Publication
First Author: Wan H
Year: 2013
Journal: Dev Biol
Title: CDC42 is required for structural patterning of the lung during development.
Volume: 374
Issue: 1
Pages: 46-57
Publication
First Author: Yang L
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: Rho GTPase Cdc42 coordinates hematopoietic stem cell quiescence and niche interaction in the bone marrow.
Volume: 104
Issue: 12
Pages: 5091-6
Publication
First Author: Gamell C
Year: 2008
Journal: J Cell Sci
Title: BMP2 induction of actin cytoskeleton reorganization and cell migration requires PI3-kinase and Cdc42 activity.
Volume: 121
Issue: Pt 23
Pages: 3960-70
Publication
First Author: Nalapareddy K
Year: 2021
Journal: iScience
Title: Suppression of elevated Cdc42 activity promotes the regenerative potential of aged intestinal stem cells.
Volume: 24
Issue: 4
Pages: 102362
Publication
First Author: Cappello S
Year: 2006
Journal: Nat Neurosci
Title: The Rho-GTPase cdc42 regulates neural progenitor fate at the apical surface.
Volume: 9
Issue: 9
Pages: 1099-107
Publication
First Author: Ikehata M
Year: 2018
Journal: Biochem Biophys Res Commun
Title: Cooperation of Rho family proteins Rac1 and Cdc42 in cartilage development and calcified tissue formation.
Volume: 500
Issue: 3
Pages: 525-529
Publication
First Author: Wu X
Year: 2007
Journal: Dev Dyn
Title: Cdc42 is crucial for the establishment of epithelial polarity during early mammalian development.
Volume: 236
Issue: 10
Pages: 2767-78
Publication
First Author: Vadodaria KC
Year: 2013
Journal: J Neurosci
Title: Stage-specific functions of the small Rho GTPases Cdc42 and Rac1 for adult hippocampal neurogenesis.
Volume: 33
Issue: 3
Pages: 1179-89
Publication
First Author: Tskvitaria-Fuller I
Year: 2006
Journal: J Immunol
Title: Specific patterns of Cdc42 activity are related to distinct elements of T cell polarization.
Volume: 177
Issue: 3
Pages: 1708-20
Protein
Organism: Mus musculus/domesticus
Length: 409  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 254  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 150  
Fragment?: false