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Search results 1 to 100 out of 902 for Cdk4

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Type Details Score
Gene
1019 | CDK4
Type: gene
Organism: human
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Gene
481131 | CDK4
Type: gene
Organism: dog, domestic
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Gene
510618 | CDK4
Type: gene
Organism: cattle
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Gene
777730 | cdk4
Type: gene
Organism: zebrafish
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Gene
715650 | CDK4
Type: gene
Organism: macaque, rhesus
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Gene
549496 | cdk4
Type: gene
Organism: frog, western clawed
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Gene
94201 | Cdk4
Type: gene
Organism: rat
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Gene
452025 | CDK4
Type: gene
Organism: chimpanzee
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Protein Coding Gene
MGI:88357 | Cdk4
Type: protein_coding_gene
Organism: mouse, laboratory
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GXD Expression
GXD Expression
   
Probe: MGI:4354231
Assay Type: RNA in situ
Annotation Date: 2009-08-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3270422
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:4354734
Age: embryonic day 14.5
Specimen Label: Table S5 - Cdk4
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:4354231
Assay Type: RNA in situ
Annotation Date: 2009-08-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3271122
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:4354734
Age: embryonic day 14.5
Note: Expression is present in the upper and lower cortical plate.
Specimen Label: Table S5 - Cdk4
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:4354231
Assay Type: RNA in situ
Annotation Date: 2009-08-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754722
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:4354734
Age: embryonic day 14.5
Specimen Label: Table S5 - Cdk4
Detected: true
Specimen Num: 1
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Publication
16213226 | J:129675
First Author: Abella A
Year: 2005
Journal: Cell Metab
Title: Cdk4 promotes adipogenesis through PPARgamma activation.
Volume: 2
Issue: 4
Pages: 239-49
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Publication
19383288 | J:125217
First Author: Barrière C
Year: 2007
Journal: Mol Oncol
Title: Mice thrive without Cdk4 and Cdk2.
Volume: 1
Issue: 1
Pages: 72-83
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Publication
16413469 | J:105043
First Author: Yu Q
Year: 2006
Journal: Cancer Cell
Title: Requirement for CDK4 kinase function in breast cancer.
Volume: 9
Issue: 1
Pages: 23-32
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Publication
10319860 | J:54534
First Author: Rane SG
Year: 1999
Journal: Nat Genet
Title: Loss of Cdk4 expression causes insulin-deficient diabetes and Cdk4 activation results in beta-islet cell hyperplasia.
Volume: 22
Issue: 1
Pages: 44-52
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Publication
27373160 | J:238582
First Author: Jin J
Year: 2016
Journal: Cell Rep
Title: Activation of CDK4 Triggers Development of Non-alcoholic Fatty Liver Disease.
Volume: 16
Issue: 3
Pages: 744-56
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Publication
30485818 | J:271066
First Author: Ruiz-Estevez M
Year: 2018
Journal: Cell Rep
Title: Promotion of Myoblast Differentiation by Fkbp5 via Cdk4 Isomerization.
Volume: 25
Issue: 9
Pages: 2537-2551.e8
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Publication
10688915 | J:60924
First Author: Hermeking H
Year: 2000
Journal: Proc Natl Acad Sci U S A
Title: Identification of CDK4 as a target of c-MYC.
Volume: 97
Issue: 5
Pages: 2229-34
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Publication
24614102 | J:209613
First Author: Lu Y
Year: 2014
Journal: J Clin Invest
Title: CDK4 deficiency promotes genomic instability and enhances Myc-driven lymphomagenesis.
Volume: 124
Issue: 4
Pages: 1672-84
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Publication
15456744 | J:95201
First Author: Jirawatnotai S
Year: 2004
Journal: J Biol Chem
Title: Cdk4 is indispensable for postnatal proliferation of the anterior pituitary.
Volume: 279
Issue: 49
Pages: 51100-6
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Publication
21844184 | J:176420
First Author: Ciznadija D
Year: 2011
Journal: Cancer Res
Title: Cyclin D1 and cdk4 mediate development of neurologically destructive oligodendroglioma.
Volume: 71
Issue: 19
Pages: 6174-83
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Publication
11867521 | J:115360
First Author: Wang H
Year: 2002
Journal: EMBO J
Title: C/EBPalpha triggers proteasome-dependent degradation of cdk4 during growth arrest.
Volume: 21
Issue: 5
Pages: 930-41
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Publication
18311721 | J:131845
First Author: Ciemerych MA
Year: 2008
Journal: Int J Dev Biol
Title: CDK4 activity in mouse embryos expressing a single D-type cyclin.
Volume: 52
Issue: 2-3
Pages: 299-305
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Publication
26657864 | J:230033
First Author: Lagarrigue S
Year: 2016
Journal: J Clin Invest
Title: CDK4 is an essential insulin effector in adipocytes.
Volume: 126
Issue: 1
Pages: 335-48
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Publication
32657019 | J:313056
First Author: Castillo-Armengol J
Year: 2020
Journal: EMBO Rep
Title: Hypothalamic CDK4 regulates thermogenesis by modulating sympathetic innervation of adipose tissues.
Volume: 21
Issue: 9
Pages: e49807
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Publication
18172308 | J:131035
First Author: Macias E
Year: 2008
Journal: Cancer Res
Title: Expression of CDK4 or CDK2 in mouse oral cavity is retained in adult pituitary with distinct effects on tumorigenesis.
Volume: 68
Issue: 1
Pages: 162-71
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Publication
29053957 | J:251885
First Author: Lopez-Mejia IC
Year: 2017
Journal: Mol Cell
Title: CDK4 Phosphorylates AMPKα2 to Inhibit Its Activity and Repress Fatty Acid Oxidation.
Volume: 68
Issue: 2
Pages: 336-349.e6
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Publication
15315761 | J:92529
First Author: Malumbres M
Year: 2004
Journal: Cell
Title: Mammalian cells cycle without the D-type cyclin-dependent kinases Cdk4 and Cdk6.
Volume: 118
Issue: 4
Pages: 493-504
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Publication
10490638 | J:57854
First Author: Tsutsui T
Year: 1999
Journal: Mol Cell Biol
Title: Targeted disruption of CDK4 delays cell cycle entry with enhanced p27(Kip1) activity.
Volume: 19
Issue: 10
Pages: 7011-9
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Publication
12163365 | J:78458
First Author: Rodriguez-Puebla ML
Year: 2002
Journal: Am J Pathol
Title: Cdk4 deficiency inhibits skin tumor development but does not affect normal keratinocyte proliferation.
Volume: 161
Issue: 2
Pages: 405-11
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Publication
24531709 | J:218629
First Author: Gillam MP
Year: 2015
Journal: Oncogene
Title: MEN1 tumorigenesis in the pituitary and pancreatic islet requires Cdk4 but not Cdk2.
Volume: 34
Issue: 7
Pages: 932-8
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Publication
15699216 | J:129435
First Author: Zhang JY
Year: 2005
Journal: J Cell Biol
Title: CDK4 regulation by TNFR1 and JNK is required for NF-kappaB-mediated epidermal growth control.
Volume: 168
Issue: 4
Pages: 561-6
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Publication
20084282 | J:157234
First Author: Lee JH
Year: 2010
Journal: PLoS One
Title: Cdk4 regulates recruitment of quiescent beta-cells and ductal epithelial progenitors to reconstitute beta-cell mass.
Volume: 5
Issue: 1
Pages: e8653
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Publication
14627982 | J:86812
First Author: Mettus RV
Year: 2003
Journal: Oncogene
Title: Characterization of the abnormal pancreatic development, reduced growth and infertility in Cdk4 mutant mice.
Volume: 22
Issue: 52
Pages: 8413-21
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Publication
11726500 | J:73034
First Author: Sotillo R
Year: 2001
Journal: EMBO J
Title: Wide spectrum of tumors in knock-in mice carrying a Cdk4 protein insensitive to INK4 inhibitors.
Volume: 20
Issue: 23
Pages: 6637-47
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Publication
32855282 | J:314121
First Author: Maurer B
Year: 2021
Journal: Haematologica
Title: Inducible deletion of CDK4 and CDK6 - deciphering CDK4/6 inhibitor effects in the hematopoietic system.
Volume: 106
Issue: 10
Pages: 2624-2632
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Publication
8528263 | J:39904
First Author: Zuo L
Year: 1996
Journal: Nat Genet
Title: Germline mutations in the p16INK4a binding domain of CDK4 in familial melanoma.
Volume: 12
Issue: 1
Pages: 97-9
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Publication
7739548 | J:24520
First Author: Chan FK
Year: 1995
Journal: Mol Cell Biol
Title: Identification of human and mouse p19, a novel CDK4 and CDK6 inhibitor with homology to p16ink4.
Volume: 15
Issue: 5
Pages: 2682-8
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Publication
16678773 | J:108720
First Author: Berthet C
Year: 2006
Journal: Dev Cell
Title: Combined loss of Cdk2 and Cdk4 results in embryonic lethality and Rb hypophosphorylation.
Volume: 10
Issue: 5
Pages: 563-73
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Publication
12917627 | J:85130
First Author: Martín J
Year: 2003
Journal: Oncogene
Title: Genetic rescue of Cdk4 null mice restores pancreatic beta-cell proliferation but not homeostatic cell number.
Volume: 22
Issue: 34
Pages: 5261-9
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Publication
25157181 | J:218704
First Author: Rodríguez-Díez E
Year: 2014
Journal: Blood
Title: Cdk4 and Cdk6 cooperate in counteracting the INK4 family of inhibitors during murine leukemogenesis.
Volume: 124
Issue: 15
Pages: 2380-90
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Publication
22532528 | J:194573
First Author: Lim S
Year: 2012
Journal: Stem Cells
Title: Loss of Cdk2 and Cdk4 induces a switch from proliferation to differentiation in neural stem cells.
Volume: 30
Issue: 7
Pages: 1509-20
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Publication
20609353 | J:161780
First Author: Puyol M
Year: 2010
Journal: Cancer Cell
Title: A synthetic lethal interaction between K-Ras oncogenes and Cdk4 unveils a therapeutic strategy for non-small cell lung carcinoma.
Volume: 18
Issue: 1
Pages: 63-73
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Publication
16877364 | J:111992
First Author: Tormo D
Year: 2006
Journal: Am J Pathol
Title: Rapid growth of invasive metastatic melanoma in carcinogen-treated hepatocyte growth factor/scatter factor-transgenic mice carrying an oncogenic CDK4 mutation.
Volume: 169
Issue: 2
Pages: 665-72
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Publication
15867383 | J:98351
First Author: Sotillo R
Year: 2005
Journal: Cancer Res
Title: Cooperation between Cdk4 and p27kip1 in tumor development: a preclinical model to evaluate cell cycle inhibitors with therapeutic activity.
Volume: 65
Issue: 9
Pages: 3846-52
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Publication
25616574 | J:243185
First Author: Jayapal SR
Year: 2015
Journal: Haematologica
Title: Hematopoiesis specific loss of Cdk2 and Cdk4 results in increased erythrocyte size and delayed platelet recovery following stress.
Volume: 100
Issue: 4
Pages: 431-8
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Publication
19933848 | J:156386
First Author: Adon AM
Year: 2010
Journal: Mol Cell Biol
Title: Cdk2 and Cdk4 regulate the centrosome cycle and are critical mediators of centrosome amplification in p53-null cells.
Volume: 30
Issue: 3
Pages: 694-710
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Publication
29570951 | J:263497
First Author: Grison A
Year: 2018
Journal: Dev Neurobiol
Title: Ablation of cdk4 and cdk6 affects proliferation of basal progenitor cells in the developing dorsal and ventral forebrain.
Volume: 78
Issue: 7
Pages: 660-670
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Publication
7739547 | J:24521
First Author: Hirai H
Year: 1995
Journal: Mol Cell Biol
Title: Novel INK4 proteins, p19 and p18, are specific inhibitors of the cyclin D-dependent kinases CDK4 and CDK6.
Volume: 15
Issue: 5
Pages: 2672-81
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Publication
21792898 | J:186013
First Author: Altirriba J
Year: 2012
Journal: Int J Cancer
Title: The sole presence of CDK4 is not a solid criterion for discriminating between tumor and healthy pancreatic tissues.
Volume: 130
Issue: 11
Pages: 2743-5
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Publication
19307310 | J:149151
First Author: Padmakumar VC
Year: 2009
Journal: Mol Cell Biol
Title: Cdk2 and Cdk4 activities are dispensable for tumorigenesis caused by the loss of p53.
Volume: 29
Issue: 10
Pages: 2582-93
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Publication
22742762 | J:222848
First Author: Wurm EM
Year: 2012
Journal: Exp Dermatol
Title: A blueprint for staging of murine melanocytic lesions based on the Cdk4 ( R24C/R24C ) ::Tyr- NRAS ( Q ) ( 61K ) model.
Volume: 21
Issue: 9
Pages: 676-81
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Publication
19619530 | J:154490
First Author: Sandoval R
Year: 2009
Journal: Exp Cell Res
Title: Deletion of the p107/p130-binding domain of Mip130/LIN-9 bypasses the requirement for CDK4 activity for the dissociation of Mip130/LIN-9 from p107/p130-E2F4 complex.
Volume: 315
Issue: 17
Pages: 2914-20
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Publication
25189354 | J:316236
First Author: Coleman DJ
Year: 2015
Journal: Mol Cancer Res
Title: Loss of keratinocytic RXRα combined with activated CDK4 or oncogenic NRAS generates UVB-induced melanomas via loss of p53 and PTEN in the tumor microenvironment.
Volume: 13
Issue: 1
Pages: 186-96
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Publication
18591257 | J:139728
First Author: Rojas A
Year: 2008
Journal: Mol Cell Biol
Title: GATA4 is a direct transcriptional activator of cyclin D2 and Cdk4 and is required for cardiomyocyte proliferation in anterior heart field-derived myocardium.
Volume: 28
Issue: 17
Pages: 5420-31
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Publication
29121869 | J:273742
First Author: Chagani S
Year: 2017
Journal: BMC Cancer
Title: Ablation of epidermal RXRα in cooperation with activated CDK4 and oncogenic NRAS generates spontaneous and acute neonatal UVB induced malignant metastatic melanomas.
Volume: 17
Issue: 1
Pages: 736
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Publication
9438420 | J:45195
First Author: Melnick M
Year: 1998
Journal: Dev Dyn
Title: Insulin-like growth factor II receptor, transforming growth factor-beta, and Cdk4 expression and the developmental epigenetics of mouse palate morphogenesis and dysmorphogenesis.
Volume: 211
Issue: 1
Pages: 11-25
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Publication
23634254 | J:198488
First Author: Baker SJ
Year: 2012
Journal: Genes Cancer
Title: CDK4: A Key Player in the Cell Cycle, Development, and Cancer.
Volume: 3
Issue: 11-12
Pages: 658-69
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Publication
15003506 | J:88855
First Author: Shin HH
Year: 2004
Journal: Biochem Biophys Res Commun
Title: The soluble glucocorticoid-induced tumor necrosis factor receptor causes cell cycle arrest and apoptosis in murine macrophages.
Volume: 316
Issue: 1
Pages: 24-32
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Publication
19409388 | J:201309
First Author: Murakami H
Year: 2009
Journal: FEBS Lett
Title: Isolation and characterization of cytoplasmic cyclin D1 mutants.
Volume: 583
Issue: 10
Pages: 1575-80
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Publication
18178859 | J:130982
First Author: Marzo N
Year: 2008
Journal: J Immunol
Title: Cyclin-dependent kinase 4 hyperactivity promotes autoreactivity in the immune system but protects pancreatic cell mass from autoimmune destruction in the nonobese diabetic mouse model.
Volume: 180
Issue: 2
Pages: 1189-98
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Publication
22326754 | J:181991
First Author: Vincent-Fabert C
Year: 2012
Journal: Am J Pathol
Title: A defect of the INK4-Cdk4 checkpoint and Myc collaborate in blastoid mantle cell lymphoma-like lymphoma formation in mice.
Volume: 180
Issue: 4
Pages: 1688-701
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Publication
16540642 | J:107061
First Author: Hacker E
Year: 2006
Journal: Cancer Res
Title: Spontaneous and UV radiation-induced multiple metastatic melanomas in Cdk4R24C/R24C/TPras mice.
Volume: 66
Issue: 6
Pages: 2946-52
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Publication
16288002 | J:103411
First Author: Reddy HK
Year: 2005
Journal: Cancer Res
Title: Cyclin-dependent kinase 4 expression is essential for neu-induced breast tumorigenesis.
Volume: 65
Issue: 22
Pages: 10174-8
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Publication
12130566 | J:78338
First Author: Moons DS
Year: 2002
Journal: Endocrinology
Title: Pituitary hypoplasia and lactotroph dysfunction in mice deficient for cyclin-dependent kinase-4.
Volume: 143
Issue: 8
Pages: 3001-8
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Publication
11796521 | J:74976
First Author: Moons DS
Year: 2002
Journal: Endocrinology
Title: Intact follicular maturation and defective luteal function in mice deficient for cyclin- dependent kinase-4.
Volume: 143
Issue: 2
Pages: 647-54
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Publication
16730350 | J:111333
First Author: Sandoval R
Year: 2006
Journal: Exp Cell Res
Title: A mutant allele of BARA/LIN-9 rescues the cdk4-/- phenotype by releasing the repression on E2F-regulated genes.
Volume: 312
Issue: 13
Pages: 2465-75
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Publication
12453415 | J:80577
First Author: Baksh S
Year: 2002
Journal: Mol Cell
Title: NFATc2-mediated repression of cyclin-dependent kinase 4 expression.
Volume: 10
Issue: 5
Pages: 1071-81
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Publication
11756559 | J:95126
First Author: Rane SG
Year: 2002
Journal: Mol Cell Biol
Title: Germ line transmission of the Cdk4(R24C) mutation facilitates tumorigenesis and escape from cellular senescence.
Volume: 22
Issue: 2
Pages: 644-56
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Publication
19144649 | J:148614
First Author: Balcazar N
Year: 2009
Journal: J Biol Chem
Title: mTORC1 activation regulates beta-cell mass and proliferation by modulation of cyclin D2 synthesis and stability.
Volume: 284
Issue: 12
Pages: 7832-42
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Publication
27181366 | J:239931
 
First Author: Fusté NP
Year: 2016
Journal: Nat Commun
Title: Cytoplasmic cyclin D1 regulates cell invasion and metastasis through the phosphorylation of paxillin.
Volume: 7
Pages: 11581
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Publication
20951943 | J:165553
First Author: Aggarwal P
Year: 2010
Journal: Cancer Cell
Title: Nuclear cyclin D1/CDK4 kinase regulates CUL4 expression and triggers neoplastic growth via activation of the PRMT5 methyltransferase.
Volume: 18
Issue: 4
Pages: 329-40
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Publication
19597485 | J:158138
First Author: Annicotte JS
Year: 2009
Journal: Nat Cell Biol
Title: The CDK4-pRB-E2F1 pathway controls insulin secretion.
Volume: 11
Issue: 8
Pages: 1017-23
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Publication
16166266 | J:101413
First Author: Rashidian J
Year: 2005
Journal: Proc Natl Acad Sci U S A
Title: Multiple cyclin-dependent kinases signals are critical mediators of ischemia/hypoxic neuronal death in vitro and in vivo.
Volume: 102
Issue: 39
Pages: 14080-5
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Publication
9144426 | J:39666
First Author: Nozaki T
Year: 1997
Journal: Biochem Biophys Res Commun
Title: Abrogation of G1 arrest after DNA damage is associated with constitutive overexpression of Mdm2, Cdk4, and Irf1 mRNAs in the BALB/c 3T3 A31 variant 1-1 clone.
Volume: 233
Issue: 1
Pages: 216-20
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Publication
21841792 | J:176966
First Author: Blanchet E
Year: 2011
Journal: Nat Cell Biol
Title: E2F transcription factor-1 regulates oxidative metabolism.
Volume: 13
Issue: 9
Pages: 1146-52
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Publication
28833887 | J:251043
First Author: Chirivella L
Year: 2017
Journal: Stem Cells
Title: Cyclin-Dependent Kinase 4 Regulates Adult Neural Stem Cell Proliferation and Differentiation in Response to Insulin.
Volume: 35
Issue: 12
Pages: 2403-2416
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Publication
15254233 | J:92146
First Author: Pei XH
Year: 2004
Journal: Mol Cell Biol
Title: Genetic evidence for functional dependency of p18Ink4c on Cdk4.
Volume: 24
Issue: 15
Pages: 6653-64
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Publication
25578653 | J:253330
 
First Author: Jin C
Year: 2015
Journal: Free Radic Biol Med
Title: CDK4-mediated MnSOD activation and mitochondrial homeostasis in radioadaptive protection.
Volume: 81
Pages: 77-87
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Publication
8033213 | J:19218
First Author: Toyoshima H
Year: 1994
Journal: Cell
Title: p27, a novel inhibitor of G1 cyclin-Cdk protein kinase activity, is related to p21.
Volume: 78
Issue: 1
Pages: 67-74
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Publication
16413468 | J:105045
First Author: Landis MW
Year: 2006
Journal: Cancer Cell
Title: Cyclin D1-dependent kinase activity in murine development and mammary tumorigenesis.
Volume: 9
Issue: 1
Pages: 13-22
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Publication
16869759 | J:115184
 
First Author: Barbacid M
Year: 2005
Journal: Cold Spring Harb Symp Quant Biol
Title: Cell cycle and cancer: genetic analysis of the role of cyclin-dependent kinases.
Volume: 70
Pages: 233-40
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Publication
18191580 | J:132685
First Author: Atanasoski S
Year: 2008
Journal: Mol Cell Neurosci
Title: Postnatal Schwann cell proliferation but not myelination is strictly and uniquely dependent on cyclin-dependent kinase 4 (cdk4).
Volume: 37
Issue: 3
Pages: 519-27
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Publication
24687853 | J:221632
First Author: Bai F
Year: 2014
Journal: Mol Cell Biol
Title: p19Ink4d is a tumor suppressor and controls pituitary anterior lobe cell proliferation.
Volume: 34
Issue: 12
Pages: 2121-34
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Publication
19385066 | J:169980
First Author: O'Carroll SJ
Year: 2009
Journal: Cell Signal
Title: Nuclear PLCbeta1 is required for 3T3-L1 adipocyte differentiation and regulates expression of the cyclin D3-cdk4 complex.
Volume: 21
Issue: 6
Pages: 926-35
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Publication
10342870 | J:55150
First Author: Zhang Q
Year: 1999
Journal: Endocrinology
Title: Developmentally regulated expression of cyclin D3 and its potential in vivo interacting proteins during murine gametogenesis.
Volume: 140
Issue: 6
Pages: 2790-800
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Publication
22456337 | J:317995
First Author: Futatsugi A
Year: 2012
Journal: Cell Cycle
Title: Cyclin-dependent kinase 5 regulates E2F transcription factor through phosphorylation of Rb protein in neurons.
Volume: 11
Issue: 8
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