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Search results 1 to 100 out of 186 for Cdk5rap3

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0.067s
Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: chicken
Gene
Type: gene
Organism: zebrafish
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: frog, western clawed
Gene
Type: gene
Organism: dog, domestic
Gene
Type: gene
Organism: chimpanzee
Protein Domain
Type: Family
Description: CDK5RAP3 (also known as C53 or LZAP) serves as a probable tumour suppressor initially identified as a CDK5R1 interactor controllingcell proliferation [, ]. It negatively regulates NF-kappa-B-mediated gene transcription through the control of RELA phosphorylation [, ]. It also regulates mitotic G2/M transition checkpoint and mitotic G2 DNA damage checkpoint [, ]. It has been shown to bind Wip1 and stimulates its phosphatase activity [].
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Gene
Type: gene
Organism: human
Publication
First Author: Quintero M
Year: 2021
Journal: Cell Death Dis
Title: Cdk5rap3 is essential for intestinal Paneth cell development and maintenance.
Volume: 12
Issue: 1
Pages: 131
Publication
First Author: Yang S
Year: 2020
Journal: Am J Pathol
Title: CDK5RAP3 Deficiency Restrains Liver Regeneration after Partial Hepatectomy Triggering Endoplasmic Reticulum Stress.
Volume: 190
Issue: 12
Pages: 2403-2416
GXD Expression
Probe: MGI:6423118
Assay Type: Immunohistochemistry
Annotation Date: 2020-05-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6423288
Age: postnatal month 1
Image: S7D
Note: Expression of Cdk5rap3 colocalized with P4hb, an endoplasmic reticulum marker.
Specimen Label: S7D
Detected: true
Specimen Num: 3
Protein
Organism: Mus musculus/domesticus
Length: 503  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 80  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 503  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 503  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 112  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 145  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 142  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 124  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 140  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 487  
Fragment?: true
Publication
First Author: Wang J
Year: 2007
Journal: Cancer Cell
Title: LZAP, a putative tumor suppressor, selectively inhibits NF-kappaB.
Volume: 12
Issue: 3
Pages: 239-51
Publication
First Author: Chen J
Year: 2002
Journal: Biochem Biophys Res Commun
Title: A novel gene IC53 stimulates ECV304 cell proliferation and is upregulated in failing heart.
Volume: 294
Issue: 1
Pages: 161-6
Publication
First Author: Jiang H
Year: 2005
Journal: J Biol Chem
Title: Cdk5 activator-binding protein C53 regulates apoptosis induced by genotoxic stress via modulating the G2/M DNA damage checkpoint.
Volume: 280
Issue: 21
Pages: 20651-9
Publication
First Author: Jiang H
Year: 2009
Journal: Cell Res
Title: Tumor suppressor protein C53 antagonizes checkpoint kinases to promote cyclin-dependent kinase 1 activation.
Volume: 19
Issue: 4
Pages: 458-68
Publication
First Author: Xie YH
Year: 2003
Journal: Cell Res
Title: Cloning and characterization of human IC53-2, a novel CDK5 activator binding protein.
Volume: 13
Issue: 2
Pages: 83-91
Publication
First Author: Wamsley JJ
Year: 2017
Journal: Cell Cycle
Title: LZAP is a novel Wip1 binding partner and positive regulator of its phosphatase activity in vitro.
Volume: 16
Issue: 2
Pages: 213-223
GXD Expression
Probe: MGI:6423118
Assay Type: Immunohistochemistry
Annotation Date: 2020-05-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:6423287
Age: postnatal month 3
Image: S4F tm1d/tm1d;Alb-Cre
Note: There was insufficient deletion of Cdk5rap3 in hepatocytes of the tm1d/tm1d;Alb-Cre liver.
Specimen Label: S4F tm1d/tm1d;Alb-Cre
Detected: true
Specimen Num: 6
Publication
First Author: Wu J
Year: 2010
Journal: J Biol Chem
Title: A novel C53/LZAP-interacting protein regulates stability of C53/LZAP and DDRGK domain-containing Protein 1 (DDRGK1) and modulates NF-kappaB signaling.
Volume: 285
Issue: 20
Pages: 15126-36
Publication
First Author: Lemaire K
Year: 2011
Journal: PLoS One
Title: Ubiquitin fold modifier 1 (UFM1) and its target UFBP1 protect pancreatic beta cells from ER stress-induced apoptosis.
Volume: 6
Issue: 4
Pages: e18517
Publication  
First Author: Shen Y
Year: 2020
Journal: Int J Mol Sci
Title: CDK5RAP3, a Novel Nucleoplasmic Shuttle, Deeply Regulates HSF1-Mediated Heat Stress Response and Protects Mammary Epithelial Cells from Heat Injury.
Volume: 21
Issue: 21
Publication
First Author: Shiwaku H
Year: 2010
Journal: EMBO J
Title: Suppression of the novel ER protein Maxer by mutant ataxin-1 in Bergman glia contributes to non-cell-autonomous toxicity.
Volume: 29
Issue: 14
Pages: 2446-60
Publication  
First Author: Yang R
Year: 2019
Journal: Development
Title: CDK5RAP3, a UFL1 substrate adaptor, is crucial for liver development.
Volume: 146
Issue: 2
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
GXD Expression    
Probe: MGI:6423123
Assay Type: RT-PCR
Annotation Date: 2020-05-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1876728
Stage: TS28
Assay Id: MGI:6423293
Age: postnatal adult
Image: 2
Specimen Label: Spleen
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:6423118
Assay Type: Western blot
Annotation Date: 2020-05-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1876728
Stage: TS28
Assay Id: MGI:6423296
Age: postnatal adult
Image: 2
Specimen Label: Spleen
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:6423123
Assay Type: RT-PCR
Annotation Date: 2020-05-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:6423293
Age: postnatal adult
Image: 2
Specimen Label: Kidney
Detected: true
Specimen Num: 7
GXD Expression    
Probe: MGI:6423118
Assay Type: Western blot
Annotation Date: 2020-05-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:6423296
Age: postnatal adult
Image: 2
Specimen Label: Kidney
Detected: true
Specimen Num: 7
GXD Expression    
Probe: MGI:6423123
Assay Type: RT-PCR
Annotation Date: 2020-05-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1672828
Stage: TS28
Assay Id: MGI:6423293
Age: postnatal adult
Image: 2
Specimen Label: Lung
Detected: true
Specimen Num: 8
GXD Expression    
Probe: MGI:6423118
Assay Type: Western blot
Annotation Date: 2020-05-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1672828
Stage: TS28
Assay Id: MGI:6423296
Age: postnatal adult
Image: 2
Specimen Label: Lung
Detected: true
Specimen Num: 8
GXD Expression    
Probe: MGI:6423123
Assay Type: RT-PCR
Annotation Date: 2020-05-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:6423293
Age: postnatal adult
Image: 2
Specimen Label: Heart
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:6423118
Assay Type: Western blot
Annotation Date: 2020-05-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:6423296
Age: postnatal adult
Image: 2
Specimen Label: Heart
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:6423118
Assay Type: Western blot
Annotation Date: 2020-05-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684624
Stage: TS24
Assay Id: MGI:6423286
Age: embryonic day 16.5
Image: 1
Specimen Label: WT
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:6423118
Assay Type: Western blot
Annotation Date: 2020-05-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684624
Stage: TS24
Assay Id: MGI:6423286
Age: embryonic day 16.5
Image: 1
Specimen Label: WT
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:6423118
Assay Type: Western blot
Annotation Date: 2020-05-19
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1684624
Stage: TS24
Assay Id: MGI:6423286
Age: embryonic day 16.5
Image: 1
Specimen Label: KO
Detected: false
Specimen Num: 3
GXD Expression    
Probe: MGI:6423118
Assay Type: Western blot
Annotation Date: 2020-05-19
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1684624
Stage: TS24
Assay Id: MGI:6423286
Age: embryonic day 16.5
Image: 1
Specimen Label: KO
Detected: false
Specimen Num: 4
GXD Expression    
Probe: MGI:6423123
Assay Type: RT-PCR
Annotation Date: 2020-05-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:6423293
Age: postnatal adult
Image: 2
Specimen Label: Liver
Detected: true
Specimen Num: 6
GXD Expression    
Probe: MGI:6423118
Assay Type: Western blot
Annotation Date: 2020-05-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:6423296
Age: postnatal adult
Image: 2
Specimen Label: Liver
Detected: true
Specimen Num: 6
GXD Expression    
Probe: MGI:6423118
Assay Type: Western blot
Annotation Date: 2020-05-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684624
Stage: TS24
Assay Id: MGI:6423312
Age: embryonic day 16.5
Image: S3
Specimen Label: WT
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:6423118
Assay Type: Western blot
Annotation Date: 2020-05-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684624
Stage: TS24
Assay Id: MGI:6423312
Age: embryonic day 16.5
Image: S3
Specimen Label: WT
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:6423118
Assay Type: Western blot
Annotation Date: 2020-05-19
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1684624
Stage: TS24
Assay Id: MGI:6423312
Age: embryonic day 16.5
Image: S3
Specimen Label: KO
Detected: false
Specimen Num: 3
GXD Expression    
Probe: MGI:6423118
Assay Type: Western blot
Annotation Date: 2020-05-19
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1684624
Stage: TS24
Assay Id: MGI:6423312
Age: embryonic day 16.5
Image: S3
Specimen Label: KO
Detected: false
Specimen Num: 4
GXD Expression    
Probe: MGI:6423118
Assay Type: Western blot
Annotation Date: 2020-05-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:6423315
Age: postnatal month 3
Image: S4
Specimen Label: tm1d/tm1d;Alb-Cre
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:6423118
Assay Type: Western blot
Annotation Date: 2020-05-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:6423315
Age: postnatal month 3
Image: S4
Specimen Label: tm1d/tm1d;Alb-Cre
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:6423118
Assay Type: Western blot
Annotation Date: 2020-05-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:6423319
Age: postnatal month 1
Image: 4
Specimen Label: CKO
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:6423118
Assay Type: Western blot
Annotation Date: 2020-05-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:6423319
Age: postnatal month 1
Image: 4
Specimen Label: CKO
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:6423118
Assay Type: Western blot
Annotation Date: 2020-05-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:6423325
Age: postnatal month 1
Image: S5
Specimen Label: CKO
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:6423118
Assay Type: Western blot
Annotation Date: 2020-05-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:6423325
Age: postnatal month 1
Image: S5
Specimen Label: CKO
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:6423118
Assay Type: Western blot
Annotation Date: 2020-05-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:6423325
Age: postnatal month 1
Image: S5
Specimen Label: Con
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:6423118
Assay Type: Western blot
Annotation Date: 2020-05-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:6423325
Age: postnatal month 1
Image: S5
Specimen Label: Con
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:6423118
Assay Type: Western blot
Annotation Date: 2020-05-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:6423319
Age: postnatal month 1
Image: 4
Specimen Label: Con
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:6423118
Assay Type: Western blot
Annotation Date: 2020-05-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:6423319
Age: postnatal month 1
Image: 4
Specimen Label: Con
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:6423118
Assay Type: Western blot
Annotation Date: 2020-05-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:6423315
Age: postnatal month 3
Image: S4
Specimen Label: Con
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:6423118
Assay Type: Western blot
Annotation Date: 2020-05-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:6423315
Age: postnatal month 3
Image: S4
Specimen Label: Con
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:6423118
Assay Type: Western blot
Annotation Date: 2020-05-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684624
Stage: TS24
Assay Id: MGI:6423427
Age: embryonic day 16.5
Image: 6
Specimen Label: Input
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:6423118
Assay Type: Western blot
Annotation Date: 2020-05-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684624
Stage: TS24
Assay Id: MGI:6423429
Age: embryonic day 16.5
Image: 6
Specimen Label: WT
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:6423118
Assay Type: Western blot
Annotation Date: 2020-05-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684624
Stage: TS24
Assay Id: MGI:6423429
Age: embryonic day 16.5
Image: 6
Specimen Label: WT
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:6423118
Assay Type: Western blot
Annotation Date: 2020-05-20
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1684624
Stage: TS24
Assay Id: MGI:6423429
Age: embryonic day 16.5
Image: 6
Specimen Label: KO
Detected: false
Specimen Num: 3
GXD Expression    
Probe: MGI:6423118
Assay Type: Western blot
Annotation Date: 2020-05-20
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1684624
Stage: TS24
Assay Id: MGI:6423429
Age: embryonic day 16.5
Image: 6
Specimen Label: KO
Detected: false
Specimen Num: 4
GXD Expression    
Probe: MGI:6423118
Assay Type: Western blot
Annotation Date: 2020-05-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684624
Stage: TS24
Assay Id: MGI:6423430
Age: embryonic day 16.5
Image: 6
Specimen Label: WT
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:6423118
Assay Type: Western blot
Annotation Date: 2020-05-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684624
Stage: TS24
Assay Id: MGI:6423430
Age: embryonic day 16.5
Image: 6
Specimen Label: WT
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:6423118
Assay Type: Western blot
Annotation Date: 2020-05-20
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1684624
Stage: TS24
Assay Id: MGI:6423430
Age: embryonic day 16.5
Image: 6
Specimen Label: KO
Detected: false
Specimen Num: 3
GXD Expression    
Probe: MGI:6423118
Assay Type: Western blot
Annotation Date: 2020-05-20
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1684624
Stage: TS24
Assay Id: MGI:6423430
Age: embryonic day 16.5
Image: 6
Specimen Label: KO
Detected: false
Specimen Num: 4
GXD Expression    
Probe: MGI:6423118
Assay Type: Western blot
Annotation Date: 2020-05-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:6423438
Age: postnatal month 1
Image: 6
Specimen Label: Con
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:6423118
Assay Type: Western blot
Annotation Date: 2020-05-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:6423438
Age: postnatal month 1
Image: 6
Specimen Label: Con
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:6423118
Assay Type: Western blot
Annotation Date: 2020-05-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:6423438
Age: postnatal month 1
Image: 6
Specimen Label: CKO
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:6423118
Assay Type: Western blot
Annotation Date: 2020-05-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:6423438
Age: postnatal month 1
Image: 6
Specimen Label: CKO
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:6423118
Assay Type: Western blot
Annotation Date: 2020-05-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:6423439
Age: postnatal month 1
Image: S6
Specimen Label: Con
Detected: true
Specimen Num: 1