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Search results 1 to 100 out of 1819 for Cdk7

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Hits by Pathway

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Hits by Strain

Type Details Score
Gene
549973 | cdk7
Type: gene
Organism: frog, western clawed
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Gene
1022 | CDK7
Type: gene
Organism: human
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Gene
171150 | Cdk7
Type: gene
Organism: rat
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Gene
608441 | CDK7
Type: gene
Organism: dog, domestic
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Gene
462378 | CDK7
Type: gene
Organism: chimpanzee
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Gene
515462 | CDK7
Type: gene
Organism: cattle
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Gene
771294 | CDK7
Type: gene
Organism: chicken
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Gene
405897 | cdk7
Type: gene
Organism: zebrafish
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Gene
699871 | CDK7
Type: gene
Organism: macaque, rhesus
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Protein Domain
IPR037770 | CDK7
Type: Family
Description: Cyclin-dependent kinase 7 (CDK7) is a serine/threonine kinase involved in cell cycle control and in RNA polymerase II-mediated RNA transcription. It is activated by binding to a cyclin; binding to a different cyclin and phosphorylation of another kinase progresses the cell cycle. CDK7 binds cyclin-B and phosphorylates CDK1 during G2-M transition, and phosphorylates CDK2 and binds to cyclins during G1-S transition [, ]. CDK7 phosphorylates and activates p53 following DNA damage [], but CDK7 is then inactivated by p53, which arrests the cell cycle, allowing the cell to recover or undergo apoptosis []. CDK7 is also the catalytic subunit of the CDK-activating kinase (CAK) complex, which also contains cyclin-H (CCNH) and MAT1 [, ]. In turn, the CAK associates with the core-TFIIH to form the TFIIH basal transcription factor [].This entry includes CDK7 from animals, Kin28 from budding yeasts and Crk1 (also known as Mcs6) from fission yeasts. S. pombe possesses two CAKs, the nonessential Csk1 and the essential Mcs6 kinases, corresponding to the yeast Cak1 and the metazoan CDK7, respectively. Mcs6 modulates gene expression through both its CAK and CTD kinase activities []. Kin28 is the closest homologue of CDK7 from budding yeasts. It forms a complex with Ccl1 and Tfb3. This complex associate with TFIIH for transcription regulating activity, but does not display CAK activity []. Instead, Cak1, a single-subunit kinase distantly related to Cdk, catalyzes Cdk activation at both transitions of the budding yeast cell cycle [].
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Protein Coding Gene
MGI:102956 | Cdk7
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
27759017 | -
 
First Author: Deshmukh AS
Year: 2016
Journal: Sci Rep
Title: Cdk7 mediates RPB1-driven mRNA synthesis in Toxoplasma gondii.
Volume: 6
Pages: 35288
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Publication
25043025 | J:217114
First Author: Kwiatkowski N
Year: 2014
Journal: Nature
Title: Targeting transcription regulation in cancer with a covalent CDK7 inhibitor.
Volume: 511
Issue: 7511
Pages: 616-20
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Publication
16327805 | -
First Author: Larochelle S
Year: 2006
Journal: Nat Struct Mol Biol
Title: Dichotomous but stringent substrate selection by the dual-function Cdk7 complex revealed by chemical genetics.
Volume: 13
Issue: 1
Pages: 55-62
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Publication
25691663 | -
First Author: Devos M
Year: 2015
Journal: Mol Cell Biol
Title: Fission yeast Cdk7 controls gene expression through both its CAK and C-terminal domain kinase activities.
Volume: 35
Issue: 9
Pages: 1480-90
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Publication
32464595 | J:305933
First Author: Ji H
Year: 2020
Journal: iScience
Title: CDK7 Mediates the Beta-Adrenergic Signaling in Thermogenic Brown and White Adipose Tissues.
Volume: 23
Issue: 6
Pages: 101163
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Publication
17386261 | -
First Author: Larochelle S
Year: 2007
Journal: Mol Cell
Title: Requirements for Cdk7 in the assembly of Cdk1/cyclin B and activation of Cdk2 revealed by chemical genetics in human cells.
Volume: 25
Issue: 6
Pages: 839-50
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Publication
9450924 | J:45802
First Author: Harper JW
Year: 1998
Journal: Genes Dev
Title: The role of Cdk7 in CAK function, a retro-retrospective.
Volume: 12
Issue: 3
Pages: 285-9
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Publication
35294049 | J:329535
First Author: Chen Y
Year: 2022
Journal: FEBS Lett
Title: Adipocyte-specific CDK7 ablation leads to progressive loss of adipose tissue and metabolic dysfunction.
Volume: 596
Issue: 11
Pages: 1434-1444
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Publication
29163040 | J:312075
 
First Author: He G
Year: 2017
Journal: Front Mol Neurosci
Title: Cdk7 Is Required for Activity-Dependent Neuronal Gene Expression, Long-Lasting Synaptic Plasticity and Long-Term Memory.
Volume: 10
Pages: 365
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Publication
27411104 | J:314580
First Author: Abdullah AI
Year: 2016
Journal: Stem Cell Reports
Title: CDK7 and miR-210 Co-regulate Cell-Cycle Progression of Neural Progenitors in the Developing Neocortex.
Volume: 7
Issue: 1
Pages: 69-79
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Publication
27693251 | J:251483
First Author: Wang H
Year: 2016
Journal: Biochim Biophys Acta
Title: Inhibition of CDK7 bypasses spindle assembly checkpoint via premature cyclin B degradation during oocyte meiosis.
Volume: 1863
Issue: 12
Pages: 2993-3000
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Publication
12748294 | J:83562
First Author: Korsisaari N
Year: 2003
Journal: Mol Cell Biol
Title: The histidine triad protein Hint is not required for murine development or Cdk7 function.
Volume: 23
Issue: 11
Pages: 3929-35
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Publication
22505032 | J:183925
First Author: Ganuza M
Year: 2012
Journal: EMBO J
Title: Genetic inactivation of Cdk7 leads to cell cycle arrest and induces premature aging due to adult stem cell exhaustion.
Volume: 31
Issue: 11
Pages: 2498-510
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Publication
9372954 | -
First Author: Ko LJ
Year: 1997
Journal: Mol Cell Biol
Title: p53 is phosphorylated by CDK7-cyclin H in a p36MAT1-dependent manner.
Volume: 17
Issue: 12
Pages: 7220-9
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Publication
9840937 | -
First Author: Schneider E
Year: 1998
Journal: Oncogene
Title: Regulation of CAK kinase activity by p53.
Volume: 17
Issue: 21
Pages: 2733-41
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Publication
8752210 | -
First Author: Kaldis P
Year: 1996
Journal: Cell
Title: The Cdk-activating kinase (CAK) from budding yeast.
Volume: 86
Issue: 4
Pages: 553-64
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Publication
10024882 | -
First Author: Tirode F
Year: 1999
Journal: Mol Cell
Title: Reconstitution of the transcription factor TFIIH: assignment of functions for the three enzymatic subunits, XPB, XPD, and cdk7.
Volume: 3
Issue: 1
Pages: 87-95
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Publication
9852112 | -
First Author: Kershnar E
Year: 1998
Journal: J Biol Chem
Title: Immunoaffinity purification and functional characterization of human transcription factor IIH and RNA polymerase II from clonal cell lines that conditionally express epitope-tagged subunits of the multiprotein complexes.
Volume: 273
Issue: 51
Pages: 34444-53
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Publication
11113184 | -
First Author: Garrett S
Year: 2001
Journal: Mol Cell Biol
Title: Reciprocal activation by cyclin-dependent kinases 2 and 7 is directed by substrate specificity determinants outside the T loop.
Volume: 21
Issue: 1
Pages: 88-99
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Protein
A0A286YDC0
Organism: Mus musculus/domesticus
Length: 309  
Fragment?: false
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Protein
Q03147
Organism: Mus musculus/domesticus
Length: 346  
Fragment?: false
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Protein
Q3THG5
Organism: Mus musculus/domesticus
Length: 346  
Fragment?: false
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Protein
Q8CAC4
Organism: Mus musculus/domesticus
Length: 252  
Fragment?: false
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Publication
35488490 | J:326752
First Author: Dion V
Year: 2022
Journal: Glia
Title: Cyclin-dependent kinase 7 contributes to myelin maintenance in the adult central nervous system and promotes myelin gene expression.
Volume: 70
Issue: 9
Pages: 1652-1665
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Publication
11319144 | J:69035
First Author: Kim JM
Year: 2001
Journal: Biol Reprod
Title: Meiotic expression of the cyclin H/Cdk7 complex in male germ cells of the mouse.
Volume: 64
Issue: 5
Pages: 1400-8
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Publication
18981214 | J:145032
First Author: Helenius K
Year: 2009
Journal: Mol Cell Biol
Title: Mat1 inhibits peroxisome proliferator-activated receptor gamma-mediated adipocyte differentiation.
Volume: 29
Issue: 2
Pages: 315-23
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Publication
20231280 | J:163900
First Author: Patel SA
Year: 2010
Journal: J Biol Chem
Title: Functional analysis of the Cdk7.cyclin H.Mat1 complex in mouse embryonic stem cells and embryos.
Volume: 285
Issue: 20
Pages: 15587-98
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Publication
17276355 | J:129766
First Author: Sano M
Year: 2007
Journal: Cell Metab
Title: Ménage-à-trois 1 is critical for the transcriptional function of PPARgamma coactivator 1.
Volume: 5
Issue: 2
Pages: 129-42
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Protein Coding Gene
MGP_CAROLIEiJ_G0018847 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0020892 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0020843 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0020818 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0020843 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0020632 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_102956 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0021277 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0020151 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0020594 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0020718 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0020700 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0020792 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0020728 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0021316 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0019904 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0020209 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0015919 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0019726 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
7935441 | J:21039
First Author: Matsuoka M
Year: 1994
Journal: Mol Cell Biol
Title: Activation of cyclin-dependent kinase 4 (cdk4) by mouse MO15-associated kinase.
Volume: 14
Issue: 11
Pages: 7265-75
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Publication
7959010 | J:21629
First Author: Stepanova LYu
Year: 1994
Journal: Gene
Title: Sequence of the cDNA encoding murine CRK4 protein kinase.
Volume: 149
Issue: 2
Pages: 321-4
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GXD Expression
GXD Expression
   
Probe: MGI:6719043
Assay Type: RT-PCR
Annotation Date: 2021-07-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603913
Stage: TS13
Assay Id: MGI:6719048
Age: embryonic day 8.25
Image: 4
Specimen Label: +/+
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:6719043
Assay Type: RT-PCR
Annotation Date: 2021-07-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603913
Stage: TS13
Assay Id: MGI:6719048
Age: embryonic day 8.25
Image: 4
Specimen Label: delta/delta
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:7336087
Assay Type: RT-PCR
Annotation Date: 2022-09-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754422
Stage: TS22
Assay Id: MGI:7336088
Age: embryonic day 14.5
Image: 1
Specimen Label: E14.5
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:7336087
Assay Type: RT-PCR
Annotation Date: 2022-09-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754427
Stage: TS27
Assay Id: MGI:7336088
Age: postnatal day 0
Image: 1
Specimen Label: P0
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:7336087
Assay Type: RT-PCR
Annotation Date: 2022-09-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754428
Stage: TS28
Assay Id: MGI:7336088
Age: postnatal day 7
Image: 1
Specimen Label: P7
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:7336087
Assay Type: RT-PCR
Annotation Date: 2022-09-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754428
Stage: TS28
Assay Id: MGI:7336088
Age: postnatal day 30
Image: 1
Specimen Label: P30
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
   
Probe: MGI:7336087
Assay Type: RT-PCR
Annotation Date: 2022-09-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754428
Stage: TS28
Assay Id: MGI:7336088
Age: postnatal day 60
Image: 1
Specimen Label: P60
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
     
Probe: MGI:7336086
Assay Type: Western blot
Annotation Date: 2022-09-14
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:1754422
Stage: TS22
Assay Id: MGI:7336089
Age: embryonic day 14.5
Image: 1
Specimen Label: E14.5
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:7336086
Assay Type: Western blot
Annotation Date: 2022-09-14
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:1754427
Stage: TS27
Assay Id: MGI:7336089
Age: postnatal day 0
Image: 1
Specimen Label: P0
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:7336086
Assay Type: Western blot
Annotation Date: 2022-09-14
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:1754428
Stage: TS28
Assay Id: MGI:7336089
Age: postnatal day 7
Image: 1
Specimen Label: P7
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:7336086
Assay Type: Western blot
Annotation Date: 2022-09-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754428
Stage: TS28
Assay Id: MGI:7336089
Age: postnatal day 30
Image: 1
Specimen Label: P30
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
   
Probe: MGI:7336086
Assay Type: Western blot
Annotation Date: 2022-09-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754428
Stage: TS28
Assay Id: MGI:7336089
Age: postnatal day 60
Image: 1
Specimen Label: P60
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
   
Probe: MGI:7412784
Assay Type: RT-PCR
Annotation Date: 2022-12-28
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1691016
Stage: TS16
Assay Id: MGI:7412856
Age: embryonic day 10.0
Image: 1
Specimen Label: E10
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:7412784
Assay Type: RT-PCR
Annotation Date: 2022-12-28
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754426
Stage: TS26
Assay Id: MGI:7412856
Age: embryonic day 18.0
Image: 1
Specimen Label: E18
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:7412784
Assay Type: RT-PCR
Annotation Date: 2022-12-28
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754428
Stage: TS28
Assay Id: MGI:7412856
Age: postnatal month 2
Image: 1
Specimen Label: 2 months
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
Probe: MGI:6865748
Assay Type: Immunohistochemistry
Annotation Date: 2022-02-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3270421
Pattern: Regionally restricted
Stage: TS21
Assay Id: MGI:6865753
Age: embryonic day 13.5
Image: 4C E13.5
Note: Co-expression with Nes in neural progenitors in ventricular zone and subventricular zone.
Specimen Label: 4C E13.5
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
Probe: MGI:6865748
Assay Type: Immunohistochemistry
Annotation Date: 2022-02-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3270423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:6865753
Age: embryonic day 15.5
Image: 4C E15.5
Note: Co-expression with Nes in neural progenitors in ventricular zone and subventricular zone.
Specimen Label: 4C E15.5
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:1098413
Assay Type: RNA in situ
Annotation Date: 2007-01-23
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1614815
Pattern: Uniform
Stage: TS15
Assay Id: MGI:3694429
Age: embryonic day 9.5
Note: Expression was detected at a uniform level.
Specimen Label: None
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:6865748
Assay Type: Immunohistochemistry
Annotation Date: 2022-02-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3271121
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:6865753
Age: embryonic day 13.5
Image: 4C E13.5
Specimen Label: 4C E13.5
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:6865748
Assay Type: Immunohistochemistry
Annotation Date: 2022-02-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3271123
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:6865753
Age: embryonic day 15.5
Image: 4C E15.5
Specimen Label: 4C E15.5
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
Probe: MGI:6865748
Assay Type: Immunohistochemistry
Annotation Date: 2022-02-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754721
Pattern: Regionally restricted
Stage: TS21
Assay Id: MGI:6865753
Age: embryonic day 13.5
Image: 4C E13.5
Note: Co-expression with Nes in neural progenitors in ventricular zone and subventricular zone.
Specimen Label: 4C E13.5
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
Probe: MGI:6865748
Assay Type: Immunohistochemistry
Annotation Date: 2022-02-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754723
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:6865753
Age: embryonic day 15.5
Image: 4C E15.5
Note: Co-expression with Nes in neural progenitors in ventricular zone and subventricular zone.
Specimen Label: 4C E15.5
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:7608358
Assay Type: Immunohistochemistry
Annotation Date: 2024-03-04
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3265122
Stage: TS22
Assay Id: MGI:7608372
Age: embryonic day 14.5
Specimen Label: 2-7
Detected: false
Specimen Num: 1
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Publication
36545778 | J:341371
First Author: Prieto S
Year: 2023
Journal: EMBO Rep
Title: CDK8 and CDK19 act redundantly to control the CFTR pathway in the intestinal epithelium.
Volume: 24
Issue: 2
Pages: e54261
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Publication
17938200 | J:130071
First Author: Oven I
Year: 2007
Journal: Mol Cell Biol
Title: AIRE recruits P-TEFb for transcriptional elongation of target genes in medullary thymic epithelial cells.
Volume: 27
Issue: 24
Pages: 8815-23
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Publication
10777215 | J:61657
First Author: De Graeve F
Year: 2000
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