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Search results 1 to 100 out of 1812 for Cdk7

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Type Details Score
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: chicken
Gene
Type: gene
Organism: zebrafish
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: frog, western clawed
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: dog, domestic
Gene
Type: gene
Organism: chimpanzee
Protein Domain
Type: Family
Description: Cyclin-dependent kinase 7 (CDK7) is a serine/threonine kinase involved in cell cycle control and in RNA polymerase II-mediated RNA transcription. It is activated by binding to a cyclin; binding to a different cyclin and phosphorylation of another kinase progresses the cell cycle. CDK7 binds cyclin-B and phosphorylates CDK1 during G2-M transition, and phosphorylates CDK2 and binds to cyclins during G1-S transition [, ]. CDK7 phosphorylates and activates p53 following DNA damage [], but CDK7 is then inactivated by p53, which arrests the cell cycle, allowing the cell to recover or undergo apoptosis []. CDK7 is also the catalytic subunit of the CDK-activating kinase (CAK) complex, which also contains cyclin-H (CCNH) and MAT1 [, ]. In turn, the CAK associates with the core-TFIIH to form the TFIIH basal transcription factor [].This entry includes CDK7 from animals, Kin28 from budding yeasts and Crk1 (also known as Mcs6) from fission yeasts. S. pombe possesses two CAKs, the nonessential Csk1 and the essential Mcs6 kinases, corresponding to the yeast Cak1 and the metazoan CDK7, respectively. Mcs6 modulates gene expression through both its CAK and CTD kinase activities []. Kin28 is the closest homologue of CDK7 from budding yeasts. It forms a complex with Ccl1 and Tfb3. This complex associate with TFIIH for transcription regulating activity, but does not display CAK activity []. Instead, Cak1, a single-subunit kinase distantly related to Cdk, catalyzes Cdk activation at both transitions of the budding yeast cell cycle [].
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Publication  
First Author: Deshmukh AS
Year: 2016
Journal: Sci Rep
Title: Cdk7 mediates RPB1-driven mRNA synthesis in Toxoplasma gondii.
Volume: 6
Pages: 35288
Publication
First Author: Kwiatkowski N
Year: 2014
Journal: Nature
Title: Targeting transcription regulation in cancer with a covalent CDK7 inhibitor.
Volume: 511
Issue: 7511
Pages: 616-20
Publication
First Author: Larochelle S
Year: 2006
Journal: Nat Struct Mol Biol
Title: Dichotomous but stringent substrate selection by the dual-function Cdk7 complex revealed by chemical genetics.
Volume: 13
Issue: 1
Pages: 55-62
Publication
First Author: Devos M
Year: 2015
Journal: Mol Cell Biol
Title: Fission yeast Cdk7 controls gene expression through both its CAK and C-terminal domain kinase activities.
Volume: 35
Issue: 9
Pages: 1480-90
Publication
First Author: Ji H
Year: 2020
Journal: iScience
Title: CDK7 Mediates the Beta-Adrenergic Signaling in Thermogenic Brown and White Adipose Tissues.
Volume: 23
Issue: 6
Pages: 101163
Publication
First Author: Larochelle S
Year: 2007
Journal: Mol Cell
Title: Requirements for Cdk7 in the assembly of Cdk1/cyclin B and activation of Cdk2 revealed by chemical genetics in human cells.
Volume: 25
Issue: 6
Pages: 839-50
Publication
First Author: Harper JW
Year: 1998
Journal: Genes Dev
Title: The role of Cdk7 in CAK function, a retro-retrospective.
Volume: 12
Issue: 3
Pages: 285-9
Publication
First Author: Chen Y
Year: 2022
Journal: FEBS Lett
Title: Adipocyte-specific CDK7 ablation leads to progressive loss of adipose tissue and metabolic dysfunction.
Volume: 596
Issue: 11
Pages: 1434-1444
Publication  
First Author: He G
Year: 2017
Journal: Front Mol Neurosci
Title: Cdk7 Is Required for Activity-Dependent Neuronal Gene Expression, Long-Lasting Synaptic Plasticity and Long-Term Memory.
Volume: 10
Pages: 365
Publication
First Author: Abdullah AI
Year: 2016
Journal: Stem Cell Reports
Title: CDK7 and miR-210 Co-regulate Cell-Cycle Progression of Neural Progenitors in the Developing Neocortex.
Volume: 7
Issue: 1
Pages: 69-79
Publication
First Author: Wang H
Year: 2016
Journal: Biochim Biophys Acta
Title: Inhibition of CDK7 bypasses spindle assembly checkpoint via premature cyclin B degradation during oocyte meiosis.
Volume: 1863
Issue: 12
Pages: 2993-3000
Publication
First Author: Korsisaari N
Year: 2003
Journal: Mol Cell Biol
Title: The histidine triad protein Hint is not required for murine development or Cdk7 function.
Volume: 23
Issue: 11
Pages: 3929-35
Publication
First Author: Ganuza M
Year: 2012
Journal: EMBO J
Title: Genetic inactivation of Cdk7 leads to cell cycle arrest and induces premature aging due to adult stem cell exhaustion.
Volume: 31
Issue: 11
Pages: 2498-510
Publication
First Author: Ko LJ
Year: 1997
Journal: Mol Cell Biol
Title: p53 is phosphorylated by CDK7-cyclin H in a p36MAT1-dependent manner.
Volume: 17
Issue: 12
Pages: 7220-9
Publication
First Author: Schneider E
Year: 1998
Journal: Oncogene
Title: Regulation of CAK kinase activity by p53.
Volume: 17
Issue: 21
Pages: 2733-41
Publication
First Author: Kaldis P
Year: 1996
Journal: Cell
Title: The Cdk-activating kinase (CAK) from budding yeast.
Volume: 86
Issue: 4
Pages: 553-64
Publication
First Author: Tirode F
Year: 1999
Journal: Mol Cell
Title: Reconstitution of the transcription factor TFIIH: assignment of functions for the three enzymatic subunits, XPB, XPD, and cdk7.
Volume: 3
Issue: 1
Pages: 87-95
Publication
First Author: Kershnar E
Year: 1998
Journal: J Biol Chem
Title: Immunoaffinity purification and functional characterization of human transcription factor IIH and RNA polymerase II from clonal cell lines that conditionally express epitope-tagged subunits of the multiprotein complexes.
Volume: 273
Issue: 51
Pages: 34444-53
Publication
First Author: Garrett S
Year: 2001
Journal: Mol Cell Biol
Title: Reciprocal activation by cyclin-dependent kinases 2 and 7 is directed by substrate specificity determinants outside the T loop.
Volume: 21
Issue: 1
Pages: 88-99
Protein
Organism: Mus musculus/domesticus
Length: 309  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 346  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 346  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 252  
Fragment?: false
Publication
First Author: Dion V
Year: 2022
Journal: Glia
Title: Cyclin-dependent kinase 7 contributes to myelin maintenance in the adult central nervous system and promotes myelin gene expression.
Volume: 70
Issue: 9
Pages: 1652-1665
Publication
First Author: Helenius K
Year: 2009
Journal: Mol Cell Biol
Title: Mat1 inhibits peroxisome proliferator-activated receptor gamma-mediated adipocyte differentiation.
Volume: 29
Issue: 2
Pages: 315-23
Publication
First Author: Kim JM
Year: 2001
Journal: Biol Reprod
Title: Meiotic expression of the cyclin H/Cdk7 complex in male germ cells of the mouse.
Volume: 64
Issue: 5
Pages: 1400-8
Publication
First Author: Patel SA
Year: 2010
Journal: J Biol Chem
Title: Functional analysis of the Cdk7.cyclin H.Mat1 complex in mouse embryonic stem cells and embryos.
Volume: 285
Issue: 20
Pages: 15587-98
Publication
First Author: Sano M
Year: 2007
Journal: Cell Metab
Title: Ménage-à-trois 1 is critical for the transcriptional function of PPARgamma coactivator 1.
Volume: 5
Issue: 2
Pages: 129-42
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Matsuoka M
Year: 1994
Journal: Mol Cell Biol
Title: Activation of cyclin-dependent kinase 4 (cdk4) by mouse MO15-associated kinase.
Volume: 14
Issue: 11
Pages: 7265-75
Publication
First Author: Stepanova LYu
Year: 1994
Journal: Gene
Title: Sequence of the cDNA encoding murine CRK4 protein kinase.
Volume: 149
Issue: 2
Pages: 321-4
GXD Expression    
Probe: MGI:6719043
Assay Type: RT-PCR
Annotation Date: 2021-07-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603913
Stage: TS13
Assay Id: MGI:6719048
Age: embryonic day 8.25
Image: 4
Specimen Label: +/+
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:6719043
Assay Type: RT-PCR
Annotation Date: 2021-07-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603913
Stage: TS13
Assay Id: MGI:6719048
Age: embryonic day 8.25
Image: 4
Specimen Label: delta/delta
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:7336087
Assay Type: RT-PCR
Annotation Date: 2022-09-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754422
Stage: TS22
Assay Id: MGI:7336088
Age: embryonic day 14.5
Image: 1
Specimen Label: E14.5
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:7336087
Assay Type: RT-PCR
Annotation Date: 2022-09-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754427
Stage: TS27
Assay Id: MGI:7336088
Age: postnatal day 0
Image: 1
Specimen Label: P0
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:7336087
Assay Type: RT-PCR
Annotation Date: 2022-09-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754428
Stage: TS28
Assay Id: MGI:7336088
Age: postnatal day 7
Image: 1
Specimen Label: P7
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:7336087
Assay Type: RT-PCR
Annotation Date: 2022-09-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754428
Stage: TS28
Assay Id: MGI:7336088
Age: postnatal day 30
Image: 1
Specimen Label: P30
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:7336087
Assay Type: RT-PCR
Annotation Date: 2022-09-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754428
Stage: TS28
Assay Id: MGI:7336088
Age: postnatal day 60
Image: 1
Specimen Label: P60
Detected: true
Specimen Num: 5
GXD Expression      
Probe: MGI:7336086
Assay Type: Western blot
Annotation Date: 2022-09-14
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:1754422
Stage: TS22
Assay Id: MGI:7336089
Age: embryonic day 14.5
Image: 1
Specimen Label: E14.5
Specimen Num: 1
GXD Expression      
Probe: MGI:7336086
Assay Type: Western blot
Annotation Date: 2022-09-14
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:1754427
Stage: TS27
Assay Id: MGI:7336089
Age: postnatal day 0
Image: 1
Specimen Label: P0
Specimen Num: 2
GXD Expression      
Probe: MGI:7336086
Assay Type: Western blot
Annotation Date: 2022-09-14
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:1754428
Stage: TS28
Assay Id: MGI:7336089
Age: postnatal day 7
Image: 1
Specimen Label: P7
Specimen Num: 3
GXD Expression    
Probe: MGI:7336086
Assay Type: Western blot
Annotation Date: 2022-09-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754428
Stage: TS28
Assay Id: MGI:7336089
Age: postnatal day 30
Image: 1
Specimen Label: P30
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:7336086
Assay Type: Western blot
Annotation Date: 2022-09-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754428
Stage: TS28
Assay Id: MGI:7336089
Age: postnatal day 60
Image: 1
Specimen Label: P60
Detected: true
Specimen Num: 5
GXD Expression    
Probe: MGI:7412784
Assay Type: RT-PCR
Annotation Date: 2022-12-28
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1691016
Stage: TS16
Assay Id: MGI:7412856
Age: embryonic day 10.0
Image: 1
Specimen Label: E10
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:7412784
Assay Type: RT-PCR
Annotation Date: 2022-12-28
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754426
Stage: TS26
Assay Id: MGI:7412856
Age: embryonic day 18.0
Image: 1
Specimen Label: E18
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:7412784
Assay Type: RT-PCR
Annotation Date: 2022-12-28
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754428
Stage: TS28
Assay Id: MGI:7412856
Age: postnatal month 2
Image: 1
Specimen Label: 2 months
Detected: true
Specimen Num: 3
GXD Expression  
Probe: MGI:1098413
Assay Type: RNA in situ
Annotation Date: 2007-01-23
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1614815
Pattern: Uniform
Stage: TS15
Assay Id: MGI:3694429
Age: embryonic day 9.5
Note: Expression was detected at a uniform level.
Specimen Label: None
Detected: true
Specimen Num: 1
GXD Expression
Probe: MGI:6865748
Assay Type: Immunohistochemistry
Annotation Date: 2022-02-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754721
Pattern: Regionally restricted
Stage: TS21
Assay Id: MGI:6865753
Age: embryonic day 13.5
Image: 4C E13.5
Note: Co-expression with Nes in neural progenitors in ventricular zone and subventricular zone.
Specimen Label: 4C E13.5
Detected: true
Specimen Num: 1
GXD Expression
Probe: MGI:6865748
Assay Type: Immunohistochemistry
Annotation Date: 2022-02-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3270421
Pattern: Regionally restricted
Stage: TS21
Assay Id: MGI:6865753
Age: embryonic day 13.5
Image: 4C E13.5
Note: Co-expression with Nes in neural progenitors in ventricular zone and subventricular zone.
Specimen Label: 4C E13.5
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:6865748
Assay Type: Immunohistochemistry
Annotation Date: 2022-02-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3271121
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:6865753
Age: embryonic day 13.5
Image: 4C E13.5
Specimen Label: 4C E13.5
Detected: true
Specimen Num: 1
GXD Expression
Probe: MGI:6865748
Assay Type: Immunohistochemistry
Annotation Date: 2022-02-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754723
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:6865753
Age: embryonic day 15.5
Image: 4C E15.5
Note: Co-expression with Nes in neural progenitors in ventricular zone and subventricular zone.
Specimen Label: 4C E15.5
Detected: true
Specimen Num: 2
GXD Expression
Probe: MGI:6865748
Assay Type: Immunohistochemistry
Annotation Date: 2022-02-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3270423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:6865753
Age: embryonic day 15.5
Image: 4C E15.5
Note: Co-expression with Nes in neural progenitors in ventricular zone and subventricular zone.
Specimen Label: 4C E15.5
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:6865748
Assay Type: Immunohistochemistry
Annotation Date: 2022-02-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3271123
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:6865753
Age: embryonic day 15.5
Image: 4C E15.5
Specimen Label: 4C E15.5
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:7608358
Assay Type: Immunohistochemistry
Annotation Date: 2024-03-04
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3265122
Stage: TS22
Assay Id: MGI:7608372
Age: embryonic day 14.5
Specimen Label: 2-7
Detected: false
Specimen Num: 1
Publication
First Author: Oven I
Year: 2007
Journal: Mol Cell Biol
Title: AIRE recruits P-TEFb for transcriptional elongation of target genes in medullary thymic epithelial cells.
Volume: 27
Issue: 24
Pages: 8815-23
Publication
First Author: De Graeve F
Year: 2000
Journal: Oncogene
Title: A murine ATFa-associated factor with transcriptional repressing activity.
Volume: 19
Issue: 14
Pages: 1807-19
Publication
First Author: Ahuja HS
Year: 1997
Journal: Dev Genet
Title: Association of cyclin-dependent kinase 5 and its activator p35 with apoptotic cell death.
Volume: 21
Issue: 4
Pages: 258-67
Publication
First Author: Jang MK
Year: 2005
Journal: Mol Cell
Title: The bromodomain protein Brd4 is a positive regulatory component of P-TEFb and stimulates RNA polymerase II-dependent transcription.
Volume: 19
Issue: 4
Pages: 523-34
Publication
First Author: Ershler M
Year: 1993
Journal: Gene
Title: Novel CDC2-related protein kinases produced in murine hematopoietic stem cells.
Volume: 124
Issue: 2
Pages: 305-6
Publication
First Author: Ishimura A
Year: 2012
Journal: Development
Title: Jmjd5, an H3K36me2 histone demethylase, modulates embryonic cell proliferation through the regulation of Cdkn1a expression.
Volume: 139
Issue: 4
Pages: 749-59
Publication
First Author: Gilardi-Hebenstreit P
Year: 1992
Journal: Oncogene
Title: An Eph-related receptor protein tyrosine kinase gene segmentally expressed in the developing mouse hindbrain.
Volume: 7
Issue: 12
Pages: 2499-506
Publication
First Author: Growney JD
Year: 2000
Journal: Genomics
Title: Evolutionary divergence of the mouse and human Lgn1/SMA repeat structures.
Volume: 64
Issue: 1
Pages: 62-81
Publication  
First Author: Kafer GR
Year: 2020
Journal: Front Cell Dev Biol
Title: A Survey of Essential Genome Stability Genes Reveals That Replication Stress Mitigation Is Critical for Peri-Implantation Embryogenesis.
Volume: 8
Pages: 416
Publication
First Author: Moon S
Year: 2018
Journal: Cell Death Dis
Title: Asxl1 exerts an antiproliferative effect on mouse lung maturation via epigenetic repression of the E2f1-Nmyc axis.
Volume: 9
Issue: 11
Pages: 1118
Publication
First Author: Chong D
Year: 2022
Journal: Cell Discov
Title: Neonatal ketone body elevation regulates postnatal heart development by promoting cardiomyocyte mitochondrial maturation and metabolic reprogramming.
Volume: 8
Issue: 1
Pages: 106
Publication  
First Author: Akagawa R
Year: 2021
Journal: Front Cell Dev Biol
Title: Alternative Functions of Cell Cycle-Related and DNA Repair Proteins in Post-mitotic Neurons.
Volume: 9
Pages: 753175
Publication      
First Author: NIH Mouse Knockout Inventory
Year: 2004
Journal: MGI Direct Data Submission
Title: Information obtained from the NIH Mouse Knockout Inventory
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Mouse Synonym Curation
Publication
First Author: Hansen J
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.
Volume: 100
Issue: 17
Pages: 9918-22
Publication
First Author: Friedel RH
Year: 2007
Journal: Brief Funct Genomic Proteomic
Title: EUCOMM--the European conditional mouse mutagenesis program.
Volume: 6
Issue: 3
Pages: 180-5
Publication
First Author: Stryke D
Year: 2003
Journal: Nucleic Acids Res
Title: BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Volume: 31
Issue: 1
Pages: 278-81