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Search results 1 to 100 out of 1459 for Cdkn1b

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Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: chicken
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: frog, western clawed
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: dog, domestic
Gene
Type: gene
Organism: chimpanzee
Protein Domain
Type: Family
Description: Cyclin-dependent kinase inhibitor 1B (CDKN1B, also known as p27Kip1) controls cell proliferation by binding to and regulating the activity of cyclin-dependent kinases (Cdks) []. It is also involved in cell migration through binding and regulation of RhoA or stathmin [, , ]. It also inhibits DNA replication by binding to the DNA replication licensing factor MCM7 [].
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Publication
First Author: Nallamshetty S
Year: 2005
Journal: FEBS Lett
Title: The cell cycle regulator p27Kip1 interacts with MCM7, a DNA replication licensing factor, to inhibit initiation of DNA replication.
Volume: 579
Issue: 29
Pages: 6529-36
Publication
First Author: Baldassarre G
Year: 2005
Journal: Cancer Cell
Title: p27(Kip1)-stathmin interaction influences sarcoma cell migration and invasion.
Volume: 7
Issue: 1
Pages: 51-63
Publication
First Author: Grimmler M
Year: 2007
Journal: Cell
Title: Cdk-inhibitory activity and stability of p27Kip1 are directly regulated by oncogenic tyrosine kinases.
Volume: 128
Issue: 2
Pages: 269-80
Publication
First Author: Le Toriellec E
Year: 2008
Journal: Blood
Title: Haploinsufficiency of CDKN1B contributes to leukemogenesis in T-cell prolymphocytic leukemia.
Volume: 111
Issue: 4
Pages: 2321-8
Publication
First Author: Lin H
Year: 2015
Journal: Biol Reprod
Title: Deficiency of CDKN1A or both CDKN1A and CDKN1B affects the pubertal development of mouse Leydig cells.
Volume: 92
Issue: 3
Pages: 77
Protein
Organism: Mus musculus/domesticus
Length: 197  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 197  
Fragment?: false
Publication
First Author: Chu IM
Year: 2008
Journal: Nat Rev Cancer
Title: The Cdk inhibitor p27 in human cancer: prognostic potential and relevance to anticancer therapy.
Volume: 8
Issue: 4
Pages: 253-67
Publication
First Author: Besson A
Year: 2008
Journal: Dev Cell
Title: CDK inhibitors: cell cycle regulators and beyond.
Volume: 14
Issue: 2
Pages: 159-69
Publication  
First Author: Pruitt SC
Year: 2013
Journal: Nat Commun
Title: Cdkn1b overexpression in adult mice alters the balance between genome and tissue ageing.
Volume: 4
Pages: 2626
GXD Expression    
Probe: MGI:7437565
Assay Type: Immunohistochemistry
Annotation Date: 2023-02-21
Strength: Present
Sex: Male
Emaps: EMAPS:2910628
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:7437576
Age: postnatal day 14
Specimen Label: S2 CDKN1B P14 Control
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:7437565
Assay Type: Immunohistochemistry
Annotation Date: 2023-02-21
Strength: Strong
Sex: Male
Emaps: EMAPS:2910628
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:7437576
Age: postnatal day 14
Note: Increase in Sertoli cell expression compared to control.
Specimen Label: S2 CDKN1B P14 AcP1KO
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:7437565
Assay Type: Immunohistochemistry
Annotation Date: 2023-02-21
Strength: Present
Sex: Male
Emaps: EMAPS:2910628
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:7437576
Age: postnatal adult
Specimen Label: S2 CDKN1B Adult Control
Detected: true
Specimen Num: 3
GXD Expression  
Probe: MGI:7437565
Assay Type: Immunohistochemistry
Annotation Date: 2023-02-21
Strength: Strong
Sex: Male
Emaps: EMAPS:2910628
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:7437576
Age: postnatal adult
Note: Increase in Sertoli cell expression compared to control.
Specimen Label: S2 CDKN1B Adult AcP1KO
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:7437565
Assay Type: Immunohistochemistry
Annotation Date: 2023-02-21
Strength: Present
Sex: Male
Emaps: EMAPS:2910628
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:7437576
Age: postnatal day 14
Specimen Label: 5E CDKN1B Control
Detected: true
Specimen Num: 5
GXD Expression  
Probe: MGI:7437565
Assay Type: Immunohistochemistry
Annotation Date: 2023-02-21
Strength: Strong
Sex: Male
Emaps: EMAPS:2910628
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:7437576
Age: postnatal day 14
Note: Increase in Sertoli cell expression compared to control.
Specimen Label: 5E CDKN1B AcP1KO
Detected: true
Specimen Num: 6
GXD Expression  
Probe: MGI:7437565
Assay Type: Immunohistochemistry
Annotation Date: 2023-02-21
Strength: Weak
Sex: Male
Emaps: EMAPS:2910628
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:7437576
Age: postnatal day 14
Note: Expression in Sertoli cells reduced compared to control.
Specimen Label: 5E CDKN1B AcP1KO; Cdkn1b+/-
Detected: true
Specimen Num: 7
Publication
First Author: Paralkar VR
Year: 2016
Journal: Mol Cell
Title: Unlinking an lncRNA from Its Associated cis Element.
Volume: 62
Issue: 1
Pages: 104-10
Publication
First Author: Uchida T
Year: 2005
Journal: Nat Med
Title: Deletion of Cdkn1b ameliorates hyperglycemia by maintaining compensatory hyperinsulinemia in diabetic mice.
Volume: 11
Issue: 2
Pages: 175-82
Publication
First Author: Kemp CJ
Year: 2000
Journal: Mamm Genome
Title: The murine gene Cdkn1b (p27(Kip1)) maps to distal chromosome 6 and is excluded as Pas1.
Volume: 11
Issue: 5
Pages: 402-4
Publication
First Author: De Marco C
Year: 2019
Journal: Mol Cancer Ther
Title: The T197A Knock-in Model of Cdkn1b Gene to Study the Effects of p27 Restoration In Vivo.
Volume: 18
Issue: 2
Pages: 482-493
ncRNA Gene
Type: lncRNA_gene
Organism: mouse, laboratory
Publication
First Author: Lin H
Year: 2009
Journal: Biol Reprod
Title: Increased proliferation but decreased steroidogenic capacity in Leydig cells from mice lacking cyclin-dependent kinase inhibitor 1B.
Volume: 80
Issue: 6
Pages: 1232-8
Publication
First Author: Fero ML
Year: 1996
Journal: Cell
Title: A syndrome of multiorgan hyperplasia with features of gigantism, tumorigenesis, and female sterility in p27(Kip1)-deficient mice.
Volume: 85
Issue: 5
Pages: 733-44
Publication  
First Author: Colon-Mesa I
Year: 2023
Journal: Int J Mol Sci
Title: p27(Kip1) Deficiency Impairs Brown Adipose Tissue Function Favouring Fat Accumulation in Mice.
Volume: 24
Issue: 3
Publication
First Author: Ale-Agha N
Year: 2018
Journal: PLoS Biol
Title: CDKN1B/p27 is localized in mitochondria and improves respiration-dependent processes in the cardiovascular system-New mode of action for caffeine.
Volume: 16
Issue: 6
Pages: e2004408
Publication
First Author: Li Y
Year: 2016
Journal: Endocrinology
Title: Inactivation of p27kip1 Promoted Nonspecific Inflammation by Enhancing Macrophage Proliferation in Islet Transplantation.
Volume: 157
Issue: 11
Pages: 4121-4132
Publication
First Author: Ogawa M
Year: 2017
Journal: Neural Dev
Title: Cell type-specific effects of p27KIP1 loss on retinal development.
Volume: 12
Issue: 1
Pages: 17
Publication
First Author: Löwenheim H
Year: 1999
Journal: Proc Natl Acad Sci U S A
Title: Gene disruption of p27(Kip1) allows cell proliferation in the postnatal and adult organ of corti.
Volume: 96
Issue: 7
Pages: 4084-8
Publication
First Author: Dyer MA
Year: 2000
Journal: Nat Neurosci
Title: Control of Müller glial cell proliferation and activation following retinal injury.
Volume: 3
Issue: 9
Pages: 873-80
Publication
First Author: Deans AJ
Year: 2004
Journal: Oncogene
Title: Brca1 inactivation induces p27(Kip1)-dependent cell cycle arrest and delayed development in the mouse mammary gland.
Volume: 23
Issue: 36
Pages: 6136-45
Publication
First Author: Ophascharoensuk V
Year: 1998
Journal: Nat Med
Title: The cyclin-dependent kinase inhibitor p27Kip1 safeguards against inflammatory injury.
Volume: 4
Issue: 5
Pages: 575-80
Publication
First Author: Hwang HC
Year: 2002
Journal: Proc Natl Acad Sci U S A
Title: Identification of oncogenes collaborating with p27Kip1 loss by insertional mutagenesis and high-throughput insertion site analysis.
Volume: 99
Issue: 17
Pages: 11293-8
Publication
First Author: Wolf G
Year: 2005
Journal: Kidney Int
Title: p27(Kip1) Knockout mice are protected from diabetic nephropathy: evidence for p27(Kip1) haplotype insufficiency.
Volume: 68
Issue: 4
Pages: 1583-9
Publication  
First Author: Zhou N
Year: 2014
Journal: Sci Rep
Title: p27 kip1 haplo-insufficiency improves cardiac function in early-stages of myocardial infarction by protecting myocardium and increasing angiogenesis by promoting IKK activation.
Volume: 4
Pages: 5978
Publication
First Author: Yan Y
Year: 2019
Journal: J Cell Biochem
Title: Loss of p27kip1 suppresses the myocardial senescence caused by estrogen deficiency.
Volume: 120
Issue: 8
Pages: 13994-14003
Publication  
First Author: Defoe DM
Year: 2007
Journal: Mol Vis
Title: Defects in retinal pigment epithelium cell proliferation and retinal attachment in mutant mice with p27(Kip1) gene ablation.
Volume: 13
Pages: 273-86
Publication
First Author: Ellis FH Jr
Year: 2001
Journal: J Thorac Cardiovasc Surg
Title: Malignant transformation of the esophageal mucosa is enhanced in p27 knockout mice.
Volume: 122
Issue: 4
Pages: 809-14
Publication
First Author: Hauck L
Year: 2008
Journal: Nat Med
Title: Protein kinase CK2 links extracellular growth factor signaling with the control of p27(Kip1) stability in the heart.
Volume: 14
Issue: 3
Pages: 315-24
Publication
First Author: Sharov AA
Year: 2006
Journal: Proc Natl Acad Sci U S A
Title: Bone morphogenetic protein signaling regulates the size of hair follicles and modulates the expression of cell cycle-associated genes.
Volume: 103
Issue: 48
Pages: 18166-71
Publication
First Author: Rowell EA
Year: 2005
Journal: J Immunol
Title: Opposing roles for the cyclin-dependent kinase inhibitor p27kip1 in the control of CD4+ T cell proliferation and effector function.
Volume: 174
Issue: 6
Pages: 3359-68
Publication
First Author: Fero ML
Year: 1998
Journal: Nature
Title: The murine gene p27Kip1 is haplo-insufficient for tumour suppression.
Volume: 396
Issue: 6707
Pages: 177-80
Publication
First Author: Rowell EA
Year: 2006
Journal: J Immunol
Title: The cyclin-dependent kinase inhibitor p27kip1 is required for transplantation tolerance induced by costimulatory blockade.
Volume: 177
Issue: 8
Pages: 5169-76
Publication
First Author: Bryja V
Year: 2004
Journal: Biochim Biophys Acta
Title: The role of p27(Kip1) in maintaining the levels of D-type cyclins in vivo.
Volume: 1691
Issue: 2-3
Pages: 105-16
Publication
First Author: Jackson LJ
Year: 2012
Journal: Cell Immunol
Title: The role of PIM kinases in human and mouse CD4+ T cell activation and inflammatory bowel disease.
Volume: 272
Issue: 2
Pages: 200-13
Publication
First Author: Ankri-Eliahoo G
Year: 2016
Journal: J Vasc Surg
Title: p27(kip1) Knockout enhances collateralization in response to hindlimb ischemia.
Volume: 63
Issue: 5
Pages: 1351-9
Publication
First Author: Besson A
Year: 2007
Journal: Genes Dev
Title: Discovery of an oncogenic activity in p27Kip1 that causes stem cell expansion and a multiple tumor phenotype.
Volume: 21
Issue: 14
Pages: 1731-46
Publication
First Author: Yu D
Year: 2015
Journal: PLoS One
Title: MARCKS Signaling Differentially Regulates Vascular Smooth Muscle and Endothelial Cell Proliferation through a KIS-, p27kip1- Dependent Mechanism.
Volume: 10
Issue: 11
Pages: e0141397
Publication
First Author: Lin J
Year: 2003
Journal: Biochem Biophys Res Commun
Title: P27 knockout mice: reduced myostatin in muscle and altered adipogenesis.
Volume: 300
Issue: 4
Pages: 938-42
Publication
First Author: Gui P
Year: 2014
Journal: J Cell Sci
Title: Rho/ROCK pathway inhibition by the CDK inhibitor p27(kip1) participates in the onset of macrophage 3D-mesenchymal migration.
Volume: 127
Issue: Pt 18
Pages: 4009-23
Publication
First Author: Jatzek A
Year: 2012
Journal: J Immunol
Title: p27(Kip1) negatively regulates the magnitude and persistence of CD4 T cell memory.
Volume: 189
Issue: 11
Pages: 5119-28
Publication
First Author: Zhou N
Year: 2019
Journal: Mol Med Rep
Title: p27kip1 haploinsufficiency preserves myocardial function in the early stages of myocardial infarction via Atg5‑mediated autophagy flux restoration.
Volume: 20
Issue: 4
Pages: 3840-3848
Publication
First Author: Roussel-Gervais A
Year: 2010
Journal: Mol Endocrinol
Title: Cooperation between cyclin E and p27(Kip1) in pituitary tumorigenesis.
Volume: 24
Issue: 9
Pages: 1835-45
Publication
First Author: Chen P
Year: 1999
Journal: Development
Title: p27(Kip1) links cell proliferation to morphogenesis in the developing organ of Corti.
Volume: 126
Issue: 8
Pages: 1581-90
Publication
First Author: Meunier D
Year: 2003
Journal: Anat Embryol (Berl)
Title: Preferential expression of the G90 gene in post-mitotic cells during mouse embryonic development.
Volume: 207
Issue: 2
Pages: 109-17
Publication
First Author: McArthur GA
Year: 2002
Journal: Mol Cell Biol
Title: MAD1 and p27(KIP1) cooperate to promote terminal differentiation of granulocytes and to inhibit Myc expression and cyclin E-CDK2 activity.
Volume: 22
Issue: 9
Pages: 3014-23
Publication
First Author: Cerqueira A
Year: 2014
Journal: Mol Cell Biol
Title: Genetic characterization of the role of the Cip/Kip family of proteins as cyclin-dependent kinase inhibitors and assembly factors.
Volume: 34
Issue: 8
Pages: 1452-9
Publication
First Author: Green ES
Year: 2003
Journal: Development
Title: Genetic rescue of cell number in a mouse model of microphthalmia: interactions between Chx10 and G1-phase cell cycle regulators.
Volume: 130
Issue: 3
Pages: 539-52
Publication
First Author: Kelly-Spratt KS
Year: 2009
Journal: Oncogene
Title: Inhibition of PI-3K restores nuclear p27Kip1 expression in a mouse model of Kras-driven lung cancer.
Volume: 28
Issue: 41
Pages: 3652-62
Publication
First Author: Dyer MA
Year: 2001
Journal: J Neurosci
Title: p27Kip1 and p57Kip2 regulate proliferation in distinct retinal progenitor cell populations.
Volume: 21
Issue: 12
Pages: 4259-71
Publication
First Author: Georgia S
Year: 2006
Journal: Diabetes
Title: p27 Regulates the transition of beta-cells from quiescence to proliferation.
Volume: 55
Issue: 11
Pages: 2950-6
Publication
First Author: Holsberger DR
Year: 2005
Journal: Biol Reprod
Title: Cell-cycle inhibitors p27Kip1 and p21Cip1 regulate murine Sertoli cell proliferation.
Volume: 72
Issue: 6
Pages: 1429-36
Publication
First Author: Kiyokawa H
Year: 1996
Journal: Cell
Title: Enhanced growth of mice lacking the cyclin-dependent kinase inhibitor function of p27(Kip1).
Volume: 85
Issue: 5
Pages: 721-32
Publication
First Author: Poolman RA
Year: 1999
Journal: Circ Res
Title: Altered expression of cell cycle proteins and prolonged duration of cardiac myocyte hyperplasia in p27KIP1 knockout mice.
Volume: 85
Issue: 2
Pages: 117-27
Publication
First Author: Sun J
Year: 2001
Journal: Circulation
Title: Role for p27(Kip1) in Vascular Smooth Muscle Cell Migration.
Volume: 103
Issue: 24
Pages: 2967-72
Publication
First Author: Yang W
Year: 2003
Journal: Cancer Res
Title: Targeted inactivation of p27kip1 is sufficient for large and small intestinal tumorigenesis in the mouse, which can be augmented by a Western-style high-risk diet.
Volume: 63
Issue: 16
Pages: 4990-6
Publication
First Author: Pérez-Sanz J
Year: 2013
Journal: Hum Reprod
Title: Increased number of multi-oocyte follicles (MOFs) in juvenile p27Kip1 mutant mice: potential role of granulosa cells.
Volume: 28
Issue: 4
Pages: 1023-30
Publication
First Author: Zhang S
Year: 2014
Journal: Cancer Lett
Title: Early or late antibiotic intervention prevents Helicobacter pylori-induced gastric cancer in a mouse model.
Volume: 355
Issue: 1
Pages: 106-12
Publication
First Author: Shaffer DR
Year: 2005
Journal: Proc Natl Acad Sci U S A
Title: Evidence for a p27 tumor suppressive function independent of its role regulating cell proliferation in the prostate.
Volume: 102
Issue: 1
Pages: 210-5
Publication
First Author: Cheng T
Year: 2000
Journal: Nat Med
Title: Stem cell repopulation efficiency but not pool size is governed by p27(kip1).
Volume: 6
Issue: 11
Pages: 1235-40
Publication
First Author: Teixeira LT
Year: 2000
Journal: Oncogene
Title: p27Kip1-deficient mice exhibit accelerated growth hormone-releasing hormone (GHRH)-induced somatotrope proliferation and adenoma formation.
Volume: 19
Issue: 15
Pages: 1875-84
Publication
First Author: Kolluri SK
Year: 1999
Journal: Genes Dev
Title: p27(Kip1) induction and inhibition of proliferation by the intracellular Ah receptor in developing thymus and hepatoma cells.
Volume: 13
Issue: 13
Pages: 1742-53
Publication
First Author: Qiu J
Year: 2009
Journal: Stem Cells
Title: p27Kip1 constrains proliferation of neural progenitor cells in adult brain under homeostatic and ischemic conditions.
Volume: 27
Issue: 4
Pages: 920-7
Publication
First Author: Kuzushita N
Year: 2005
Journal: Gastroenterology
Title: p27kip1 deficiency confers susceptibility to gastric carcinogenesis in Helicobacter pylori-infected mice.
Volume: 129
Issue: 5
Pages: 1544-56
Publication
First Author: Legrier ME
Year: 2001
Journal: Cell Growth Differ
Title: Cell cycle regulation during mouse olfactory neurogenesis.
Volume: 12
Issue: 12
Pages: 591-601
Publication
First Author: Doetsch F
Year: 2002
Journal: J Neurosci
Title: Lack of the cell-cycle inhibitor p27Kip1 results in selective increase of transit-amplifying cells for adult neurogenesis.
Volume: 22
Issue: 6
Pages: 2255-64
Publication
First Author: Muraoka RS
Year: 2001
Journal: J Cell Biol
Title: Cyclin-dependent kinase inhibitor p27(Kip1) is required for mouse mammary gland morphogenesis and function.
Volume: 153
Issue: 5
Pages: 917-32
Publication
First Author: Feng Z
Year: 2005
Journal: Am J Pathol
Title: Glomerular aging in females is a multi-stage reversible process mediated by phenotypic changes in progenitors.
Volume: 167
Issue: 2
Pages: 355-63
Publication
First Author: Kanzaki S
Year: 2006
Journal: Hear Res
Title: p27(Kip1) deficiency causes organ of Corti pathology and hearing loss.
Volume: 214
Issue: 1-2
Pages: 28-36
Publication
First Author: Casaccia-Bonnefil P
Year: 1997
Journal: Genes Dev
Title: Oligodendrocyte precursor differentiation is perturbed in the absence of the cyclin-dependent kinase inhibitor p27Kip1.
Volume: 11
Issue: 18
Pages: 2335-46
Publication
First Author: Di Cristofano A
Year: 2001
Journal: Nat Genet
Title: Pten and p27KIP1 cooperate in prostate cancer tumor suppression in the mouse.
Volume: 27
Issue: 2
Pages: 222-4
Publication
First Author: Mukai M
Year: 2005
Journal: Biol Reprod
Title: Altered prostatic epithelial proliferation and apoptosis, prostatic development, and serum testosterone in mice lacking cyclin-dependent kinase inhibitors.
Volume: 73
Issue: 5
Pages: 951-8
Publication
First Author: Short JD
Year: 2008
Journal: Cancer Res
Title: AMP-activated protein kinase signaling results in cytoplasmic sequestration of p27.
Volume: 68
Issue: 16
Pages: 6496-506
Publication
First Author: Park MS
Year: 1999
Journal: Proc Natl Acad Sci U S A
Title: p27 and Rb are on overlapping pathways suppressing tumorigenesis in mice.
Volume: 96
Issue: 11
Pages: 6382-7
Publication
First Author: Choi SH
Year: 2020
Journal: Oncoimmunology
Title: Loss of p27Kip1 leads to expansion of CD4+ effector memory T cells and accelerates colitis-associated colon cancer in mice with a T cell lineage restricted deletion of Smad4.
Volume: 9
Issue: 1
Pages: 1847832
Publication
First Author: Yu L
Year: 2005
Journal: Circ Res
Title: Cyclin-dependent kinase inhibitor p27Kip1, but not p21WAF1/Cip1, is required for inhibition of hypoxia-induced pulmonary hypertension and remodeling by heparin in mice.
Volume: 97
Issue: 9
Pages: 937-45
Publication
First Author: Philipp J
Year: 1999
Journal: Oncogene
Title: Tumor suppression by p27Kip1 and p21Cip1 during chemically induced skin carcinogenesis.
Volume: 18
Issue: 33
Pages: 4689-98
Publication
First Author: Sun D
Year: 2007
Journal: Carcinogenesis
Title: Loss of p27Kip1 enhances tumor progression in chronic hepatocyte injury-induced liver tumorigenesis with widely ranging effects on Cdk2 or Cdc2 activation.
Volume: 28
Issue: 9
Pages: 1859-66
Publication
First Author: Monahan P
Year: 2012
Journal: Mech Dev
Title: p21, an important mediator of quiescence during pituitary tumor formation, is dispensable for normal pituitary development during embryogenesis.
Volume: 128
Issue: 11-12
Pages: 640-52
Publication
First Author: Casaccia-Bonnefil P
Year: 1999
Journal: Development
Title: Loss of p27Kip1 function results in increased proliferative capacity of oligodendrocyte progenitors but unaltered timing of differentiation.
Volume: 126
Issue: 18
Pages: 4027-37