Type |
Details |
Score |
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
frog, western clawed |
|
•
•
•
•
•
|
Gene |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
dog, domestic |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chimpanzee |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
cattle |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chicken |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
Cyclin-dependent kinase inhibitor 1B (CDKN1B, also known as p27Kip1) controls cell proliferation by binding to and regulating the activity of cyclin-dependent kinases (Cdks) []. It is also involved in cell migration through binding and regulation of RhoA or stathmin [, , ]. It also inhibits DNA replication by binding to the DNA replication licensing factor MCM7 []. |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Publication |
First Author: |
Nallamshetty S |
Year: |
2005 |
Journal: |
FEBS Lett |
Title: |
The cell cycle regulator p27Kip1 interacts with MCM7, a DNA replication licensing factor, to inhibit initiation of DNA replication. |
Volume: |
579 |
Issue: |
29 |
Pages: |
6529-36 |
|
•
•
•
•
•
|
Publication |
First Author: |
Baldassarre G |
Year: |
2005 |
Journal: |
Cancer Cell |
Title: |
p27(Kip1)-stathmin interaction influences sarcoma cell migration and invasion. |
Volume: |
7 |
Issue: |
1 |
Pages: |
51-63 |
|
•
•
•
•
•
|
Publication |
First Author: |
Grimmler M |
Year: |
2007 |
Journal: |
Cell |
Title: |
Cdk-inhibitory activity and stability of p27Kip1 are directly regulated by oncogenic tyrosine kinases. |
Volume: |
128 |
Issue: |
2 |
Pages: |
269-80 |
|
•
•
•
•
•
|
Publication |
First Author: |
Le Toriellec E |
Year: |
2008 |
Journal: |
Blood |
Title: |
Haploinsufficiency of CDKN1B contributes to leukemogenesis in T-cell prolymphocytic leukemia. |
Volume: |
111 |
Issue: |
4 |
Pages: |
2321-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lin H |
Year: |
2015 |
Journal: |
Biol Reprod |
Title: |
Deficiency of CDKN1A or both CDKN1A and CDKN1B affects the pubertal development of mouse Leydig cells. |
Volume: |
92 |
Issue: |
3 |
Pages: |
77 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
197
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
197
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Chu IM |
Year: |
2008 |
Journal: |
Nat Rev Cancer |
Title: |
The Cdk inhibitor p27 in human cancer: prognostic potential and relevance to anticancer therapy. |
Volume: |
8 |
Issue: |
4 |
Pages: |
253-67 |
|
•
•
•
•
•
|
Publication |
First Author: |
Besson A |
Year: |
2008 |
Journal: |
Dev Cell |
Title: |
CDK inhibitors: cell cycle regulators and beyond. |
Volume: |
14 |
Issue: |
2 |
Pages: |
159-69 |
|
•
•
•
•
•
|
Publication |
First Author: |
Pruitt SC |
Year: |
2013 |
Journal: |
Nat Commun |
Title: |
Cdkn1b overexpression in adult mice alters the balance between genome and tissue ageing. |
Volume: |
4 |
|
Pages: |
2626 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7437565 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2023-02-21 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:2910628 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:7437576 |
Age: |
postnatal day 14 |
|
|
Specimen Label: |
S2 CDKN1B P14 Control |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7437565 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2023-02-21 |
Strength: |
Strong |
Sex: |
Male |
Emaps: |
EMAPS:2910628 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:7437576 |
Age: |
postnatal day 14 |
|
Note: |
Increase in Sertoli cell expression compared to control. |
Specimen Label: |
S2 CDKN1B P14 AcP1KO |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7437565 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2023-02-21 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:2910628 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:7437576 |
Age: |
postnatal adult |
|
|
Specimen Label: |
S2 CDKN1B Adult Control |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7437565 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2023-02-21 |
Strength: |
Strong |
Sex: |
Male |
Emaps: |
EMAPS:2910628 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:7437576 |
Age: |
postnatal adult |
|
Note: |
Increase in Sertoli cell expression compared to control. |
Specimen Label: |
S2 CDKN1B Adult AcP1KO |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7437565 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2023-02-21 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:2910628 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:7437576 |
Age: |
postnatal day 14 |
|
|
Specimen Label: |
5E CDKN1B Control |
Detected: |
true |
Specimen Num: |
5 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7437565 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2023-02-21 |
Strength: |
Strong |
Sex: |
Male |
Emaps: |
EMAPS:2910628 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:7437576 |
Age: |
postnatal day 14 |
|
Note: |
Increase in Sertoli cell expression compared to control. |
Specimen Label: |
5E CDKN1B AcP1KO |
Detected: |
true |
Specimen Num: |
6 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7437565 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2023-02-21 |
Strength: |
Weak |
Sex: |
Male |
Emaps: |
EMAPS:2910628 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:7437576 |
Age: |
postnatal day 14 |
|
Note: |
Expression in Sertoli cells reduced compared to control. |
Specimen Label: |
5E CDKN1B AcP1KO; Cdkn1b+/- |
Detected: |
true |
Specimen Num: |
7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Paralkar VR |
Year: |
2016 |
Journal: |
Mol Cell |
Title: |
Unlinking an lncRNA from Its Associated cis Element. |
Volume: |
62 |
Issue: |
1 |
Pages: |
104-10 |
|
•
•
•
•
•
|
Publication |
First Author: |
Uchida T |
Year: |
2005 |
Journal: |
Nat Med |
Title: |
Deletion of Cdkn1b ameliorates hyperglycemia by maintaining compensatory hyperinsulinemia in diabetic mice. |
Volume: |
11 |
Issue: |
2 |
Pages: |
175-82 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kemp CJ |
Year: |
2000 |
Journal: |
Mamm Genome |
Title: |
The murine gene Cdkn1b (p27(Kip1)) maps to distal chromosome 6 and is excluded as Pas1. |
Volume: |
11 |
Issue: |
5 |
Pages: |
402-4 |
|
•
•
•
•
•
|
Publication |
First Author: |
De Marco C |
Year: |
2019 |
Journal: |
Mol Cancer Ther |
Title: |
The T197A Knock-in Model of Cdkn1b Gene to Study the Effects of p27 Restoration In Vivo. |
Volume: |
18 |
Issue: |
2 |
Pages: |
482-493 |
|
•
•
•
•
•
|
ncRNA Gene |
Type: |
lncRNA_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Publication |
First Author: |
Lin H |
Year: |
2009 |
Journal: |
Biol Reprod |
Title: |
Increased proliferation but decreased steroidogenic capacity in Leydig cells from mice lacking cyclin-dependent kinase inhibitor 1B. |
Volume: |
80 |
Issue: |
6 |
Pages: |
1232-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Fero ML |
Year: |
1996 |
Journal: |
Cell |
Title: |
A syndrome of multiorgan hyperplasia with features of gigantism, tumorigenesis, and female sterility in p27(Kip1)-deficient mice. |
Volume: |
85 |
Issue: |
5 |
Pages: |
733-44 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yan Y |
Year: |
2019 |
Journal: |
J Cell Biochem |
Title: |
Loss of p27kip1 suppresses the myocardial senescence caused by estrogen deficiency. |
Volume: |
120 |
Issue: |
8 |
Pages: |
13994-14003 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ophascharoensuk V |
Year: |
1998 |
Journal: |
Nat Med |
Title: |
The cyclin-dependent kinase inhibitor p27Kip1 safeguards against inflammatory injury. |
Volume: |
4 |
Issue: |
5 |
Pages: |
575-80 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hwang HC |
Year: |
2002 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Identification of oncogenes collaborating with p27Kip1 loss by insertional mutagenesis and high-throughput insertion site analysis. |
Volume: |
99 |
Issue: |
17 |
Pages: |
11293-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ale-Agha N |
Year: |
2018 |
Journal: |
PLoS Biol |
Title: |
CDKN1B/p27 is localized in mitochondria and improves respiration-dependent processes in the cardiovascular system-New mode of action for caffeine. |
Volume: |
16 |
Issue: |
6 |
Pages: |
e2004408 |
|
•
•
•
•
•
|
Publication |
First Author: |
Li Y |
Year: |
2016 |
Journal: |
Endocrinology |
Title: |
Inactivation of p27kip1 Promoted Nonspecific Inflammation by Enhancing Macrophage Proliferation in Islet Transplantation. |
Volume: |
157 |
Issue: |
11 |
Pages: |
4121-4132 |
|
•
•
•
•
•
|
Publication |
First Author: |
Dyer MA |
Year: |
2000 |
Journal: |
Nat Neurosci |
Title: |
Control of Müller glial cell proliferation and activation following retinal injury. |
Volume: |
3 |
Issue: |
9 |
Pages: |
873-80 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhou N |
Year: |
2014 |
Journal: |
Sci Rep |
Title: |
p27 kip1 haplo-insufficiency improves cardiac function in early-stages of myocardial infarction by protecting myocardium and increasing angiogenesis by promoting IKK activation. |
Volume: |
4 |
|
Pages: |
5978 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ellis FH Jr |
Year: |
2001 |
Journal: |
J Thorac Cardiovasc Surg |
Title: |
Malignant transformation of the esophageal mucosa is enhanced in p27 knockout mice. |
Volume: |
122 |
Issue: |
4 |
Pages: |
809-14 |
|
•
•
•
•
•
|
Publication |
First Author: |
Colon-Mesa I |
Year: |
2023 |
Journal: |
Int J Mol Sci |
Title: |
p27(Kip1) Deficiency Impairs Brown Adipose Tissue Function Favouring Fat Accumulation in Mice. |
Volume: |
24 |
Issue: |
3 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Bryja V |
Year: |
2004 |
Journal: |
Biochim Biophys Acta |
Title: |
The role of p27(Kip1) in maintaining the levels of D-type cyclins in vivo. |
Volume: |
1691 |
Issue: |
2-3 |
Pages: |
105-16 |
|
•
•
•
•
•
|
Publication |
First Author: |
Löwenheim H |
Year: |
1999 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Gene disruption of p27(Kip1) allows cell proliferation in the postnatal and adult organ of corti. |
Volume: |
96 |
Issue: |
7 |
Pages: |
4084-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hauck L |
Year: |
2008 |
Journal: |
Nat Med |
Title: |
Protein kinase CK2 links extracellular growth factor signaling with the control of p27(Kip1) stability in the heart. |
Volume: |
14 |
Issue: |
3 |
Pages: |
315-24 |
|
•
•
•
•
•
|
Publication |
First Author: |
Fero ML |
Year: |
1998 |
Journal: |
Nature |
Title: |
The murine gene p27Kip1 is haplo-insufficient for tumour suppression. |
Volume: |
396 |
Issue: |
6707 |
Pages: |
177-80 |
|
•
•
•
•
•
|
Publication |
First Author: |
Rowell EA |
Year: |
2005 |
Journal: |
J Immunol |
Title: |
Opposing roles for the cyclin-dependent kinase inhibitor p27kip1 in the control of CD4+ T cell proliferation and effector function. |
Volume: |
174 |
Issue: |
6 |
Pages: |
3359-68 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ogawa M |
Year: |
2017 |
Journal: |
Neural Dev |
Title: |
Cell type-specific effects of p27KIP1 loss on retinal development. |
Volume: |
12 |
Issue: |
1 |
Pages: |
17 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ankri-Eliahoo G |
Year: |
2016 |
Journal: |
J Vasc Surg |
Title: |
p27(kip1) Knockout enhances collateralization in response to hindlimb ischemia. |
Volume: |
63 |
Issue: |
5 |
Pages: |
1351-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Jackson LJ |
Year: |
2012 |
Journal: |
Cell Immunol |
Title: |
The role of PIM kinases in human and mouse CD4+ T cell activation and inflammatory bowel disease. |
Volume: |
272 |
Issue: |
2 |
Pages: |
200-13 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wolf G |
Year: |
2005 |
Journal: |
Kidney Int |
Title: |
p27(Kip1) Knockout mice are protected from diabetic nephropathy: evidence for p27(Kip1) haplotype insufficiency. |
Volume: |
68 |
Issue: |
4 |
Pages: |
1583-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Deans AJ |
Year: |
2004 |
Journal: |
Oncogene |
Title: |
Brca1 inactivation induces p27(Kip1)-dependent cell cycle arrest and delayed development in the mouse mammary gland. |
Volume: |
23 |
Issue: |
36 |
Pages: |
6136-45 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sharov AA |
Year: |
2006 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Bone morphogenetic protein signaling regulates the size of hair follicles and modulates the expression of cell cycle-associated genes. |
Volume: |
103 |
Issue: |
48 |
Pages: |
18166-71 |
|
•
•
•
•
•
|
Publication |
First Author: |
Defoe DM |
Year: |
2007 |
Journal: |
Mol Vis |
Title: |
Defects in retinal pigment epithelium cell proliferation and retinal attachment in mutant mice with p27(Kip1) gene ablation. |
Volume: |
13 |
|
Pages: |
273-86 |
|
•
•
•
•
•
|
Publication |
First Author: |
Rowell EA |
Year: |
2006 |
Journal: |
J Immunol |
Title: |
The cyclin-dependent kinase inhibitor p27kip1 is required for transplantation tolerance induced by costimulatory blockade. |
Volume: |
177 |
Issue: |
8 |
Pages: |
5169-76 |
|
•
•
•
•
•
|
Publication |
First Author: |
Besson A |
Year: |
2007 |
Journal: |
Genes Dev |
Title: |
Discovery of an oncogenic activity in p27Kip1 that causes stem cell expansion and a multiple tumor phenotype. |
Volume: |
21 |
Issue: |
14 |
Pages: |
1731-46 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lin J |
Year: |
2003 |
Journal: |
Biochem Biophys Res Commun |
Title: |
P27 knockout mice: reduced myostatin in muscle and altered adipogenesis. |
Volume: |
300 |
Issue: |
4 |
Pages: |
938-42 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yu D |
Year: |
2015 |
Journal: |
PLoS One |
Title: |
MARCKS Signaling Differentially Regulates Vascular Smooth Muscle and Endothelial Cell Proliferation through a KIS-, p27kip1- Dependent Mechanism. |
Volume: |
10 |
Issue: |
11 |
Pages: |
e0141397 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gui P |
Year: |
2014 |
Journal: |
J Cell Sci |
Title: |
Rho/ROCK pathway inhibition by the CDK inhibitor p27(kip1) participates in the onset of macrophage 3D-mesenchymal migration. |
Volume: |
127 |
Issue: |
Pt 18 |
Pages: |
4009-23 |
|
•
•
•
•
•
|
Publication |
First Author: |
Meunier D |
Year: |
2003 |
Journal: |
Anat Embryol (Berl) |
Title: |
Preferential expression of the G90 gene in post-mitotic cells during mouse embryonic development. |
Volume: |
207 |
Issue: |
2 |
Pages: |
109-17 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhou N |
Year: |
2019 |
Journal: |
Mol Med Rep |
Title: |
p27kip1 haploinsufficiency preserves myocardial function in the early stages of myocardial infarction via Atg5‑mediated autophagy flux restoration. |
Volume: |
20 |
Issue: |
4 |
Pages: |
3840-3848 |
|
•
•
•
•
•
|
Publication |
First Author: |
Jatzek A |
Year: |
2012 |
Journal: |
J Immunol |
Title: |
p27(Kip1) negatively regulates the magnitude and persistence of CD4 T cell memory. |
Volume: |
189 |
Issue: |
11 |
Pages: |
5119-28 |
|
•
•
•
•
•
|
Publication |
First Author: |
Roussel-Gervais A |
Year: |
2010 |
Journal: |
Mol Endocrinol |
Title: |
Cooperation between cyclin E and p27(Kip1) in pituitary tumorigenesis. |
Volume: |
24 |
Issue: |
9 |
Pages: |
1835-45 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chen P |
Year: |
1999 |
Journal: |
Development |
Title: |
p27(Kip1) links cell proliferation to morphogenesis in the developing organ of Corti. |
Volume: |
126 |
Issue: |
8 |
Pages: |
1581-90 |
|
•
•
•
•
•
|
Publication |
First Author: |
Green ES |
Year: |
2003 |
Journal: |
Development |
Title: |
Genetic rescue of cell number in a mouse model of microphthalmia: interactions between Chx10 and G1-phase cell cycle regulators. |
Volume: |
130 |
Issue: |
3 |
Pages: |
539-52 |
|
•
•
•
•
•
|
Publication |
First Author: |
McArthur GA |
Year: |
2002 |
Journal: |
Mol Cell Biol |
Title: |
MAD1 and p27(KIP1) cooperate to promote terminal differentiation of granulocytes and to inhibit Myc expression and cyclin E-CDK2 activity. |
Volume: |
22 |
Issue: |
9 |
Pages: |
3014-23 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kelly-Spratt KS |
Year: |
2009 |
Journal: |
Oncogene |
Title: |
Inhibition of PI-3K restores nuclear p27Kip1 expression in a mouse model of Kras-driven lung cancer. |
Volume: |
28 |
Issue: |
41 |
Pages: |
3652-62 |
|
•
•
•
•
•
|
Publication |
First Author: |
Cerqueira A |
Year: |
2014 |
Journal: |
Mol Cell Biol |
Title: |
Genetic characterization of the role of the Cip/Kip family of proteins as cyclin-dependent kinase inhibitors and assembly factors. |
Volume: |
34 |
Issue: |
8 |
Pages: |
1452-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Dyer MA |
Year: |
2001 |
Journal: |
J Neurosci |
Title: |
p27Kip1 and p57Kip2 regulate proliferation in distinct retinal progenitor cell populations. |
Volume: |
21 |
Issue: |
12 |
Pages: |
4259-71 |
|
•
•
•
•
•
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Publication |
First Author: |
Georgia S |
Year: |
2006 |
Journal: |
Diabetes |
Title: |
p27 Regulates the transition of beta-cells from quiescence to proliferation. |
Volume: |
55 |
Issue: |
11 |
Pages: |
2950-6 |
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Publication |
First Author: |
Holsberger DR |
Year: |
2005 |
Journal: |
Biol Reprod |
Title: |
Cell-cycle inhibitors p27Kip1 and p21Cip1 regulate murine Sertoli cell proliferation. |
Volume: |
72 |
Issue: |
6 |
Pages: |
1429-36 |
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Publication |
First Author: |
Zhang S |
Year: |
2014 |
Journal: |
Cancer Lett |
Title: |
Early or late antibiotic intervention prevents Helicobacter pylori-induced gastric cancer in a mouse model. |
Volume: |
355 |
Issue: |
1 |
Pages: |
106-12 |
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Publication |
First Author: |
Sun J |
Year: |
2001 |
Journal: |
Circulation |
Title: |
Role for p27(Kip1) in Vascular Smooth Muscle Cell Migration. |
Volume: |
103 |
Issue: |
24 |
Pages: |
2967-72 |
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Publication |
First Author: |
Poolman RA |
Year: |
1999 |
Journal: |
Circ Res |
Title: |
Altered expression of cell cycle proteins and prolonged duration of cardiac myocyte hyperplasia in p27KIP1 knockout mice. |
Volume: |
85 |
Issue: |
2 |
Pages: |
117-27 |
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Publication |
First Author: |
Muraoka RS |
Year: |
2001 |
Journal: |
J Cell Biol |
Title: |
Cyclin-dependent kinase inhibitor p27(Kip1) is required for mouse mammary gland morphogenesis and function. |
Volume: |
153 |
Issue: |
5 |
Pages: |
917-32 |
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Publication |
First Author: |
Teixeira LT |
Year: |
2000 |
Journal: |
Oncogene |
Title: |
p27Kip1-deficient mice exhibit accelerated growth hormone-releasing hormone (GHRH)-induced somatotrope proliferation and adenoma formation. |
Volume: |
19 |
Issue: |
15 |
Pages: |
1875-84 |
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Publication |
First Author: |
Cheng T |
Year: |
2000 |
Journal: |
Nat Med |
Title: |
Stem cell repopulation efficiency but not pool size is governed by p27(kip1). |
Volume: |
6 |
Issue: |
11 |
Pages: |
1235-40 |
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Publication |
First Author: |
Kolluri SK |
Year: |
1999 |
Journal: |
Genes Dev |
Title: |
p27(Kip1) induction and inhibition of proliferation by the intracellular Ah receptor in developing thymus and hepatoma cells. |
Volume: |
13 |
Issue: |
13 |
Pages: |
1742-53 |
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Publication |
First Author: |
Qiu J |
Year: |
2009 |
Journal: |
Stem Cells |
Title: |
p27Kip1 constrains proliferation of neural progenitor cells in adult brain under homeostatic and ischemic conditions. |
Volume: |
27 |
Issue: |
4 |
Pages: |
920-7 |
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Publication |
First Author: |
Casaccia-Bonnefil P |
Year: |
1997 |
Journal: |
Genes Dev |
Title: |
Oligodendrocyte precursor differentiation is perturbed in the absence of the cyclin-dependent kinase inhibitor p27Kip1. |
Volume: |
11 |
Issue: |
18 |
Pages: |
2335-46 |
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Publication |
First Author: |
Kiyokawa H |
Year: |
1996 |
Journal: |
Cell |
Title: |
Enhanced growth of mice lacking the cyclin-dependent kinase inhibitor function of p27(Kip1). |
Volume: |
85 |
Issue: |
5 |
Pages: |
721-32 |
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Publication |
First Author: |
Feng Z |
Year: |
2005 |
Journal: |
Am J Pathol |
Title: |
Glomerular aging in females is a multi-stage reversible process mediated by phenotypic changes in progenitors. |
Volume: |
167 |
Issue: |
2 |
Pages: |
355-63 |
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Publication |
First Author: |
Kanzaki S |
Year: |
2006 |
Journal: |
Hear Res |
Title: |
p27(Kip1) deficiency causes organ of Corti pathology and hearing loss. |
Volume: |
214 |
Issue: |
1-2 |
Pages: |
28-36 |
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Publication |
First Author: |
Shaffer DR |
Year: |
2005 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Evidence for a p27 tumor suppressive function independent of its role regulating cell proliferation in the prostate. |
Volume: |
102 |
Issue: |
1 |
Pages: |
210-5 |
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Publication |
First Author: |
Doetsch F |
Year: |
2002 |
Journal: |
J Neurosci |
Title: |
Lack of the cell-cycle inhibitor p27Kip1 results in selective increase of transit-amplifying cells for adult neurogenesis. |
Volume: |
22 |
Issue: |
6 |
Pages: |
2255-64 |
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Publication |
First Author: |
Legrier ME |
Year: |
2001 |
Journal: |
Cell Growth Differ |
Title: |
Cell cycle regulation during mouse olfactory neurogenesis. |
Volume: |
12 |
Issue: |
12 |
Pages: |
591-601 |
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Publication |
First Author: |
Yang W |
Year: |
2003 |
Journal: |
Cancer Res |
Title: |
Targeted inactivation of p27kip1 is sufficient for large and small intestinal tumorigenesis in the mouse, which can be augmented by a Western-style high-risk diet. |
Volume: |
63 |
Issue: |
16 |
Pages: |
4990-6 |
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Publication |
First Author: |
Kuzushita N |
Year: |
2005 |
Journal: |
Gastroenterology |
Title: |
p27kip1 deficiency confers susceptibility to gastric carcinogenesis in Helicobacter pylori-infected mice. |
Volume: |
129 |
Issue: |
5 |
Pages: |
1544-56 |
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Publication |
First Author: |
Pérez-Sanz J |
Year: |
2013 |
Journal: |
Hum Reprod |
Title: |
Increased number of multi-oocyte follicles (MOFs) in juvenile p27Kip1 mutant mice: potential role of granulosa cells. |
Volume: |
28 |
Issue: |
4 |
Pages: |
1023-30 |
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Publication |
First Author: |
Di Cristofano A |
Year: |
2001 |
Journal: |
Nat Genet |
Title: |
Pten and p27KIP1 cooperate in prostate cancer tumor suppression in the mouse. |
Volume: |
27 |
Issue: |
2 |
Pages: |
222-4 |
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Publication |
First Author: |
Mukai M |
Year: |
2005 |
Journal: |
Biol Reprod |
Title: |
Altered prostatic epithelial proliferation and apoptosis, prostatic development, and serum testosterone in mice lacking cyclin-dependent kinase inhibitors. |
Volume: |
73 |
Issue: |
5 |
Pages: |
951-8 |
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Publication |
First Author: |
Short JD |
Year: |
2008 |
Journal: |
Cancer Res |
Title: |
AMP-activated protein kinase signaling results in cytoplasmic sequestration of p27. |
Volume: |
68 |
Issue: |
16 |
Pages: |
6496-506 |
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Publication |
First Author: |
Park MS |
Year: |
1999 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
p27 and Rb are on overlapping pathways suppressing tumorigenesis in mice. |
Volume: |
96 |
Issue: |
11 |
Pages: |
6382-7 |
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•
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Publication |
First Author: |
Choi SH |
Year: |
2020 |
Journal: |
Oncoimmunology |
Title: |
Loss of p27Kip1 leads to expansion of CD4+ effector memory T cells and accelerates colitis-associated colon cancer in mice with a T cell lineage restricted deletion of Smad4. |
Volume: |
9 |
Issue: |
1 |
Pages: |
1847832 |
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Publication |
First Author: |
Philipp J |
Year: |
1999 |
Journal: |
Oncogene |
Title: |
Tumor suppression by p27Kip1 and p21Cip1 during chemically induced skin carcinogenesis. |
Volume: |
18 |
Issue: |
33 |
Pages: |
4689-98 |
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•
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Publication |
First Author: |
Yu L |
Year: |
2005 |
Journal: |
Circ Res |
Title: |
Cyclin-dependent kinase inhibitor p27Kip1, but not p21WAF1/Cip1, is required for inhibition of hypoxia-induced pulmonary hypertension and remodeling by heparin in mice. |
Volume: |
97 |
Issue: |
9 |
Pages: |
937-45 |
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Publication |
First Author: |
Sun D |
Year: |
2007 |
Journal: |
Carcinogenesis |
Title: |
Loss of p27Kip1 enhances tumor progression in chronic hepatocyte injury-induced liver tumorigenesis with widely ranging effects on Cdk2 or Cdc2 activation. |
Volume: |
28 |
Issue: |
9 |
Pages: |
1859-66 |
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Publication |
First Author: |
Monahan P |
Year: |
2012 |
Journal: |
Mech Dev |
Title: |
p21, an important mediator of quiescence during pituitary tumor formation, is dispensable for normal pituitary development during embryogenesis. |
Volume: |
128 |
Issue: |
11-12 |
Pages: |
640-52 |
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Publication |
First Author: |
Casaccia-Bonnefil P |
Year: |
1999 |
Journal: |
Development |
Title: |
Loss of p27Kip1 function results in increased proliferative capacity of oligodendrocyte progenitors but unaltered timing of differentiation. |
Volume: |
126 |
Issue: |
18 |
Pages: |
4027-37 |
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