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Search results 1 to 100 out of 1381 for Cdkn1c

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Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
Gene
1028 | CDKN1C
Type: gene
Organism: human
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Gene
101731332 | cdkn1c
Type: gene
Organism: frog, western clawed
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Gene
246060 | Cdkn1c
Type: gene
Organism: rat
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Gene
747666 | CDKN1C
Type: gene
Organism: chimpanzee
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Gene
510972 | CDKN1C
Type: gene
Organism: cattle
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Gene
721220 | CDKN1C
Type: gene
Organism: macaque, rhesus
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Gene
101751827 | CDKN1C
Type: gene
Organism: chicken
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Gene
102154676 | CDKN1C
Type: gene
Organism: dog, domestic
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Protein Domain
IPR029842 | CDKN1C
Type: Family
Description: Cyclin-dependent kinase inhibitor 1C (CDKN1C, also known p57Kip2) is a cyclin-dependent kinase inhibitor that inhibits cell-cycle progression [, ]. CDKN1C contains a PCNA-binding domain. Mutations in the PCNA-binding domain of CDKN1C cause IMAGe syndrome, which is an undergrowth developmental disorder with life-threatening consequences [].
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Protein Coding Gene
MGI:104564 | Cdkn1c
Type: protein_coding_gene
Organism: mouse, laboratory
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GXD Expression
GXD Expression
 
Probe: MGI:3724860
Assay Type: RNA in situ
Annotation Date: 2009-01-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:2622022
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:3826183
Age: embryonic day 14.5
Image: Additional file 4 Cdkn1c
Specimen Label: Additional file 4 Cdkn1c
Detected: true
Specimen Num: 2
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Publication
11218061 | J:74094
First Author: Nagahama H
Year: 2001
Journal: Anat Embryol (Berl)
Title: Spatial and temporal expression patterns of the cyclin-dependent kinase (CDK) inhibitors p27Kip1 and p57Kip2 during mouse development.
Volume: 203
Issue: 2
Pages: 77-87
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Publication
7729683 | J:24408
First Author: Lee MH
Year: 1995
Journal: Genes Dev
Title: Cloning of p57KIP2, a cyclin-dependent kinase inhibitor with unique domain structure and tissue distribution.
Volume: 9
Issue: 6
Pages: 639-49
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Publication
21729874 | J:177542
First Author: Tunster SJ
Year: 2011
Journal: Dis Model Mech
Title: Fetal overgrowth in the Cdkn1c mouse model of Beckwith-Wiedemann syndrome.
Volume: 4
Issue: 6
Pages: 814-21
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Protein
A0A140LJA8
Organism: Mus musculus/domesticus
Length: 146  
Fragment?: true
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Protein
A0A140LJ83
Organism: Mus musculus/domesticus
Length: 179  
Fragment?: true
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Publication
22735584 | -
First Author: Riccio A
Year: 2012
Journal: Nat Genet
Title: Gain of function in CDKN1C.
Volume: 44
Issue: 7
Pages: 737-8
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Protein
P49919
Organism: Mus musculus/domesticus
Length: 348  
Fragment?: false
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Protein
Q91V06
Organism: Mus musculus/domesticus
Length: 335  
Fragment?: false
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Protein
Q8BP34
Organism: Mus musculus/domesticus
Length: 335  
Fragment?: false
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Protein
Q791X1
Organism: Mus musculus/domesticus
Length: 335  
Fragment?: false
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Publication
15647320 | J:96925
First Author: Fan T
Year: 2005
Journal: Development
Title: Lsh controls silencing of the imprinted Cdkn1c gene.
Volume: 132
Issue: 4
Pages: 635-44
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GXD Expression
GXD Expression
Probe: MGI:6194280
Assay Type: Immunohistochemistry
Annotation Date: 2018-08-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1778721
Pattern: Regionally restricted
Stage: TS21
Assay Id: MGI:6194655
Age: embryonic day 12.5
Image: 5G,I
Note: Cdkn1c was co-expressed with Olig2.
Specimen Label: 5G,I
Detected: true
Specimen Num: 1
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Publication
31924768 | J:286700
First Author: Laukoter S
Year: 2020
Journal: Nat Commun
Title: Imprinted Cdkn1c genomic locus cell-autonomously promotes cell survival in cerebral cortex development.
Volume: 11
Issue: 1
Pages: 195
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Publication
26963625 | J:232408
First Author: Van De Pette M
Year: 2016
Journal: PLoS Genet
Title: Cdkn1c Boosts the Development of Brown Adipose Tissue in a Murine Model of Silver Russell Syndrome.
Volume: 12
Issue: 3
Pages: e1005916
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Publication
30284969 | J:269759
   
First Author: Mademtzoglou D
Year: 2018
Journal: Elife
Title: Cellular localization of the cell cycle inhibitor Cdkn1c controls growth arrest of adult skeletal muscle stem cells.
Volume: 7
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Publication
28147266 | J:251258
First Author: Van de Pette M
Year: 2017
Journal: Cell Rep
Title: Visualizing Changes in Cdkn1c Expression Links Early-Life Adversity to Imprint Mis-regulation in Adults.
Volume: 18
Issue: 5
Pages: 1090-1099
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Publication
17517131 | J:126494
 
First Author: Andrews SC
Year: 2007
Journal: BMC Dev Biol
Title: Cdkn1c (p57Kip2) is the major regulator of embryonic growth within its imprinted domain on mouse distal chromosome 7.
Volume: 7
Pages: 53
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Publication
30014245 | J:317273
First Author: Li Q
Year: 2018
Journal: J Mol Histol
Title: Methylation of Cdkn1c may be involved in the regulation of tooth development through cell cycle inhibition.
Volume: 49
Issue: 5
Pages: 459-469
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Publication
32024956 | J:293051
First Author: Imaizumi Y
Year: 2020
Journal: Sci Rep
Title: Role of the imprinted allele of the Cdkn1c gene in mouse neocortical development.
Volume: 10
Issue: 1
Pages: 1884
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Publication
15890200 | J:99106
First Author: Bean C
Year: 2005
Journal: J Mol Biol
Title: The Ankrd2, Cdkn1c and calcyclin genes are under the control of MyoD during myogenic differentiation.
Volume: 349
Issue: 2
Pages: 349-66
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Publication
36633189 | J:334421
 
First Author: Lozano-Ureña A
Year: 2023
Journal: Development
Title: IGF2 interacts with the imprinted gene Cdkn1c to promote terminal differentiation of neural stem cells.
Volume: 150
Issue: 1
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Publication
23440043 | J:197456
First Author: Brenet F
Year: 2013
Journal: J Exp Med
Title: TGFβ restores hematopoietic homeostasis after myelosuppressive chemotherapy.
Volume: 210
Issue: 3
Pages: 623-39
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Publication
29632530 | J:264918
 
First Author: Chen G
Year: 2018
Journal: Front Immunol
Title: Ezh2 Regulates Activation-Induced CD8+ T Cell Cycle Progression via Repressing Cdkn2a and Cdkn1c Expression.
Volume: 9
Pages: 549
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Publication
21717222 | J:177543
First Author: Hillhouse AE
Year: 2011
Journal: Mamm Genome
Title: Quantitative trait loci in a bacterially induced model of inflammatory bowel disease.
Volume: 22
Issue: 9-10
Pages: 544-55
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Publication
17464323 | J:139269
First Author: Vlachos P
Year: 2007
Journal: Cell Death Differ
Title: The cell cycle inhibitor p57(Kip2) promotes cell death via the mitochondrial apoptotic pathway.
Volume: 14
Issue: 8
Pages: 1497-507
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Publication
19158303 | J:144844
First Author: Mairet-Coello G
Year: 2009
Journal: J Neurosci
Title: Insulin-like growth factor-1 promotes G(1)/S cell cycle progression through bidirectional regulation of cyclins and cyclin-dependent kinase inhibitors via the phosphatidylinositol 3-kinase/Akt pathway in developing rat cerebral cortex.
Volume: 29
Issue: 3
Pages: 775-88
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Publication
28560351 | J:329138
First Author: Hwang Y
Year: 2017
Journal: Sci Adv
Title: Global increase in replication fork speed during a p57KIP2-regulated erythroid cell fate switch.
Volume: 3
Issue: 5
Pages: e1700298
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Publication
18483241 | J:135026
First Author: Jin RJ
Year: 2008
Journal: Cancer Res
Title: Down-regulation of p57Kip2 induces prostate cancer in the mouse.
Volume: 68
Issue: 10
Pages: 3601-8
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Publication
10601037 | J:58998
First Author: Caspary T
Year: 1999
Journal: Genes Dev
Title: Oppositely imprinted genes p57(Kip2) and igf2 interact in a mouse model for Beckwith-Wiedemann syndrome.
Volume: 13
Issue: 23
Pages: 3115-24
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Publication
10903183 | J:63217
First Author: Dyer MA
Year: 2000
Journal: Development
Title: p57(Kip2) regulates progenitor cell proliferation and amacrine interneuron development in the mouse retina.
Volume: 127
Issue: 16
Pages: 3593-605
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Publication
15475262 | J:118454
First Author: Hagan JP
Year: 2004
Journal: Genomics
Title: Intraspecific mating with CzechII/Ei mice rescue lethality associated with loss of function mutations of the imprinted genes, Igf2r and Cdkn1c.
Volume: 84
Issue: 5
Pages: 836-43
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Publication
19794138 | J:154998
First Author: Mascarenhas MI
Year: 2009
Journal: Blood
Title: Identification of novel regulators of hematopoietic stem cell development through refinement of stem cell localization and expression profiling.
Volume: 114
Issue: 21
Pages: 4645-53
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Publication
27798108 | J:239325
First Author: McNamara GI
Year: 2016
Journal: Hum Mol Genet
Title: Behavioural abnormalities in a novel mouse model for Silver Russell Syndrome.
Volume: 25
Issue: 24
Pages: 5407-5417
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Publication
11737597 | J:104004
First Author: Hiromura K
Year: 2001
Journal: Kidney Int
Title: Podocyte expression of the CDK-inhibitor p57 during development and disease.
Volume: 60
Issue: 6
Pages: 2235-46
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Publication
9144284 | J:40203
First Author: Zhang P
Year: 1997
Journal: Nature
Title: Altered cell differentiation and proliferation in mice lacking p57KIP2 indicates a role in Beckwith-Wiedemann syndrome.
Volume: 387
Issue: 6629
Pages: 151-8
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Publication
9925645 | J:52552
First Author: Zhang P
Year: 1999
Journal: Genes Dev
Title: p21(CIP1) and p57(KIP2) control muscle differentiation at the myogenin step.
Volume: 13
Issue: 2
Pages: 213-24
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Publication
20062522 | J:156755
First Author: Han L
Year: 2010
Journal: PLoS Genet
Title: Postnatal survival of mice with maternal duplication of distal chromosome 7 induced by a Igf2/H19 imprinting control region lacking insulator function.
Volume: 6
Issue: 1
Pages: e1000803
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Publication
22223678 | J:179730
First Author: Mairet-Coello G
Year: 2012
Journal: Development
Title: p57(KIP2) regulates radial glia and intermediate precursor cell cycle dynamics and lower layer neurogenesis in developing cerebral cortex.
Volume: 139
Issue: 3
Pages: 475-87
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Publication
21885020 | J:176210
First Author: Zou P
Year: 2011
Journal: Cell Stem Cell
Title: p57(Kip2) and p27(Kip1) cooperate to maintain hematopoietic stem cell quiescence through interactions with Hsc70.
Volume: 9
Issue: 3
Pages: 247-61
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Publication
20713691 | J:165729
First Author: Rentsendorj A
Year: 2010
Journal: Genetics
Title: A genomic imprinting defect in mice traced to a single gene.
Volume: 186
Issue: 3
Pages: 917-27
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Publication
15640248 | J:96366
First Author: Cerrato F
Year: 2005
Journal: Hum Mol Genet
Title: The two-domain hypothesis in Beckwith-Wiedemann syndrome: autonomous imprinting of the telomeric domain of the distal chromosome 7 cluster.
Volume: 14
Issue: 4
Pages: 503-11
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Publication
9784491 | J:50769
First Author: Zhang P
Year: 1998
Journal: Genes Dev
Title: Cooperation between the Cdk inhibitors p27(KIP1) and p57(KIP2) in the control of tissue growth and development.
Volume: 12
Issue: 20
Pages: 3162-7
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Publication
16899237 | J:119274
First Author: Georgia S
Year: 2006
Journal: Dev Biol
Title: p57 and Hes1 coordinate cell cycle exit with self-renewal of pancreatic progenitors.
Volume: 298
Issue: 1
Pages: 22-31
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Publication
12627233 | J:82790
First Author: Mager J
Year: 2003
Journal: Nat Genet
Title: Genome imprinting regulated by the mouse Polycomb group protein Eed.
Volume: 33
Issue: 4
Pages: 502-7
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Publication
17123502 | J:117093
First Author: Gui H
Year: 2007
Journal: Dev Biol
Title: A cell-autonomous requirement for Cip/Kip cyclin-kinase inhibitors in regulating neuronal cell cycle exit but not differentiation in the developing spinal cord.
Volume: 301
Issue: 1
Pages: 14-26
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Publication
11468278 | J:70843
First Author: John RM
Year: 2001
Journal: Hum Mol Genet
Title: Distant cis-elements regulate imprinted expression of the mouse p57( Kip2) (Cdkn1c) gene: implications for the human disorder, Beckwith--Wiedemann syndrome.
Volume: 10
Issue: 15
Pages: 1601-9
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Publication
21816904 | J:205220
First Author: Borriello A
Year: 2011
Journal: Mol Cancer Res
Title: p57(Kip2) and cancer: time for a critical appraisal.
Volume: 9
Issue: 10
Pages: 1269-84
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Publication
19139274 | J:147778
First Author: Bilodeau S
Year: 2009
Journal: Mol Cell Biol
Title: Distinct developmental roles of cell cycle inhibitors p57Kip2 and p27Kip1 distinguish pituitary progenitor cell cycle exit from cell cycle reentry of differentiated cells.
Volume: 29
Issue: 7
Pages: 1895-908
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Publication
26988311 | J:233762
First Author: Saunders AC
Year: 2016
Journal: Mol Reprod Dev
Title: The developmental expression of the CDK inhibitor p57(kip2) (Cdkn1c) in the early mouse placenta.
Volume: 83
Issue: 5
Pages: 405-12
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Publication
35905741 | J:327428
First Author: Zaidan N
Year: 2022
Journal: Stem Cell Reports
Title: Endothelial-specific Gata3 expression is required for hematopoietic stem cell generation.
Volume: 17
Issue: 8
Pages: 1788-1798
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Publication
22187428 | J:182447
First Author: Jiang Z
Year: 2012
Journal: J Biol Chem
Title: Trinucleotide repeat containing 6a (Tnrc6a)-mediated microRNA function is required for development of yolk sac endoderm.
Volume: 287
Issue: 8
Pages: 5979-87
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Publication
25539921 | J:223238
First Author: Schultz BM
Year: 2015
Journal: Nucleic Acids Res
Title: Enhancers compete with a long non-coding RNA for regulation of the Kcnq1 domain.
Volume: 43
Issue: 2
Pages: 745-59
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Publication
11528397 | J:71531
First Author: Cleary MA
Year: 2001
Journal: Nat Genet
Title: Disruption of an imprinted gene cluster by a targeted chromosomal translocation in mice.
Volume: 29
Issue: 1
Pages: 78-82
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Publication
26100882 | J:223739
First Author: Asahara S
Year: 2015
Journal: Proc Natl Acad Sci U S A
Title: Paternal allelic mutation at the Kcnq1 locus reduces pancreatic β-cell mass by epigenetic modification of Cdkn1c.
Volume: 112
Issue: 27
Pages: 8332-7
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Publication
15124025 | J:89721
First Author: MacLean HE
Year: 2004
Journal: J Clin Invest
Title: The cyclin-dependent kinase inhibitor p57(Kip2) mediates proliferative actions of PTHrP in chondrocytes.
Volume: 113
Issue: 9
Pages: 1334-43
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Publication
10779549 | J:62178
First Author: Grandjean V
Year: 2000
Journal: Proc Natl Acad Sci U S A
Title: Increased IGF-II protein affects p57kip2 expression in vivo and in vitro: implications for Beckwith-Wiedemann syndrome.
Volume: 97
Issue: 10
Pages: 5279-84
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Publication
36880956 | J:335767
First Author: Oka T
Year: 2023
Journal: Cancer Res
Title: Ablation of p57+ Quiescent Cancer Stem Cells Suppresses Recurrence after Chemotherapy of Intestinal Tumors.
Volume: 83
Issue: 9
Pages: 1393-1409
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Publication
27015986 | J:241179
First Author: Duquesnes N
Year: 2016
Journal: J Pathol
Title: p57(Kip2) knock-in mouse reveals CDK-independent contribution in the development of Beckwith-Wiedemann syndrome.
Volume: 239
Issue: 3
Pages: 250-61
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Publication
16957025 | J:115946
First Author: Dokras A
Year: 2006
Journal: Biol Reprod
Title: Severe feto-placental abnormalities precede the onset of hypertension and proteinuria in a mouse model of preeclampsia.
Volume: 75
Issue: 6
Pages: 899-907
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Publication
26872540 | J:327397
First Author: Thomas DD
Year: 2016
Journal: Exp Hematol
Title: Insulin-like growth factor 2 modulates murine hematopoietic stem cell maintenance through upregulation of p57.
Volume: 44
Issue: 5
Pages: 422-433.e1
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Publication
15665276 | J:95440
First Author: Pantoja C
Year: 2005
Journal: Cancer Res
Title: Inactivation of imprinted genes induced by cellular stress and tumorigenesis.
Volume: 65
Issue: 1
Pages: 26-33
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Publication
29284139 | J:320851
 
First Author: Fink DM
Year: 2018
Journal: Cell Signal
Title: Coordinated d-cyclin/Foxd1 activation drives mitogenic activity of the Sonic Hedgehog signaling pathway.
Volume: 44
Pages: 1-9
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Publication
9618174 | J:48435
First Author: Paulsen M
Year: 1998
Journal: Hum Mol Genet
Title: Syntenic organization of the mouse distal chromosome 7 imprinting cluster and the Beckwith-Wiedemann syndrome region in chromosome 11p15.5.
Volume: 7
Issue: 7
Pages: 1149-59
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Publication
18079696 | J:130529
First Author: Shin JY
Year: 2008
Journal: EMBO J
Title: Two distinct mechanisms of silencing by the KvDMR1 imprinting control region.
Volume: 27
Issue: 1
Pages: 168-78
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Publication
12410230 | J:79882
First Author: Fitzpatrick GV
Year: 2002
Journal: Nat Genet
Title: Regional loss of imprinting and growth deficiency in mice with a targeted deletion of KvDMR1.
Volume: 32
Issue: 3
Pages: 426-31
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Publication
30771304 | J:275000
First Author: Sharma A
Year: 2019
Journal: Dev Biol
Title: miR-126 regulates glycogen trophoblast proliferation and DNA methylation in the murine placenta.
Volume: 449
Issue: 1
Pages: 21-34
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Publication
23968833 | J:229227
First Author: Colasante G
Year: 2015
Journal: Cereb Cortex
Title: ARX regulates cortical intermediate progenitor cell expansion and upper layer neuron formation through repression of Cdkn1c.
Volume: 25
Issue: 2
Pages: 322-35
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Publication
28939666 | J:245925
First Author: Pfurr S
Year: 2017
Journal: Development
Title: The E2A splice variant E47 regulates the differentiation of projection neurons via p57(KIP2) during cortical development.
Volume: 144
Issue: 21
Pages: 3917-3931
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Publication
16214126 | J:103817
First Author: Nef S
Year: 2005
Journal: Dev Biol
Title: Gene expression during sex determination reveals a robust female genetic program at the onset of ovarian development.
Volume: 287
Issue: 2
Pages: 361-77
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Publication
10691133 | J:66461
First Author: Kato R
Year: 1999
Journal: DNA Res
Title: Sequence-ready 1-Mb YAC, BAC and cosmid contigs covering the distal imprinted region of mouse chromosome 7.
Volume: 6
Issue: 6
Pages: 401-5
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Publication
30158284 | J:267708
 
First Author: Tunster SJ
Year: 2018
Journal: Dis Model Mech
Title: Fetal growth restriction in a genetic model of sporadic Beckwith-Wiedemann syndrome.
Volume: 11
Issue: 11
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Publication
16702402 | J:108700
First Author: Mancini-Dinardo D
Year: 2006
Journal: Genes Dev
Title: Elongation of the Kcnq1ot1 transcript is required for genomic imprinting of neighboring genes.
Volume: 20
Issue: 10
Pages: 1268-82
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Publication
22958929 | J:193430
First Author: Rossi L
Year: 2012
Journal: Cell Stem Cell
Title: Less is more: unveiling the functional core of hematopoietic stem cells through knockout mice.
Volume: 11
Issue: 3
Pages: 302-17
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Publication
27432740 | J:257052
First Author: Roker LA
Year: 2017
Journal: J Am Soc Nephrol
Title: Wnt7b Signaling from the Ureteric Bud Epithelium Regulates Medullary Capillary Development.
Volume: 28
Issue: 1
Pages: 250-259
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Publication
35314700 | J:323000
First Author: Higa T
Year: 2022
Journal: Nat Commun
Title: Spatiotemporal reprogramming of differentiated cells underlies regeneration and neoplasia in the intestinal epithelium.
Volume: 13
Issue: 1
Pages: 1500
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Protein Coding Gene
MGP_CAROLIEiJ_G0030738 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0033272 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0033255 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0033186 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0033255 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0032971 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_104564 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0033765 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0032293 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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•
•
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Protein Coding Gene
MGP_CBAJ_G0032942 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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•
•
•
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Protein Coding Gene
MGP_DBA2J_G0033096 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_FVBNJ_G0033044 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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•
•
•
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Protein Coding Gene
MGP_LPJ_G0033188 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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•
•
•
•
Protein Coding Gene
MGP_NODShiLtJ_G0033078 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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•
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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