Type |
Details |
Score |
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
frog, western clawed |
|
•
•
•
•
•
|
Gene |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
dog, domestic |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chimpanzee |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
cattle |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chicken |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
zebrafish |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
348
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus caroli |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus pahari |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus spretus |
|
•
•
•
•
•
|
Publication |
First Author: |
Fan X |
Year: |
2016 |
Journal: |
Oncotarget |
Title: |
CARF activates beta-catenin/TCF signaling in the hepatocellular carcinoma. |
Volume: |
7 |
Issue: |
49 |
Pages: |
80404-80414 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3614497 |
Assay Type: |
RT-PCR |
Annotation Date: |
2006-03-15 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1689421 |
|
Stage: |
TS21 |
Assay Id: |
MGI:3616314 |
Age: |
embryonic day 13.5 |
|
|
Specimen Label: |
RT-PCR E13.5 brain |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3614497 |
Assay Type: |
RT-PCR |
Annotation Date: |
2006-03-15 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1689427 |
|
Stage: |
TS27 |
Assay Id: |
MGI:3616314 |
Age: |
postnatal day 0 |
|
|
Specimen Label: |
RT-PCR P0 brain |
Detected: |
false |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3615471 |
Assay Type: |
RNA in situ |
Annotation Date: |
2006-03-20 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1665821 |
|
Stage: |
TS21 |
Assay Id: |
MGI:3616985 |
Age: |
embryonic day 13.5 |
Image: |
E13.5 |
|
Specimen Label: |
E13.5 |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3615471 |
Assay Type: |
RNA in situ |
Annotation Date: |
2006-03-20 |
Strength: |
Ambiguous |
Sex: |
Not Specified |
Emaps: |
EMAPS:1691621 |
Pattern: |
Not Specified |
Stage: |
TS21 |
Assay Id: |
MGI:3616985 |
Age: |
embryonic day 13.5 |
Image: |
E13.5 |
Note: |
Authors indicate that there was either ubiquitous or background expression. |
Specimen Label: |
E13.5 |
|
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3615471 |
Assay Type: |
RNA in situ |
Annotation Date: |
2006-03-20 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1691627 |
|
Stage: |
TS27 |
Assay Id: |
MGI:3616985 |
Age: |
postnatal day 0 |
Image: |
P0 |
|
Specimen Label: |
P0 |
Detected: |
false |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3615471 |
Assay Type: |
RNA in situ |
Annotation Date: |
2006-03-20 |
Strength: |
Ambiguous |
Sex: |
Not Specified |
Emaps: |
EMAPS:1760621 |
Pattern: |
Not Specified |
Stage: |
TS21 |
Assay Id: |
MGI:3616985 |
Age: |
embryonic day 13.5 |
Image: |
E13.5 |
Note: |
Authors indicate that there was either ubiquitous or background expression. |
Specimen Label: |
E13.5 |
|
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3615471 |
Assay Type: |
RNA in situ |
Annotation Date: |
2006-03-20 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1760627 |
|
Stage: |
TS27 |
Assay Id: |
MGI:3616985 |
Age: |
postnatal day 0 |
Image: |
P0 |
|
Specimen Label: |
P0 |
Detected: |
false |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3615471 |
Assay Type: |
RNA in situ |
Annotation Date: |
2006-03-20 |
Strength: |
Ambiguous |
Sex: |
Not Specified |
Emaps: |
EMAPS:1754921 |
Pattern: |
Not Specified |
Stage: |
TS21 |
Assay Id: |
MGI:3616985 |
Age: |
embryonic day 13.5 |
Image: |
E13.5 |
Note: |
Authors indicate that there was either ubiquitous or background expression. |
Specimen Label: |
E13.5 |
|
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3615471 |
Assay Type: |
RNA in situ |
Annotation Date: |
2006-03-20 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1754927 |
|
Stage: |
TS27 |
Assay Id: |
MGI:3616985 |
Age: |
postnatal day 0 |
Image: |
P0 |
|
Specimen Label: |
P0 |
Detected: |
false |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3615471 |
Assay Type: |
RNA in situ |
Annotation Date: |
2006-03-20 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1697427 |
|
Stage: |
TS27 |
Assay Id: |
MGI:3616985 |
Age: |
postnatal day 0 |
Image: |
P0 |
|
Specimen Label: |
P0 |
Detected: |
false |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3615471 |
Assay Type: |
RNA in situ |
Annotation Date: |
2006-03-20 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1716821 |
|
Stage: |
TS21 |
Assay Id: |
MGI:3616985 |
Age: |
embryonic day 13.5 |
Image: |
E13.5 |
|
Specimen Label: |
E13.5 |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3615471 |
Assay Type: |
RNA in situ |
Annotation Date: |
2006-03-20 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1716827 |
|
Stage: |
TS27 |
Assay Id: |
MGI:3616985 |
Age: |
postnatal day 0 |
Image: |
P0 |
|
Specimen Label: |
P0 |
Detected: |
false |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3615471 |
Assay Type: |
RNA in situ |
Annotation Date: |
2006-03-20 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1753627 |
|
Stage: |
TS27 |
Assay Id: |
MGI:3616985 |
Age: |
postnatal day 0 |
Image: |
P0 |
|
Specimen Label: |
P0 |
Detected: |
false |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3615471 |
Assay Type: |
RNA in situ |
Annotation Date: |
2006-03-20 |
Strength: |
Ambiguous |
Sex: |
Not Specified |
Emaps: |
EMAPS:1754421 |
Pattern: |
Not Specified |
Stage: |
TS21 |
Assay Id: |
MGI:3616985 |
Age: |
embryonic day 13.5 |
Image: |
E13.5 |
Note: |
Authors indicate that there was either ubiquitous or background expression in precortical tissue. |
Specimen Label: |
E13.5 |
|
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3615471 |
Assay Type: |
RNA in situ |
Annotation Date: |
2006-03-20 |
Strength: |
Ambiguous |
Sex: |
Not Specified |
Emaps: |
EMAPS:1754427 |
Pattern: |
Not Specified |
Stage: |
TS27 |
Assay Id: |
MGI:3616985 |
Age: |
postnatal day 0 |
Image: |
P0 |
Note: |
Authors indicate that there was either ubiquitous or background expression. |
Specimen Label: |
P0 |
|
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3615471 |
Assay Type: |
RNA in situ |
Annotation Date: |
2006-03-20 |
Strength: |
Ambiguous |
Sex: |
Not Specified |
Emaps: |
EMAPS:3284527 |
Pattern: |
Not Specified |
Stage: |
TS27 |
Assay Id: |
MGI:3616985 |
Age: |
postnatal day 0 |
Image: |
P0 |
Note: |
Authors indicate that there was either ubiquitous or background expression. |
Specimen Label: |
P0 |
|
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3615471 |
Assay Type: |
RNA in situ |
Annotation Date: |
2006-03-20 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1679727 |
|
Stage: |
TS27 |
Assay Id: |
MGI:3616985 |
Age: |
postnatal day 0 |
Image: |
P0 |
|
Specimen Label: |
P0 |
Detected: |
false |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3615471 |
Assay Type: |
RNA in situ |
Annotation Date: |
2006-03-20 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1754027 |
|
Stage: |
TS27 |
Assay Id: |
MGI:3616985 |
Age: |
postnatal day 0 |
Image: |
P0 |
|
Specimen Label: |
P0 |
Detected: |
false |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3615471 |
Assay Type: |
RNA in situ |
Annotation Date: |
2006-03-20 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:3280927 |
|
Stage: |
TS27 |
Assay Id: |
MGI:3616985 |
Age: |
postnatal day 0 |
Image: |
P0 |
|
Specimen Label: |
P0 |
Detected: |
false |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3615471 |
Assay Type: |
RNA in situ |
Annotation Date: |
2006-03-20 |
Strength: |
Ambiguous |
Sex: |
Not Specified |
Emaps: |
EMAPS:3267921 |
Pattern: |
Not Specified |
Stage: |
TS21 |
Assay Id: |
MGI:3616985 |
Age: |
embryonic day 13.5 |
Image: |
E13.5 |
Note: |
Authors indicate that there was either ubiquitous or background expression. |
Specimen Label: |
E13.5 |
|
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3615471 |
Assay Type: |
RNA in situ |
Annotation Date: |
2006-03-20 |
Strength: |
Ambiguous |
Sex: |
Not Specified |
Emaps: |
EMAPS:1757721 |
Pattern: |
Not Specified |
Stage: |
TS21 |
Assay Id: |
MGI:3616985 |
Age: |
embryonic day 13.5 |
Image: |
E13.5 |
Note: |
Authors indicate that there was either ubiquitous or background expression. |
Specimen Label: |
E13.5 |
|
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3615471 |
Assay Type: |
RNA in situ |
Annotation Date: |
2006-03-20 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1757727 |
|
Stage: |
TS27 |
Assay Id: |
MGI:3616985 |
Age: |
postnatal day 0 |
Image: |
P0 |
|
Specimen Label: |
P0 |
Detected: |
false |
Specimen Num: |
2 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wadhwa R |
Year: |
2003 |
Journal: |
Exp Gerontol |
Title: |
A novel putative collaborator of p19ARF. |
Volume: |
38 |
Issue: |
3 |
Pages: |
245-52 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hasan MK |
Year: |
2002 |
Journal: |
J Biol Chem |
Title: |
CARF is a novel protein that cooperates with mouse p19ARF (human p14ARF) in activating p53. |
Volume: |
277 |
Issue: |
40 |
Pages: |
37765-70 |
|
•
•
•
•
•
|
Publication |
First Author: |
Carninci P |
Year: |
2005 |
Journal: |
Science |
Title: |
The transcriptional landscape of the mammalian genome. |
Volume: |
309 |
Issue: |
5740 |
Pages: |
1559-63 |
|
•
•
•
•
•
|
Publication |
First Author: |
McKee AE |
Year: |
2005 |
Journal: |
BMC Dev Biol |
Title: |
A genome-wide in situ hybridization map of RNA-binding proteins reveals anatomically restricted expression in the developing mouse brain. |
Volume: |
5 |
|
Pages: |
14 |
|
•
•
•
•
•
|
Publication |
First Author: |
The Jackson Laboratory |
Year: |
2012 |
Journal: |
MGI Direct Data Submission |
Title: |
Alleles produced for the KOMP project by The Jackson Laboratory |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
|
Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations for FANTOM2 data |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC) |
Year: |
2014 |
Journal: |
Database Release |
Title: |
Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
UniProt-GOA |
Year: |
2012 |
|
Title: |
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Kawai J |
Year: |
2001 |
Journal: |
Nature |
Title: |
Functional annotation of a full-length mouse cDNA collection. |
Volume: |
409 |
Issue: |
6821 |
Pages: |
685-90 |
|
•
•
•
•
•
|
Publication |
First Author: |
Adams DJ |
Year: |
2024 |
Journal: |
Nature |
Title: |
Genetic determinants of micronucleus formation in vivo. |
Volume: |
627 |
Issue: |
8002 |
Pages: |
130-136 |
|
•
•
•
•
•
|
Publication |
First Author: |
MGD Nomenclature Committee |
Year: |
1995 |
|
Title: |
Nomenclature Committee Use |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Cyagen Biosciences Inc. |
Year: |
2022 |
|
Title: |
Cyagen Biosciences Website. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators |
Year: |
2011 |
|
Title: |
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
UniProt-GOA |
Year: |
2012 |
|
Title: |
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
GOA curators |
Year: |
2016 |
|
Title: |
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
The Jackson Laboratory Mouse Radiation Hybrid Database |
Year: |
2004 |
Journal: |
Database Release |
Title: |
Mouse T31 Radiation Hybrid Data Load |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Okazaki Y |
Year: |
2002 |
Journal: |
Nature |
Title: |
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. |
Volume: |
420 |
Issue: |
6915 |
Pages: |
563-73 |
|
•
•
•
•
•
|
Publication |
First Author: |
The Gene Ontology Consortium |
Year: |
2010 |
|
Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
|
Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2). |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
MGI Genome Annotation Group and UniGene Staff |
Year: |
2015 |
Journal: |
Database Download |
Title: |
MGI-UniGene Interconnection Effort |
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•
•
•
•
•
|
Publication |
First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
Year: |
2010 |
|
Title: |
Annotation inferences using phylogenetic trees |
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•
•
•
•
•
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Publication |
First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
Year: |
2000 |
Journal: |
Database Release |
Title: |
Entrez Gene Load |
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•
•
•
•
•
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Publication |
First Author: |
Allen Institute for Brain Science |
Year: |
2004 |
Journal: |
Allen Institute |
Title: |
Allen Brain Atlas: mouse riboprobes |
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•
•
•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
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•
•
•
•
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Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
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•
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•
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Publication |
First Author: |
Mouse Genome Informatics Group |
Year: |
2003 |
Journal: |
Database Procedure |
Title: |
Automatic Encodes (AutoE) Reference |
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•
•
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•
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Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
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•
•
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•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
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Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
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•
•
•
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•
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Publication |
First Author: |
Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
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•
•
•
•
•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
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•
•
•
•
•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
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•
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UniProt Feature |
Begin: |
1 |
Description: |
CDKN2AIP N-terminal-like protein |
Type: |
chain |
End: |
116 |
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•
•
•
•
•
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
116
 |
Fragment?: |
false |
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•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
51
 |
Fragment?: |
true |
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•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
119
 |
Fragment?: |
false |
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•
•
•
•
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Publication |
First Author: |
Miki TS |
Year: |
2014 |
Journal: |
Mol Cell |
Title: |
PAXT-1 promotes XRN2 activity by stabilizing it through a conserved domain. |
Volume: |
53 |
Issue: |
2 |
Pages: |
351-60 |
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•
•
•
•
•
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Publication |
First Author: |
Richter H |
Year: |
2016 |
Journal: |
Nat Struct Mol Biol |
Title: |
Structural basis and function of XRN2 binding by XTB domains. |
Volume: |
23 |
Issue: |
2 |
Pages: |
164-71 |
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•
•
•
•
•
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Publication |
First Author: |
Hasan MK |
Year: |
2004 |
Journal: |
Biochem J |
Title: |
Alternative reading frame protein (ARF)-independent function of CARF (collaborator of ARF) involves its interactions with p53: evidence for a novel p53-activation pathway and its negative feedback control. |
Volume: |
380 |
Issue: |
Pt 3 |
Pages: |
605-10 |
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•
•
•
•
•
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Publication |
First Author: |
Cheung CT |
Year: |
2014 |
Journal: |
J Biol Chem |
Title: |
Collaborator of ARF (CARF) regulates proliferative fate of human cells by dose-dependent regulation of DNA damage signaling. |
Volume: |
289 |
Issue: |
26 |
Pages: |
18258-69 |
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•
•
•
•
•
|
Protein Domain |
Type: |
Domain |
Description: |
XRN2 is an essential eukaryotic exoribonuclease that processes and degrades various substrates. The ~80-residue XRN2-binding domain (XTBD) constitutes an XRN2-binding module that is employed by different metazoan proteins to link to XRN2 [, ], such as:Caenorhabditis elegans Partner of Xrn-Two protein 1, or PAXT-1 for short. Plays a role in maintenance of steady-state concentration and turnover ofmicroRNAs (miRNA) by degradation of mature miRNA in complex with theexoribonuclease XRN-2 [].Mammalian CDKN2A-interacting protein (CDKN2AIP) or Collaborator of ARF(CARF) that regulates DNA damage response in a dose-dependent manner through a number of signaling pathways involved in cell proliferation, apoptosis [, ]. Mammalian CDKN2AIP N-terminal-like protein (CDKN2AIPNL).The XTBD domain folds into a globular four-helix bundle (H1-H4) connected by three loops (L1-L3). H1-H3 form an antiparallel helical array and H4 folds back on top of H2 and H3 at a 90degree angle. The four-helical bundle is mainly stabilized by hydrophobic helix-helix interactions together with additional polar interactions between side chains located on neighbouring helices. The four-helix bundle of XTBD represents a structurally unique arrangement for XRN2 binding []. |
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•
•
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•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
563
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
784
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Gerhard DS |
Year: |
2004 |
Journal: |
Genome Res |
Title: |
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |
Volume: |
14 |
Issue: |
10B |
Pages: |
2121-7 |
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•
•
•
•
•
|
Publication |
First Author: |
Church DM |
Year: |
2009 |
Journal: |
PLoS Biol |
Title: |
Lineage-specific biology revealed by a finished genome assembly of the mouse. |
Volume: |
7 |
Issue: |
5 |
Pages: |
e1000112 |
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•
•
•
•
•
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