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Search results 1 to 90 out of 90 for Cdr1

0.043s

Categories

Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
Gene
1038 | CDR1
Type: gene
Organism: human
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Gene
106995343 | CDR1
Type: gene
Organism: macaque, rhesus
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Protein Coding Gene
MGI:88359 | Cdr1
Type: protein_coding_gene
Organism: mouse, laboratory
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GXD Expression
GXD Expression
Probe: MGI:6725772
Assay Type: Immunohistochemistry
Annotation Date: 2021-07-23
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3801428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6725790
Age: postnatal week 6
Image: 1H CDR1
Note: Expression in cortical thymic epithelial cells.
Specimen Label: 1H CDR1
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:6725772
Assay Type: Immunohistochemistry
Annotation Date: 2021-07-23
Strength: Ambiguous
Sex: Not Specified
Emaps: EMAPS:3801428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6725790
Age: postnatal week 6
Image: 3C CDR1
Note: Expression severely dowregulated.
Specimen Label: 3C CDR1
Specimen Num: 2
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GXD Expression
GXD Expression
Probe: MGI:6725772
Assay Type: Immunohistochemistry
Annotation Date: 2021-07-23
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3801428
Pattern: Single cells
Stage: TS28
Assay Id: MGI:6725790
Age: postnatal adult
Image: 4B R/- CDR1
Note: Authors report expression in occasional cells.
Specimen Label: 4B R/- CDR1
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
   
Probe: MGI:6725772
Assay Type: Immunohistochemistry
Annotation Date: 2021-07-23
Strength: Ambiguous
Sex: Not Specified
Emaps: EMAPS:3801428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6725790
Age: postnatal adult
Image: 4B -/- CDR1
Specimen Label: 4B -/- CDR1
Specimen Num: 5
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GXD Expression
GXD Expression
Probe: MGI:6725772
Assay Type: Immunohistochemistry
Annotation Date: 2021-07-23
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3801528
Pattern: Single cells
Stage: TS28
Assay Id: MGI:6725790
Age: postnatal adult
Image: 4B R/- CDR1
Note: Authors report expression in occasional cells.
Specimen Label: 4B R/- CDR1
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
   
Probe: MGI:6725772
Assay Type: Immunohistochemistry
Annotation Date: 2021-07-23
Strength: Ambiguous
Sex: Not Specified
Emaps: EMAPS:3801528
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6725790
Age: postnatal adult
Image: 4B -/- CDR1
Specimen Label: 4B -/- CDR1
Specimen Num: 5
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Gene
103611090 | CDR1-AS
Type: gene
Organism: human
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Protein Coding Gene
MGP_CAROLIEiJ_G0033110 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0035760 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0035742 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0035662 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0035729 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0035431 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_88359 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0036258 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0034724 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0035406 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0035560 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0035510 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0035648 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0035546 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0036274 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0034419 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0034867 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
2326268 | J:10431
First Author: Chen YT
Year: 1990
Journal: Proc Natl Acad Sci U S A
Title: Cerebellar degeneration-related antigen: a highly conserved neuroectodermal marker mapped to chromosomes X in human and mouse.
Volume: 87
Issue: 8
Pages: 3077-81
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Publication
23446348 | J:195132
First Author: Memczak S
Year: 2013
Journal: Nature
Title: Circular RNAs are a large class of animal RNAs with regulatory potency.
Volume: 495
Issue: 7441
Pages: 333-8
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GXD Expression
GXD Expression
   
Probe: MGI:6725772
Assay Type: Immunohistochemistry
Annotation Date: 2021-07-23
Strength: Ambiguous
Sex: Not Specified
Emaps: EMAPS:3801428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6725790
Age: postnatal week 4
Image: 3I -4OHT AIRE
Specimen Label: 3I -4OHT AIRE
Specimen Num: 3
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Publication
1339316 | J:3046
First Author: Kingsley DM
Year: 1992
Journal: Cell
Title: The mouse short ear skeletal morphogenesis locus is associated with defects in a bone morphogenetic member of the TGF beta superfamily.
Volume: 71
Issue: 3
Pages: 399-410
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Publication
8001979 | J:19877
First Author: Quaderi NA
Year: 1994
Journal: Genomics
Title: Genetic and physical mapping of a gene encoding a methyl CpG binding protein, Mecp2, to the mouse X chromosome.
Volume: 22
Issue: 3
Pages: 648-51
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Publication
10330429 | J:55108
First Author: Rocca B
Year: 1999
Journal: J Clin Invest
Title: Distinct roles of prostaglandin H synthases 1 and 2 in T-cell development.
Volume: 103
Issue: 10
Pages: 1469-77
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Publication
9933564 | J:52871
First Author: De Plaen E
Year: 1999
Journal: Genomics
Title: A new family of mouse genes homologous to the human MAGE genes.
Volume: 55
Issue: 2
Pages: 176-84
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Publication
1572655 | J:1611
First Author: Laval SH
Year: 1992
Journal: Genomics
Title: Mapping of FMR1, the gene implicated in fragile X-linked mental retardation, on the mouse X chromosome.
Volume: 12
Issue: 4
Pages: 818-21
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Publication
34157123 | J:307672
First Author: Knupp D
Year: 2021
Journal: Nucleic Acids Res
Title: NOVA2 regulates neural circRNA biogenesis.
Volume: 49
Issue: 12
Pages: 6849-6862
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Publication
22072979 | J:177992
First Author: Nowell CS
Year: 2011
Journal: PLoS Genet
Title: Foxn1 regulates lineage progression in cortical and medullary thymic epithelial cells but is dispensable for medullary sublineage divergence.
Volume: 7
Issue: 11
Pages: e1002348
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Publication
10920247 | J:63696
First Author: Blair HJ
Year: 2000
Journal: Mamm Genome
Title: Positioning of five genes (CASK, ARX, SAT, IMAGE cDNAs 248928 and 253949) from the human X chromosome short arm with respect to evolutionary breakpoints on the mouse X chromosome.
Volume: 11
Issue: 8
Pages: 710-2
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Publication
- | J:94790
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Mouse Synonym Curation
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Publication
- | J:73796
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Function or Process or Component Unknown following Literature Review
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Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
8688082 | J:127083
First Author: Sim BC
Year: 1996
Journal: Science
Title: Control of MHC restriction by TCR Valpha CDR1 and CDR2.
Volume: 273
Issue: 5277
Pages: 963-6
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Publication
22982754 | J:188284
First Author: Lynch JN
Year: 2013
Journal: Mol Immunol
Title: Subtle changes in TCRα CDR1 profoundly increase the sensitivity of CD4 T cells.
Volume: 53
Issue: 3
Pages: 283-94
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Publication
8860695 | J:33912
First Author: Dehghanpisheh K
Year: 1996
Journal: Immunol Invest
Title: Peptide epitope binding specificity and V K and V H gene usage in a monoclonal IgM natural autoantibody to T cell receptor CDR1 from a viable motheaten mouse.
Volume: 25
Issue: 3
Pages: 241-52
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Publication
21856931 | -
First Author: Shukla S
Year: 2011
Journal: Eukaryot Cell
Title: Ncb2 is involved in activated transcription of CDR1 in azole-resistant clinical isolates of Candida albicans.
Volume: 10
Issue: 10
Pages: 1357-66
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Allele
Igh<tm6Cgn> | MGI:3046857
 
Name: immunoglobulin heavy chain complex; targeted mutation 6, University of Cologne
Allele Type: Targeted
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Publication
20038519 | J:157657
First Author: Kat I
Year: 2010
Journal: Int Immunol
Title: B-cell anergy is maintained in anti-DNA transgenic NZB/NZW mice.
Volume: 22
Issue: 2
Pages: 101-11
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Publication
23319731 | J:193319
First Author: Makdasi E
Year: 2013
Journal: J Immunol
Title: L chain allelic inclusion does not increase autoreactivity in lupus-prone New Zealand Black/New Zealand White mice.
Volume: 190
Issue: 4
Pages: 1472-80
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Publication
31969561 | -
First Author: Furukawa T
Year: 2020
Journal: Nat Commun
Title: The negative cofactor 2 complex is a key regulator of drug resistance in Aspergillus fumigatus.
Volume: 11
Issue: 1
Pages: 427
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Protein Domain
IPR042225 | Ncb2
Type: Family
Description: This entry includes budding yeast Ncb2 and its homologues. Ncb2 is a component of the NC2 complex which represses RNA polymerase II transcription through binding to Spt15/TBP and thereby inhibiting the assembly of the preinitiation complex []. Its human homologue, DR1, associates with DRAP1 through histone fold motifs to form the NC2 complex, which negatively regulates transcription initiation [].This entry also includes proteins from fungi, such as NctB from Neosartorya fumigata and Ncb2 from Candida albicans. NctB forms a complex with NctA, and this complex acts as a general transcriptional cofactor []. In Candida albicans, conditional Ncb2 null mutants have been shown to display decreased susceptibility toward azole and an enhanced transcription of CDR1 [].
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Publication
16356863 | J:113312
First Author: Chang HC
Year: 2005
Journal: Immunity
Title: Structural and mutational analyses of a CD8alphabeta heterodimer and comparison with the CD8alphaalpha homodimer.
Volume: 23
Issue: 6
Pages: 661-71
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Publication
1318787 | J:1156
First Author: Hong SC
Year: 1992
Journal: Cell
Title: An MHC interaction site maps to the amino-terminal half of the T cell receptor alpha chain variable domain.
Volume: 69
Issue: 6
Pages: 999-1009
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Publication
9659216 | J:46902
First Author: Liang B
Year: 1998
Journal: Immunology
Title: Injection of T-cell receptor peptide reduces immunosenescence in aged C57BL/6 mice.
Volume: 93
Issue: 4
Pages: 462-8
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Publication
18308592 | J:132878
First Author: Dai S
Year: 2008
Journal: Immunity
Title: Crossreactive T Cells spotlight the germline rules for alphabeta T cell-receptor interactions with MHC molecules.
Volume: 28
Issue: 3
Pages: 324-34
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Publication
16983722 | J:118137
First Author: Yarkoni Y
Year: 2006
Journal: Eur J Immunol
Title: Peripheral B cell receptor editing may promote the production of high-affinity autoantibodies in CD22-deficient mice.
Volume: 36
Issue: 10
Pages: 2755-67
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Publication
9794392 | J:76117
First Author: Pewzner-Jung Y
Year: 1998
Journal: J Immunol
Title: B cell deletion, anergy, and receptor editing in "knock in" mice targeted with a germline-encoded or somatically mutated anti-DNA heavy chain.
Volume: 161
Issue: 9
Pages: 4634-45
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Publication
19414767 | J:150296
First Author: Makdasi E
Year: 2009
Journal: J Immunol
Title: Autoreactive anti-DNA transgenic B cells in lupus-prone New Zealand black/New Zealand white mice show near perfect L chain allelic exclusion.
Volume: 182
Issue: 10
Pages: 6143-8
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Publication
12237409 | -
First Author: Cang Y
Year: 2002
Journal: Proc Natl Acad Sci U S A
Title: Direct stimulation of transcription by negative cofactor 2 (NC2) through TATA-binding protein (TBP).
Volume: 99
Issue: 20
Pages: 12727-32
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Publication
18929574 | J:168951
First Author: Shore DA
Year: 2008
Journal: J Mol Biol
Title: The crystal structure of CD8 in complex with YTS156.7.7 Fab and interaction with other CD8 antibodies define the binding mode of CD8 alphabeta to MHC class I.
Volume: 384
Issue: 5
Pages: 1190-202
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Publication
12218131 | J:120444
First Author: Wang B
Year: 2002
Journal: J Immunol
Title: Peptidic termini play a significant role in TCR recognition.
Volume: 169
Issue: 6
Pages: 3137-45
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Publication
7680688 | J:90982
First Author: Patten PA
Year: 1993
Journal: J Immunol
Title: Transfer of putative complementarity-determining region loops of T cell receptor V domains confers toxin reactivity but not peptide/MHC specificity.
Volume: 150
Issue: 6
Pages: 2281-94
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Publication
10553073 | J:133108
First Author: Correia-Neves M
Year: 1999
Journal: J Immunol
Title: Amino acids specifying MHC class preference in TCR V alpha 2 regions.
Volume: 163
Issue: 10
Pages: 5471-7
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Publication
8683128 | J:34227
First Author: Kariv I
Year: 1996
Journal: J Immunol
Title: Analysis of the site of interaction of CD28 with its counter-receptors CD80 and CD86 and correlation with function.
Volume: 157
Issue: 1
Pages: 29-38
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Publication
8806815 | J:34902
First Author: Liang B
Year: 1996
Journal: Cell Immunol
Title: Effects of vaccination against different T cell receptors on maintenance of immune function during murine retrovirus infection.
Volume: 172
Issue: 1
Pages: 126-34
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Publication
9201304 | J:42317
First Author: Dehghanpisheh K
Year: 1997
Journal: Scand J Immunol
Title: Retrovirally induced mouse anti-TCR monoclonals can synergize the in vitro proliferative T cell response to bacterial superantigens.
Volume: 45
Issue: 6
Pages: 645-54
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Publication
10092765 | J:53421
First Author: Sim BC
Year: 1999
Journal: J Immunol
Title: Reciprocal expression in CD4 or CD8 subsets of different members of the V alpha 11 gene family correlates with sequence polymorphism.
Volume: 162
Issue: 6
Pages: 3153-9
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Publication
9570535 | J:123716
First Author: Sim BC
Year: 1998
Journal: J Immunol
Title: Polymorphism within a TCRAV family influences the repertoire through class I/II restriction.
Volume: 160
Issue: 3
Pages: 1204-11
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Publication
23178972 | J:330626
First Author: Lee G
Year: 2012
Journal: Mol Cells
Title: Thymic epithelial requirement for γδ T cell development revealed in the cell ablation transgenic system with TSCOT promoter.
Volume: 34
Issue: 5
Pages: 481-93
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Protein
Q91WV0
Organism: Mus musculus/domesticus
Length: 176  
Fragment?: false
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Protein
Q3UMQ2
Organism: Mus musculus/domesticus
Length: 176  
Fragment?: false
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Publication
8670811 | -
First Author: Goppelt A
Year: 1996
Journal: EMBO J
Title: A mechanism for repression of class II gene transcription through specific binding of NC2 to TBP-promoter complexes via heterodimeric histone fold domains.
Volume: 15
Issue: 12
Pages: 3105-16
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Publication
26750480 | -
First Author: Fejfarová K
Year: 2016
Journal: Acta Crystallogr F Struct Biol Commun
Title: Crystallization of nepenthesin I using a low-pH crystallization screen.
Volume: 72
Issue: Pt 1
Pages: 24-8
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Publication
17650510 | -
First Author: Simões I
Year: 2007
Journal: J Biol Chem
Title: Characterization of recombinant CDR1, an Arabidopsis aspartic proteinase involved in disease resistance.
Volume: 282
Issue: 43
Pages: 31358-65
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Publication
15723040 | -
First Author: Ge X
Year: 2005
Journal: EMBO Rep
Title: An Arabidopsis aspartic protease functions as an anti-cell-death component in reproduction and embryogenesis.
Volume: 6
Issue: 3
Pages: 282-8
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Publication
22218926 | -
First Author: Ji Q
Year: 2012
Journal: Plant Physiol
Title: Molecular basis underlying the S5-dependent reproductive isolation and compatibility of indica/japonica rice hybrids.
Volume: 158
Issue: 3
Pages: 1319-28
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Protein Domain
IPR034161 | Pepsin-like_plant
Type: Domain
Description: This entry represents a domain found in aspartic endopeptidases from plants including nepenthesin (MEROPS identifier A01.040), a digestive enzyme from the pitcher of the carnivorous pitcher plant Nepenthes []; CDR1 endopeptidase (=Constitutive Disease Resistance 1; MEROPS identifier A01.069) from the Arabidopsis apoplast involved in disease resistance signalling and which is not inhibited by pepstatin []; PCS1 peptidase (MEROPS identifier A01.074) which is important for protecting cells from apoptosis during embryo development []; and S5 peptidases (MEROPS identifier A01.086), which exist as homo- and hetero- dimers and formation of heterodimers leads to embryo-sac abortion resulting in sterility []. Proteins containing this domain belong to the aspartic peptidase A1 family (peptidase family A1, subfamily A1B).Aspartyl proteases (APs), also known as acid proteases, ([intenz:3.4.23.-]) are a widely distributed family of proteolytic enzymes [, , , , , ]known to exist in vertebrates, fungi, plants, retroviruses and some plant viruses. APs use an Asp dyad to hydrolyze peptide bonds.APs found in eukaryotic cells are alpha/beta monomers composed of two asymmetric lobes ("bilobed"). Each of the lobes provides a catalytic Asp residue, positioned within the hallmark motif Asp-Thr/Ser-Gly, to the active site. The N- and C-terminal domains, although structurally related by a 2-fold axis, have only limited sequence homology except the vicinity of the active site. This suggests that the enzymes evolved by an ancient duplication event. The enzymes specifically cleave bonds in peptides which have at least six residues in length with hydrophobic residues in both the P1 and P1' positions. The active site is located at the groove formed by the two lobes, with an extended loop projecting over the cleft to form an 11-residue flap, which encloses substrates and inhibitors in the active site. Specificity is determined by nearest-neighbour hydrophobic residues surrounding the catalytic aspartates, and by three residues in the flap. The enzymes are mostly secreted from cells as inactive proenzymes that activate autocatalytically at acidic pH. Eukaryotic APs form peptidase family A1 of clan AA.
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Publication
33577922 | J:307703
 
First Author: Canet-Pons J
Year: 2021
Journal: Neurobiol Dis
Title: Atxn2-CAG100-KnockIn mouse spinal cord shows progressive TDP43 pathology associated with cholesterol biosynthesis suppression.
Volume: 152
Pages: 105289
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Publication
7774057 | J:25918
First Author: Bedin C
Year: 1995
Journal: Clin Exp Immunol
Title: Molecular heterogeneity of antigen- or idiotype-induced anti-thyroglobulin monoclonal autoantibodies.
Volume: 100
Issue: 3
Pages: 463-9
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Publication
9218760 | J:41405
First Author: Simone EA
Year: 1997
Journal: J Autoimmun
Title: T cell receptor gene polymorphisms associated with anti-insulin, autoimmune T cells in diabetes-prone NOD mice.
Volume: 10
Issue: 3
Pages: 317-21
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Publication
15771507 | -
First Author: Cascella M
Year: 2005
Journal: J Am Chem Soc
Title: Evolutionarily conserved functional mechanics across pepsin-like and retroviral aspartic proteases.
Volume: 127
Issue: 11
Pages: 3734-42
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Publication
24869856 | -
First Author: Revuelta MV
Year: 2014
Journal: Genome Biol Evol
Title: Extensive expansion of A1 family aspartic proteinases in fungi revealed by evolutionary analyses of 107 complete eukaryotic proteomes.
Volume: 6
Issue: 6
Pages: 1480-94
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Publication
1455179 | -
 
First Author: Szecsi PB
Year: 1992
Journal: Scand J Clin Lab Invest Suppl
Title: The aspartic proteases.
Volume: 210
Pages: 5-22
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Publication
2194475 | -
 
First Author: Davies DR
Year: 1990
Journal: Annu Rev Biophys Biophys Chem
Title: The structure and function of the aspartic proteinases.
Volume: 19
Pages: 189-215
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Publication
1851433 | -
First Author: Rao JK
Year: 1991
Journal: Biochemistry
Title: Structural and evolutionary relationships between retroviral and eucaryotic aspartic proteinases.
Volume: 30
Issue: 19
Pages: 4663-71
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Publication
6795036 | -
 
First Author: Foltmann B
Year: 1981
Journal: Essays Biochem
Title: Gastric proteinases--structure, function, evolution and mechanism of action.
Volume: 17
Pages: 52-84
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