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Search results 1 to 100 out of 105 for Cep55

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Hits by Pathway

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Hits by Category

Type Details Score
Gene
55165 | CEP55
Type: gene
Organism: human
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Gene
477773 | CEP55
Type: gene
Organism: dog, domestic
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Gene
513594 | CEP55
Type: gene
Organism: cattle
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Gene
423804 | CEP55
Type: gene
Organism: chicken
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Gene
699890 | CEP55
Type: gene
Organism: macaque, rhesus
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Gene
100487561 | cep55
Type: gene
Organism: frog, western clawed
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Gene
294074 | Cep55
Type: gene
Organism: rat
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Gene
466162 | CEP55
Type: gene
Organism: chimpanzee
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Protein Domain
IPR038926 | CEP55
Type: Family
Description: Cep55 is a centrosome protein that plays a role in mitotic exit and cytokinesis []. It is a regulator of the PI3K/AKT pathway and has been linked to cancers [].
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Protein Coding Gene
MGI:1921357 | Cep55
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
Q8BT07
Organism: Mus musculus/domesticus
Length: 462  
Fragment?: false
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Publication
25915844 | -
First Author: Jeffery J
Year: 2016
Journal: Oncogene
Title: Beyond cytokinesis: the emerging roles of CEP55 in tumorigenesis.
Volume: 35
Issue: 6
Pages: 683-90
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Publication
20176808 | J:161709
First Author: Iwamori T
Year: 2010
Journal: Mol Cell Biol
Title: TEX14 interacts with CEP55 to block cell abscission.
Volume: 30
Issue: 9
Pages: 2280-92
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Publication
33087841 | J:301215
First Author: Sinha D
Year: 2020
Journal: Commun Biol
Title: Cep55 overexpression promotes genomic instability and tumorigenesis in mice.
Volume: 3
Issue: 1
Pages: 593
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Publication
33475699 | J:313163
 
First Author: Zhang YC
Year: 2021
Journal: J Cell Biol
Title: CEP55 promotes cilia disassembly through stabilizing Aurora A kinase.
Volume: 220
Issue: 2
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Publication
34710087 | J:314161
First Author: Rashidieh B
Year: 2021
Journal: PLoS Genet
Title: Cep55 regulation of PI3K/Akt signaling is required for neocortical development and ciliogenesis.
Volume: 17
Issue: 10
Pages: e1009334
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Publication
32269212 | J:287102
First Author: Tedeschi A
Year: 2020
Journal: Nat Commun
Title: Cep55 promotes cytokinesis of neural progenitors but is dispensable for most mammalian cell divisions.
Volume: 11
Issue: 1
Pages: 1746
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Publication
20186884 | J:161244
First Author: Chang YC
Year: 2010
Journal: J Cell Biochem
Title: Characterization of centrosomal proteins Cep55 and pericentrin in intercellular bridges of mouse testes.
Volume: 109
Issue: 6
Pages: 1274-85
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Publication
29683733 | J:280601
First Author: Sinha D
Year: 2018
Journal: FASEB J
Title: Cep55 overexpression causes male-specific sterility in mice by suppressing Foxo1 nuclear retention through sustained activation of PI3K/Akt signaling.
Volume: 32
Issue: 9
Pages: 4984-4999
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Publication
33622776 | J:304629
First Author: Little JN
Year: 2021
Journal: J Neurosci
Title: Loss of Coiled-Coil Protein Cep55 Impairs Neural Stem Cell Abscission and Results in p53-Dependent Apoptosis in Developing Cortex.
Volume: 41
Issue: 15
Pages: 3344-3365
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Protein
Q9CZP8
Organism: Mus musculus/domesticus
Length: 189  
Fragment?: false
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Publication
16198290 | -
First Author: Fabbro M
Year: 2005
Journal: Dev Cell
Title: Cdk1/Erk2- and Plk1-dependent phosphorylation of a centrosome protein, Cep55, is required for its recruitment to midbody and cytokinesis.
Volume: 9
Issue: 4
Pages: 477-88
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Publication
19638580 | J:151773
First Author: van der Horst A
Year: 2009
Journal: Cancer Res
Title: The peptidyl-prolyl isomerase Pin1 regulates cytokinesis through Cep55.
Volume: 69
Issue: 16
Pages: 6651-9
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Publication
31427428 | J:287822
 
First Author: Zhou C
Year: 2019
Journal: J Cell Sci
Title: First meiotic anaphase requires Cep55-dependent inhibitory cyclin-dependent kinase 1 phosphorylation.
Volume: 132
Issue: 18
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Protein Coding Gene
MGP_CAROLIEiJ_G0022920 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0025086 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0025062 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0025030 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0025060 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0024819 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1921357 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0025501 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0024286 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0024796 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0024928 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0024889 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0025014 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0024920 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0025559 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0024038 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0024353 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0014413 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0023838 | -
Type: protein_coding_gene
Organism: Mus spretus
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GXD Expression
GXD Expression
   
Probe: MGI:4428016
Assay Type: RNA in situ
Annotation Date: 2024-02-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754722
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:7595806
Age: embryonic day 14.5
Specimen Label: Supplementary table 2
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:4845883
Assay Type: Immunohistochemistry
Annotation Date: 2010-12-15
Strength: Present
Sex: Male
Emaps: EMAPS:1797528
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:4845890
Age: postnatal day 15
Note: Expression was detected in ring-shaped intercellular bridge structures in germ cells throughout the seminiferous tubules. Expression co-localized with Tex14.
Specimen Label: 2B, 2D, 2E
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:4845883
Assay Type: Immunohistochemistry
Annotation Date: 2010-12-15
Strength: Present
Sex: Male
Emaps: EMAPS:1797528
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:4845890
Age: postnatal week 6
Note: Expression was detected in ring-shaped intercellular bridge structures in germ cells throughout the seminiferous tubules. Expression co-localized with Tex14.
Specimen Label: 2G, 2I, 2J
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:4845883
Assay Type: Immunohistochemistry
Annotation Date: 2010-12-15
Strength: Present
Sex: Male
Emaps: EMAPS:1797528
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:4845890
Age: postnatal week 6
Note: Expression was detected in ring-shaped intercellular bridge structures in germ cells throughout the seminiferous tubules.
Specimen Label: 2L
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
 
Probe: MGI:4845883
Assay Type: Immunohistochemistry
Annotation Date: 2010-12-15
Strength: Present
Sex: Male
Emaps: EMAPS:1797528
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:4845890
Age: postnatal day 21
Note: Expression was detected in intercellular bridge structures in germ cells. Expression co-localized with Tex14.
Specimen Label: 10B, 10D
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
 
Probe: MGI:4845883
Assay Type: Immunohistochemistry
Annotation Date: 2010-12-15
Strength: Present
Sex: Male
Emaps: EMAPS:1797528
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:4845890
Age: postnatal day 21
Note: Expression was detected in midbodies.
Specimen Label: 10F, 10H
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
 
Probe: MGI:4845883
Assay Type: Immunohistochemistry
Annotation Date: 2010-12-15
Strength: Present
Sex: Male
Emaps: EMAPS:1797528
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:4845890
Age: postnatal day 21
Note: Expression was detected in abscissed midbodies.
Specimen Label: 10J, 10L
Detected: true
Specimen Num: 7
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GXD Expression
GXD Expression
 
Probe: MGI:4845883
Assay Type: Immunohistochemistry
Annotation Date: 2010-12-15
Strength: Present
Sex: Female
Emaps: EMAPS:1796226
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:4845890
Age: embryonic day 18.5
Note: Expression colocalized with Tex14.
Specimen Label: 3B, 3D, 3F, 3H
Detected: true
Specimen Num: 4
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Publication
21909099 | J:176955
First Author: Kuo TC
Year: 2011
Journal: Nat Cell Biol
Title: Midbody accumulation through evasion of autophagy contributes to cellular reprogramming and tumorigenicity.
Volume: 13
Issue: 10
Pages: 1214-23
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Publication
- | J:237616
     
First Author: MGI and IMPC
Year: 2017
Journal: MGI Direct Data Submission
Title: MGI Curation of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC)
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Publication
- | J:73065
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Gene Ontology Annotation by the MGI Curatorial Staff
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Publication
12904583 | J:85162
First Author: Hansen J
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.
Volume: 100
Issue: 17
Pages: 9918-22
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Publication
17967808 | J:152068
First Author: Friedel RH
Year: 2007
Journal: Brief Funct Genomic Proteomic
Title: EUCOMM--the European conditional mouse mutagenesis program.
Volume: 6
Issue: 3
Pages: 180-5
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Publication
34321999 | J:313619
 
First Author: Bedogni F
Year: 2021
Journal: Front Mol Neurosci
Title: Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development.
Volume: 14
Pages: 686034
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Publication
12520002 | J:91812
First Author: Stryke D
Year: 2003
Journal: Nucleic Acids Res
Title: BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Volume: 31
Issue: 1
Pages: 278-81
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Publication
- | J:157065
     
First Author: Helmholtz Zentrum Muenchen GmbH
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu)
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Publication
- | J:72247
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Gene Ontology Annotation by the MGI Curatorial Staff
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Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
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Publication
- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:342604
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
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Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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Publication
- | J:78475
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Protein Domain
IPR022008 | EABR
Type: Domain
Description: This domain family is found in eukaryotes, and is approximately 40 amino acids in length. This domain is the active domain of CEP55. CEP55 is a protein involved in cytokinesis, specifically in abscission of the plasma membrane at the midbody. To perform this function, CEP55 complexes with ESCRT-I (by a Proline rich sequence in its TSG101 domain) and ALIX. This is the domain on CEP55 which binds to both TSG101 and ALIX. It also acts as a hinge between the N and C termini. This domain is called EABR.
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Protein
Q8BT07-2
Organism: Mus musculus/domesticus
Length: 461  
Fragment?: false
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Protein
Q99JG7
Organism: Mus musculus/domesticus
Length: 430  
Fragment?: false
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Protein
Q80VZ7
Organism: Mus musculus/domesticus
Length: 451  
Fragment?: false
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GXD Expression
GXD Expression
 
Probe: MGI:4845887
Assay Type: Immunohistochemistry
Annotation Date: 2010-12-15
Strength: Present
Sex: Male
Emaps: EMAPS:1797528
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:4845891
Age: postnatal week 6
Note: Expression was detected in ring-shaped intercellular bridge structures in germ cells throughout the seminiferous tubules. Expression co-localized with Cep55
Specimen Label: 2F, 2I, 2J
Detected: true
Specimen Num: 2
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DO Term
DOID:0080327 | multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia and hydranencephaly
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Publication
30069007 | J:266258
First Author: de Cárcer G
Year: 2018
Journal: Nat Commun
Title: Plk1 overexpression induces chromosomal instability and suppresses tumor development.
Volume: 9
Issue: 1
Pages: 3012
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Publication
22405274 | J:183245
First Author: Mondal G
Year: 2012
Journal: Mol Cell
Title: Tex14, a Plk1-regulated protein, is required for kinetochore-microtubule attachment and regulation of the spindle assembly checkpoint.
Volume: 45
Issue: 5
Pages: 680-95
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Publication
19020301 | J:145878
First Author: Greenbaum MP
Year: 2009
Journal: Biol Reprod
Title: Mouse TEX14 is required for embryonic germ cell intercellular bridges but not female fertility.
Volume: 80
Issue: 3
Pages: 449-57
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Publication
16549803 | J:107660
First Author: Greenbaum MP
Year: 2006
Journal: Proc Natl Acad Sci U S A
Title: TEX14 is essential for intercellular bridges and fertility in male mice.
Volume: 103
Issue: 13
Pages: 4982-7
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Protein Domain
IPR039339 | Tex14
Type: Family
Description: TEX14 is an inactive serine/threonine-protein kinase because the active site aspartic acid residue has been replaced. It localizes to germ cell intercellular bridges during spermatogenesis. In germ cell cytokinesis a permanent intercellular bridge connecting the daughter cells through a large cytoplasmic channel forms, unlike in somatic cells. This bridge does not form in TEX14 deficient mice and male mice are sterile []; female knockout mice are fertile []. TEX14 binds to CEP55, which is a stable component of the intercellular bridge, via a GPPX3Y motif and preventing proteins with a similar motif (such as ALIX and TSG101) from binding to CEP55 []. During mitosis, TEX14 is recruited to kinetochores by Plk1 and without TEX14, kinetochores are unable to bind other essential components leading to chromosome instability. Phosphorylation of TEX14 by Plk1 leads to its degradation, which is essential for metaphase-to-anaphase transition and chromosome segregation []. TEX14 contains ankyrin repeat-containing domains and a protein kinase domain.
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