| Type |
Details |
Score |
| Gene |
| Type: |
gene |
| Organism: |
human |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
frog, western clawed |
|
•
•
•
•
•
|
| Gene |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
dog, domestic |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
chimpanzee |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
cattle |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
chicken |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
human |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Rabionet M |
| Year: |
2015 |
| Journal: |
Hum Mol Genet |
| Title: |
Male meiotic cytokinesis requires ceramide synthase 3-dependent sphingolipids with unique membrane anchors. |
| Volume: |
24 |
| Issue: |
17 |
| Pages: |
4792-808 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Jennemann R |
| Year: |
2012 |
| Journal: |
Hum Mol Genet |
| Title: |
Loss of ceramide synthase 3 causes lethal skin barrier disruption. |
| Volume: |
21 |
| Issue: |
3 |
| Pages: |
586-608 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Sassa T |
| Year: |
2016 |
| Journal: |
J Biol Chem |
| Title: |
Enzyme Activities of the Ceramide Synthases CERS2-6 Are Regulated by Phosphorylation in the C-terminal Region. |
| Volume: |
291 |
| Issue: |
14 |
| Pages: |
7477-87 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Rabionet M |
| Year: |
2008 |
| Journal: |
J Biol Chem |
| Title: |
Male germ cells require polyenoic sphingolipids with complex glycosylation for completion of meiosis: a link to ceramide synthase-3. |
| Volume: |
283 |
| Issue: |
19 |
| Pages: |
13357-69 |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
Mus caroli |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
Mus pahari |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
Mus spretus |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mizutani Y |
| Year: |
2006 |
| Journal: |
Biochem J |
| Title: |
LASS3 (longevity assurance homologue 3) is a mainly testis-specific (dihydro)ceramide synthase with relatively broad substrate specificity. |
| Volume: |
398 |
| Issue: |
3 |
| Pages: |
531-8 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:6423351 |
| Assay Type: |
RT-PCR |
| Annotation Date: |
2020-05-19 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1752826 |
|
| Stage: |
TS26 |
| Assay Id: |
MGI:6423364 |
| Age: |
embryonic day 18.5 |
|
|
| Specimen Label: |
WT |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:6423351 |
| Assay Type: |
RT-PCR |
| Annotation Date: |
2020-05-19 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1752826 |
|
| Stage: |
TS26 |
| Assay Id: |
MGI:6423364 |
| Age: |
embryonic day 18.5 |
|
|
| Specimen Label: |
KO |
| Detected: |
true |
| Specimen Num: |
2 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:7461599 |
| Assay Type: |
RT-PCR |
| Annotation Date: |
2023-04-13 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1752526 |
|
| Stage: |
TS26 |
| Assay Id: |
MGI:7461621 |
| Age: |
embryonic day 18.5 |
|
|
| Specimen Label: |
WT |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:7461599 |
| Assay Type: |
RT-PCR |
| Annotation Date: |
2023-04-13 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1752526 |
|
| Stage: |
TS26 |
| Assay Id: |
MGI:7461621 |
| Age: |
embryonic day 18.5 |
|
|
| Specimen Label: |
Pnpla1 tm1a |
| Detected: |
true |
| Specimen Num: |
2 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:7543486 |
| Assay Type: |
RT-PCR |
| Annotation Date: |
2023-10-26 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1752524 |
|
| Stage: |
TS24 |
| Assay Id: |
MGI:7543519 |
| Age: |
embryonic day 16.5 |
|
|
| Specimen Label: |
a E16.5 |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:7543486 |
| Assay Type: |
RT-PCR |
| Annotation Date: |
2023-10-26 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1752525 |
|
| Stage: |
TS25 |
| Assay Id: |
MGI:7543519 |
| Age: |
embryonic day 17.5 |
|
|
| Specimen Label: |
b E17.5 |
| Detected: |
true |
| Specimen Num: |
2 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:7543486 |
| Assay Type: |
RT-PCR |
| Annotation Date: |
2023-10-26 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1752526 |
|
| Stage: |
TS26 |
| Assay Id: |
MGI:7543519 |
| Age: |
embryonic day 18.5 |
|
|
| Specimen Label: |
c E18.5 |
| Detected: |
true |
| Specimen Num: |
3 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:5824382 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2017-02-17 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:3278626 |
| Pattern: |
Not Specified |
| Stage: |
TS26 |
| Assay Id: |
MGI:5824520 |
| Age: |
embryonic day 18.5 |
|
|
| Specimen Label: |
6A |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:5824382 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2017-02-17 |
| Strength: |
Absent |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:3277926 |
|
| Stage: |
TS26 |
| Assay Id: |
MGI:5824520 |
| Age: |
embryonic day 18.5 |
|
|
| Specimen Label: |
6A |
| Detected: |
false |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:5908262 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2017-09-06 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:3665720 |
| Pattern: |
Regionally restricted |
| Stage: |
TS20 |
| Assay Id: |
MGI:5908370 |
| Age: |
embryonic day 12.5 |
| Image: |
S4K |
| Note: |
Expression in components of facial ectoderm. |
| Specimen Label: |
S4K |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:5824382 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2017-02-17 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:3278526 |
| Pattern: |
Not Specified |
| Stage: |
TS26 |
| Assay Id: |
MGI:5824520 |
| Age: |
embryonic day 18.5 |
|
|
| Specimen Label: |
6A |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Riebeling C |
| Year: |
2003 |
| Journal: |
J Biol Chem |
| Title: |
Two mammalian longevity assurance gene (LAG1) family members, trh1 and trh4, regulate dihydroceramide synthesis using different fatty acyl-CoA donors. |
| Volume: |
278 |
| Issue: |
44 |
| Pages: |
43452-9 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Venkataraman K |
| Year: |
2002 |
| Journal: |
FEBS Lett |
| Title: |
Do longevity assurance genes containing Hox domains regulate cell development via ceramide synthesis? |
| Volume: |
528 |
| Issue: |
1-3 |
| Pages: |
3-4 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kato A |
| Year: |
2022 |
| Journal: |
Biochim Biophys Acta Mol Cell Biol Lipids |
| Title: |
Acsl1 is essential for skin barrier function through the activation of linoleic acid and biosynthesis of ω-O-acylceramide in mice. |
| Volume: |
1867 |
| Issue: |
2 |
| Pages: |
159085 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Sassa T |
| Year: |
2013 |
| Journal: |
Mol Cell Biol |
| Title: |
Impaired epidermal permeability barrier in mice lacking elovl1, the gene responsible for very-long-chain fatty acid production. |
| Volume: |
33 |
| Issue: |
14 |
| Pages: |
2787-96 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Hooper JE |
| Year: |
2017 |
| Journal: |
Dev Biol |
| Title: |
Systems biology of facial development: contributions of ectoderm and mesenchyme. |
| Volume: |
426 |
| Issue: |
1 |
| Pages: |
97-114 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Oberbeck N |
| Year: |
2019 |
| Journal: |
Nature |
| Title: |
The RIPK4-IRF6 signalling axis safeguards epidermal differentiation and barrier function. |
| Volume: |
574 |
| Issue: |
7777 |
| Pages: |
249-253 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Miyamoto M |
| Year: |
2020 |
| Journal: |
J Invest Dermatol |
| Title: |
Severe Skin Permeability Barrier Dysfunction in Knockout Mice Deficient in a Fatty Acid ω-Hydroxylase Crucial to Acylceramide Production. |
| Volume: |
140 |
| Issue: |
2 |
| Pages: |
319-326.e4 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Pichery M |
| Year: |
2017 |
| Journal: |
Hum Mol Genet |
| Title: |
PNPLA1 defects in patients with autosomal recessive congenital ichthyosis and KO mice sustain PNPLA1 irreplaceable function in epidermal omega-O-acylceramide synthesis and skin permeability barrier. |
| Volume: |
26 |
| Issue: |
10 |
| Pages: |
1787-1800 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Zhang J |
| Year: |
2024 |
| Journal: |
Nat Commun |
| Title: |
Regulation of meiotic telomere dynamics through membrane fluidity promoted by AdipoR2-ELOVL2. |
| Volume: |
15 |
| Issue: |
1 |
| Pages: |
2315 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wang Z |
| Year: |
2013 |
| Journal: |
J Invest Dermatol |
| Title: |
Transcription factor Ctip2 controls epidermal lipid metabolism and regulates expression of genes involved in sphingolipid biosynthesis during skin development. |
| Volume: |
133 |
| Issue: |
3 |
| Pages: |
668-76 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Lau CG |
| Year: |
2014 |
| Journal: |
Mol Reprod Dev |
| Title: |
Morphology-based mammalian stem cell tests reveal potential developmental toxicity of donepezil. |
| Volume: |
81 |
| Issue: |
11 |
| Pages: |
994-1008 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Shanghai Model Organisms Center |
| Year: |
2017 |
| Journal: |
MGI Direct Data Submission |
| Title: |
Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2003 |
| Journal: |
Database Download |
| Title: |
Integrating Computational Gene Models into the Mouse Genome Informatics (MGI) Database |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Helmholtz Zentrum Muenchen GmbH |
| Year: |
2010 |
| Journal: |
MGI Direct Data Submission |
| Title: |
Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu) |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
UniProt-GOA |
| Year: |
2012 |
|
| Title: |
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt |
|
|
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|
•
•
•
•
•
|
| Publication |
| First Author: |
DDB, FB, MGI, GOA, ZFIN curators |
| Year: |
2001 |
|
| Title: |
Gene Ontology annotation through association of InterPro records with GO terms |
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•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2003 |
|
| Title: |
MGI Sequence Curation Reference |
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•
•
•
•
•
|
| Publication |
| First Author: |
Kawai J |
| Year: |
2001 |
| Journal: |
Nature |
| Title: |
Functional annotation of a full-length mouse cDNA collection. |
| Volume: |
409 |
| Issue: |
6821 |
| Pages: |
685-90 |
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•
•
•
•
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| First Author: |
MGD Nomenclature Committee |
| Year: |
1995 |
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| Title: |
Nomenclature Committee Use |
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•
•
•
•
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| First Author: |
GemPharmatech |
| Year: |
2020 |
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| Title: |
GemPharmatech Website. |
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•
•
•
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| Publication |
| First Author: |
Okazaki Y |
| Year: |
2002 |
| Journal: |
Nature |
| Title: |
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. |
| Volume: |
420 |
| Issue: |
6915 |
| Pages: |
563-73 |
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•
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| First Author: |
The Gene Ontology Consortium |
| Year: |
2010 |
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| Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs |
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| First Author: |
Diez-Roux G |
| Year: |
2011 |
| Journal: |
PLoS Biol |
| Title: |
A high-resolution anatomical atlas of the transcriptome in the mouse embryo. |
| Volume: |
9 |
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1 |
| Pages: |
e1000582 |
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| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2002 |
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| Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations |
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| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2010 |
| Journal: |
Database Download |
| Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2). |
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Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
| Year: |
2010 |
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| Title: |
Annotation inferences using phylogenetic trees |
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•
•
•
•
•
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| Publication |
| First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
| Year: |
2000 |
| Journal: |
Database Release |
| Title: |
Entrez Gene Load |
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•
•
•
•
•
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Allen Institute for Brain Science |
| Year: |
2004 |
| Journal: |
Allen Institute |
| Title: |
Allen Brain Atlas: mouse riboprobes |
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•
•
•
•
•
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| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2009 |
| Journal: |
Database Download |
| Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
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•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
| Year: |
2010 |
| Journal: |
Database Download |
| Title: |
Consensus CDS project |
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•
•
•
•
•
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| Publication |
| First Author: |
Mouse Genome Informatics Group |
| Year: |
2003 |
| Journal: |
Database Procedure |
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Automatic Encodes (AutoE) Reference |
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•
•
•
•
•
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| Publication |
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Bairoch A |
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1999 |
| Journal: |
Database Release |
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SWISS-PROT Annotated protein sequence database |
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•
•
•
•
•
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| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2005 |
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| Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
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•
•
•
•
•
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| Publication |
| First Author: |
Mouse Genome Informatics |
| Year: |
2010 |
| Journal: |
Database Release |
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Protein Ontology Association Load. |
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•
•
•
•
•
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| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2005 |
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| Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
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•
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| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2009 |
| Journal: |
Database Download |
| Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
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| Allele |
| Name: |
ceramide synthase 3; endonuclease-mediated mutation 1, Shanghai Model Organisms Center |
| Allele Type: |
Endonuclease-mediated |
| Attribute String: |
Null/knockout |
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| Strain |
| Attribute String: |
coisogenic, endonuclease-mediated mutation, mutant strain |
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| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
383
 |
| Fragment?: |
false |
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•
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| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
419
 |
| Fragment?: |
false |
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| DO Term |
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| Publication |
| First Author: |
Ferreira NS |
| Year: |
2017 |
| Journal: |
J Biol Chem |
| Title: |
Regulation of very-long acyl chain ceramide synthesis by acyl-CoA-binding protein. |
| Volume: |
292 |
| Issue: |
18 |
| Pages: |
7588-7597 |
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•
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•
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| Publication |
| First Author: |
Ebel P |
| Year: |
2014 |
| Journal: |
Biochem J |
| Title: |
Ceramide synthase 4 deficiency in mice causes lipid alterations in sebum and results in alopecia. |
| Volume: |
461 |
| Issue: |
1 |
| Pages: |
147-58 |
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