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Search results 1 to 100 out of 346 for Cgas

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Hits by Strain

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Type Details Score
Gene
115004 | CGAS
Type: gene
Organism: human
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Gene
682147 | Cgas
Type: gene
Organism: rat
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Gene
782472 | CGAS
Type: gene
Organism: cattle
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Gene
421864 | CGAS
Type: gene
Organism: chicken
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Gene
717665 | CGAS
Type: gene
Organism: macaque, rhesus
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Gene
100488048 | cgas
Type: gene
Organism: frog, western clawed
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Gene
611033 | CGAS
Type: gene
Organism: dog, domestic
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Gene
462822 | CGAS
Type: gene
Organism: chimpanzee
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Protein Coding Gene
MGI:2442261 | Cgas
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
30135424 | J:271802
First Author: Lian H
Year: 2018
Journal: Nat Commun
Title: ZCCHC3 is a co-sensor of cGAS for dsDNA recognition in innate immune response.
Volume: 9
Issue: 1
Pages: 3349
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Publication
32913000 | J:314911
First Author: Boyer JA
Year: 2020
Journal: Science
Title: Structural basis of nucleosome-dependent cGAS inhibition.
Volume: 370
Issue: 6515
Pages: 450-454
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Publication
28363908 | J:241001
First Author: Tao J
Year: 2017
Journal: J Immunol
Title: Nonspecific DNA Binding of cGAS N Terminus Promotes cGAS Activation.
Volume: 198
Issue: 9
Pages: 3627-3636
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Publication
31665636 | J:298560
First Author: Schadt L
Year: 2019
Journal: Cell Rep
Title: Cancer-Cell-Intrinsic cGAS Expression Mediates Tumor Immunogenicity.
Volume: 29
Issue: 5
Pages: 1236-1248.e7
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Publication
35210392 | J:326061
First Author: Xiao Y
Year: 2022
Journal: Bone Res
Title: RIOX1-demethylated cGAS regulates ionizing radiation-elicited DNA repair.
Volume: 10
Issue: 1
Pages: 19
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Publication
28533362 | J:242280
First Author: Yang H
Year: 2017
Journal: Proc Natl Acad Sci U S A
Title: cGAS is essential for cellular senescence.
Volume: 114
Issue: 23
Pages: E4612-E4620
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Publication
29426904 | J:257953
First Author: Seo GJ
Year: 2018
Journal: Nat Commun
Title: TRIM56-mediated monoubiquitination of cGAS for cytosolic DNA sensing.
Volume: 9
Issue: 1
Pages: 613
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Publication
30356214 | J:267189
First Author: Liu H
Year: 2018
Journal: Nature
Title: Nuclear cGAS suppresses DNA repair and promotes tumorigenesis.
Volume: 563
Issue: 7729
Pages: 131-136
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Publication
32911480 | J:314373
First Author: Michalski S
Year: 2020
Journal: Nature
Title: Structural basis for sequestration and autoinhibition of cGAS by chromatin.
Volume: 587
Issue: 7835
Pages: 678-682
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Publication
29176737 | J:255750
First Author: Kerur N
Year: 2018
Journal: Nat Med
Title: cGAS drives noncanonical-inflammasome activation in age-related macular degeneration.
Volume: 24
Issue: 1
Pages: 50-61
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Publication
34507063 | J:339057
 
First Author: Tan C
Year: 2021
Journal: Biochem Biophys Res Commun
Title: Deficiency of cGAS signaling protects against sepsis-associated encephalopathy.
Volume: 577
Pages: 38-44
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Publication
28738408 | J:250116
First Author: Mackenzie KJ
Year: 2017
Journal: Nature
Title: cGAS surveillance of micronuclei links genome instability to innate immunity.
Volume: 548
Issue: 7668
Pages: 461-465
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Publication
32861998 | J:338658
First Author: Zhang Y
Year: 2020
Journal: iScience
Title: Streptavidin Promotes DNA Binding and Activation of cGAS to Enhance Innate Immunity.
Volume: 23
Issue: 9
Pages: 101463
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Publication
28095500 | J:246297
First Author: Cui Y
Year: 2017
Journal: PLoS Pathog
Title: SENP7 Potentiates cGAS Activation by Relieving SUMO-Mediated Inhibition of Cytosolic DNA Sensing.
Volume: 13
Issue: 1
Pages: e1006156
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Publication
33296647 | J:304672
First Author: Cui S
Year: 2020
Journal: Cell Rep
Title: Nuclear cGAS Functions Non-canonically to Enhance Antiviral Immunity via Recruiting Methyltransferase Prmt5.
Volume: 33
Issue: 10
Pages: 108490
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Publication
32034061 | J:287628
First Author: Han Y
Year: 2020
Journal: J Immunol
Title: Airway Epithelial cGAS Is Critical for Induction of Experimental Allergic Airway Inflammation.
Volume: 204
Issue: 6
Pages: 1437-1447
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Publication
34074794 | J:306531
 
First Author: Hu S
Year: 2021
Journal: Proc Natl Acad Sci U S A
Title: cGAS restricts colon cancer development by protecting intestinal barrier integrity.
Volume: 118
Issue: 23
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Publication
30872316 | J:273191
 
First Author: Liu H
Year: 2019
Journal: EMBO Rep
Title: cGAS facilitates sensing of extracellular cyclic dinucleotides to activate innate immunity.
Volume: 20
Issue: 4
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Publication
30872080 | J:295560
 
First Author: Xiao N
Year: 2019
Journal: J Autoimmun
Title: cGAS activation causes lupus-like autoimmune disorders in a TREX1 mutant mouse model.
Volume: 100
Pages: 84-94
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Publication
33881503 | J:323903
First Author: Wang R
Year: 2021
Journal: Blood
Title: Neutrophil extracellular traps promote tPA-induced brain hemorrhage via cGAS in mice with stroke.
Volume: 138
Issue: 1
Pages: 91-103
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Publication
24284630 | J:207826
First Author: Schoggins JW
Year: 2014
Journal: Nature
Title: Pan-viral specificity of IFN-induced genes reveals new roles for cGAS in innate immunity.
Volume: 505
Issue: 7485
Pages: 691-5
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Publication
32239625 | J:292740
First Author: Li Q
Year: 2020
Journal: EMBO Mol Med
Title: Inhibition of double-strand DNA-sensing cGAS ameliorates brain injury after ischemic stroke.
Volume: 12
Issue: 4
Pages: e11002
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Publication
23722158 | J:198729
First Author: Ablasser A
Year: 2013
Journal: Nature
Title: cGAS produces a 2'-5'-linked cyclic dinucleotide second messenger that activates STING.
Volume: 498
Issue: 7454
Pages: 380-4
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Publication
37352855 | J:338214
First Author: Lei Y
Year: 2023
Journal: Cell
Title: Cooperative sensing of mitochondrial DNA by ZBP1 and cGAS promotes cardiotoxicity.
Volume: 186
Issue: 14
Pages: 3013-3032.e22
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Publication
30092200 | J:272646
First Author: Zhang J
Year: 2018
Journal: Cell Host Microbe
Title: Species-Specific Deamidation of cGAS by Herpes Simplex Virus UL37 Protein Facilitates Viral Replication.
Volume: 24
Issue: 2
Pages: 234-248.e5
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Publication
36070120 | J:340072
First Author: Han C
Year: 2022
Journal: Mol Neurobiol
Title: Inhibition of cGAS in Paraventricular Nucleus Attenuates Hypertensive Heart Injury Via Regulating Microglial Autophagy.
Volume: 59
Issue: 11
Pages: 7006-7024
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Publication
36881861 | J:339050
First Author: Shen X
Year: 2023
Journal: J Immunol
Title: cGAS Mediates Inflammation by Polarizing Macrophages to M1 Phenotype via the mTORC1 Pathway.
Volume: 210
Issue: 8
Pages: 1098-1107
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Publication
30842662 | J:274355
First Author: Gui X
Year: 2019
Journal: Nature
Title: Autophagy induction via STING trafficking is a primordial function of the cGAS pathway.
Volume: 567
Issue: 7747
Pages: 262-266
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Publication
31544964 | J:280913
First Author: Jiang H
Year: 2019
Journal: EMBO J
Title: Chromatin-bound cGAS is an inhibitor of DNA repair and hence accelerates genome destabilization and cell death.
Volume: 38
Issue: 21
Pages: e102718
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Publication
26048136 | J:339046
First Author: Watson RO
Year: 2015
Journal: Cell Host Microbe
Title: The Cytosolic Sensor cGAS Detects Mycobacterium tuberculosis DNA to Induce Type I Interferons and Activate Autophagy.
Volume: 17
Issue: 6
Pages: 811-819
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Publication
28137885 | J:240932
First Author: Wang H
Year: 2017
Journal: Proc Natl Acad Sci U S A
Title: cGAS is essential for the antitumor effect of immune checkpoint blockade.
Volume: 114
Issue: 7
Pages: 1637-1642
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Publication
23707065 | J:198667
First Author: Diner EJ
Year: 2013
Journal: Cell Rep
Title: The innate immune DNA sensor cGAS produces a noncanonical cyclic dinucleotide that activates human STING.
Volume: 3
Issue: 5
Pages: 1355-61
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Publication
32383996 | J:293479
First Author: Hu D
Year: 2020
Journal: Am J Physiol Heart Circ Physiol
Title: Cytosolic DNA sensor cGAS plays an essential pathogenetic role in pressure overload-induced heart failure.
Volume: 318
Issue: 6
Pages: H1525-H1537
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Publication
36591278 | J:332441
 
First Author: Kumpunya S
Year: 2022
Journal: Front Immunol
Title: cGAS deficiency enhances inflammasome activation in macrophages and inflammatory pathology in pristane-induced lupus.
Volume: 13
Pages: 1010764
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Publication
27666593 | J:249057
First Author: Chen M
Year: 2016
Journal: Mol Cell
Title: TRIM14 Inhibits cGAS Degradation Mediated by Selective Autophagy Receptor p62 to Promote Innate Immune Responses.
Volume: 64
Issue: 1
Pages: 105-119
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Publication
32474700 | J:314393
First Author: Li M
Year: 2020
Journal: Protein Cell
Title: Dephosphorylation of cGAS by PPP6C impairs its substrate binding activity and innate antiviral response.
Volume: 11
Issue: 8
Pages: 584-599
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Publication
28214358 | J:241014
First Author: Lee A
Year: 2017
Journal: FEBS Lett
Title: The N terminus of cGAS de-oligomerizes the cGAS:DNA complex and lifts the DNA size restriction of core-cGAS activity.
Volume: 591
Issue: 6
Pages: 954-961
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Publication
30827685 | J:273551
First Author: Barnett KC
Year: 2019
Journal: Cell
Title: Phosphoinositide Interactions Position cGAS at the Plasma Membrane to Ensure Efficient Distinction between Self- and Viral DNA.
Volume: 176
Issue: 6
Pages: 1432-1446.e11
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Publication
30811988 | J:273171
First Author: Gentili M
Year: 2019
Journal: Cell Rep
Title: The N-Terminal Domain of cGAS Determines Preferential Association with Centromeric DNA and Innate Immune Activation in the Nucleus.
Volume: 26
Issue: 9
Pages: 2377-2393.e13
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Publication
35420160 | J:340073
First Author: Wang B
Year: 2022
Journal: Immunology
Title: cGAS modulates cytokine secretion and bacterial burdens by altering the release of mitochondrial DNA in pseudomonas pulmonary infection.
Volume: 166
Issue: 3
Pages: 408-423
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Publication
32164878 | J:290377
First Author: Huang LS
Year: 2020
Journal: Immunity
Title: mtDNA Activates cGAS Signaling and Suppresses the YAP-Mediated Endothelial Cell Proliferation Program to Promote Inflammatory Injury.
Volume: 52
Issue: 3
Pages: 475-486.e5
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Publication
28963528 | J:281254
First Author: Vincent J
Year: 2017
Journal: Nat Commun
Title: Small molecule inhibition of cGAS reduces interferon expression in primary macrophages from autoimmune mice.
Volume: 8
Issue: 1
Pages: 750
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Publication
33589571 | J:339042
First Author: Lu GF
Year: 2021
Journal: Aging (Albany NY)
Title: Synergistic inflammatory signaling by cGAS may be involved in the development of atherosclerosis.
Volume: 13
Issue: 4
Pages: 5650-5673
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Publication
28759028 | J:243563
First Author: Glück S
Year: 2017
Journal: Nat Cell Biol
Title: Innate immune sensing of cytosolic chromatin fragments through cGAS promotes senescence.
Volume: 19
Issue: 9
Pages: 1061-1070
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Publication
26829768 | J:231311
First Author: Xia P
Year: 2016
Journal: Nat Immunol
Title: Glutamylation of the DNA sensor cGAS regulates its binding and synthase activity in antiviral immunity.
Volume: 17
Issue: 4
Pages: 369-78
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Publication
35108342 | J:319753
First Author: Liang L
Year: 2022
Journal: PLoS Pathog
Title: cGAS exacerbates Schistosoma japonicum infection in a STING-type I IFN-dependent and independent manner.
Volume: 18
Issue: 2
Pages: e1010233
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Publication
33721834 | J:339056
 
First Author: Wu M
Year: 2021
Journal: Biochem Biophys Res Commun
Title: cGAS promotes sepsis in radiotherapy of cancer by up-regulating caspase-11 signaling.
Volume: 551
Pages: 86-92
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Publication
25710914 | J:339048
First Author: Storek KM
Year: 2015
Journal: J Immunol
Title: cGAS and Ifi204 cooperate to produce type I IFNs in response to Francisella infection.
Volume: 194
Issue: 7
Pages: 3236-45
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Publication
26223655 | J:236438
First Author: Gray EE
Year: 2015
Journal: J Immunol
Title: Cutting Edge: cGAS Is Required for Lethal Autoimmune Disease in the Trex1-Deficient Mouse Model of Aicardi-Goutières Syndrome.
Volume: 195
Issue: 5
Pages: 1939-43
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Publication
31877196 | J:287071
First Author: Wong EB
Year: 2019
Journal: PLoS Pathog
Title: Resistance to ectromelia virus infection requires cGAS in bone marrow-derived cells which can be bypassed with cGAMP therapy.
Volume: 15
Issue: 12
Pages: e1008239
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Publication
32404939 | J:292344
First Author: Skopelja-Gardner S
Year: 2020
Journal: Sci Rep
Title: The early local and systemic Type I interferon responses to ultraviolet B light exposure are cGAS dependent.
Volume: 10
Issue: 1
Pages: 7908
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Publication
27637147 | J:259271
First Author: Hu MM
Year: 2016
Journal: Immunity
Title: Sumoylation Promotes the Stability of the DNA Sensor cGAS and the Adaptor STING to Regulate the Kinetics of Response to DNA Virus.
Volume: 45
Issue: 3
Pages: 555-569
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Publication
23258413 | J:196208
First Author: Sun L
Year: 2013
Journal: Science
Title: Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway.
Volume: 339
Issue: 6121
Pages: 786-91
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Publication
23929945 | J:199863
First Author: Gao D
Year: 2013
Journal: Science
Title: Cyclic GMP-AMP synthase is an innate immune sensor of HIV and other retroviruses.
Volume: 341
Issue: 6148
Pages: 903-6
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Publication
30007416 | J:268008
First Author: Zhou W
Year: 2018
Journal: Cell
Title: Structure of the Human cGAS-DNA Complex Reveals Enhanced Control of Immune Surveillance.
Volume: 174
Issue: 2
Pages: 300-311.e11
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Publication
24332030 | J:209295
First Author: Li X
Year: 2013
Journal: Immunity
Title: Cyclic GMP-AMP synthase is activated by double-stranded DNA-induced oligomerization.
Volume: 39
Issue: 6
Pages: 1019-31
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Publication
37118112 | J:334150
First Author: Xie X
Year: 2023
Journal: Nat Aging
Title: Activation of innate immune cGAS-STING pathway contributes to Alzheimer's pathogenesis in 5×FAD mice.
Volume: 3
Issue: 2
Pages: 202-212
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Publication
28920955 | J:246736
First Author: Wu MZ
Year: 2017
Journal: Nat Cell Biol
Title: miR-25/93 mediates hypoxia-induced immunosuppression by repressing cGAS.
Volume: 19
Issue: 10
Pages: 1286-1296
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Publication
34586646 | J:319469
First Author: Beck MA
Year: 2021
Journal: EMBO J
Title: DNA hypomethylation leads to cGAS-induced autoinflammation in the epidermis.
Volume: 40
Issue: 22
Pages: e108234
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Publication
32911481 | J:313955
First Author: Zhao B
Year: 2020
Journal: Nature
Title: The molecular basis of tight nuclear tethering and inactivation of cGAS.
Volume: 587
Issue: 7835
Pages: 673-677
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Publication
37993259 | J:342956
 
First Author: El-Mortada F
Year: 2024
Journal: Life Sci Alliance
Title: Megakaryocytes possess a STING pathway that is transferred to platelets to potentiate activation.
Volume: 7
Issue: 2
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Publication
37206668 | J:336537
 
First Author: Elzinga SE
Year: 2023
Journal: Front Cell Neurosci
Title: Modeling the innate inflammatory cGAS/STING pathway: sexually dimorphic effects on microglia and cognition in obesity and prediabetes.
Volume: 17
Pages: 1167688
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Publication
31619733 | J:284653
First Author: Nascimento M
Year: 2019
Journal: Sci Rep
Title: Self-DNA release and STING-dependent sensing drives inflammation to cigarette smoke in mice.
Volume: 9
Issue: 1
Pages: 14848
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Publication
26229117 | J:263151
First Author: Bridgeman A
Year: 2015
Journal: Science
Title: Viruses transfer the antiviral second messenger cGAMP between cells.
Volume: 349
Issue: 6253
Pages: 1228-32
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Publication
38352859 | J:345622
First Author: Zhou S
Year: 2024
Journal: Mol Ther Nucleic Acids
Title: Engineering cGAS-agonistic oligonucleotides as therapeutics for cancer immunotherapy.
Volume: 35
Issue: 1
Pages: 102126
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Publication
26048137 | J:339047
First Author: Collins AC
Year: 2015
Journal: Cell Host Microbe
Title: Cyclic GMP-AMP Synthase Is an Innate Immune DNA Sensor for Mycobacterium tuberculosis.
Volume: 17
Issue: 6
Pages: 820-8
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Publication
27830700 | J:242718
 
First Author: Reinert LS
Year: 2016
Journal: Nat Commun
Title: Sensing of HSV-1 by the cGAS-STING pathway in microglia orchestrates antiviral defence in the CNS.
Volume: 7
Pages: 13348
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Publication
32532422 | J:339041
First Author: Yuan C
Year: 2020
Journal: Biochem Biophys Res Commun
Title: DNA damage/cGAS-triggered up-regulation of MALAT1 promotes undesirable inflammatory responses in radiotherapy of cancer.
Volume: 528
Issue: 4
Pages: 746-752
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Publication
33273464 | J:299391
First Author: Sun X
Year: 2020
Journal: Nat Commun
Title: DNA-PK deficiency potentiates cGAS-mediated antiviral innate immunity.
Volume: 11
Issue: 1
Pages: 6182
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Publication
34768881 | J:328124
 
First Author: Visitchanakun P
Year: 2021
Journal: Int J Mol Sci
Title: Interference on Cytosolic DNA Activation Attenuates Sepsis Severity: Experiments on Cyclic GMP-AMP Synthase (cGAS) Deficient Mice.
Volume: 22
Issue: 21
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Publication
34158863 | J:310095
First Author: Wang Z
Year: 2021
Journal: Theranostics
Title: Microbial and genetic-based framework identifies drug targets in inflammatory bowel disease.
Volume: 11
Issue: 15
Pages: 7491-7506
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Publication
32283527 | J:338647
First Author: Fu Y
Year: 2020
Journal: iScience
Title: Inhibition of cGAS-Mediated Interferon Response Facilitates Transgene Expression.
Volume: 23
Issue: 4
Pages: 101026
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Publication
34368651 | J:310084
First Author: Jütte BB
Year: 2021
Journal: iScience
Title: Intercellular cGAMP transmission induces innate immune activation and tissue inflammation in Trex1 deficiency.
Volume: 24
Issue: 8
Pages: 102833
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Publication
26944200 | J:263542
First Author: Carroll EC
Year: 2016
Journal: Immunity
Title: The Vaccine Adjuvant Chitosan Promotes Cellular Immunity via DNA Sensor cGAS-STING-Dependent Induction of Type I Interferons.
Volume: 44
Issue: 3
Pages: 597-608
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Publication
32721945 | J:339052
 
First Author: Piperno GM
Year: 2020
Journal: JCI Insight
Title: Wiskott-Aldrich syndrome protein restricts cGAS/STING activation by dsDNA immune complexes.
Volume: 5
Issue: 17
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Publication
34758308 | J:328220
First Author: Willemsen J
Year: 2021
Journal: Cell Rep
Title: TNF leads to mtDNA release and cGAS/STING-dependent interferon responses that support inflammatory arthritis.
Volume: 37
Issue: 6
Pages: 109977
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Publication
34648591 | J:313689
First Author: Sato H
Year: 2021
Journal: PLoS Pathog
Title: Downregulation of mitochondrial biogenesis by virus infection triggers antiviral responses by cyclic GMP-AMP synthase.
Volume: 17
Issue: 10
Pages: e1009841
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Publication
35503863 | J:341074
First Author: Yang X
Year: 2022
Journal: Sci Signal
Title: MARCH8 attenuates cGAS-mediated innate immune responses through ubiquitylation.
Volume: 15
Issue: 732
Pages: eabk3067
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Publication
30878284 | J:274136
First Author: Ning X
Year: 2019
Journal: Mol Cell
Title: Apoptotic Caspases Suppress Type I Interferon Production via the Cleavage of cGAS, MAVS, and IRF3.
Volume: 74
Issue: 1
Pages: 19-31.e7
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Publication
37095396 | J:344021
First Author: Udeochu JC
Year: 2023
Journal: Nat Neurosci
Title: Tau activation of microglial cGAS-IFN reduces MEF2C-mediated cognitive resilience.
Volume: 26
Issue: 5
Pages: 737-750
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Publication
33031745 | J:298617
First Author: Yu CH
Year: 2020
Journal: Cell
Title: TDP-43 Triggers Mitochondrial DNA Release via mPTP to Activate cGAS/STING in ALS.
Volume: 183
Issue: 3
Pages: 636-649.e18
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Publication
27477283 | J:238978
First Author: Maelfait J
Year: 2016
Journal: Cell Rep
Title: Restriction by SAMHD1 Limits cGAS/STING-Dependent Innate and Adaptive Immune Responses to HIV-1.
Volume: 16
Issue: 6
Pages: 1492-1501
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Journal: Elife
Title: LRRK2 maintains mitochondrial homeostasis and regulates innate immune responses to Mycobacterium tuberculosis.
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First Author: Li W
Year: 2020
Journal: Sci Transl Med
Title: cGAS-STING-mediated DNA sensing maintains CD8+ T cell stemness and promotes antitumor T cell therapy.
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First Author: Alonso Paiva IM
Year: 2023
Journal: Front Immunol
Title: Role of the cGAS/STING pathway in the control of Brucella abortus infection acquired through the respiratory route.
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First Author: Souza C
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Journal: Sci Rep
Title: The role of the adaptor molecule STING during Schistosoma mansoni infection.
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First Author: Ruiz-Moreno JS
Year: 2018
Journal: Infect Immun
Title: The cGAS/STING Pathway Detects Streptococcus pneumoniae but Appears Dispensable for Antipneumococcal Defense in Mice and Humans.
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First Author: Li J
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Journal: Int Immunopharmacol
Title: Blocking cGAS/STING signaling protects against sepsis-associated acute liver injury.
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Title: Absence of cGAS-mediated type I IFN responses in HIV-1-infected T cells.
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First Author: Su X
Year: 2022
Journal: Infect Immun
Title: Evidence for cGAS-STING Signaling in the Female Genital Tract Resistance to Chlamydia trachomatis Infection.
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