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Search results 1 to 100 out of 246 for Chi3l1

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0.048s
Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: dog, domestic
Gene
Type: gene
Organism: chimpanzee
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: macaque, rhesus
Protein Domain
Type: Family
Description: Chitinase-3-like protein (CHI3L1), also known as cartilage glycoprotein 39 (YKL-40), is a carbohydrate-binding lectin with a preference for chitin [, ]. It is a a member of the glycosyl hydrolase 18 family, but lacks hydrolytic activity, probably because of a single amino acid substitution in the catalytic centre region []. Chitinase-3-like protein is implicated in cell proliferation and angiogenesis and has been shown to stimulate migration and adhesion of cultured vascular smooth muscle cells [, ]. It is secreted by various immune, connective tissue and cancer cells and it is associated with inflammatory disorders, like asthma and atopy [, , ].
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein
Organism: Mus musculus/domesticus
Length: 106  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 110  
Fragment?: true
Publication
First Author: Recklies AD
Year: 2005
Journal: J Biol Chem
Title: Inflammatory cytokines induce production of CHI3L1 by articular chondrocytes.
Volume: 280
Issue: 50
Pages: 41213-21
Publication
First Author: Ober C
Year: 2008
Journal: N Engl J Med
Title: Effect of variation in CHI3L1 on serum YKL-40 level, risk of asthma, and lung function.
Volume: 358
Issue: 16
Pages: 1682-91
Publication
First Author: Song Y
Year: 2024
Journal: Cell Rep
Title: Astrocyte-derived CHI3L1 signaling impairs neurogenesis and cognition in the demyelinated hippocampus.
Volume: 43
Issue: 5
Pages: 114226
Publication
First Author: Rathcke CN
Year: 2009
Journal: PLoS One
Title: Association of polymorphisms of the CHI3L1 gene with asthma and atopy: a populations-based study of 6514 Danish adults.
Volume: 4
Issue: 7
Pages: e6106
Publication  
First Author: Ma B
Year: 2022
Journal: Front Immunol
Title: CHI3L1 enhances melanoma lung metastasis via regulation of T cell co-stimulators and CTLA-4/B7 axis.
Volume: 13
Pages: 1056397
Publication
First Author: Zhou Y
Year: 2018
Journal: J Immunol
Title: Galectin-3 Interacts with the CHI3L1 Axis and Contributes to Hermansky-Pudlak Syndrome Lung Disease.
Volume: 200
Issue: 6
Pages: 2140-2153
Publication
First Author: Taifour T
Year: 2023
Journal: Immunity
Title: The tumor-derived cytokine Chi3l1 induces neutrophil extracellular traps that promote T cell exclusion in triple-negative breast cancer.
Volume: 56
Issue: 12
Pages: 2755-2772.e8
Protein
Organism: Mus musculus/domesticus
Length: 389  
Fragment?: false
Publication
First Author: Nishikawa KC
Year: 2003
Journal: Exp Cell Res
Title: gp38k (CHI3L1) is a novel adhesion and migration factor for vascular cells.
Volume: 287
Issue: 1
Pages: 79-87
Publication
First Author: Renkema GH
Year: 1998
Journal: Eur J Biochem
Title: Chitotriosidase, a chitinase, and the 39-kDa human cartilage glycoprotein, a chitin-binding lectin, are homologues of family 18 glycosyl hydrolases secreted by human macrophages.
Volume: 251
Issue: 1-2
Pages: 504-9
Publication
First Author: Faibish M
Year: 2011
Journal: Mol Cancer Ther
Title: A YKL-40-neutralizing antibody blocks tumor angiogenesis and progression: a potential therapeutic agent in cancers.
Volume: 10
Issue: 5
Pages: 742-51
Publication
First Author: Hakala BE
Year: 1993
Journal: J Biol Chem
Title: Human cartilage gp-39, a major secretory product of articular chondrocytes and synovial cells, is a mammalian member of a chitinase protein family.
Volume: 268
Issue: 34
Pages: 25803-10
Publication  
First Author: Kamle S
Year: 2021
Journal: JCI Insight
Title: Chitinase 3-like-1 is a therapeutic target that mediates the effects of aging in COVID-19.
Volume: 6
Issue: 21
Publication
First Author: Zhou Y
Year: 2014
Journal: Sci Transl Med
Title: Chitinase 3-like 1 suppresses injury and promotes fibroproliferative responses in Mammalian lung fibrosis.
Volume: 6
Issue: 240
Pages: 240ra76
Publication
First Author: He CH
Year: 2020
Journal: Am J Respir Cell Mol Biol
Title: N-Glycosylation Regulates Chitinase 3-like-1 and IL-13 Ligand Binding to IL-13 Receptor α2.
Volume: 63
Issue: 3
Pages: 386-395
Publication
First Author: He CH
Year: 2013
Journal: Cell Rep
Title: Chitinase 3-like 1 regulates cellular and tissue responses via IL-13 receptor α2.
Volume: 4
Issue: 4
Pages: 830-41
Publication
First Author: Zhou Y
Year: 2015
Journal: J Clin Invest
Title: Chitinase 3-like-1 and its receptors in Hermansky-Pudlak syndrome-associated lung disease.
Volume: 125
Issue: 8
Pages: 3178-92
Publication
First Author: Ma B
Year: 2015
Journal: Cancer Res
Title: Role of chitinase 3-like-1 and semaphorin 7a in pulmonary melanoma metastasis.
Volume: 75
Issue: 3
Pages: 487-96
Publication
First Author: Chen CC
Year: 2011
Journal: Clin Immunol
Title: Carbohydrate-binding motif in chitinase 3-like 1 (CHI3L1/YKL-40) specifically activates Akt signaling pathway in colonic epithelial cells.
Volume: 140
Issue: 3
Pages: 268-75
Publication
First Author: Kim DH
Year: 2018
Journal: Nat Commun
Title: Regulation of chitinase-3-like-1 in T cell elicits Th1 and cytotoxic responses to inhibit lung metastasis.
Volume: 9
Issue: 1
Pages: 503
Publication
First Author: Lee CG
Year: 2009
Journal: J Exp Med
Title: Role of breast regression protein 39 (BRP-39)/chitinase 3-like-1 in Th2 and IL-13-induced tissue responses and apoptosis.
Volume: 206
Issue: 5
Pages: 1149-66
Publication  
First Author: Zhang S
Year: 2021
Journal: Cells
Title: Role of Chitinase 3-Like 1 Protein in the Pathogenesis of Hepatic Insulin Resistance in Nonalcoholic Fatty Liver Disease.
Volume: 10
Issue: 2
Publication  
First Author: Curtiss ML
Year: 2023
Journal: Front Immunol
Title: Chitinase-3-like 1 regulates T(H)2 cells, T(FH) cells and IgE responses to helminth infection.
Volume: 14
Pages: 1158493
Publication
First Author: Montgomery TA
Year: 2017
Journal: J Am Soc Nephrol
Title: Breast Regression Protein-39/Chitinase 3-Like 1 Promotes Renal Fibrosis after Kidney Injury via Activation of Myofibroblasts.
Volume: 28
Issue: 11
Pages: 3218-3226
Publication
First Author: Kawada M
Year: 2008
Journal: Lab Invest
Title: Chitinase 3-like-1 enhances bacterial adhesion to colonic epithelial cells through the interaction with bacterial chitin-binding protein.
Volume: 88
Issue: 8
Pages: 883-95
Publication  
First Author: Kim M
Year: 2023
Journal: Mol Immunol
Title: Chitinase 3 like 1 deficiency ameliorates lipopolysaccharide-induced acute liver injury by inhibition of M2 macrophage polarization.
Volume: 156
Pages: 98-110
Publication
First Author: Cantó E
Year: 2015
Journal: Clin Immunol
Title: Breast regression protein-39 is not required for experimental autoimmune encephalomyelitis induction.
Volume: 160
Issue: 2
Pages: 133-41
Publication
First Author: Mizoguchi E
Year: 2006
Journal: Gastroenterology
Title: Chitinase 3-like-1 exacerbates intestinal inflammation by enhancing bacterial adhesion and invasion in colonic epithelial cells.
Volume: 130
Issue: 2
Pages: 398-411
Publication
First Author: Dela Cruz CS
Year: 2012
Journal: Cell Host Microbe
Title: Chitinase 3-like-1 promotes Streptococcus pneumoniae killing and augments host tolerance to lung antibacterial responses.
Volume: 12
Issue: 1
Pages: 34-46
Publication
First Author: Low D
Year: 2015
Journal: Oncotarget
Title: Chitinase 3-like 1 induces survival and proliferation of intestinal epithelial cells during chronic inflammation and colitis-associated cancer by regulating S100A9.
Volume: 6
Issue: 34
Pages: 36535-50
Publication
First Author: Kim AD
Year: 2023
Journal: J Mol Med (Berl)
Title: Myeloid-specific deletion of chitinase-3-like 1 protein ameliorates murine diet-induced steatohepatitis progression.
Volume: 101
Issue: 7
Pages: 813-828
Publication
First Author: Yan C
Year: 2013
Journal: PLoS One
Title: Stat3 downstream gene product chitinase 3-like 1 is a potential biomarker of inflammation-induced lung cancer in multiple mouse lung tumor models and humans.
Volume: 8
Issue: 4
Pages: e61984
Publication  
First Author: Jian J
Year: 2018
Journal: EBioMedicine
Title: Chitinase-3-like Protein 1: A Progranulin Downstream Molecule and Potential Biomarker for Gaucher Disease.
Volume: 28
Pages: 251-260
Publication
First Author: Kui L
Year: 2024
Journal: Cell Mol Gastroenterol Hepatol
Title: BRP39 Regulates Neutrophil Recruitment in NLRP3 Inflammasome-Induced Liver Inflammation.
Volume: 17
Issue: 3
Pages: 481-497
Publication
First Author: Jung YY
Year: 2018
Journal: Theranostics
Title: Atherosclerosis is exacerbated by chitinase-3-like-1 in amyloid precursor protein transgenic mice.
Volume: 8
Issue: 3
Pages: 749-766
Publication  
First Author: Lee DH
Year: 2019
Journal: Metabolism
Title: Chitinase-3-like-1 deficiency attenuates ethanol-induced liver injury by inhibition of sterol regulatory element binding protein 1-dependent triglyceride synthesis.
Volume: 95
Pages: 46-56
Publication
First Author: Antonson P
Year: 2015
Journal: Biochem Biophys Res Commun
Title: Identification of proteins highly expressed in uterine fluid from mice with hydrometra.
Volume: 466
Issue: 4
Pages: 650-5
Publication
First Author: Hussain M
Year: 2013
Journal: J Mol Evol
Title: New paralogues and revised time line in the expansion of the vertebrate GH18 family.
Volume: 76
Issue: 4
Pages: 240-60
Publication    
First Author: Shan Z
Year: 2021
Journal: Elife
Title: Chitinase 3-like-1 contributes to acetaminophen-induced liver injury by promoting hepatic platelet recruitment.
Volume: 10
Publication
First Author: Kim KC
Year: 2018
Journal: Theranostics
Title: Suppression of metastasis through inhibition of chitinase 3-like 1 expression by miR-125a-3p-mediated up-regulation of USF1.
Volume: 8
Issue: 16
Pages: 4409-4428
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Hector A
Year: 2011
Journal: PLoS One
Title: The chitinase-like protein YKL-40 modulates cystic fibrosis lung disease.
Volume: 6
Issue: 9
Pages: e24399
Publication
First Author: Zeng X
Year: 2023
Journal: J Neuroinflammation
Title: Astrocyte-specific knockout of YKL-40/Chi3l1 reduces Aβ burden and restores memory functions in 5xFAD mice.
Volume: 20
Issue: 1
Pages: 290
Publication
First Author: Bonneh-Barkay D
Year: 2012
Journal: J Neuropathol Exp Neurol
Title: Exacerbation of experimental autoimmune encephalomyelitis in the absence of breast regression protein 39/chitinase 3-like 1.
Volume: 71
Issue: 11
Pages: 948-58
Publication
First Author: Mackel JJ
Year: 2021
Journal: Am J Physiol Lung Cell Mol Physiol
Title: Chitinase 3-like-1 protects airway function despite promoting type 2 inflammation during fungal-associated allergic airway inflammation.
Volume: 320
Issue: 4
Pages: L615-L626
Publication
First Author: Jang JY
Year: 2019
Journal: Reprod Sci
Title: Alteration in Uterine Protease-Activated Receptor 2 Expression in Preterm Birth Induced Experimentally in Brp-39 Null Mutant Mice.
Volume: 26
Issue: 6
Pages: 713-723
Publication
First Author: Schmidt IM
Year: 2013
Journal: J Am Soc Nephrol
Title: Chitinase-like protein Brp-39/YKL-40 modulates the renal response to ischemic injury and predicts delayed allograft function.
Volume: 24
Issue: 2
Pages: 309-19
Publication
First Author: Shackelton LM
Year: 1995
Journal: J Biol Chem
Title: Identification of a 38-kDa heparin-binding glycoprotein (gp38k) in differentiating vascular smooth muscle cells as a member of a group of proteins associated with tissue remodeling.
Volume: 270
Issue: 22
Pages: 13076-83
GXD Expression    
Probe: MGI:6865649
Assay Type: RT-PCR
Annotation Date: 2022-02-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603910
Stage: TS10
Assay Id: MGI:6865657
Age: embryonic day 7.0
Image: 6
Specimen Label: 7-day
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:6865649
Assay Type: RT-PCR
Annotation Date: 2022-02-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603918
Stage: TS18
Assay Id: MGI:6865657
Age: embryonic day 11.0
Image: 6
Specimen Label: 11-day
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:6865649
Assay Type: RT-PCR
Annotation Date: 2022-02-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603923
Stage: TS23
Assay Id: MGI:6865657
Age: embryonic day 15.0
Image: 6
Specimen Label: 15-day
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:6865649
Assay Type: RT-PCR
Annotation Date: 2022-02-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603925
Stage: TS25
Assay Id: MGI:6865657
Age: embryonic day 17.0
Image: 6
Specimen Label: 17-day
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:6865649
Assay Type: RT-PCR
Annotation Date: 2022-02-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1619828
Stage: TS28
Assay Id: MGI:6865657
Age: postnatal adult
Image: 6
Specimen Label: Eye
Detected: true
Specimen Num: 5
GXD Expression    
Probe: MGI:6865649
Assay Type: RT-PCR
Annotation Date: 2022-02-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1881228
Stage: TS28
Assay Id: MGI:6865657
Age: postnatal adult
Image: 6
Specimen Label: Submax. gland
Detected: true
Specimen Num: 6
GXD Expression    
Probe: MGI:6865649
Assay Type: RT-PCR
Annotation Date: 2022-02-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1672828
Stage: TS28
Assay Id: MGI:6865657
Age: postnatal adult
Image: 6
Specimen Label: Lung
Detected: true
Specimen Num: 7
GXD Expression    
Probe: MGI:6865649
Assay Type: RT-PCR
Annotation Date: 2022-02-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1702128
Stage: TS28
Assay Id: MGI:6865657
Age: postnatal adult
Image: 6
Specimen Label: Stomach
Detected: true
Specimen Num: 8
GXD Expression    
Probe: MGI:6865649
Assay Type: RT-PCR
Annotation Date: 2022-02-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:6865657
Age: postnatal adult
Image: 6
Specimen Label: Liver
Detected: true
Specimen Num: 9
GXD Expression    
Probe: MGI:6865649
Assay Type: RT-PCR
Annotation Date: 2022-02-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:6865657
Age: postnatal adult
Image: 6
Specimen Label: Kidney
Detected: true
Specimen Num: 10
GXD Expression    
Probe: MGI:6865649
Assay Type: RT-PCR
Annotation Date: 2022-02-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3271728
Stage: TS28
Assay Id: MGI:6865657
Age: postnatal adult
Image: 6
Specimen Label: Smooth muscle
Detected: true
Specimen Num: 11
GXD Expression    
Probe: MGI:6865649
Assay Type: RT-PCR
Annotation Date: 2022-02-08
Strength: Present
Sex: Male
Emaps: EMAPS:1797228
Stage: TS28
Assay Id: MGI:6865657
Age: postnatal adult
Image: 6
Specimen Label: Testis
Detected: true
Specimen Num: 12
GXD Expression    
Probe: MGI:7466607
Assay Type: RT-PCR
Annotation Date: 2023-04-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1672825
Stage: TS25
Assay Id: MGI:7466714
Age: embryonic day 17.5
Image: 9
Specimen Label: wildtype
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:7466607
Assay Type: RT-PCR
Annotation Date: 2023-04-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1672825
Stage: TS25
Assay Id: MGI:7466714
Age: embryonic day 17.5
Image: 9
Specimen Label: Creb1-/-
Detected: true
Specimen Num: 2
GXD Expression        
Probe: MGI:7529660
Assay Type: RT-PCR
Annotation Date: 2023-09-22
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:1672828
Stage: TS28
Assay Id: MGI:7529673
Age: postnatal
Specimen Label: Balb/c
Specimen Num: 1
GXD Expression        
Probe: MGI:7529660
Assay Type: RT-PCR
Annotation Date: 2023-09-22
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:1672828
Stage: TS28
Assay Id: MGI:7529673
Age: postnatal
Specimen Label: C57BL/6
Specimen Num: 3
GXD Expression        
Probe: MGI:7529660
Assay Type: RT-PCR
Annotation Date: 2023-09-22
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:1672828
Stage: TS28
Assay Id: MGI:7529673
Age: postnatal
Specimen Label: ChiaRed C/C (C57BL/6)
Specimen Num: 4
GXD Expression      
Probe: MGI:5310091
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3516422
Stage: TS22
Assay Id: MGI:5423415
Age: embryonic day 14.5
Specimen Label: EB885; Specimen B458
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5310091
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1716122
Stage: TS22
Assay Id: MGI:5423415
Age: embryonic day 14.5
Specimen Label: EB885; Specimen B458
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5310091
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1691622
Stage: TS22
Assay Id: MGI:5423415
Age: embryonic day 14.5
Specimen Label: EB885; Specimen B458
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5310091
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1760622
Stage: TS22
Assay Id: MGI:5423415
Age: embryonic day 14.5
Specimen Label: EB885; Specimen B458
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5310091
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1737322
Stage: TS22
Assay Id: MGI:5423415
Age: embryonic day 14.5
Specimen Label: EB885; Specimen B458
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5310091
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3284222
Stage: TS22
Assay Id: MGI:5423415
Age: embryonic day 14.5
Specimen Label: EB885; Specimen B458
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5310091
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1666522
Stage: TS22
Assay Id: MGI:5423415
Age: embryonic day 14.5
Specimen Label: EB885; Specimen B458
Detected: false
Specimen Num: 1