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Search results 1 to 85 out of 85 for Chrdl2

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Categories

Hits by Pathway

Hits by Strain

Hits by Category

Type Details Score
Gene
25884 | CHRDL2
Type: gene
Organism: human
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Gene
466898 | CHRDL2
Type: gene
Organism: chimpanzee
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Gene
533631 | CHRDL2
Type: gene
Organism: cattle
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Gene
419054 | CHRDL2
Type: gene
Organism: chicken
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Gene
563085 | chrdl2
Type: gene
Organism: zebrafish
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Gene
693657 | CHRDL2
Type: gene
Organism: macaque, rhesus
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Gene
101733103 | chrdl2
Type: gene
Organism: frog, western clawed
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Gene
308854 | Chrdl2
Type: gene
Organism: rat
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Gene
609312 | CHRDL2
Type: gene
Organism: dog, domestic
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Protein Coding Gene
MGI:1916371 | Chrdl2
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
14660436 | J:87049
First Author: Nakayama N
Year: 2004
Journal: Development
Title: A novel chordin-like BMP inhibitor, CHL2, expressed preferentially in chondrocytes of developing cartilage and osteoarthritic joint cartilage.
Volume: 131
Issue: 1
Pages: 229-40
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Protein Coding Gene
MGP_CAROLIEiJ_G0030038 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0032561 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0032535 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0032471 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0032546 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0032261 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1916371 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0033044 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0031588 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0032228 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0032379 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0032336 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0032469 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0032369 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0033066 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0031306 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0031705 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0013260 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0031149 | -
Type: protein_coding_gene
Organism: Mus spretus
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GXD Expression
GXD Expression
     
Probe: MGI:5691691
Assay Type: Northern blot
Annotation Date: 2015-10-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:5691779
Age: postnatal adult
Specimen Label: None
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:5691691
Assay Type: Northern blot
Annotation Date: 2015-10-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:5691779
Age: postnatal adult
Specimen Label: None
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:5691691
Assay Type: Northern blot
Annotation Date: 2015-10-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3598828
Stage: TS28
Assay Id: MGI:5691779
Age: postnatal adult
Specimen Label: None
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
     
Probe: MGI:5691691
Assay Type: Northern blot
Annotation Date: 2015-10-16
Strength: Present
Sex: Male
Emaps: EMAPS:1797228
Stage: TS28
Assay Id: MGI:5691779
Age: postnatal adult
Specimen Label: None
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
 
Probe: MGI:5691692
Assay Type: RNA in situ
Annotation Date: 2015-10-16
Strength: Present
Sex: Female
Emaps: EMAPS:3568928
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:5691705
Age: postnatal adult
Note: Expression was detected in maternally-derived placental tissue.
Specimen Label: not shown
Detected: true
Specimen Num: 8
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GXD Expression
GXD Expression
   
Probe: MGI:5691692
Assay Type: RNA in situ
Annotation Date: 2015-10-16
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:3267028
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:5691705
Age: postnatal adult
Specimen Label: not shown
Detected: true
Specimen Num: 7
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GXD Expression
GXD Expression
Probe: MGI:5691692
Assay Type: RNA in situ
Annotation Date: 2015-10-16
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:3514928
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:5691705
Age: postnatal adult
Image: 4C,D
Note: Weak expression was detected over the articular cartilage surface of the femoral head and patella. Expression was seen in chondrocytes on both sides of the joint.
Specimen Label: 4C,D
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
Probe: MGI:5691692
Assay Type: RNA in situ
Annotation Date: 2015-10-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3514928
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:5691705
Age: postnatal adult
Image: 4E,F
Note: Expression was detected in the superficial articular chondrocytes on both sides of the zygapophyseal joint.
Specimen Label: 4E,F
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
Probe: MGI:5691692
Assay Type: RNA in situ
Annotation Date: 2015-10-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3649025
Pattern: Regionally restricted
Stage: TS25
Assay Id: MGI:5691705
Age: embryonic day 17.5
Image: 4A
Note: Expression was detected in the surface chondrocytes of developing joint cartilage. Expression was in chondrocytes on both sides of the costochondral junction.
Specimen Label: 4A
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:5691692
Assay Type: RNA in situ
Annotation Date: 2015-10-16
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3550528
Stage: TS28
Assay Id: MGI:5691705
Age: postnatal adult
Image: 4C,D
Specimen Label: 4C,D
Detected: false
Specimen Num: 3
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GXD Expression
GXD Expression
Probe: MGI:5691692
Assay Type: RNA in situ
Annotation Date: 2015-10-16
Strength: Trace
Sex: Not Specified
Emaps: EMAPS:1893928
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:5691705
Age: postnatal adult
Image: 5Bb
Note: Trace signal was found on colonic serosa.
Specimen Label: 5Bb
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
 
Probe: MGI:5691692
Assay Type: RNA in situ
Annotation Date: 2015-10-16
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:2992328
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:5691705
Age: postnatal adult
Image: 5Ba
Specimen Label: 5Ba
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
 
Probe: MGI:6195618
Assay Type: RNA in situ
Annotation Date: 2018-08-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1721420
Pattern: Regionally restricted
Stage: TS20
Assay Id: MGI:6195660
Age: embryonic day 12.5
Note: Expression in intervertebral disc.
Specimen Label: not shown
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
Probe: MGI:5691692
Assay Type: RNA in situ
Annotation Date: 2015-10-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1834426
Pattern: Regionally restricted
Stage: TS26
Assay Id: MGI:5691705
Age: embryonic day 18.5
Image: 4B
Note: Expression was detected in areas where ribs converge.
Specimen Label: 4B
Detected: true
Specimen Num: 2
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Publication
18789316 | J:141243
First Author: Zakin L
Year: 2008
Journal: Dev Biol
Title: Development of the vertebral morphogenetic field in the mouse: interactions between Crossveinless-2 and Twisted Gastrulation.
Volume: 323
Issue: 1
Pages: 6-18
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Publication
26952187 | J:236505
 
First Author: Souilhol C
Year: 2016
Journal: Nat Commun
Title: Inductive interactions mediated by interplay of asymmetric signalling underlie development of adult haematopoietic stem cells.
Volume: 7
Pages: 10784
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Publication
23103586 | J:192165
First Author: Forsman CL
Year: 2013
Journal: Dev Biol
Title: BMP-binding protein twisted gastrulation is required in mammary gland epithelium for normal ductal elongation and myoepithelial compartmentalization.
Volume: 373
Issue: 1
Pages: 95-106
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Publication
- | J:238766
     
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
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Publication
20562862 | J:161922
First Author: Tang T
Year: 2010
Journal: Nat Biotechnol
Title: A mouse knockout library for secreted and transmembrane proteins.
Volume: 28
Issue: 7
Pages: 749-55
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Publication
- | J:171883
     
First Author: Lexicon Genetics, Inc
Year: 2011
Journal: Database Download
Title: MGI download of Lexicon knockout data
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Publication
- | J:345476
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2023
Title: TreeGrafter-generated GO annotations
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Publication
- | J:148605
     
First Author: Wellcome Trust Sanger Institute
Year: 2009
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:60000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2000
Title: Gene Ontology Annotation by electronic association of SwissProt Keywords with GO terms
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Allele
Chrdl2<em1Smoc> | MGI:7288971
Name: chordin-like 2; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Protein Domain
IPR045716 | CHRDL_1/2_C
Type: Domain
Description: This is the C-terminal domain of Chordin-like proteins 1 and 2 (CHRDL1/2). CHRDL1 antagonizes the function of BMP4 by binding to it and preventing its interaction with receptors []. CHRDL2 inhibit bone morphogenetic proteins (BMPs) activity by blocking their interaction with their receptor []. CHRDL2 may play a role during myoblast and osteoblast differentiation and maturation []. It's worth noting that there are different results regarding its binding partners; according to [], CHRDL2 interacts with INHBA but not BMP2, BMP4 and BMP6.
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Publication
18587495 | -
 
First Author: Kane R
Year: 2008
Journal: Mol Vis
Title: Chordin-like 1, a bone morphogenetic protein-4 antagonist, is upregulated by hypoxia in human retinal pericytes and plays a role in regulating angiogenesis.
Volume: 14
Pages: 1138-48
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Publication
15094188 | -
 
First Author: Oren A
Year: 2004
Journal: Gene
Title: hCHL2, a novel chordin-related gene, displays differential expression and complex alternative splicing in human tissues and during myoblast and osteoblast maturation.
Volume: 331
Pages: 17-31
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Protein
F6WCT1
Organism: Mus musculus/domesticus
Length: 221  
Fragment?: true
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Protein Domain
IPR045717 | CHRDL1/2
Type: Family
Description: This entry includes chordin-like protein 1/2 (CHRDL1/2). CHRDL1 antagonizes the function of BMP4 by binding to it and preventing its interaction with receptors []. CHRDL2 inhibit bone morphogenetic proteins (BMPs) activity by blocking their interaction with their receptor []. CHRDL2 may play a role during myoblast and osteoblast differentiation and maturation []. It's worth noting that there are different results regarding its binding partners; according to [], CHRDL2 interacts with INHBA but not BMP2, BMP4 and BMP6.Bone is composed of an organic matrix that is principally collagenous and is mineralised with inorganic crystals of hydroxyapatite. Demineralisation of the bone results in a demineralised bone matrix []. In 1965, Urist M.R demonstrates the decalcified bone matrix (DBM) can induce ectopic bone/cartilage formation []. The morphogens in DBM that induce such skeletogenesis were named as bone morphogenetic proteins (BMPs) []. Since then, more than 20 members of BMPs have been identified. BMPs are potent effectors in almost all crucial biological events, such development, maintenance and regeneration of organs/tissues [].
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Protein
Q920C1
Organism: Mus musculus/domesticus
Length: 447  
Fragment?: false
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Protein
Q8VEA6
Organism: Mus musculus/domesticus
Length: 426  
Fragment?: false
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Protein
A0A0B4J1E8
Organism: Mus musculus/domesticus
Length: 426  
Fragment?: false
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Protein
D3YV59
Organism: Mus musculus/domesticus
Length: 433  
Fragment?: false
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Publication
22209847 | -
First Author: Ohyama Y
Year: 2012
Journal: Biochem Biophys Res Commun
Title: Modulation of matrix mineralization by Vwc2-like protein and its novel splicing isoforms.
Volume: 418
Issue: 1
Pages: 12-6
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Publication
5319761 | -
First Author: Urist MR
Year: 1965
Journal: Science
Title: Bone: formation by autoinduction.
Volume: 150
Issue: 3698
Pages: 893-9
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Publication
19900831 | -
First Author: Reddi AH
Year: 2009
Journal: Cytokine Growth Factor Rev
Title: Bone morphogenetic proteins (BMPs): from morphogens to metabologens.
Volume: 20
Issue: 5-6
Pages: 341-2
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Protein
Q3TP73
Organism: Mus musculus/domesticus
Length: 333  
Fragment?: false
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Protein
A0A140LIV5
Organism: Mus musculus/domesticus
Length: 159  
Fragment?: true
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Protein
Q6NXY0
Organism: Mus musculus/domesticus
Length: 333  
Fragment?: false
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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