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Search results 1 to 100 out of 107 for Clec16a

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Categories

Hits by Strain

Hits by Category

Type Details Score
Gene
23274 | CLEC16A
Type: gene
Organism: human
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Gene
453918 | CLEC16A
Type: gene
Organism: chimpanzee
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Gene
615054 | CLEC16A
Type: gene
Organism: cattle
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Gene
100685190 | CLEC16A
Type: gene
Organism: dog, domestic
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Gene
416632 | CLEC16A
Type: gene
Organism: chicken
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Gene
393184 | clec16a
Type: gene
Organism: zebrafish
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Gene
711016 | CLEC16A
Type: gene
Organism: macaque, rhesus
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Gene
100488730 | clec16a
Type: gene
Organism: frog, western clawed
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Gene
287044 | Clec16a
Type: gene
Organism: rat
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Protein Coding Gene
MGI:1921624 | Clec16a
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
24949970 | J:214528
First Author: Soleimanpour SA
Year: 2014
Journal: Cell
Title: The diabetes susceptibility gene Clec16a regulates mitophagy.
Volume: 157
Issue: 7
Pages: 1577-90
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Publication
26987296 | J:251104
 
First Author: Redmann V
Year: 2016
Journal: Sci Rep
Title: Clec16a is Critical for Autolysosome Function and Purkinje Cell Survival.
Volume: 6
Pages: 23326
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Publication
33927318 | J:306703
First Author: Hain HS
Year: 2021
Journal: Sci Rep
Title: Inducible knockout of Clec16a in mice results in sensory neurodegeneration.
Volume: 11
Issue: 1
Pages: 9319
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Publication
25979422 | J:229746
First Author: Schuster C
Year: 2015
Journal: Immunity
Title: The Autoimmunity-Associated Gene CLEC16A Modulates Thymic Epithelial Cell Autophagy and Alters T Cell Selection.
Volume: 42
Issue: 5
Pages: 942-52
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Publication
30226884 | J:266444
First Author: Pandey R
Year: 2018
Journal: PLoS One
Title: CLEC16A regulates splenocyte and NK cell function in part through MEK signaling.
Volume: 13
Issue: 9
Pages: e0203952
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Publication
25891430 | J:222707
 
First Author: Li J
Year: 2015
Journal: Nat Commun
Title: Association of CLEC16A with human common variable immunodeficiency disorder and role in murine B cells.
Volume: 6
Pages: 6804
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Publication
33795715 | J:313763
First Author: Pandey R
Year: 2021
Journal: Sci Rep
Title: JAK/STAT inhibitor therapy partially rescues the lipodystrophic autoimmune phenotype in Clec16a KO mice.
Volume: 11
Issue: 1
Pages: 7372
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Publication
- | J:190968
     
First Author: Harris BS
Year: 2013
Journal: MGI Direct Data Submission
Title: The first Clec16a mutant mouse exhibits defects in digits and tail
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Publication
26085571 | J:247099
First Author: Soleimanpour SA
Year: 2015
Journal: Diabetes
Title: Diabetes Susceptibility Genes Pdx1 and Clec16a Function in a Pathway Regulating Mitophagy in β-Cells.
Volume: 64
Issue: 10
Pages: 3475-84
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Publication
30774629 | J:294959
 
First Author: Pandey R
Year: 2019
Journal: Front Immunol
Title: The Autoimmune Disorder Susceptibility Gene CLEC16A Restrains NK Cell Function in YTS NK Cell Line and Clec16a Knockout Mice.
Volume: 10
Pages: 68
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Publication
29180353 | J:257843
First Author: Pearson G
Year: 2018
Journal: Diabetes
Title: Clec16a, Nrdp1, and USP8 Form a Ubiquitin-Dependent Tripartite Complex That Regulates β-Cell Mitophagy.
Volume: 67
Issue: 2
Pages: 265-277
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Publication
- | J:172931
     
First Author: Harris BS
Year: 2011
Journal: MGI Direct Data Submission
Title: Curvy tail: a new skeletal mutation that maps to Chromosome 16
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Publication
25918232 | J:246476
First Author: Raum JC
Year: 2015
Journal: Diabetes
Title: Tshz1 Regulates Pancreatic β-Cell Maturation.
Volume: 64
Issue: 8
Pages: 2905-14
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Protein Coding Gene
MGP_CAROLIEiJ_G0020446 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0022510 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0022472 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0022448 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0022476 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0022243 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1921624 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0022925 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0021770 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0022212 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0022343 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0022319 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0022411 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0022341 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0022938 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0021510 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0021818 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0016153 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0021340 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
30676324 | J:294954
 
First Author: Cui H
Year: 2019
Journal: JCI Insight
Title: Long noncoding RNA Malat1 regulates differential activation of macrophages and response to lung injury.
Volume: 4
Issue: 4
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GXD Expression
GXD Expression
     
Probe: MGI:7344095
Assay Type: RT-PCR
Annotation Date: 2022-10-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3292728
Stage: TS28
Assay Id: MGI:7344139
Age: postnatal week 10-13
Specimen Label: WT
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:7344095
Assay Type: RT-PCR
Annotation Date: 2022-10-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3292728
Stage: TS28
Assay Id: MGI:7344139
Age: postnatal week 10-13
Specimen Label: Tshz1-/-
Detected: true
Specimen Num: 2
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Publication
35472764 | J:326794
First Author: Georgiadou E
Year: 2022
Journal: Diabetes
Title: Mitofusins Mfn1 and Mfn2 Are Required to Preserve Glucose- but Not Incretin-Stimulated β-Cell Connectivity and Insulin Secretion.
Volume: 71
Issue: 7
Pages: 1472-1489
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Publication
33232298 | J:344420
 
First Author: Sidarala V
Year: 2020
Journal: JCI Insight
Title: Mitophagy protects β cells from inflammatory damage in diabetes.
Volume: 5
Issue: 24
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Publication
12693553 | J:83413
First Author: Okazaki N
Year: 2003
Journal: DNA Res
Title: Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.
Volume: 10
Issue: 1
Pages: 35-48
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UniProt Feature
UniProt Feature
Begin: 1
Description: Protein CLEC16A
Type: chain
End: 1036
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Publication
25917818 | J:222308
First Author: Fairfield H
Year: 2015
Journal: Genome Res
Title: Exome sequencing reveals pathogenic mutations in 91 strains of mice with Mendelian disorders.
Volume: 25
Issue: 7
Pages: 948-57
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
- | J:188991
     
First Author: The Jackson Laboratory
Year: 2012
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by The Jackson Laboratory
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Publication
- | J:80155
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations for FANTOM2 data
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Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
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Publication
- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
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Publication
16602821 | J:162220
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
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Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:60000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2000
Title: Gene Ontology Annotation by electronic association of SwissProt Keywords with GO terms
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Protein
Q80U30
Organism: Mus musculus/domesticus
Length: 1036  
Fragment?: false
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Protein
H7BXB6
Organism: Mus musculus/domesticus
Length: 667  
Fragment?: false
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Protein
Z4YLG3
Organism: Mus musculus/domesticus
Length: 1036  
Fragment?: false
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Protein
Q80U30-3
Organism: Mus musculus/domesticus
Length: 912  
Fragment?: false
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Protein
Q80U30-2
Organism: Mus musculus/domesticus
Length: 1034  
Fragment?: false
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Protein
Q80U30-4
Organism: Mus musculus/domesticus
Length: 883  
Fragment?: false
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Protein
Q80U30-5
Organism: Mus musculus/domesticus
Length: 522  
Fragment?: false
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Protein
D3YVA1
Organism: Mus musculus/domesticus
Length: 67  
Fragment?: true
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Interaction Experiment
Soleimanpour SA (2014)
Description: The diabetes susceptibility gene clec16a regulates mitophagy.
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Publication
28223137 | -
First Author: Tam RC
Year: 2017
Journal: Exp Cell Res
Title: Human CLEC16A regulates autophagy through modulating mTOR activity.
Volume: 352
Issue: 2
Pages: 304-312
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Publication
19855005 | J:154661
First Author: Sachdeva MM
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: Pdx1 (MODY4) regulates pancreatic beta cell susceptibility to ER stress.
Volume: 106
Issue: 45
Pages: 19090-5
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Allele
Tg(UBC-GFP,-RNAi:Clec16a)KD5Kslr | MGI:6393885
Name: transgene lentiviral insertion KD5, Stephan Kissler
Allele Type: Transgenic
Attribute String: Knockdown, Reporter
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Allele
Tg(CMV-GFP,-RNAi:Clec16a)KD3Kslr | MGI:6393884
Name: transgene lentiviral insertion KD3, Stephan Kissler
Allele Type: Transgenic
Attribute String: Knockdown, Reporter
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Strain
MGI:6393949 | NOD-Tg(CMV-GFP,-RNAi:Clec16a)KD3Kslr
Attribute String: transgenic, mutant strain, coisogenic
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Genotype
Genotype
Symbol: Tg(CMV-GFP,-RNAi:Clec16a)KD3Kslr/?
Background: NOD-Tg(CMV-GFP,-RNAi:Clec16a)KD3Kslr
Zygosity: ot
Has Mutant Allele: true
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Publication
31435002 | J:285312
First Author: Nieves-Bonilla JM
Year: 2020
Journal: Genes Immun
Title: The type 1 diabetes candidate gene Dexi does not affect disease risk in the nonobese diabetic mouse model.
Volume: 21
Issue: 1
Pages: 71-77
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Protein Domain
IPR019155 | CLEC16A/TT9_N
Type: Domain
Description: CLEC16A (C-Type Lectin Domain Containing 16A) has an inhibitory role in autophagy, probably by activating the mTOR pathway []. It also has a role in beta-cells as a regulator of mitophagy [].GFS9/TT9 (TRANSPARENT TESTA 9) is a protein from Arabidopsis required for vacuolar development through membrane fusion at vacuoles. It contributes to intracellular membrane trafficking and flavonoid accumulation [].This entry represents a domain found at the N terminus of CLEC16A and GFS9/TT9.
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Protein Domain
IPR045820 | CLEC16A/TT9_C
Type: Domain
Description: This entry represents a domain found at the C terminus of CLEC16A and TT9. CLEC16A (C-Type Lectin Domain Containing 16A) an evolutionarily conserved endosomal membrane protein required for trafficking of fluid-phase and receptor-mediated endocytic cargos. It is required for mitophagy, autophagy and endosome maturation [, ]. This protein has been identified as a susceptibility gene for autoimmune diseases like type 1 diabetes, multiple sclerosis and adrenal dysfunction []. It has an inhibitory role in autophagy, probably by activating the mTOR pathway [].GFS9/TT9 (TRANSPARENT TESTA 9) is a protein from Arabidopsis required for vacuolar development through membrane fusion at vacuoles. It contributes to intracellular membrane trafficking and flavonoid accumulation [].
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Strain
MGI:6393951 | NOD-Dexi<em1Kslr> Tg(CMV-GFP,-RNAi:Clec16a)KD3Kslr
Attribute String: coisogenic, mutant strain, targeted mutation, transgenic
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Genotype
Genotype
Symbol: Dexi/Dexi Tg(CMV-GFP,-RNAi:Clec16a)KD3Kslr/?
Background: NOD-Dexi Tg(CMV-GFP,-RNAi:Clec16a)KD3Kslr
Zygosity: cx
Has Mutant Allele: true
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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