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Search results 1 to 100 out of 134 for Clpp

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0.062s
Type Details Score
Gene
Type: gene
Organism: Homo sapiens
Gene
Type: gene
Organism: Drosophila melanogaster
Gene
Type: gene
Organism: Rattus norvegicus
Gene
Type: gene
Organism: Danio rerio
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Domain
Type: Family
Description: Clp is an ATP-dependent protease that cleaves a number of proteins, such as casein and albumin []and is a member of peptidase family S14. It exists as a heterodimer of ATP-binding regulatory A and catalytic P subunits, both of which are required for effective levels of protease activity in the presence of ATP [, ], although the P subunit alone does possess some catalytic activity []. This entry represents the P subunit.Proteases highly similar to ClpP have been found to be encoded in the genomeof bacteria, metazoa, some viruses and in the chloroplast of plants, but seems to be absent in archaea, mollicutes and some fungi []. Clp proteasesare involved in a number of cellular processes such as degradation of misfolded proteins, regulation of short-lived proteins and housekeeping removal of dysfunctional proteins. They are also implicated in the control of cell growth, targeting DNA-binding protein from starved cells. ClpP has also been linked to the tight regulation of virulence genes in the pathogens Listeria monocytogenes and Salmonella typhimurium []. Active site consists of the triad Ser, His and Asp []; some members have lost all of these active site residues and are therefore inactive, while others may have one or two large insertions. ClpP seems to prefer hydrophobic or non-polar residues at P1 or P1' positions in its substrate. The protease exists as a tetradecamer made up of two heptameric rings stacked back-to-back such that the catalytic triad of each subunit is located at the interface between three monomers, thus making oligomerization essential for function [, ].
Publication  
First Author: Becker C
Year: 2018
Journal: EMBO Rep
Title: CLPP deficiency protects against metabolic syndrome but hinders adaptive thermogenesis.
Volume: 19
Issue: 5
Publication
First Author: Szczepanowska K
Year: 2016
Journal: EMBO J
Title: CLPP coordinates mitoribosomal assembly through the regulation of ERAL1 levels.
Volume: 35
Issue: 23
Pages: 2566-2583
Publication
First Author: Andresen BS
Year: 2000
Journal: Mamm Genome
Title: Characterization of mouse Clpp protease cDNA, gene, and protein.
Volume: 11
Issue: 4
Pages: 275-80
Publication
First Author: Seiferling D
Year: 2016
Journal: EMBO Rep
Title: Loss of CLPP alleviates mitochondrial cardiomyopathy without affecting the mammalian UPRmt.
Volume: 17
Issue: 7
Pages: 953-64
Publication
First Author: Cole A
Year: 2015
Journal: Cancer Cell
Title: Inhibition of the Mitochondrial Protease ClpP as a Therapeutic Strategy for Human Acute Myeloid Leukemia.
Volume: 27
Issue: 6
Pages: 864-76
Publication  
First Author: Bhaskaran S
Year: 2018
Journal: EMBO Rep
Title: Loss of mitochondrial protease ClpP protects mice from diet-induced obesity and insulin resistance.
Volume: 19
Issue: 3
Publication
First Author: Hu D
Year: 2019
Journal: Acta Neuropathol
Title: Alpha-synuclein suppresses mitochondrial protease ClpP to trigger mitochondrial oxidative damage and neurotoxicity.
Volume: 137
Issue: 6
Pages: 939-960
Publication
First Author: Wang J
Year: 1997
Journal: Cell
Title: The structure of ClpP at 2.3 A resolution suggests a model for ATP-dependent proteolysis.
Volume: 91
Issue: 4
Pages: 447-56
Publication
First Author: Frees D
Year: 2007
Journal: Mol Microbiol
Title: Clp ATPases and ClpP proteolytic complexes regulate vital biological processes in low GC, Gram-positive bacteria.
Volume: 63
Issue: 5
Pages: 1285-95
Publication
First Author: Guillon B
Year: 2009
Journal: FEBS J
Title: Frataxin deficiency causes upregulation of mitochondrial Lon and ClpP proteases and severe loss of mitochondrial Fe-S proteins.
Volume: 276
Issue: 4
Pages: 1036-47
Publication
First Author: Gispert S
Year: 2013
Journal: Hum Mol Genet
Title: Loss of mitochondrial peptidase Clpp leads to infertility, hearing loss plus growth retardation via accumulation of CLPX, mtDNA and inflammatory factors.
Volume: 22
Issue: 24
Pages: 4871-87
Publication
First Author: Maurizi MR
Year: 1990
Journal: J Biol Chem
Title: Sequence and structure of Clp P, the proteolytic component of the ATP-dependent Clp protease of Escherichia coli.
Volume: 265
Issue: 21
Pages: 12536-45
Publication
First Author: Yu AY
Year: 2007
Journal: FEBS Lett
Title: ClpP: a distinctive family of cylindrical energy-dependent serine proteases.
Volume: 581
Issue: 19
Pages: 3749-57
Publication
First Author: Porankiewicz J
Year: 1999
Journal: Mol Microbiol
Title: New insights into the ATP-dependent Clp protease: Escherichia coli and beyond.
Volume: 32
Issue: 3
Pages: 449-58
Publication
First Author: Goldberg AL
Year: 1990
Journal: Semin Cell Biol
Title: ATP-dependent proteases in prokaryotic and eukaryotic cells.
Volume: 1
Issue: 6
Pages: 423-32
Publication
First Author: Bewley MC
Year: 2009
Journal: J Struct Biol
Title: Turned on for degradation: ATPase-independent degradation by ClpP.
Volume: 165
Issue: 2
Pages: 118-25
Protein
Organism: Mus musculus
Length: 272  
Fragment?: false
Protein
Organism: Mus musculus
Length: 269  
Fragment?: true
Protein
Organism: Mus musculus
Length: 189  
Fragment?: false
Publication
First Author: Ekici OD
Year: 2008
Journal: Protein Sci
Title: Unconventional serine proteases: variations on the catalytic Ser/His/Asp triad configuration.
Volume: 17
Issue: 12
Pages: 2023-37
Publication
First Author: Santagata S
Year: 1999
Journal: J Biol Chem
Title: Molecular cloning and characterization of a mouse homolog of bacterial ClpX, a novel mammalian class II member of the Hsp100/Clp chaperone family.
Volume: 274
Issue: 23
Pages: 16311-9
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Szczepanowska K
Year: 2020
Journal: Nat Commun
Title: A salvage pathway maintains highly functional respiratory complex I.
Volume: 11
Issue: 1
Pages: 1643
GXD Expression      
Probe: MGI:1859246
Assay Type: Northern blot
Annotation Date: 2000-06-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:1859327
Age: postnatal adult
Detected: true
Specimen Num: 7
GXD Expression      
Probe: MGI:1859246
Assay Type: Northern blot
Annotation Date: 2000-06-20
Strength: Present
Sex: Female
Emaps: EMAPS:3568928
Stage: TS28
Assay Id: MGI:1859327
Age: postnatal adult
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:1859246
Assay Type: Northern blot
Annotation Date: 2000-06-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1672828
Stage: TS28
Assay Id: MGI:1859327
Age: postnatal adult
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:1859246
Assay Type: Northern blot
Annotation Date: 2000-06-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3598828
Stage: TS28
Assay Id: MGI:1859327
Age: postnatal adult
Detected: true
Specimen Num: 6
GXD Expression      
Probe: MGI:1859246
Assay Type: Northern blot
Annotation Date: 2000-06-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:1859327
Age: postnatal adult
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:1332177
Assay Type: RT-PCR
Annotation Date: 1999-03-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603911
Stage: TS11
Assay Id: MGI:1332178
Age: embryonic day 7.5
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:1332177
Assay Type: RT-PCR
Annotation Date: 1999-03-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603911
Stage: TS11
Assay Id: MGI:1332178
Age: embryonic day 7.5
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:1332177
Assay Type: RT-PCR
Annotation Date: 1999-03-18
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1603911
Stage: TS11
Assay Id: MGI:1332178
Age: embryonic day 7.5
Detected: false
Specimen Num: 3
GXD Expression      
Probe: MGI:1332177
Assay Type: RT-PCR
Annotation Date: 1999-03-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1604211
Stage: TS11
Assay Id: MGI:1332178
Age: embryonic day 7.5
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:1332177
Assay Type: RT-PCR
Annotation Date: 1999-03-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1604211
Stage: TS11
Assay Id: MGI:1332178
Age: embryonic day 7.5
Detected: true
Specimen Num: 5
GXD Expression      
Probe: MGI:1332177
Assay Type: RT-PCR
Annotation Date: 1999-03-18
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1604211
Stage: TS11
Assay Id: MGI:1332178
Age: embryonic day 7.5
Detected: false
Specimen Num: 6
GXD Expression      
Probe: MGI:1859246
Assay Type: Northern blot
Annotation Date: 2000-06-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:1859327
Age: postnatal adult
Detected: true
Specimen Num: 5
GXD Expression      
Probe: MGI:1859246
Assay Type: Northern blot
Annotation Date: 2000-06-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1750328
Stage: TS28
Assay Id: MGI:1859327
Age: postnatal adult
Detected: true
Specimen Num: 8
GXD Expression      
Probe: MGI:1859246
Assay Type: Northern blot
Annotation Date: 2000-06-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:1859327
Age: postnatal adult
Detected: true
Specimen Num: 2
Publication
First Author: Key J
Year: 2020
Journal: Neurogenetics
Title: Loss of mitochondrial ClpP, Lonp1, and Tfam triggers transcriptional induction of Rnf213, a susceptibility factor for moyamoya disease.
Volume: 21
Issue: 3
Pages: 187-203
Publication      
First Author: MouseBookTM
Year: 2005
Journal: Unpublished
Title: Information obtained from MouseBookTM, Medical Research Council Mammalian Genetics Unit, Harwell, UK.
Publication
First Author: Ko MS
Year: 1998
Journal: Hum Mol Genet
Title: Genome-wide mapping of unselected transcripts from extraembryonic tissue of 7.5-day mouse embryos reveals enrichment in the t-complex and under-representation on the X chromosome.
Volume: 7
Issue: 12
Pages: 1967-78
Publication
First Author: Mootha VK
Year: 2003
Journal: Cell
Title: Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria.
Volume: 115
Issue: 5
Pages: 629-40
Publication      
First Author: The Jackson Laboratory Backcross DNA Panel Mapping Resource
Year: 1999
Journal: Database Release
Title: JAX BSS Panel Mapping Data
Publication
First Author: Pagliarini DJ
Year: 2008
Journal: Cell
Title: A mitochondrial protein compendium elucidates complex I disease biology.
Volume: 134
Issue: 1
Pages: 112-23
Publication
First Author: Ko MS
Year: 2000
Journal: Development
Title: Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development.
Volume: 127
Issue: 8
Pages: 1737-49
Publication      
First Author: International Mouse Strain Resource
Year: 2014
Journal: Database Download
Title: MGI download of germline transmission data for alleles from IMSR strain data
Publication      
First Author: Wellcome Trust Sanger Institute
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute
Publication      
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
Publication
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
Publication
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
Publication
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
Publication
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
Publication
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
Publication      
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
Publication
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Gene Ontology Annotation by the MGI Curatorial Staff
Publication      
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
Publication      
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
Publication
First Author: Gaudet P
Year: 2011
Journal: Brief Bioinform
Title: Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.
Volume: 12
Issue: 5
Pages: 449-62
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2000
Title: Gene Ontology Annotation by electronic association of SwissProt Keywords with GO terms
Publication      
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
Publication      
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
Publication      
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
Publication      
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
Publication      
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
Publication      
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
HT Experiment
Series Id: GSE40207
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
Interaction Experiment
Description: Alpha-synuclein suppresses mitochondrial protease ClpP to trigger mitochondrial oxidative damage and neurotoxicity.
Publication  
First Author: Esencan E
Year: 2020
Journal: Antioxidants (Basel)
Title: Mitochondrial Stress Response Gene Clpp Is Not Required for Granulosa Cell Function.
Volume: 10
Issue: 1
Publication
First Author: Giffard PM
Year: 1993
Journal: J Gen Microbiol
Title: The ftf gene encoding the cell-bound fructosyltransferase of Streptococcus salivarius ATCC 25975 is preceded by an insertion sequence and followed by FUR1 and clpP homologues.
Volume: 139
Issue: 5
Pages: 913-20