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Search results 1 to 97 out of 97 for Clptm1l

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Hits by Strain

Type Details Score
Gene
81037 | CLPTM1L
Type: gene
Organism: human
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Gene
780231 | clptm1l
Type: gene
Organism: frog, western clawed
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Protein Domain
IPR030434 | CLPTM1L
Type: Family
Description: Cleft lip and palate transmembrane protein 1-like protein (CLPTM1L), also known as CRR9 (cisplatin resistance-related protein 9), is a scramblase that mediates the translocation glucosaminylphosphatidylinositol (alpha-D-GlcN-1-6-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol, GlcN-PI) across the endoplasmic reticulum (ER) membrane, from the cytosolic leaflet to the luminal leaflet of the ER membrane, where it participates in the biosynthesis of glycosylphosphatidylinositol (GPI) []. This transmembrane protein is overexpressed in non-small cell lung cancer, where it protects tumour cells from genotoxic apoptosis []. It has been identified as an overexpressed protein in human ovarian tumour cell lines that are resistant to cisplatin []. CLPTM1L may protect cells from genotoxic stress induced apoptosis through regulation of Bcl-xL []. It interacts with phosphoinositide 3-kinase and is essential for Ras-induced AKT phosphorylation []. The CLPTM1L gene lies within a cancer susceptibility locus at chromosome 5p15.33 (TERT-CLPTM1L) defined by genome-wide association studies [].This entry also includes CLPTM1-like membrane protein cnrB from slime molds
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Gene
316916 | Clptm1l
Type: gene
Organism: rat
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Gene
478630 | CLPTM1L
Type: gene
Organism: dog, domestic
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Gene
461696 | CLPTM1L
Type: gene
Organism: chimpanzee
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Gene
506200 | CLPTM1L
Type: gene
Organism: cattle
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Gene
420973 | CLPTM1L
Type: gene
Organism: chicken
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Gene
436653 | clptm1l
Type: gene
Organism: zebrafish
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Gene
709968 | CLPTM1L
Type: gene
Organism: macaque, rhesus
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Protein Coding Gene
MGI:2442892 | Clptm1l
Type: protein_coding_gene
Organism: mouse, laboratory
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Gene
106480241 | CLPTM1LP1
Type: gene
Organism: human
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Publication
22675468 | -
First Author: James MA
Year: 2012
Journal: PLoS One
Title: Functional characterization of CLPTM1L as a lung cancer risk candidate gene in the 5p15.33 locus.
Volume: 7
Issue: 6
Pages: e36116
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Publication
35344438 | -
First Author: Wang Y
Year: 2022
Journal: Proc Natl Acad Sci U S A
Title: Genome-wide CRISPR screen reveals CLPTM1L as a lipid scramblase required for efficient glycosylphosphatidylinositol biosynthesis.
Volume: 119
Issue: 14
Pages: e2115083119
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Publication
24366883 | J:208170
First Author: James MA
Year: 2014
Journal: Cancer Res
Title: CRR9/CLPTM1L regulates cell survival signaling and is required for Ras transformation and lung tumorigenesis.
Volume: 74
Issue: 4
Pages: 1116-27
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Protein
Q8VBZ3
Organism: Mus musculus/domesticus
Length: 664  
Fragment?: false
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Protein
Q8BXA5
Organism: Mus musculus/domesticus
Length: 539  
Fragment?: false
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Publication
30042348 | J:265892
 
First Author: Trezise S
Year: 2018
Journal: Int J Mol Sci
Title: Mining the Plasma Cell Transcriptome for Novel Cell Surface Proteins.
Volume: 19
Issue: 8
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Protein Coding Gene
MGP_CAROLIEiJ_G0018704 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0020747 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0020703 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0020677 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0020700 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0020494 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_2442892 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0021137 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0020011 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0020453 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0020578 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0020558 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0020651 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0020586 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0021176 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0019765 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0020069 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0015785 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0019588 | -
Type: protein_coding_gene
Organism: Mus spretus
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GXD Expression
GXD Expression
     
Probe: MGI:3653669
Assay Type: Northern blot
Annotation Date: 2006-09-06
Strength: Present
Sex: Male
Emaps: EMAPS:3592628
Stage: TS28
Assay Id: MGI:3653670
Age: postnatal
Specimen Label: wt
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:3653669
Assay Type: Northern blot
Annotation Date: 2006-09-06
Strength: Present
Sex: Male
Emaps: EMAPS:3592628
Stage: TS28
Assay Id: MGI:3653670
Age: postnatal
Specimen Label: db/db
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:6444273
Assay Type: RT-PCR
Annotation Date: 2020-07-28
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1716828
Stage: TS28
Assay Id: MGI:6445570
Age: postnatal week 5
Specimen Label: wild type control
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:6444273
Assay Type: RT-PCR
Annotation Date: 2020-07-28
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1716828
Stage: TS28
Assay Id: MGI:6445570
Age: postnatal week 5
Specimen Label: miR-183C
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:1699240
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603923
Pattern: Ubiquitous
Stage: TS23
Assay Id: MGI:4823936
Age: embryonic day 14.5
Image: euxassay_013627_12
Specimen Label: euxassay_013627_12
Detected: true
Specimen Num: 1
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Publication
12652657 | J:106181
First Author: Chiellini C
Year: 2003
Journal: J Cell Physiol
Title: Identification of cathepsin K as a novel marker of adiposity in white adipose tissue.
Volume: 195
Issue: 2
Pages: 309-21
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Publication
23341629 | J:193822
First Author: Lumayag S
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Inactivation of the microRNA-183/96/182 cluster results in syndromic retinal degeneration.
Volume: 110
Issue: 6
Pages: E507-16
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Publication
- | J:238766
     
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
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Publication
- | J:188991
     
First Author: The Jackson Laboratory
Year: 2012
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by The Jackson Laboratory
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Publication
- | J:73796
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Function or Process or Component Unknown following Literature Review
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Publication
- | J:346132
       
First Author: The Gene Ontology Consortium
Year: 2016
Title: Automatic assignment of GO terms using logical inference, based on on inter-ontology links
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Publication
- | J:155845
     
First Author: Wellcome Trust Sanger Institute
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute
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Publication
- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
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Publication
- | J:157065
     
First Author: Helmholtz Zentrum Muenchen GmbH
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu)
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Publication
16602821 | J:162220
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
38355793 | J:345621
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:60000
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Allele
Clptm1l<em1Smoc> | MGI:7289037
Name: CLPTM1-like; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Strain
MGI:6475017 | C57BL/6JSmoc-Clptm1l<em1Smoc>/Smoc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Allele
Tg(TERT-rluc)DJzhu | MGI:5318989
Name: transgene insertion D, Jiyue Zhu
Allele Type: Transgenic
Attribute String: Reporter
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Allele
Tg(Slc6a3-icre/ERT2)2Gloss | MGI:5049906
Name: transgene insertion 2, Bernd Gloss
Allele Type: Transgenic
Attribute String: Inducible, Recombinase
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Strain
MGI:5318990 | FVB-Tg(TERT-rluc)DJzhu/J
Attribute String: transgenic, mutant strain, coisogenic
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Publication
21135040 | J:182426
First Author: Jia W
Year: 2011
Journal: FASEB J
Title: A BAC transgenic reporter recapitulates in vivo regulation of human telomerase reverse transcriptase in development and tumorigenesis.
Volume: 25
Issue: 3
Pages: 979-89
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Strain
MGI:5049911 | C57BL/6-Tg(Slc6a3-icre/ERT2)2Gloss/J
Attribute String: mutant strain, transgenic, coisogenic
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Publication
- | J:173676
     
First Author: Gloss B
Year: 2011
Journal: MGI Direct Data Submission
Title: Generation of an inducible Slc6a3 cre transgene
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Publication
9828125 | J:51399
First Author: Yoshiura K
Year: 1998
Journal: Genomics
Title: Characterization of a novel gene disrupted by a balanced chromosomal translocation t(2;19)(q11.2;q13.3) in a family with cleft lip and palate.
Volume: 54
Issue: 2
Pages: 231-40
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Publication
16122939 | -
First Author: Turhani D
Year: 2005
Journal: J Craniomaxillofac Surg
Title: Mutation analysis of CLPTM 1 and PVRL 1 genes in patients with non-syndromic clefts of lip, alveolus and palate.
Volume: 33
Issue: 5
Pages: 301-6
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Publication
11559849 | -
First Author: Sözen MA
Year: 2001
Journal: Nat Genet
Title: Mutation of PVRL1 is associated with sporadic, non-syndromic cleft lip/palate in northern Venezuela.
Volume: 29
Issue: 2
Pages: 141-2
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Publication
19715471 | -
First Author: Sözen MA
Year: 2009
Journal: Genet Test Mol Biomarkers
Title: Mutation analysis of the PVRL1 gene in caucasians with nonsyndromic cleft lip/palate.
Volume: 13
Issue: 5
Pages: 617-21
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Protein Domain
IPR008429 | CLPTM1
Type: Family
Description: This entry includes cleft lip and palate transmembrane protein 1 (CLPTM1) and cleft lip and palate transmembrane protein 1-like protein (CLPTM1L, also known as CRR9). This entry also includes uncharacterised proteins from fungi and plants. Clefts of the lip and/or palate (CL/P) are some of the most common birth defects. They may be categorised into syndromic or non-syndromic types, with syndromic defects having an underlying chromosomal or teratogenic cause. Around 70% of clefts are non-syndromic and individuals have no typical physical or developmental abnormalities; these clefts generally show polygenetic behaviour and complex inheritance []. Studies have identified regions on chromosomes 19 and 11 which may be involved in non-syndromic cleft lip and palates; this included a novel gene on chromosome 19, cleft lip and palate-associated transmembrane protein 1 (CLPTM1) []. The Poliovirus receptor-related 1 gene (PVRL1), which is located on chromosome 11, has also been shown to associate with non-syndromic cleft lip and palates [, ].Human CLPTM1L is a scramblase that mediates the translocation glucosaminylphosphatidylinositol (alpha-D-GlcN-1-6-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol, GlcN-PI) across the endoplasmic reticulum (ER) membrane, from the cytosolic leaflet to the luminal leaflet of the ER membrane, where it participates in the biosynthesis of glycosylphosphatidylinositol (GPI) []. It protects non-small cell lung cancer tumour cells from genotoxic apoptosis and may contribute to lung cancer risk [, ].
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Publication
37591240 | J:339951
First Author: Terauchi A
Year: 2023
Journal: Cell
Title: The projection-specific signals that establish functionally segregated dopaminergic synapses.
Volume: 186
Issue: 18
Pages: 3845-3861.e24
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Publication
28627418 | J:244291
 
First Author: Schriever SC
Year: 2017
Journal: Neuroscience
Title: Alterations in neuronal control of body weight and anxiety behavior by glutathione peroxidase 4 deficiency.
Volume: 357
Pages: 241-254
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Publication
28394253 | J:256676
   
First Author: Gore BB
Year: 2017
Journal: Elife
Title: Roundabout receptor 2 maintains inhibitory control of the adult midbrain.
Volume: 6
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Publication
27516377 | J:284437
First Author: Xu P
Year: 2017
Journal: Biol Psychiatry
Title: Activation of Serotonin 2C Receptors in Dopamine Neurons Inhibits Binge-like Eating in Mice.
Volume: 81
Issue: 9
Pages: 737-747
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Publication
35501380 | J:335647
First Author: Cai X
Year: 2022
Journal: Nat Neurosci
Title: A D2 to D1 shift in dopaminergic inputs to midbrain 5-HT neurons causes anorexia in mice.
Volume: 25
Issue: 5
Pages: 646-658
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Publication
29106398 | J:251851
First Author: Duerrschmid C
Year: 2017
Journal: Nat Med
Title: Asprosin is a centrally acting orexigenic hormone.
Volume: 23
Issue: 12
Pages: 1444-1453
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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