|  Help  |  About  |  Contact Us

Search our database by keyword

Examples

  • Search this entire website. Enter identifiers, names or keywords for genes, diseases, strains, ontology terms, etc. (e.g. Pax6, Parkinson, ataxia)
  • Use OR to search for either of two terms (e.g. OR mus) or quotation marks to search for phrases (e.g. "dna binding").
  • Boolean search syntax is supported: e.g. Balb* for partial matches or mus AND NOT embryo to exclude a term

Search results 1 to 100 out of 594 for Clu

<< First    < Previous  |  Next >    Last >>
0.037s
Type Details Score
Gene
Type: gene
Organism: Homo sapiens
Gene
Type: gene
Organism: Drosophila melanogaster
Gene
Type: gene
Organism: Rattus norvegicus
Gene
Type: gene
Organism: Danio rerio
Protein Domain
Type: Family
Description: This entry includes protein clueless from Drosophila, Clu1 from yeasts and protein CLU from plants. They are involved in proper cytoplasmic distribution of mitochondria [, ].Protein clueless from Drosophila is required for mitochondrial subcellular localisation, interacts genetically with parkin []. It is highly expressed in larval neuroblasts, affects mitochondrial localisation and suppresses mitochondrial oxidative damage [].Budding yeast Clu1 is a subunit of the eukaryotic translation initiation factor 3 (eIF3). It can influence mitochondrial morphology and distribution []. Arabidopsis CLU, also known as FRIENDLY (At3g52140), is involved in regulating intermitochondrial association, a prelude to mitochondria fusion [, ].
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Publication      
First Author: The Jackson Laboratory
Year: 2012
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by The Jackson Laboratory
Publication
First Author: Sen A
Year: 2013
Journal: PLoS One
Title: Drosophila clueless is highly expressed in larval neuroblasts, affects mitochondrial localization and suppresses mitochondrial oxidative damage.
Volume: 8
Issue: 1
Pages: e54283
Publication
First Author: Zhu Q
Year: 1997
Journal: Proc Natl Acad Sci U S A
Title: The cluA- mutant of Dictyostelium identifies a novel class of proteins required for dispersion of mitochondria.
Volume: 94
Issue: 14
Pages: 7308-13
Publication
First Author: Cox RT
Year: 2009
Journal: Dis Model Mech
Title: Clueless, a conserved Drosophila gene required for mitochondrial subcellular localization, interacts genetically with parkin.
Volume: 2
Issue: 9-10
Pages: 490-9
Publication
First Author: Logan DC
Year: 2003
Journal: Plant J
Title: The genetic control of plant mitochondrial morphology and dynamics.
Volume: 36
Issue: 4
Pages: 500-9
Publication  
First Author: Fields SD
Year: 1998
Journal: J Cell Sci
Title: The S. cerevisiae CLU1 and D. discoideum cluA genes are functional homologues that influence mitochondrial morphology and distribution.
Volume: 111 ( Pt 12)
Pages: 1717-27
Protein
Organism: Mus musculus
Length: 1315  
Fragment?: false
Protein
Organism: Mus musculus
Length: 1302  
Fragment?: false
Protein
Organism: Mus musculus
Length: 1353  
Fragment?: false
GXD Expression  
Probe: MGI:3724598
Assay Type: RNA in situ
Annotation Date: 2009-01-15
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:3564922
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:3826242
Age: embryonic day 14.5
Image: Additional file 4 Clu
Detected: true
Specimen Num: 1
Strain
Attribute String: congenic, mutant strain, targeted mutation
Allele
Name: clusterin; targeted mutation 2, Wellcome Trust Sanger Institute
Allele Type: Targeted
Attribute String: Conditional ready, Inducible, Recombinase, Reporter
Publication categories: ProxyCollection
Genotype
Symbol: Clu/Clu<+> Gt(ROSA)26Sor/Gt(ROSA)26Sor<+>
Background: B6.Cg-Gt(ROSA)26Sor Clu
Zygosity: cn
Has Mutant Allele: true
Publication
First Author: El Zawily AM
Year: 2014
Journal: Plant Physiol
Title: FRIENDLY regulates mitochondrial distribution, fusion, and quality control in Arabidopsis.
Volume: 166
Issue: 2
Pages: 808-28
GXD Expression  
Probe: MGI:6280440
Assay Type: Immunohistochemistry
Annotation Date: 2019-03-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3541628
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6280979
Age: postnatal adult
Note: Immunostaining in adult neuronal cell populations was more intense compared with early postnatal time points. Most, if not all, Clu-immunoreactive motor cells express Clu mRNA.
Detected: true
Specimen Num: 1
Publication
First Author: Sugden C
Year: 2010
Journal: J Biol Chem
Title: Two novel Src homology 2 domain proteins interact to regulate dictyostelium gene expression during growth and early development.
Volume: 285
Issue: 30
Pages: 22927-35
Protein Domain
Type: Domain
Description: The CLU domain (CLUstered mitochondria) is a eukaryotic domain found in highly conserved eukaryotic proteins required for correct mitochondrial dispersal [, ]. The exact function of the domain is unknown [].
Publication  
First Author: Cunin P
Year: 2016
Journal: Cell Death Dis
Title: Clusterin facilitates apoptotic cell clearance and prevents apoptotic cell-induced autoimmune responses.
Volume: 7
Pages: e2215
Publication
First Author: Bettuzzi S
Year: 2009
Journal: Oncogene
Title: Genetic inactivation of ApoJ/clusterin: effects on prostate tumourigenesis and metastatic spread.
Volume: 28
Issue: 49
Pages: 4344-52
Publication
First Author: Nguan CY
Year: 2014
Journal: Am J Physiol Renal Physiol
Title: Promotion of cell proliferation by clusterin in the renal tissue repair phase after ischemia-reperfusion injury.
Volume: 306
Issue: 7
Pages: F724-33
Publication
First Author: Okada N
Year: 2011
Journal: Invest Ophthalmol Vis Sci
Title: Clusterin promotes corneal epithelial cell growth through upregulation of hepatocyte growth factor by mesenchymal cells in vitro.
Volume: 52
Issue: 6
Pages: 2905-10
Publication  
First Author: Abdallah BM
Year: 2018
Journal: Bone
Title: Secreted Clusterin protein inhibits osteoblast differentiation of bone marrow mesenchymal stem cells by suppressing ERK1/2 signaling pathway.
Volume: 110
Pages: 221-229
Publication
First Author: Leskov KS
Year: 2003
Journal: J Biol Chem
Title: Synthesis and functional analyses of nuclear clusterin, a cell death protein.
Volume: 278
Issue: 13
Pages: 11590-600
Publication
First Author: White RA
Year: 1995
Journal: Genomics
Title: Assignment of the transcription factor GATA4 gene to human chromosome 8 and mouse chromosome 14: Gata4 is a candidate gene for Ds (disorganization).
Volume: 27
Issue: 1
Pages: 20-6
Publication
First Author: Caporali A
Year: 2004
Journal: Carcinogenesis
Title: The chemopreventive action of catechins in the TRAMP mouse model of prostate carcinogenesis is accompanied by clusterin over-expression.
Volume: 25
Issue: 11
Pages: 2217-24
Publication
First Author: Alnasser HA
Year: 2016
Journal: Am J Physiol Renal Physiol
Title: Requirement of clusterin expression for prosurvival autophagy in hypoxic kidney tubular epithelial cells.
Volume: 310
Issue: 2
Pages: F160-73
Publication
First Author: Kang SS
Year: 2016
Journal: Hum Mol Genet
Title: Identification of plexin A4 as a novel clusterin receptor links two Alzheimer's disease risk genes.
Volume: 25
Issue: 16
Pages: 3467-3475
Publication
First Author: Griffiths GS
Year: 2009
Journal: Biol Reprod
Title: Clusterin facilitates exchange of glycosyl phosphatidylinositol-linked SPAM1 between reproductive luminal fluids and mouse and human sperm membranes.
Volume: 81
Issue: 3
Pages: 562-70
Publication
First Author: Jeong S
Year: 2012
Journal: Am J Pathol
Title: Interaction of clusterin and matrix metalloproteinase-9 and its implication for epithelial homeostasis and inflammation.
Volume: 180
Issue: 5
Pages: 2028-39
Publication
First Author: Wojtas AM
Year: 2017
Journal: Proc Natl Acad Sci U S A
Title: Loss of clusterin shifts amyloid deposition to the cerebrovasculature via disruption of perivascular drainage pathways.
Volume: 114
Issue: 33
Pages: E6962-E6971
Publication
First Author: Wright MC
Year: 2014
Journal: J Neurosci
Title: Novel roles for osteopontin and clusterin in peripheral motor and sensory axon regeneration.
Volume: 34
Issue: 5
Pages: 1689-700
Publication
First Author: Grizenkova J
Year: 2010
Journal: PLoS One
Title: The retinoic acid receptor beta (Rarb) region of Mmu14 is associated with prion disease incubation time in mouse.
Volume: 5
Issue: 12
Pages: e15019
Publication
First Author: Lee S
Year: 2017
Journal: Cell Tissue Res
Title: Spatiotemporal expression patterns of clusterin in the mouse inner ear.
Volume: 370
Issue: 1
Pages: 89-97
Publication
First Author: Vornlocher HP
Year: 1999
Journal: J Biol Chem
Title: A 110-kilodalton subunit of translation initiation factor eIF3 and an associated 135-kilodalton protein are encoded by the Saccharomyces cerevisiae TIF32 and TIF31 genes.
Volume: 274
Issue: 24
Pages: 16802-12
Publication  
First Author: Schimmel BG
Year: 2012
Journal: BMC Res Notes
Title: Mitochondrial fission and fusion in Dictyostelium discoideum: a search for proteins involved in membrane dynamics.
Volume: 5
Pages: 505
Protein Domain
Type: Domain
Description: Mutations in the mitochondrial CLU proteins have been shown to result in clustered mitochondria [, , ]. CLU proteins include Saccharomyces cerevisiae clustered mitochondria protein (Clu1p, alias translation initiation factor 31/TIF31p), Dictyostelium discoideum clustered mitochondria protein homologue (CluA), Caenorhabditis elegans clustered mitochondria protein homologue (CLUH/ Protein KIAA0664), Drosophila clueless (alias clustered mitochondria protein homologue), Arabidopsis clustered mitochondria protein (CLU, alias friendly mitochondria protein/FMT), and human clustered mitochondria protein homologue (CLUH).Dictyostelium CluA is involved in mitochondrial dynamics and is necessary for both, mitochondrial fission and fusion []. Drosophila clueless is essential for cytoplasmic localization and function of cellular mitochondria []. The Drosophila clu gene interacts genetically with parkin (park, the Drosophila ortholog of a human gene responsible for many familial cases of Parkinson's disease) []. Arabidopsis CLU/FMT is required for correct mitochondrial distribution and morphology []. The specific role CLU proteins play in mitochondrial processes in not yet known. In an early study, S. cerevisiae Clu1/TIF31p was reported as sometimes being associated with the elF3 translation initiation factor. The authors noted, however, that its tentative assignment as a subunit of elf3 was uncertain, and to date there has been no direct evidence for a role of this protein in translation [].This entry represents a central domain in CLU proteins.
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Lee KH
Year: 1993
Journal: Biochem Biophys Res Commun
Title: Molecular cloning and sequencing of sulfated glycoprotein-2 cDNA from testis of mouse: implications of two different mRNAs of SGP-2.
Volume: 194
Issue: 3
Pages: 1175-80
Publication
First Author: French LE
Year: 1993
Journal: J Cell Biol
Title: Murine clusterin: molecular cloning and mRNA localization of a gene associated with epithelial differentiation processes during embryogenesis.
Volume: 122
Issue: 5
Pages: 1119-30
Publication
First Author: McLaughlin L
Year: 2000
Journal: J Clin Invest
Title: Apolipoprotein J/clusterin limits the severity of murine autoimmune myocarditis.
Volume: 106
Issue: 9
Pages: 1105-13
Publication
First Author: Wilson MR
Year: 2000
Journal: Trends Biochem Sci
Title: Clusterin is a secreted mammalian chaperone.
Volume: 25
Issue: 3
Pages: 95-8
Publication
First Author: Chayka O
Year: 2009
Journal: J Natl Cancer Inst
Title: Clusterin, a haploinsufficient tumor suppressor gene in neuroblastomas.
Volume: 101
Issue: 9
Pages: 663-77
Publication
First Author: DeMattos RB
Year: 2002
Journal: Proc Natl Acad Sci U S A
Title: Clusterin promotes amyloid plaque formation and is critical for neuritic toxicity in a mouse model of Alzheimer's disease.
Volume: 99
Issue: 16
Pages: 10843-8
Publication
First Author: Donner L
Year: 2016
Journal: Sci Signal
Title: Platelets contribute to amyloid-β aggregation in cerebral vessels through integrin αIIbβ3-induced outside-in signaling and clusterin release.
Volume: 9
Issue: 429
Pages: ra52
Publication
First Author: Habiel DM
Year: 2017
Journal: Sci Rep
Title: Divergent roles for Clusterin in Lung Injury and Repair.
Volume: 7
Issue: 1
Pages: 15444
Publication
First Author: Kempster S
Year: 2004
Journal: Neuroreport
Title: Clusterin shortens the incubation and alters the histopathology of bovine spongiform encephalopathy in mice.
Volume: 15
Issue: 11
Pages: 1735-8
Publication
First Author: Savković V
Year: 2007
Journal: Biochem Biophys Res Commun
Title: Clusterin is protective in pancreatitis through anti-apoptotic and anti-inflammatory properties.
Volume: 356
Issue: 2
Pages: 431-7
Publication
First Author: Imhof A
Year: 2006
Journal: Neurobiol Dis
Title: Sustained astrocytic clusterin expression improves remodeling after brain ischemia.
Volume: 22
Issue: 2
Pages: 274-83
Publication
First Author: Bailey RW
Year: 2002
Journal: Biol Reprod
Title: Heat shock-initiated apoptosis is accelerated and removal of damaged cells is delayed in the testis of clusterin/ApoJ knock-out mice.
Volume: 66
Issue: 4
Pages: 1042-53
Publication
First Author: Wicher GK
Year: 2005
Journal: Eur J Neurosci
Title: Adult motor neurons show increased susceptibility to axotomy-induced death in mice lacking clusterin.
Volume: 21
Issue: 7
Pages: 2024-8
Publication
First Author: Thomas-Tikhonenko A
Year: 2004
Journal: Cancer Res
Title: Myc-transformed epithelial cells down-regulate clusterin, which inhibits their growth in vitro and carcinogenesis in vivo.
Volume: 64
Issue: 9
Pages: 3126-36
Publication
First Author: Zhou W
Year: 2010
Journal: Am J Physiol Renal Physiol
Title: Loss of clusterin expression worsens renal ischemia-reperfusion injury.
Volume: 298
Issue: 3
Pages: F568-78
Publication
First Author: Seo HY
Year: 2013
Journal: Endocrinology
Title: Clusterin decreases hepatic SREBP-1c expression and lipid accumulation.
Volume: 154
Issue: 5
Pages: 1722-30
Publication
First Author: Rosenberg ME
Year: 2002
Journal: Mol Cell Biol
Title: Apolipoprotein J/clusterin prevents a progressive glomerulopathy of aging.
Volume: 22
Issue: 6
Pages: 1893-902
Publication
First Author: Jung GS
Year: 2012
Journal: J Am Soc Nephrol
Title: Clusterin attenuates the development of renal fibrosis.
Volume: 23
Issue: 1
Pages: 73-85
Publication
First Author: Wehrli P
Year: 2001
Journal: Nat Med
Title: Inhibition of post-ischemic brain injury by clusterin overexpression.
Volume: 7
Issue: 9
Pages: 977-9
Publication
First Author: Lee S
Year: 2011
Journal: Dev Dyn
Title: Essential role of clusterin in pancreas regeneration.
Volume: 240
Issue: 3
Pages: 605-15
Publication
First Author: Jenne DE
Year: 1989
Journal: Proc Natl Acad Sci U S A
Title: Molecular structure and functional characterization of a human complement cytolysis inhibitor found in blood and seminal plasma: identity to sulfated glycoprotein 2, a constituent of rat testis fluid.
Volume: 86
Issue: 18
Pages: 7123-7
Publication
First Author: Purrello M
Year: 1991
Journal: Genomics
Title: The gene for SP-40,40, human homolog of rat sulfated glycoprotein 2, rat clusterin, and rat testosterone-repressed prostate message 2, maps to chromosome 8.
Volume: 10
Issue: 1
Pages: 151-6
Publication
First Author: Birkenmeier EH
Year: 1993
Journal: Mamm Genome
Title: Sulfated glycoprotein-2 (Sgp-2) maps to mouse chromosome 14.
Volume: 4
Issue: 2
Pages: 131-2
Publication
First Author: Seiberg M
Year: 1995
Journal: Dev Dyn
Title: Clusterin expression within skin correlates with hair growth.
Volume: 202
Issue: 3
Pages: 294-301
Publication
First Author: Brown TL
Year: 1996
Journal: Biol Reprod
Title: Apolipoprotein J/clusterin expression defines distinct stages of blastocyst implantation in the mouse uterus.
Volume: 55
Issue: 4
Pages: 740-7
Publication
First Author: Furlong EE
Year: 1996
Journal: J Biol Chem
Title: Expression of a 74-kDa nuclear factor 1 (NF1) protein is induced in mouse mammary gland involution. Involution-enhanced occupation of a twin NF1 binding element in the testosterone-repressed prostate message-2/clusterin promoter.
Volume: 271
Issue: 47
Pages: 29688-97
Publication
First Author: Ahuja HS
Year: 1996
Journal: J Androl
Title: Differential expression of clusterin in the testis and epididymis of postnatal and germ cell deficient mice.
Volume: 17
Issue: 5
Pages: 491-501
Publication
First Author: Clark AM
Year: 1997
Journal: J Androl
Title: Expression of clusterin/sulfated glycoprotein-2 under conditions of heat stress in rat Sertoli cells and a mouse Sertoli cell line.
Volume: 18
Issue: 3
Pages: 257-63
Publication  
First Author: Michel D
Year: 1997
Journal: J Cell Sci
Title: Clusterin/ApoJ expression is associated with neuronal apoptosis in the olfactory mucosa of the adult mouse.
Volume: 110 ( Pt 14)
Pages: 1635-45
Publication  
First Author: Michel D
Year: 1997
Journal: Biochem J
Title: Stress-induced transcription of the clusterin/apoJ gene.
Volume: 328 ( Pt 1)
Pages: 45-50
Publication
First Author: Sun B
Year: 2007
Journal: FEBS Lett
Title: Clusterin is associated with spontaneous breast cancer in TA2 mice.
Volume: 581
Issue: 17
Pages: 3277-82
Publication
First Author: Hakkoum D
Year: 2008
Journal: J Neurochem
Title: Clusterin increases post-ischemic damages in organotypic hippocampal slice cultures.
Volume: 106
Issue: 4
Pages: 1791-803
Publication
First Author: Park JS
Year: 2018
Journal: Biochem Biophys Res Commun
Title: Hepatocyte-specific clusterin overexpression attenuates diet-induced nonalcoholic steatohepatitis.
Volume: 495
Issue: 2
Pages: 1775-1781
GXD Expression      
Probe: MGI:3758791
Assay Type: RT-PCR
Annotation Date: 2007-10-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1791726
Stage: TS26
Assay Id: MGI:3758796
Age: embryonic day 19.5
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:3758791
Assay Type: RT-PCR
Annotation Date: 2007-10-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1791723
Stage: TS23
Assay Id: MGI:3758796
Age: embryonic day 15.5
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:3758791
Assay Type: RT-PCR
Annotation Date: 2007-10-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1791721
Stage: TS21
Assay Id: MGI:3758796
Age: embryonic day 13.5
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:3826413
Assay Type: RT-PCR
Annotation Date: 2009-01-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3295228
Stage: TS28
Assay Id: MGI:3826489
Age: postnatal adult
Image: 4
Detected: true
Specimen Num: 5
GXD Expression      
Probe: MGI:4829907
Assay Type: RT-PCR
Annotation Date: 2010-09-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1792127
Stage: TS27
Assay Id: MGI:4829988
Age: postnatal day 2
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:4829907
Assay Type: RT-PCR
Annotation Date: 2010-09-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1792127
Stage: TS27
Assay Id: MGI:4829988
Age: postnatal day 2
Detected: true
Specimen Num: 3