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Search results 1 to 97 out of 97 for Cmtr1

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Hits by Strain

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Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: dog, domestic
Gene
Type: gene
Organism: chicken
Gene
Type: gene
Organism: zebrafish
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: frog, western clawed
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: chimpanzee
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Publication
First Author: Dohnalkova M
Year: 2023
Journal: Cell Rep
Title: Essential roles of RNA cap-proximal ribose methylation in mammalian embryonic development and fertility.
Volume: 42
Issue: 7
Pages: 112786
Publication
First Author: Lee YL
Year: 2020
Journal: Cell Rep
Title: CMTR1-Catalyzed 2'-O-Ribose Methylation Controls Neuronal Development by Regulating Camk2α Expression Independent of RIG-I Signaling.
Volume: 33
Issue: 3
Pages: 108269
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
GXD Expression      
Probe: MGI:3614529
Assay Type: RT-PCR
Annotation Date: 2006-03-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689421
Stage: TS21
Assay Id: MGI:3616473
Age: embryonic day 13.5
Specimen Label: RT-PCR E13.5 brain
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:3614529
Assay Type: RT-PCR
Annotation Date: 2006-03-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689427
Stage: TS27
Assay Id: MGI:3616473
Age: postnatal day 0
Specimen Label: RT-PCR P0 brain
Detected: true
Specimen Num: 2
GXD Expression
Probe: MGI:3615423
Assay Type: RNA in situ
Annotation Date: 2006-03-28
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754421
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:3617973
Age: embryonic day 13.5
Image: E13.5
Note: Expression was detected in precortical tissue.
Specimen Label: E13.5
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:3615423
Assay Type: RNA in situ
Annotation Date: 2006-03-28
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1665821
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:3617973
Age: embryonic day 13.5
Image: E13.5
Specimen Label: E13.5
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:3615423
Assay Type: RNA in situ
Annotation Date: 2006-03-28
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1691621
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:3617973
Age: embryonic day 13.5
Image: E13.5
Specimen Label: E13.5
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:3615423
Assay Type: RNA in situ
Annotation Date: 2006-03-28
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754921
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:3617973
Age: embryonic day 13.5
Image: E13.5
Specimen Label: E13.5
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:3615423
Assay Type: RNA in situ
Annotation Date: 2006-03-28
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1716821
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:3617973
Age: embryonic day 13.5
Image: E13.5
Specimen Label: E13.5
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:3615423
Assay Type: RNA in situ
Annotation Date: 2006-03-28
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3267921
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:3617973
Age: embryonic day 13.5
Image: E13.5
Specimen Label: E13.5
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:3615423
Assay Type: RNA in situ
Annotation Date: 2006-03-28
Strength: Ambiguous
Sex: Not Specified
Emaps: EMAPS:1760621
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:3617973
Age: embryonic day 13.5
Image: E13.5
Note: Authors indicate that there was either ubiquitous or background expression.
Specimen Label: E13.5
Specimen Num: 1
GXD Expression  
Probe: MGI:3615423
Assay Type: RNA in situ
Annotation Date: 2006-03-28
Strength: Ambiguous
Sex: Not Specified
Emaps: EMAPS:1757721
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:3617973
Age: embryonic day 13.5
Image: E13.5
Note: Authors indicate that there was either ubiquitous or background expression.
Specimen Label: E13.5
Specimen Num: 1
GXD Expression  
Probe: MGI:3615423
Assay Type: RNA in situ
Annotation Date: 2006-03-28
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1691627
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:3617973
Age: postnatal day 0
Image: P0
Specimen Label: P0
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:3615423
Assay Type: RNA in situ
Annotation Date: 2006-03-28
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1760627
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:3617973
Age: postnatal day 0
Image: P0
Specimen Label: P0
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:3615423
Assay Type: RNA in situ
Annotation Date: 2006-03-28
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754927
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:3617973
Age: postnatal day 0
Image: P0
Specimen Label: P0
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:3615423
Assay Type: RNA in situ
Annotation Date: 2006-03-28
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1697427
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:3617973
Age: postnatal day 0
Image: P0
Specimen Label: P0
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:3615423
Assay Type: RNA in situ
Annotation Date: 2006-03-28
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1716827
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:3617973
Age: postnatal day 0
Image: P0
Specimen Label: P0
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:3615423
Assay Type: RNA in situ
Annotation Date: 2006-03-28
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1753627
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:3617973
Age: postnatal day 0
Image: P0
Specimen Label: P0
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:3615423
Assay Type: RNA in situ
Annotation Date: 2006-03-28
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754427
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:3617973
Age: postnatal day 0
Image: P0
Specimen Label: P0
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:3615423
Assay Type: RNA in situ
Annotation Date: 2006-03-28
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3284527
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:3617973
Age: postnatal day 0
Image: P0
Specimen Label: P0
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:3615423
Assay Type: RNA in situ
Annotation Date: 2006-03-28
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1679727
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:3617973
Age: postnatal day 0
Image: P0
Specimen Label: P0
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:3615423
Assay Type: RNA in situ
Annotation Date: 2006-03-28
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754027
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:3617973
Age: postnatal day 0
Image: P0
Specimen Label: P0
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:3615423
Assay Type: RNA in situ
Annotation Date: 2006-03-28
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3280927
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:3617973
Age: postnatal day 0
Image: P0
Specimen Label: P0
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:3615423
Assay Type: RNA in situ
Annotation Date: 2006-03-28
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1757727
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:3617973
Age: postnatal day 0
Image: P0
Specimen Label: P0
Detected: true
Specimen Num: 2
GXD Expression
Probe: MGI:3834401
Assay Type: RNA in situ
Annotation Date: 2009-03-10
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1915728
Pattern: Scattered
Stage: TS28
Assay Id: MGI:3834988
Age: postnatal adult
Image: S5 wt
Note: Expression was detected in scattered cells localized to the scleral edge of the outer nuclear layer (cone gene expression).
Specimen Label: S5 wt
Detected: true
Specimen Num: 2
GXD Expression
Probe: MGI:3834401
Assay Type: RNA in situ
Annotation Date: 2009-03-10
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1915728
Pattern: Scattered
Stage: TS28
Assay Id: MGI:3834988
Age: postnatal adult
Image: S5 Nr2e3-/-
Note: Expression was detected in scattered cells localized to the scleral edge of the outer nuclear layer as in wild type.
Specimen Label: S5 Nr2e3-/-
Detected: true
Specimen Num: 3
GXD Expression  
Probe: MGI:3834401
Assay Type: RNA in situ
Annotation Date: 2009-03-10
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1716824
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:3834988
Age: embryonic day 16.0
Image: S5 wt e16
Specimen Label: S5 wt e16
Detected: true
Specimen Num: 4
GXD Expression
Probe: MGI:3834401
Assay Type: RNA in situ
Annotation Date: 2009-03-10
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1716825
Pattern: Regionally restricted
Stage: TS25
Assay Id: MGI:3834988
Age: embryonic day 17.5
Image: 5 1300018I05
Note: Expression was detected at the scleral border of the retina (early photoreceptor precursor pattern).
Specimen Label: 5 1300018I05
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:1062960
Assay Type: RNA in situ
Annotation Date: 2023-11-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3271122
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:7549156
Age: embryonic day 14.5
Specimen Label: Supplementary table 2
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:1062960
Assay Type: RNA in situ
Annotation Date: 2023-11-17
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1754722
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:7549156
Age: embryonic day 14.5
Specimen Label: Supplementary table 2
Detected: true
Specimen Num: 1
Publication
First Author: Corbo JC
Year: 2005
Journal: PLoS Genet
Title: A hybrid photoreceptor expressing both rod and cone genes in a mouse model of enhanced S-cone syndrome.
Volume: 1
Issue: 2
Pages: e11
Publication  
First Author: McKee AE
Year: 2005
Journal: BMC Dev Biol
Title: A genome-wide in situ hybridization map of RNA-binding proteins reveals anatomically restricted expression in the developing mouse brain.
Volume: 5
Pages: 14
Publication      
First Author: The RIKEN BioResource Center
Year: 2006
Journal: Unpublished
Title: Information obtained from The RIKEN BioResource Center
Publication      
First Author: The Jackson Laboratory
Year: 2012
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by The Jackson Laboratory
Publication  
First Author: Bedogni F
Year: 2021
Journal: Front Mol Neurosci
Title: Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development.
Volume: 14
Pages: 686034
Publication      
First Author: Lennon G
Year: 1999
Journal: Database Download
Title: WashU-HHMI Mouse EST Project
Publication      
First Author: Helmholtz Zentrum Muenchen GmbH
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu)
Publication        
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
Publication      
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
Publication
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
Publication
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
Publication        
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
Publication        
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Gene Ontology Annotation by the MGI Curatorial Staff
Publication      
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
Publication
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2000
Title: Gene Ontology Annotation by electronic association of SwissProt Keywords with GO terms
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
Publication
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
Publication
First Author: Gaudet P
Year: 2011
Journal: Brief Bioinform
Title: Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.
Volume: 12
Issue: 5
Pages: 449-62
Publication      
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
Publication      
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
Publication      
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
Publication      
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
Publication      
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
Publication      
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
Publication
First Author: von Grotthuss M
Year: 2003
Journal: Cell
Title: mRNA cap-1 methyltransferase in the SARS genome.
Volume: 113
Issue: 6
Pages: 701-2
Publication
First Author: Decroly E
Year: 2008
Journal: J Virol
Title: Coronavirus nonstructural protein 16 is a cap-0 binding enzyme possessing (nucleoside-2'O)-methyltransferase activity.
Volume: 82
Issue: 16
Pages: 8071-84
Publication
First Author: Vithani N
Year: 2021
Journal: Biophys J
Title: SARS-CoV-2 Nsp16 activation mechanism and a cryptic pocket with pan-coronavirus antiviral potential.
Volume: 120
Issue: 14
Pages: 2880-2889
Protein Domain
Type: Domain
Description: This domain covers the NSP16 region of the coronavirus polyprotein. It was originally named NSP13 and later changed to NSP16 to distinguish it from the helicase region []. NSP16 is a 7-methylguanine-triphosphate-adenosine (m7GpppA)-specific, SAM-dependent 2'-O-MTase that has selective RNA binding properties and is a cap-0 binding protein. It contains a highly conserved catalytic tetrad (K-D-K-E) that is a hallmark of RNA 2'O-MTases [, , ]. NSP16 plays a key role in viral replication as it is involved in immune response evasion through the 2'-O-methylation of coronavirus RNA, which is essential for preventing recognition by the host. It mimics the human protein CMTr1 and, unlike CMTr1, it requires NSP10 as a binding partner to activate its enzymatic activity []. Structural analysis in NSP16 from SARS-CoV-2 identified a cryptic pocket (also present in other coronavirus such as SARS-CoV-1 and MERS) not present in human CMTr1, and the fact that NSP16 is one of the most conserved proteins of SARS-CoV-2 and related viruses, make it an interesting target for developing new antiviral treatment for COVID-19 and other diseases caused by coronaviruses [].
Publication  
First Author: Rosas-Lemus M
Year: 2020
Journal: Sci Signal
Title: High-resolution structures of the SARS-CoV-2 2'-O-methyltransferase reveal strategies for structure-based inhibitor design.
Volume: 13
Issue: 651