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Search results 1 to 100 out of 435 for Cop1

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Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: chimpanzee
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: dog, domestic
Gene
Type: gene
Organism: zebrafish
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: frog, western clawed
Protein Domain
Type: Family
Description: COP1 is a RING finger-type ubiquitin E3 ligase. In Arabidopsis, it is a central switch for the transition from plant growth underground in darkness (etiolation) to growth under light exposure (photomorphogenesis) []. In mammals, it functions as an E3 ubiquitin-protein ligase involved in tumorigenesis, gluconeogenesis, and lipid metabolism. It is regulated by the COP9 signalosome []and is involved in 14-3-3 delta ubiquitin-mediated degradation []. COP1 contains a classic leucine-rich NES and a novel bipartite NLS bridged by a RING finger domain [].
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein
Organism: Mus musculus/domesticus
Length: 159  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 227  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 733  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 155  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 202  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 346  
Fragment?: true
Publication
First Author: Choi HH
Year: 2011
Journal: Oncogene
Title: COP9 signalosome subunit 6 stabilizes COP1, which functions as an E3 ubiquitin ligase for 14-3-3σ.
Volume: 30
Issue: 48
Pages: 4791-801
Publication  
First Author: Yi C
Year: 2002
Journal: BMC Cell Biol
Title: An initial biochemical and cell biological characterization of the mammalian homologue of a central plant developmental switch, COP1.
Volume: 3
Pages: 30
Publication
First Author: Sanchez-Barcelo EJ
Year: 2016
Journal: J Pineal Res
Title: Constitutive photomorphogenesis protein 1 (COP1) and COP9 signalosome, evolutionarily conserved photomorphogenic proteins as possible targets of melatonin.
Volume: 61
Issue: 1
Pages: 41-51
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: human
Publication
First Author: Newton K
Year: 2018
Journal: Proc Natl Acad Sci U S A
Title: Ubiquitin ligase COP1 coordinates transcriptional programs that control cell type specification in the developing mouse brain.
Volume: 115
Issue: 44
Pages: 11244-11249
Publication
First Author: Srivastava AK
Year: 2015
Journal: Plant Physiol
Title: Short Hypocotyl in White Light1 Interacts with Elongated Hypocotyl5 (HY5) and Constitutive Photomorphogenic1 (COP1) and Promotes COP1-Mediated Degradation of HY5 during Arabidopsis Seedling Development.
Volume: 169
Issue: 4
Pages: 2922-34
Publication
First Author: Wang H
Year: 1999
Journal: Curr Biol
Title: Evidence for functional conservation of a mammalian homologue of the light-responsive plant protein COP1.
Volume: 9
Issue: 13
Pages: 711-4
Publication
First Author: Ndoja A
Year: 2020
Journal: Cell
Title: Ubiquitin Ligase COP1 Suppresses Neuroinflammation by Degrading c/EBPβ in Microglia.
Volume: 182
Issue: 5
Pages: 1156-1169.e12
Publication
First Author: Vitari AC
Year: 2011
Journal: Nature
Title: COP1 is a tumour suppressor that causes degradation of ETS transcription factors.
Volume: 474
Issue: 7351
Pages: 403-6
Publication
First Author: Qi L
Year: 2006
Journal: Science
Title: TRB3 links the E3 ubiquitin ligase COP1 to lipid metabolism.
Volume: 312
Issue: 5781
Pages: 1763-6
Publication
First Author: Li DQ
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: E3 ubiquitin ligase COP1 regulates the stability and functions of MTA1.
Volume: 106
Issue: 41
Pages: 17493-8
Protein
Organism: Mus musculus/domesticus
Length: 733  
Fragment?: false
Publication
First Author: Migliorini D
Year: 2011
Journal: J Clin Invest
Title: Cop1 constitutively regulates c-Jun protein stability and functions as a tumor suppressor in mice.
Volume: 121
Issue: 4
Pages: 1329-43
Publication
First Author: Wang X
Year: 2021
Journal: Cell
Title: In vivo CRISPR screens identify the E3 ligase Cop1 as a modulator of macrophage infiltration and cancer immunotherapy target.
Volume: 184
Issue: 21
Pages: 5357-5374.e22
Publication
First Author: Rizzini L
Year: 2019
Journal: Curr Biol
Title: Cryptochromes-Mediated Inhibition of the CRL4Cop1-Complex Assembly Defines an Evolutionary Conserved Signaling Mechanism.
Volume: 29
Issue: 12
Pages: 1954-1962.e4
Gene
Type: gene
Organism: human
Publication
First Author: Zhang Z
Year: 2017
Journal: Proc Natl Acad Sci U S A
Title: Transcription factor Etv5 is essential for the maintenance of alveolar type II cells.
Volume: 114
Issue: 15
Pages: 3903-3908
Publication
First Author: Suriben R
Year: 2015
Journal: Cell
Title: β-Cell Insulin Secretion Requires the Ubiquitin Ligase COP1.
Volume: 163
Issue: 6
Pages: 1457-67
Publication
First Author: Lin H
Year: 2021
Journal: Nat Commun
Title: IP6-assisted CSN-COP1 competition regulates a CRL4-ETV5 proteolytic checkpoint to safeguard glucose-induced insulin secretion.
Volume: 12
Issue: 1
Pages: 2461
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
GXD Expression    
Probe: MGI:7345585
Assay Type: Western blot
Annotation Date: 2022-10-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1640521
Stage: TS21
Assay Id: MGI:7345595
Age: embryonic day 13.5
Image: 6
Specimen Label: Limb WT-1
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:7345585
Assay Type: Western blot
Annotation Date: 2022-10-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1640521
Stage: TS21
Assay Id: MGI:7345595
Age: embryonic day 13.5
Image: 6
Specimen Label: Limb WT-2
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:7345585
Assay Type: Western blot
Annotation Date: 2022-10-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1640521
Stage: TS21
Assay Id: MGI:7345595
Age: embryonic day 13.5
Image: 6
Specimen Label: Limb WT-3
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:7345585
Assay Type: Western blot
Annotation Date: 2022-10-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1640521
Stage: TS21
Assay Id: MGI:7345595
Age: embryonic day 13.5
Image: 6
Specimen Label: Limb KO-1
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:7345585
Assay Type: Western blot
Annotation Date: 2022-10-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1640521
Stage: TS21
Assay Id: MGI:7345595
Age: embryonic day 13.5
Image: 6
Specimen Label: Limb KO-2
Detected: true
Specimen Num: 5
GXD Expression    
Probe: MGI:7345585
Assay Type: Western blot
Annotation Date: 2022-10-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1640521
Stage: TS21
Assay Id: MGI:7345595
Age: embryonic day 13.5
Image: 6
Specimen Label: Limb KO-3
Detected: true
Specimen Num: 6
GXD Expression    
Probe: MGI:7345585
Assay Type: Western blot
Annotation Date: 2022-10-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3185821
Stage: TS21
Assay Id: MGI:7345595
Age: embryonic day 13.5
Image: 6
Specimen Label: Head WT-1
Detected: true
Specimen Num: 13
GXD Expression    
Probe: MGI:7345585
Assay Type: Western blot
Annotation Date: 2022-10-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3185821
Stage: TS21
Assay Id: MGI:7345595
Age: embryonic day 13.5
Image: 6
Specimen Label: Head WT-2
Detected: true
Specimen Num: 14
GXD Expression    
Probe: MGI:7345585
Assay Type: Western blot
Annotation Date: 2022-10-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3185821
Stage: TS21
Assay Id: MGI:7345595
Age: embryonic day 13.5
Image: 6
Specimen Label: Head WT-3
Detected: true
Specimen Num: 15
GXD Expression    
Probe: MGI:7345585
Assay Type: Western blot
Annotation Date: 2022-10-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3185821
Stage: TS21
Assay Id: MGI:7345595
Age: embryonic day 13.5
Image: 6
Specimen Label: Head KO-1
Detected: true
Specimen Num: 16
GXD Expression    
Probe: MGI:7345585
Assay Type: Western blot
Annotation Date: 2022-10-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3185821
Stage: TS21
Assay Id: MGI:7345595
Age: embryonic day 13.5
Image: 6
Specimen Label: Head KO-2
Detected: true
Specimen Num: 17
GXD Expression    
Probe: MGI:7345585
Assay Type: Western blot
Annotation Date: 2022-10-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3185821
Stage: TS21
Assay Id: MGI:7345595
Age: embryonic day 13.5
Image: 6
Specimen Label: Head KO-3
Detected: true
Specimen Num: 18
GXD Expression    
Probe: MGI:7345585
Assay Type: Western blot
Annotation Date: 2022-10-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684621
Stage: TS21
Assay Id: MGI:7345595
Age: embryonic day 13.5
Image: 6
Specimen Label: Liver WT-1
Detected: true
Specimen Num: 7
GXD Expression    
Probe: MGI:7345585
Assay Type: Western blot
Annotation Date: 2022-10-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684621
Stage: TS21
Assay Id: MGI:7345595
Age: embryonic day 13.5
Image: 6
Specimen Label: Liver WT-2
Detected: true
Specimen Num: 8
GXD Expression    
Probe: MGI:7345585
Assay Type: Western blot
Annotation Date: 2022-10-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684621
Stage: TS21
Assay Id: MGI:7345595
Age: embryonic day 13.5
Image: 6
Specimen Label: Liver WT-3
Detected: true
Specimen Num: 9
GXD Expression    
Probe: MGI:7345585
Assay Type: Western blot
Annotation Date: 2022-10-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684621
Stage: TS21
Assay Id: MGI:7345595
Age: embryonic day 13.5
Image: 6
Specimen Label: Liver KO-1
Detected: true
Specimen Num: 10
GXD Expression    
Probe: MGI:7345585
Assay Type: Western blot
Annotation Date: 2022-10-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684621
Stage: TS21
Assay Id: MGI:7345595
Age: embryonic day 13.5
Image: 6
Specimen Label: Liver KO-2
Detected: true
Specimen Num: 11
GXD Expression    
Probe: MGI:7345585
Assay Type: Western blot
Annotation Date: 2022-10-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684621
Stage: TS21
Assay Id: MGI:7345595
Age: embryonic day 13.5
Image: 6
Specimen Label: Liver KO-3
Detected: true
Specimen Num: 12
GXD Expression    
Probe: MGI:3506793
Assay Type: RNA in situ
Annotation Date: 2004-12-03
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1691621
Stage: TS21
Assay Id: MGI:3508235
Age: embryonic day 13.5
Image: 1
Specimen Label: 1
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:3506793
Assay Type: RNA in situ
Annotation Date: 2004-12-03
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1691627
Stage: TS27
Assay Id: MGI:3508235
Age: postnatal newborn
Specimen Label: 2
Detected: false
Specimen Num: 2
GXD Expression  
Probe: MGI:3506793
Assay Type: RNA in situ
Annotation Date: 2004-12-03
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1777821
Stage: TS21
Assay Id: MGI:3508235
Age: embryonic day 13.5
Image: 1
Note: The tissue was olfactory epithelium and/or bulb.
Specimen Label: 1
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:3506793
Assay Type: RNA in situ
Annotation Date: 2004-12-03
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1754921
Stage: TS21
Assay Id: MGI:3508235
Age: embryonic day 13.5
Image: 1
Specimen Label: 1
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:3506793
Assay Type: RNA in situ
Annotation Date: 2004-12-03
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1754927
Stage: TS27
Assay Id: MGI:3508235
Age: postnatal newborn
Specimen Label: 2
Detected: false
Specimen Num: 2
GXD Expression    
Probe: MGI:3506793
Assay Type: RNA in situ
Annotation Date: 2004-12-03
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1697421
Stage: TS21
Assay Id: MGI:3508235
Age: embryonic day 13.5
Image: 1
Specimen Label: 1
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:3506793
Assay Type: RNA in situ
Annotation Date: 2004-12-03
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1697427
Stage: TS27
Assay Id: MGI:3508235
Age: postnatal newborn
Specimen Label: 2
Detected: false
Specimen Num: 2
GXD Expression    
Probe: MGI:3506793
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Female
Emaps: EMAPS:2769723
Stage: TS23
Assay Id: MGI:5539765
Age: embryonic day 15.5
Image: GUDMAP:6144
Specimen Label: GUDMAP:6144
Detected: false
Specimen Num: 1
GXD Expression  
Probe: MGI:3506793
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Male
Emaps: EMAPS:2769723
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:5539765
Age: embryonic day 15.5
Image: GUDMAP:11843
Specimen Label: GUDMAP:11843
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:3506793
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Female
Emaps: EMAPS:2769723
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:5539765
Age: embryonic day 15.5
Image: GUDMAP:11936
Specimen Label: GUDMAP:11936
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:3506793
Assay Type: RNA in situ
Annotation Date: 2004-12-03
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1665921
Stage: TS21
Assay Id: MGI:3508235
Age: embryonic day 13.5
Image: 1
Specimen Label: 1
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:3506793
Assay Type: RNA in situ
Annotation Date: 2004-12-03
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1665927
Stage: TS27
Assay Id: MGI:3508235
Age: postnatal newborn
Specimen Label: 2
Detected: false
Specimen Num: 2
GXD Expression    
Probe: MGI:3506793
Assay Type: RNA in situ
Annotation Date: 2004-12-03
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1716821
Stage: TS21
Assay Id: MGI:3508235
Age: embryonic day 13.5
Image: 1
Specimen Label: 1
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:3506793
Assay Type: RNA in situ
Annotation Date: 2004-12-03
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1716827
Stage: TS27
Assay Id: MGI:3508235
Age: postnatal newborn
Specimen Label: 2
Detected: false
Specimen Num: 2
GXD Expression  
Probe: MGI:3506793
Assay Type: RNA in situ
Annotation Date: 2004-12-03
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1619321
Stage: TS21
Assay Id: MGI:3508235
Age: embryonic day 13.5
Image: 1
Note: The tissue was inner ear and ear structures.
Specimen Label: 1
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:3506793
Assay Type: RNA in situ
Annotation Date: 2004-12-03
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1619327
Stage: TS27
Assay Id: MGI:3508235
Age: postnatal newborn
Note: The tissue was inner ear and ear structures.
Specimen Label: 2
Detected: false
Specimen Num: 2
GXD Expression  
Probe: MGI:3506793
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Male
Emaps: EMAPS:2853323
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:5539765
Age: embryonic day 15.5
Image: GUDMAP:11843
Specimen Label: GUDMAP:11843
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:3506793
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Female
Emaps: EMAPS:2845723
Stage: TS23
Assay Id: MGI:5539765
Age: embryonic day 15.5
Image: GUDMAP:6144
Specimen Label: GUDMAP:6144
Detected: false
Specimen Num: 1
GXD Expression  
Probe: MGI:3506793
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Male
Emaps: EMAPS:2845723
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:5539765
Age: embryonic day 15.5
Image: GUDMAP:11843
Specimen Label: GUDMAP:11843
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:3506793
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Female
Emaps: EMAPS:2845723
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:5539765
Age: embryonic day 15.5
Image: GUDMAP:11936
Specimen Label: GUDMAP:11936
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:3506793
Assay Type: RNA in situ
Annotation Date: 2004-12-03
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1753621
Stage: TS21
Assay Id: MGI:3508235
Age: embryonic day 13.5
Image: 1
Specimen Label: 1
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:3506793
Assay Type: RNA in situ
Annotation Date: 2004-12-03
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1753627
Stage: TS27
Assay Id: MGI:3508235
Age: postnatal newborn
Specimen Label: 2
Detected: false
Specimen Num: 2
GXD Expression  
Probe: MGI:3506793
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Female
Emaps: EMAPS:1795023
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:5539765
Age: embryonic day 15.5
Image: GUDMAP:6144
Specimen Label: GUDMAP:6144
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:3506793
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Male
Emaps: EMAPS:1795023
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:5539765
Age: embryonic day 15.5
Image: GUDMAP:11843
Specimen Label: GUDMAP:11843
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:3506793
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Female
Emaps: EMAPS:1795023
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:5539765
Age: embryonic day 15.5
Image: GUDMAP:11936
Specimen Label: GUDMAP:11936
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:3506793
Assay Type: RNA in situ
Annotation Date: 2004-12-03
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1778727
Stage: TS27
Assay Id: MGI:3508235
Age: postnatal newborn
Specimen Label: 2
Detected: false
Specimen Num: 2
GXD Expression    
Probe: MGI:3506793
Assay Type: RNA in situ
Annotation Date: 2004-12-03
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1754421
Stage: TS21
Assay Id: MGI:3508235
Age: embryonic day 13.5
Image: 1
Specimen Label: 1
Detected: false
Specimen Num: 1