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Search results 1 to 100 out of 291 for Corin

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Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: chicken
Gene
Type: gene
Organism: zebrafish
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: frog, western clawed
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: dog, domestic
Gene
Type: gene
Organism: chimpanzee
Protein Domain
Type: Family
Description: Atrial natriuretic peptide (ANP) is a cardiac hormone essential for the regulation of blood pressure. In cardiac myocytes, ANP is synthesized as a precursor, pro-ANP, which is converted to biologically active ANP by the serine peptidase corin []. This entry represents the atrial natriuretic peptide-converting enzyme corin, which is a type II transmembrane serine protease that belongs to MEROPS peptidase family S1A (clan PA(S)), which is abundantly expressed in the heart. Other serine proteases such as thrombin and kallikrein had previously also been shown to cleave pro-ANP in vitro, but corin has now been shown to be the endogenous pro-ANP convertase in cardiomyocytes []. For corin to cleave its substrate, pro-ANP, it should be catalytically active and located in close proximity []. Corin is highly sequence specific. Corin-mediated pro-ANP activation may play a role in regulating blood pressure [].N-Glycosylation may influence the subcellular localization and biological activity of corin and tunicamycin treatment also significantly reduces corin activity [].Corin in involved in promoting trophoblast invasion and spiral artery remodelling in pregnancy. Mutations in the corin gene cause pre-eclampsia/eclampsia 5 (PEE5) [].
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Publication
First Author: Wu F
Year: 2002
Journal: J Biol Chem
Title: Processing of pro-atrial natriuretic peptide by corin in cardiac myocytes.
Volume: 277
Issue: 19
Pages: 16900-5
Publication
First Author: Cui Y
Year: 2012
Journal: Nature
Title: Role of corin in trophoblast invasion and uterine spiral artery remodelling in pregnancy.
Volume: 484
Issue: 7393
Pages: 246-50
Publication
First Author: Gladysheva IP
Year: 2008
Journal: J Mol Cell Cardiol
Title: Corin is co-expressed with pro-ANP and localized on the cardiomyocyte surface in both zymogen and catalytically active forms.
Volume: 44
Issue: 1
Pages: 131-42
Publication
First Author: Gladysheva IP
Year: 2008
Journal: Biochem Biophys Res Commun
Title: N-glycosylation modulates the cell-surface expression and catalytic activity of corin.
Volume: 373
Issue: 1
Pages: 130-5
Protein
Organism: Mus musculus/domesticus
Length: 1000  
Fragment?: false
Publication
First Author: Yan W
Year: 2000
Journal: Proc Natl Acad Sci U S A
Title: Corin, a transmembrane cardiac serine protease, acts as a pro-atrial natriuretic peptide-converting enzyme.
Volume: 97
Issue: 15
Pages: 8525-9
Protein
Organism: Mus musculus/domesticus
Length: 1113  
Fragment?: false
Publication
First Author: Chen S
Year: 2010
Journal: Am J Physiol Heart Circ Physiol
Title: Protease corin expression and activity in failing hearts.
Volume: 299
Issue: 5
Pages: H1687-92
Publication
First Author: Chen S
Year: 2015
Journal: Nat Med
Title: PCSK6-mediated corin activation is essential for normal blood pressure.
Volume: 21
Issue: 9
Pages: 1048-53
Publication
First Author: He M
Year: 2021
Journal: PLoS Biol
Title: The protease corin regulates electrolyte homeostasis in eccrine sweat glands.
Volume: 19
Issue: 2
Pages: e3001090
Publication
First Author: Polzin D
Year: 2010
Journal: Kidney Int
Title: Decreased renal corin expression contributes to sodium retention in proteinuric kidney diseases.
Volume: 78
Issue: 7
Pages: 650-9
Publication
First Author: Enshell-Seijffers D
Year: 2008
Journal: Development
Title: The serine protease Corin is a novel modifier of the Agouti pathway.
Volume: 135
Issue: 2
Pages: 217-25
Publication
First Author: Pan J
Year: 2002
Journal: J Biol Chem
Title: Genomic structures of the human and murine corin genes and functional GATA elements in their promoters.
Volume: 277
Issue: 41
Pages: 38390-8
Publication
First Author: Gladysheva IP
Year: 2013
Journal: Hypertension
Title: Corin overexpression improves cardiac function, heart failure, and survival in mice with dilated cardiomyopathy.
Volume: 61
Issue: 2
Pages: 327-32
Publication  
First Author: Sullivan RD
Year: 2020
Journal: Int J Mol Sci
Title: Corin Overexpression Reduces Myocardial Infarct Size and Modulates Cardiomyocyte Apoptotic Cell Death.
Volume: 21
Issue: 10
Publication
First Author: Wang D
Year: 2018
Journal: PLoS One
Title: Increases in plasma corin levels following experimental myocardial infarction reflect the severity of ischemic injury.
Volume: 13
Issue: 9
Pages: e0202571
Publication
First Author: Wang C
Year: 2020
Journal: Proc Natl Acad Sci U S A
Title: Krüppel-like factor 17 upregulates uterine corin expression and promotes spiral artery remodeling in pregnancy.
Volume: 117
Issue: 32
Pages: 19425-19434
Publication  
First Author: Zhou T
Year: 2022
Journal: Int J Mol Sci
Title: Renal Corin Is Essential for Normal Blood Pressure and Sodium Homeostasis.
Volume: 23
Issue: 19
Publication
First Author: Wang W
Year: 2012
Journal: Hypertension
Title: Salt-sensitive hypertension and cardiac hypertrophy in transgenic mice expressing a corin variant identified in blacks.
Volume: 60
Issue: 5
Pages: 1352-8
Publication
First Author: Nigrovic PA
Year: 2008
Journal: Am J Pathol
Title: Genetic inversion in mast cell-deficient (Wsh) mice interrupts corin and manifests as hematopoietic and cardiac aberrancy.
Volume: 173
Issue: 6
Pages: 1693-701
Publication
First Author: Wang W
Year: 2008
Journal: Circ Res
Title: Corin variant associated with hypertension and cardiac hypertrophy exhibits impaired zymogen activation and natriuretic peptide processing activity.
Volume: 103
Issue: 5
Pages: 502-8
Publication  
First Author: Tripathi R
Year: 2019
Journal: Int J Mol Sci
Title: Cardiac-Specific Overexpression of Catalytically Inactive Corin Reduces Edema, Contractile Dysfunction, and Death in Mice with Dilated Cardiomyopathy.
Volume: 21
Issue: 1
Protein
Organism: Mus musculus/domesticus
Length: 980  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 1007  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 972  
Fragment?: true
Publication
First Author: Chi WY
Year: 2010
Journal: J Invest Dermatol
Title: De novo production of dermal papilla cells during the anagen phase of the hair cycle.
Volume: 130
Issue: 11
Pages: 2664-6
Publication
First Author: Yan W
Year: 1999
Journal: J Biol Chem
Title: Corin, a mosaic transmembrane serine protease encoded by a novel cDNA from human heart.
Volume: 274
Issue: 21
Pages: 14926-35
Publication
First Author: Aamar E
Year: 2021
Journal: J Invest Dermatol
Title: Hair-Follicle Mesenchymal Stem Cell Activity during Homeostasis and Wound Healing.
Volume: 141
Issue: 12
Pages: 2797-2807.e6
Publication
First Author: Enshell-Seijffers D
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: Beta-catenin activity in the dermal papilla of the hair follicle regulates pigment-type switching.
Volume: 107
Issue: 50
Pages: 21564-9
Publication
First Author: Chi W
Year: 2017
Journal: J Invest Dermatol
Title: Stabilization of β-Catenin Does Not Increase Dermal Papilla Cell Number in the Hair Follicle.
Volume: 137
Issue: 1
Pages: 245-246
Publication  
First Author: El Abdellaoui-Soussi F
Year: 2022
Journal: Int J Mol Sci
Title: Interplay between the Chd4/NuRD Complex and the Transcription Factor Znf219 Controls Cardiac Cell Identity.
Volume: 23
Issue: 17
Publication
First Author: Chi W
Year: 2013
Journal: Development
Title: Dermal papilla cell number specifies hair size, shape and cycling and its reduction causes follicular decline.
Volume: 140
Issue: 8
Pages: 1676-83
Publication
First Author: Baird RC
Year: 2019
Journal: Can J Cardiol
Title: Pregnancy-Associated Cardiac Hypertrophy in Corin-Deficient Mice: Observations in a Transgenic Model of Preeclampsia.
Volume: 35
Issue: 1
Pages: 68-76
Publication
First Author: Wang W
Year: 2012
Journal: Kidney Int
Title: Impaired sodium excretion and salt-sensitive hypertension in corin-deficient mice.
Volume: 82
Issue: 1
Pages: 26-33
Publication
First Author: Jiang J
Year: 2011
Journal: J Biol Chem
Title: Ectodomain shedding and autocleavage of the cardiac membrane protease corin.
Volume: 286
Issue: 12
Pages: 10066-72
Publication
First Author: Chan JC
Year: 2005
Journal: Proc Natl Acad Sci U S A
Title: Hypertension in mice lacking the proatrial natriuretic peptide convertase corin.
Volume: 102
Issue: 3
Pages: 785-90
Publication
First Author: Avigad Laron E
Year: 2018
Journal: Cell Rep
Title: The Mesenchymal Niche of the Hair Follicle Induces Regeneration by Releasing Primed Progenitors from Inhibitory Effects of Quiescent Stem Cells.
Volume: 24
Issue: 4
Pages: 909-921.e3
Publication
First Author: Enshell-Seijffers D
Year: 2010
Journal: Dev Cell
Title: beta-catenin activity in the dermal papilla regulates morphogenesis and regeneration of hair.
Volume: 18
Issue: 4
Pages: 633-42
Publication
First Author: Harshuk-Shabso S
Year: 2020
Journal: Nat Commun
Title: Fgf and Wnt signaling interaction in the mesenchymal niche regulates the murine hair cycle clock.
Volume: 11
Issue: 1
Pages: 5114
Publication
First Author: Buckley CL
Year: 2011
Journal: Regul Pept
Title: Corin-deficient W-sh mice poorly tolerate increased cardiac afterload.
Volume: 172
Issue: 1-3
Pages: 44-50
Publication
First Author: Sibony-Benyamini H
Year: 2023
Journal: Nat Commun
Title: Hdac1 and Hdac2 regulate the quiescent state and survival of hair-follicle mesenchymal niche.
Volume: 14
Issue: 1
Pages: 4820
Publication
First Author: Nagashima T
Year: 2013
Journal: J Clin Invest
Title: BMPR2 is required for postimplantation uterine function and pregnancy maintenance.
Volume: 123
Issue: 6
Pages: 2539-50
Publication
First Author: Yan CH
Year: 2011
Journal: J Neurosci
Title: Lmx1a and lmx1b function cooperatively to regulate proliferation, specification, and differentiation of midbrain dopaminergic progenitors.
Volume: 31
Issue: 35
Pages: 12413-25
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Tomita Y
Year: 1998
Journal: J Biochem
Title: A novel low-density lipoprotein receptor-related protein with type II membrane protein-like structure is abundant in heart.
Volume: 124
Issue: 4
Pages: 784-9
GXD Expression    
Probe: MGI:5775388
Assay Type: Northern blot
Annotation Date: 2016-06-08
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1876728
Stage: TS28
Assay Id: MGI:5775390
Age: postnatal adult
Image: 4
Specimen Label: Spleen
Detected: false
Specimen Num: 6
GXD Expression    
Probe: MGI:5775388
Assay Type: Northern blot
Annotation Date: 2016-06-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:5775390
Age: postnatal adult
Image: 4
Specimen Label: Kidney
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:5775388
Assay Type: Northern blot
Annotation Date: 2016-06-08
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1672828
Stage: TS28
Assay Id: MGI:5775390
Age: postnatal adult
Image: 4
Specimen Label: Lung
Detected: false
Specimen Num: 5
GXD Expression    
Probe: MGI:5775388
Assay Type: Northern blot
Annotation Date: 2016-06-08
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3598828
Stage: TS28
Assay Id: MGI:5775390
Age: postnatal adult
Image: 4
Specimen Label: Sk. Muscle
Detected: false
Specimen Num: 3
GXD Expression    
Probe: MGI:5775388
Assay Type: Northern blot
Annotation Date: 2016-06-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:5775390
Age: postnatal adult
Image: 4
Specimen Label: Heart
Detected: true
Specimen Num: 8
GXD Expression    
Probe: MGI:5775388
Assay Type: Northern blot
Annotation Date: 2016-06-08
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:5775390
Age: postnatal adult
Image: 4
Specimen Label: Liver
Detected: false
Specimen Num: 4
GXD Expression    
Probe: MGI:5775388
Assay Type: Northern blot
Annotation Date: 2016-06-08
Strength: Present
Sex: Male
Emaps: EMAPS:1797228
Stage: TS28
Assay Id: MGI:5775390
Age: postnatal adult
Image: 4
Specimen Label: Testis
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:6890446
Assay Type: RT-PCR
Annotation Date: 2022-03-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1736221
Stage: TS21
Assay Id: MGI:7256349
Age: embryonic day 13.5
Image: 5
Specimen Label: Control
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:6890446
Assay Type: RT-PCR
Annotation Date: 2022-03-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1736221
Stage: TS21
Assay Id: MGI:7256349
Age: embryonic day 13.5
Image: 5
Specimen Label: (Foxf2/Foxq1)-/-
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:4355376
Assay Type: RT-PCR
Annotation Date: 2009-08-31
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1752527
Stage: TS27
Assay Id: MGI:4355417
Age: postnatal day 0
Image: 7
Specimen Label: P0
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:4355376
Assay Type: RT-PCR
Annotation Date: 2009-08-31
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1752527
Stage: TS27
Assay Id: MGI:4355417
Age: postnatal day 1
Image: 7
Specimen Label: P1
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:4355376
Assay Type: RT-PCR
Annotation Date: 2009-08-31
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1752527
Stage: TS27
Assay Id: MGI:4355417
Age: postnatal day 2
Image: 7
Specimen Label: P2
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:4355376
Assay Type: RT-PCR
Annotation Date: 2009-08-31
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1752527
Stage: TS27
Assay Id: MGI:4355417
Age: postnatal day 3
Image: 7
Specimen Label: P3
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:4355376
Assay Type: RT-PCR
Annotation Date: 2009-08-31
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1752528
Stage: TS28
Assay Id: MGI:4355417
Age: postnatal day 4
Image: 7
Specimen Label: P4
Detected: true
Specimen Num: 5
GXD Expression    
Probe: MGI:4355376
Assay Type: RT-PCR
Annotation Date: 2009-08-31
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1752528
Stage: TS28
Assay Id: MGI:4355417
Age: postnatal day 5
Image: 7
Specimen Label: P5
Detected: true
Specimen Num: 6
GXD Expression    
Probe: MGI:4355376
Assay Type: RT-PCR
Annotation Date: 2009-08-31
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1752528
Stage: TS28
Assay Id: MGI:4355417
Age: postnatal day 6
Image: 7
Specimen Label: P6
Detected: true
Specimen Num: 7
GXD Expression    
Probe: MGI:4355376
Assay Type: RT-PCR
Annotation Date: 2009-08-31
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1752528
Stage: TS28
Assay Id: MGI:4355417
Age: postnatal day 7
Image: 7
Specimen Label: P7
Detected: true
Specimen Num: 8
GXD Expression    
Probe: MGI:4355376
Assay Type: RT-PCR
Annotation Date: 2009-08-31
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1752528
Stage: TS28
Assay Id: MGI:4355417
Age: postnatal day 8
Image: 7
Specimen Label: P8
Detected: true
Specimen Num: 9
GXD Expression    
Probe: MGI:4355376
Assay Type: RT-PCR
Annotation Date: 2009-08-31
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1752528
Stage: TS28
Assay Id: MGI:4355417
Age: postnatal day 9
Image: 7
Specimen Label: P9
Detected: true
Specimen Num: 10
GXD Expression    
Probe: MGI:5775388
Assay Type: Northern blot
Annotation Date: 2016-06-08
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:5775390
Age: postnatal adult
Image: 4
Specimen Label: Brain
Detected: false
Specimen Num: 7
GXD Expression  
Probe: MGI:7447349
Assay Type: Immunohistochemistry
Annotation Date: 2023-03-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3648427
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:7447386
Age: postnatal day 2
Image: 3O
Specimen Label: 3O
Detected: true
Specimen Num: 1
GXD Expression
Probe: MGI:7447349
Assay Type: Immunohistochemistry
Annotation Date: 2023-03-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3648427
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:7447386
Age: postnatal day 2
Image: 3P
Note: Similar as in the control.
Specimen Label: 3P
Detected: true
Specimen Num: 2
GXD Expression
Probe: MGI:5774794
Assay Type: RNA in situ
Annotation Date: 2016-06-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1697417
Pattern: Regionally restricted
Stage: TS17
Assay Id: MGI:5774802
Age: embryonic day 10.5
Image: 2B
Note: Most medially restricted in the dopaminergic precursor domain.
Specimen Label: 2B
Detected: true
Specimen Num: 1
GXD Expression
Probe: MGI:5774794
Assay Type: RNA in situ
Annotation Date: 2016-06-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1697420
Pattern: Regionally restricted
Stage: TS20
Assay Id: MGI:5774802
Age: embryonic day 12.5
Image: 2G
Note: Most medially restricted in the dopaminergic precursor domain.
Specimen Label: 2G
Detected: true
Specimen Num: 2
GXD Expression
Probe: MGI:5775388
Assay Type: RNA in situ
Annotation Date: 2016-06-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1733120
Pattern: Regionally restricted
Stage: TS20
Assay Id: MGI:5775392
Age: embryonic day 12.5
Image: 6F
Note: Prominent expression in trabecular ventricular compartment.
Specimen Label: 6F
Detected: true
Specimen Num: 5
GXD Expression  
Probe: MGI:5775388
Assay Type: RNA in situ
Annotation Date: 2016-06-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3526928
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:5775392
Age: postnatal adult
Image: 7L
Specimen Label: 7L
Detected: true
Specimen Num: 13