|  Help  |  About  |  Contact Us

Search our database by keyword

Examples

  • Search this entire website. Enter identifiers, names or keywords for genes, diseases, strains, ontology terms, etc. (e.g. Pax6, Parkinson, ataxia)
  • Use OR to search for either of two terms (e.g. OR mus) or quotation marks to search for phrases (e.g. "dna binding").
  • Boolean search syntax is supported: e.g. Balb* for partial matches or mus AND NOT embryo to exclude a term

Search results 1 to 100 out of 118 for Cpa2

<< First    < Previous  |  Next >    Last >>
0.072s

Categories

Hits by Pathway

Hits by Strain

Hits by Category

Type Details Score
Gene
1358 | CPA2
Type: gene
Organism: human
•
•
•
•
•
Gene
416682 | CPA2
Type: gene
Organism: chicken
•
•
•
•
•
Gene
445052 | cpa2
Type: gene
Organism: zebrafish
•
•
•
•
•
Gene
706684 | CPA2
Type: gene
Organism: macaque, rhesus
•
•
•
•
•
Gene
296959 | Cpa2
Type: gene
Organism: rat
•
•
•
•
•
Gene
475193 | CPA2
Type: gene
Organism: dog, domestic
•
•
•
•
•
Gene
742070 | CPA2
Type: gene
Organism: chimpanzee
•
•
•
•
•
Protein Coding Gene
MGI:3617840 | Cpa2
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_CAROLIEiJ_G0028187 | -
Type: protein_coding_gene
Organism: Mus caroli
•
•
•
•
•
Protein Coding Gene
MGP_129S1SvImJ_G0030539 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_AJ_G0030512 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_AKRJ_G0030439 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_BALBcJ_G0030522 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_C3HHeJ_G0030235 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGI_C57BL6J_3617840 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_C57BL6NJ_G0030976 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_CASTEiJ_G0029637 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_CBAJ_G0030213 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_DBA2J_G0030357 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_FVBNJ_G0030311 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_LPJ_G0030444 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_NODShiLtJ_G0030347 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_NZOHlLtJ_G0031006 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_PWKPhJ_G0029351 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_WSBEiJ_G0029713 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_PahariEiJ_G0021945 | -
Type: protein_coding_gene
Organism: Mus pahari
•
•
•
•
•
Protein Coding Gene
MGP_SPRETEiJ_G0029187 | -
Type: protein_coding_gene
Organism: Mus spretus
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:6506496
Assay Type: RNA in situ
Annotation Date: 2021-02-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737323
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:6506663
Age: embryonic day 15.5
Note: All detected expression is outside the ureteric bud.
Specimen Label: 2 - Category 3
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:6450207
Assay Type: RNA in situ
Annotation Date: 2020-08-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1678117
Pattern: Regionally restricted
Stage: TS17
Assay Id: MGI:6450524
Age: embryonic day 10.5
Note: Expressed in the distal.
Specimen Label: S7l E10.5
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:6506496
Assay Type: RNA in situ
Annotation Date: 2021-02-17
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:2840723
Stage: TS23
Assay Id: MGI:6506663
Age: embryonic day 15.5
Note: No expression is seen in the ureteric bud.
Specimen Label: 2 - Category 3
Detected: false
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:6450207
Assay Type: RNA in situ
Annotation Date: 2020-08-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1640817
Pattern: Regionally restricted
Stage: TS17
Assay Id: MGI:6450524
Age: embryonic day 10.5
Note: Expressed in the distal.
Specimen Label: S7l E10.5
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
Probe: MGI:6501789
Assay Type: RNA in situ
Annotation Date: 2021-01-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1640819
Pattern: Regionally restricted
Stage: TS19
Assay Id: MGI:6501958
Age: embryonic day 11.5
Image: 4b - E11.5
Note: Expression is seen in a subset of distal cells.
Specimen Label: 4b - E11.5
Detected: true
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
Probe: MGI:6501789
Assay Type: RNA in situ
Annotation Date: 2021-01-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1640817
Pattern: Regionally restricted
Stage: TS17
Assay Id: MGI:6501958
Age: embryonic day 10.5
Image: 4b - E10.5
Note: Expression is seen in a subset of distal cells.
Specimen Label: 4b - E10.5
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:1750328
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692931
Age: postnatal adult
Image: HMGU_1366534
Specimen Label: HMGU_1366534
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1750328
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692931
Age: postnatal adult
Image: HMGU_692071
Specimen Label: HMGU_692071
Detected: true
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:6501789
Assay Type: RNA in situ
Annotation Date: 2021-01-26
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1741220
Stage: TS20
Assay Id: MGI:6501958
Age: embryonic day 12.5
Image: 4b - E12.5
Note: Only rare expressing cells are seen at this stage.
Specimen Label: 4b - E12.5
Detected: false
Specimen Num: 3
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:6450207
Assay Type: RNA in situ
Annotation Date: 2020-08-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1725219
Pattern: Regionally restricted
Stage: TS19
Assay Id: MGI:6450524
Age: embryonic day 11.5
Note: Expressed in the distal.
Specimen Label: S7l E11.5
Detected: true
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:6506496
Assay Type: RNA in situ
Annotation Date: 2021-02-17
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:2760524
Stage: TS24
Assay Id: MGI:6506663
Age: embryonic day 16.5
Specimen Label: not shown
Detected: false
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:6450207
Assay Type: RNA in situ
Annotation Date: 2020-08-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1724819
Pattern: Regionally restricted
Stage: TS19
Assay Id: MGI:6450524
Age: embryonic day 11.5
Note: Expressed in the distal.
Specimen Label: S7l E11.5
Detected: true
Specimen Num: 2
•
•
•
•
•
Publication
33297480 | J:297656
 
First Author: Desanlis I
Year: 2020
Journal: J Dev Biol
Title: Transcriptional Trajectories in Mouse Limb Buds Reveal the Transition from Anterior-Posterior to Proximal-Distal Patterning at Early Limb Bud Stage.
Volume: 8
Issue: 4
•
•
•
•
•
Publication
17065330 | J:116542
First Author: Georgia S
Year: 2006
Journal: Diabetes
Title: p27 Regulates the transition of beta-cells from quiescence to proliferation.
Volume: 55
Issue: 11
Pages: 2950-6
•
•
•
•
•
Publication
30787437 | J:274320
First Author: Cao J
Year: 2019
Journal: Nature
Title: The single-cell transcriptional landscape of mammalian organogenesis.
Volume: 566
Issue: 7745
Pages: 496-502
•
•
•
•
•
Publication
17222338 | J:119908
 
First Author: Wells JM
Year: 2007
Journal: BMC Dev Biol
Title: Wnt/beta-catenin signaling is required for development of the exocrine pancreas.
Volume: 7
Pages: 4
•
•
•
•
•
Publication
20857084 | J:164654
First Author: Valtat B
Year: 2011
Journal: Diabetologia
Title: Genetic evidence of the programming of beta cell mass and function by glucocorticoids in mice.
Volume: 54
Issue: 2
Pages: 350-9
•
•
•
•
•
Publication
25063451 | J:214089
First Author: Hale MA
Year: 2014
Journal: Development
Title: The nuclear hormone receptor family member NR5A2 controls aspects of multipotent progenitor cell formation and acinar differentiation during pancreatic organogenesis.
Volume: 141
Issue: 16
Pages: 3123-33
•
•
•
•
•
Publication
30135482 | J:266255
First Author: Scavuzzo MA
Year: 2018
Journal: Nat Commun
Title: Endocrine lineage biases arise in temporally distinct endocrine progenitors during pancreatic morphogenesis.
Volume: 9
Issue: 1
Pages: 3356
•
•
•
•
•
Publication
28705898 | J:243411
First Author: Rutledge EA
Year: 2017
Journal: Development
Title: Cellular heterogeneity in the ureteric progenitor niche and distinct profiles of branching morphogenesis in organ development.
Volume: 144
Issue: 17
Pages: 3177-3188
•
•
•
•
•
Publication
- | J:238766
     
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
•
•
•
•
•
Publication
27626380 | J:236599
First Author: Dickinson ME
Year: 2016
Journal: Nature
Title: High-throughput discovery of novel developmental phenotypes.
Volume: 537
Issue: 7621
Pages: 508-514
•
•
•
•
•
Publication
- | J:81858
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: Data Curation Using Mouse Genome Assembly
•
•
•
•
•
Publication
24194600 | J:228563
First Author: Koscielny G
Year: 2014
Journal: Nucleic Acids Res
Title: The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data.
Volume: 42
Issue: Database issue
Pages: D802-9
•
•
•
•
•
Publication
- | J:204739
     
First Author: International Knockout Mouse Consortium
Year: 2014
Journal: Database Download
Title: MGI download of modified allele data from IKMC and creation of new knockout alleles
•
•
•
•
•
Publication
- | J:204812
     
First Author: International Mouse Strain Resource
Year: 2014
Journal: Database Download
Title: MGI download of germline transmission data for alleles from IMSR strain data
•
•
•
•
•
Publication
- | J:157065
     
First Author: Helmholtz Zentrum Muenchen GmbH
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu)
•
•
•
•
•
Publication
- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
•
•
•
•
•
Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
•
•
•
•
•
Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
•
•
•
•
•
Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
•
•
•
•
•
Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
•
•
•
•
•
Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
•
•
•
•
•
Publication
- | J:164563
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
•
•
•
•
•
Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
•
•
•
•
•
Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
•
•
•
•
•
Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
•
•
•
•
•
Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
•
•
•
•
•
Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
•
•
•
•
•
Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
•
•
•
•
•
Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
•
•
•
•
•
Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
•
•
•
•
•
Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
•
•
•
•
•
Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
•
•
•
•
•
Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
•
•
•
•
•
Allele
Cpa2<em1Smoc> | MGI:7289112
Name: carboxypeptidase A2, pancreatic; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
•
•
•
•
•
Publication
26324901 | J:226919
First Author: Chintapalli VR
Year: 2015
Journal: Proc Natl Acad Sci U S A
Title: Transport proteins NHA1 and NHA2 are essential for survival, but have distinct transport modalities.
Volume: 112
Issue: 37
Pages: 11720-5
•
•
•
•
•
Publication
37554015 | J:341163
First Author: Holling T
Year: 2023
Journal: J Bone Miner Res
Title: TMCO3, a Putative K(+) :Proton Antiporter at the Golgi Apparatus, Is Important for Longitudinal Growth in Mice and Humans.
Volume: 38
Issue: 9
Pages: 1334-1349
•
•
•
•
•
Publication
11455960 | J:70943
First Author: Liu Q
Year: 2000
Journal: Mol Biol Rep
Title: Cloning, tissue expression pattern and genomic organization of latexin, a human homologue of rat carboxypeptidase A inhibitor.
Volume: 27
Issue: 4
Pages: 241-6
•
•
•
•
•
Publication
10698712 | -
 
First Author: Uratani Y
Year: 2000
Journal: Biochem J
Title: Latexin, a carboxypeptidase A inhibitor, is expressed in rat peritoneal mast cells and is associated with granular structures distinct from secretory granules and lysosomes.
Volume: 346 Pt 3
Pages: 817-26
•
•
•
•
•
Publication
12952168 | -
 
First Author: Hincke MT
Year: 2003
Journal: Connect Tissue Res
Title: Purification of ovocalyxin-32, a novel chicken eggshell matrix protein.
Volume: 44 Suppl 1
Pages: 16-9
•
•
•
•
•
Publication
11929948 | -
First Author: Jing C
Year: 2002
Journal: J Natl Cancer Inst
Title: Tazarotene-induced gene 1 (TIG1) expression in prostate carcinomas and its relationship to tumorigenicity.
Volume: 94
Issue: 7
Pages: 482-90
•
•
•
•
•
Publication
2957359 | -
First Author: Bakker EP
Year: 1987
Journal: J Bacteriol
Title: High-affinity potassium uptake system in Bacillus acidocaldarius showing immunological cross-reactivity with the Kdp system from Escherichia coli.
Volume: 169
Issue: 9
Pages: 4342-8
•
•
•
•
•
Publication
1312090 | -
First Author: Waser M
Year: 1992
Journal: J Biol Chem
Title: Cloning and disruption of a putative NaH-antiporter gene of Enterococcus hirae.
Volume: 267
Issue: 8
Pages: 5396-400
•
•
•
•
•
Publication
1325937 | -
First Author: Reizer J
Year: 1992
Journal: FEMS Microbiol Lett
Title: The putative Na+/H+ antiporter (NapA) of Enterococcus hirae is homologous to the putative K+/H+ antiporter (KefC) of Escherichia coli.
Volume: 73
Issue: 1-2
Pages: 161-3
•
•
•
•
•
Publication
7934942 | -
First Author: Ferguson GP
Year: 1993
Journal: Mol Microbiol
Title: Activation of potassium channels during metabolite detoxification in Escherichia coli.
Volume: 9
Issue: 6
Pages: 1297-303
•
•
•
•
•
Publication
9023177 | -
First Author: Ferguson GP
Year: 1997
Journal: J Bacteriol
Title: Survival during exposure to the electrophilic reagent N-ethylmaleimide in Escherichia coli: role of KefB and KefC potassium channels.
Volume: 179
Issue: 4
Pages: 1007-12
•
•
•
•
•
Publication
9489668 | -
First Author: MacLean MJ
Year: 1998
Journal: Mol Microbiol
Title: The role of glyoxalase I in the detoxification of methylglyoxal and in the activation of the KefB K+ efflux system in Escherichia coli.
Volume: 27
Issue: 3
Pages: 563-71
•
•
•
•
•
Protein Domain
IPR009684 | Prot_inh_latexin
Type: Family
Description: This family consists of several animal specific latexin and proteins related to latexin that belong to MEROPS proteinase inhibitor family I47, clan I- []. Latexin, a protein possessing inhibitory activity against rat carboxypeptidase A1 (CPA1) and CPA2 (MEROPS peptidase family M14A), is expressed in a neuronal subset in the cerebral cortexand cells in other neural and non-neural tissues of rat [, ]. OCX-32, the 32kDa eggshell matrix protein, is present at high levels in the uterine fluid during the terminal phase of eggshell formation, and is localised predominantly in the outer eggshell. The timing of OCX-32 secretion into the uterine fluid suggests that it may play a role in the termination of mineral deposition []. OCX-32 protein possesses limited identity (32%) to two unrelated proteins: latexin and to a skin protein that is encoded by a retinoic acid receptor-responsive gene, TIG1. Tazarotene Induced Gene 1 (TIG1) is a putative 228 transmembrane protein with a small N-terminal intracellular region, a single membrane-spanning hydrophobic region, and a large C-terminal extracellular region containing a glycosylation signal. TIG1 is up-regulated by retinoic acid receptor but not by retinoid X receptor-specific synthetic retinoids []. TIG1 may be a tumour suppressor gene whose diminished expression is involved in the malignant progression of prostate cancer [].
•
•
•
•
•
Protein Domain
IPR020884 | K_H_efflux_KefB
Type: Family
Description: The CPA2 family is a moderately large family (over 100 sequenced members) from bacteria, archaea and eukaryotes. Among the functionally well-characterised members of the family are (1) the KefB/KefC K+ efflux proteins of Escherichia coli which may be capable of catalysing both K+/H+ antiport and K+ uniport, depending on conditions [, ], (2) the Na+/H+ antiporter of Enterococcus hirae []and (3) the K+/H+ antiporter of Saccharomyces cerevisiae. It has been proposed that under normal physiological conditions, these proteins may function by essentially the same mechanism [].KefC and KefB of E. coli are responsible for glutathione-gated K+ efflux [, ]. Each of these proteins consists of a transmembrane hydrophobic N-terminal domain, and a less well-conserved C-terminal hydrophilic domain. Each protein interacts with a second protein encoded by genes that overlap the gene encoding the primary transporter. The KefB ancillary protein is YheR. The ancillary proteins stimulate transport activity about 10-fold []. They are important for cell survival during exposure to toxic metabolites, possibly because they can release K+, allowing H+ uptake. Activation of the KefB or KefC K+ efflux system only occurs in the presence of glutathione and a reactive electrophile such as methylglyoxal or N-ethylmaleimide. Formation of the methylglyoxal-glutathione conjugate, S-lactoylglutathione, is catalysed by glyoxalase I, and S-lactoylglutathione activates KefB and KefC []. H+ uptake (acidification of the cytoplasm) accompanying or following K+ efflux may serve as a further protective mechanism against electrophile toxicity [, ]. Inhibition of transport by glutathione is enhanced by NADH []. This entry represents the Glutathione-regulated potassium-efflux system protein KefB.
•
•
•
•
•
Publication
8601727 | -
First Author: Nagpal S
Year: 1996
Journal: J Invest Dermatol
Title: Tazarotene-induced gene 1 (TIG1), a novel retinoic acid receptor-responsive gene in skin.
Volume: 106
Issue: 2
Pages: 269-74
•
•
•
•
•
Protein
P70202
Organism: Mus musculus/domesticus
Length: 222  
Fragment?: false
•
•
•
•
•
Protein
F6ZIS7
Organism: Mus musculus/domesticus
Length: 283  
Fragment?: false
•
•
•
•
•
Protein
Q8BVL6
Organism: Mus musculus/domesticus
Length: 319  
Fragment?: true
•
•
•
•
•
Protein
Q14BZ3
Organism: Mus musculus/domesticus
Length: 222  
Fragment?: false
•
•
•
•
•
Publication
17679694 | -
First Author: Fujisawa M
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: Three two-component transporters with channel-like properties have monovalent cation/proton antiport activity.
Volume: 104
Issue: 33
Pages: 13289-94
•
•
•
•
•
Publication
11053405 | -
First Author: Miller S
Year: 2000
Journal: J Bacteriol
Title: Identification of an ancillary protein, YabF, required for activity of the KefC glutathione-gated potassium efflux system in Escherichia coli.
Volume: 182
Issue: 22
Pages: 6536-40
•
•
•
•
•
Publication
2046548 | -
First Author: Munro AW
Year: 1991
Journal: Mol Microbiol
Title: The cloning and DNA sequence of the gene for the glutathione-regulated potassium-efflux system KefC of Escherichia coli.
Volume: 5
Issue: 3
Pages: 607-16
•
•
•
•
•
Publication
2982857 | -
First Author: Zalkin H
Year: 1985
Journal: J Biol Chem
Title: Identification of a trpG-related glutamine amide transfer domain in Escherichia coli GMP synthetase.
Volume: 260
Issue: 6
Pages: 3350-4
•
•
•
•
•
Protein Domain
IPR017926 | GATASE
Type: Domain
Description: Glutamine amidotransferase (GATase) enzymes catalyse the removal of the ammonia group from glutamine and then transfer this group to a substrate to form a new carbon-nitrogen group []. The GATase domain exists either as a separate polypeptidic subunit or as part of a larger polypeptide fused in different ways to a synthase domain. Two classes of GATase domains have been identified [, ]: class-I (also known as trpG-type or triad) and class-II (also known as purF-type or Ntn). Class-I (or type 1) GATase domains have been found in the following enzymes:The second component of anthranilate synthase (AS) []. AS catalyzes the biosynthesis of anthranilate from chorismate and glutamine. AS is generally a dimeric enzyme: the first component can synthesize anthranilate using ammonia rather than glutamine, whereas component II provides the GATase activity []. In some bacteria and in fungi the GATase component of AS is part of a multifunctional protein that also catalyzes other steps of the biosynthesis of tryptophan.The second component of 4-amino-4-deoxychorismate (ADC) synthase, a dimeric prokaryotic enzyme that functions in the pathway that catalyzes the biosynthesis of para-aminobenzoate (PABA) from chorismate and glutamine. The second component (gene pabA) provides the GATase activity [].CTP synthase. CTP synthase catalyzes the final reaction in the biosynthesis of pyrimidine, the ATP-dependent formation of CTP from UTP and glutamine. CTP synthase is a single chain enzyme that contains two distinct domains; the GATase domain is in the C-terminal section [].GMP synthase (glutamine-hydrolyzing). GMP synthase catalyzes the ATP-dependent formation of GMP from xanthosine 5'-phosphate and glutamine. GMP synthase is a single chain enzyme that contains two distinct domains; the GATase domain is in the N-terminal section [, ].Glutamine-dependent carbamoyl-phosphate synthase (GD-CPSase); an enzyme involved in both arginine and pyrimidine biosynthesis and which catalyzes the ATP-dependent formation of carbamoyl phosphate from glutamine and carbon dioxide. In bacteria GD-CPSase is composed of two subunits: the large chain (gene carB) provides the CPSase activity, while the small chain (gene carA) provides the GATase activity. In yeast the enzyme involved in arginine biosynthesis is also composed of two subunits: CPA1 (GATase), and CPA2 (CPSase). In most eukaryotes, the first three steps of pyrimidine biosynthesis are catalyzed by a large multifunctional enzyme (called URA2 in yeast, rudimentary in Drosophila, and CAD in mammals). The GATase domain is located at the N-terminal extremity of this polyprotein [].Phosphoribosylformylglycinamidine synthase, an enzyme that catalyzes the fourth step in the de novo biosynthesis of purines. In some species of bacteria and rchaea, FGAM synthase II is composed of two subunits: a small chain (gene purQ) which provides the GATase activity and a large chain (gene purL) which provides the aminator activity. In eukaryotes and Gram-negative bacteria a single polypeptide (large type of purL) contains a FGAM synthethase domain and the GATase as the C-terminal domain [].Imidazole glycerol phosphate synthase subunit hisH, an enzyme that catalyzes the fifth step in the biosynthesis of histidine.A triad of conserved Cys-His-Glu forms the active site, wherein the catalytic cysteine is essential for the amidotransferase activity [, ]. Different structures show that the active site Cys of type 1 GATase is located at the tip of a nucleophile elbow.
•
•
•
•
•
Protein
A2AEQ5
Organism: Mus musculus/domesticus
Length: 151  
Fragment?: false
•
•
•
•
•
Protein
Q3THK7
Organism: Mus musculus/domesticus
Length: 693  
Fragment?: false
•
•
•
•
•
Protein
P70698
Organism: Mus musculus/domesticus
Length: 591  
Fragment?: false
•
•
•
•
•




MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

© 2002 - 2017 Department of Genetics, University of Cambridge, Downing Street,
Cambridge CB2 3EH, United Kingdom