Type |
Details |
Score |
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
dog, domestic |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chimpanzee |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chicken |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
zebrafish |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus caroli |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus pahari |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus spretus |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6506496 |
Assay Type: |
RNA in situ |
Annotation Date: |
2021-02-17 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1737323 |
Pattern: |
Regionally restricted |
Stage: |
TS23 |
Assay Id: |
MGI:6506663 |
Age: |
embryonic day 15.5 |
|
Note: |
All detected expression is outside the ureteric bud. |
Specimen Label: |
2 - Category 3 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6450207 |
Assay Type: |
RNA in situ |
Annotation Date: |
2020-08-18 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1678117 |
Pattern: |
Regionally restricted |
Stage: |
TS17 |
Assay Id: |
MGI:6450524 |
Age: |
embryonic day 10.5 |
|
Note: |
Expressed in the distal. |
Specimen Label: |
S7l E10.5 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6506496 |
Assay Type: |
RNA in situ |
Annotation Date: |
2021-02-17 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:2840723 |
|
Stage: |
TS23 |
Assay Id: |
MGI:6506663 |
Age: |
embryonic day 15.5 |
|
Note: |
No expression is seen in the ureteric bud. |
Specimen Label: |
2 - Category 3 |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6450207 |
Assay Type: |
RNA in situ |
Annotation Date: |
2020-08-18 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1640817 |
Pattern: |
Regionally restricted |
Stage: |
TS17 |
Assay Id: |
MGI:6450524 |
Age: |
embryonic day 10.5 |
|
Note: |
Expressed in the distal. |
Specimen Label: |
S7l E10.5 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6501789 |
Assay Type: |
RNA in situ |
Annotation Date: |
2021-01-26 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1640819 |
Pattern: |
Regionally restricted |
Stage: |
TS19 |
Assay Id: |
MGI:6501958 |
Age: |
embryonic day 11.5 |
Image: |
4b - E11.5 |
Note: |
Expression is seen in a subset of distal cells. |
Specimen Label: |
4b - E11.5 |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6501789 |
Assay Type: |
RNA in situ |
Annotation Date: |
2021-01-26 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1640817 |
Pattern: |
Regionally restricted |
Stage: |
TS17 |
Assay Id: |
MGI:6501958 |
Age: |
embryonic day 10.5 |
Image: |
4b - E10.5 |
Note: |
Expression is seen in a subset of distal cells. |
Specimen Label: |
4b - E10.5 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2021-04-16 |
Strength: |
Present |
Sex: |
Female |
Emaps: |
EMAPS:1750328 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6692931 |
Age: |
postnatal adult |
Image: |
HMGU_1366534 |
|
Specimen Label: |
HMGU_1366534 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2021-04-16 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1750328 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6692931 |
Age: |
postnatal adult |
Image: |
HMGU_692071 |
|
Specimen Label: |
HMGU_692071 |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6501789 |
Assay Type: |
RNA in situ |
Annotation Date: |
2021-01-26 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1741220 |
|
Stage: |
TS20 |
Assay Id: |
MGI:6501958 |
Age: |
embryonic day 12.5 |
Image: |
4b - E12.5 |
Note: |
Only rare expressing cells are seen at this stage. |
Specimen Label: |
4b - E12.5 |
Detected: |
false |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6450207 |
Assay Type: |
RNA in situ |
Annotation Date: |
2020-08-18 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1725219 |
Pattern: |
Regionally restricted |
Stage: |
TS19 |
Assay Id: |
MGI:6450524 |
Age: |
embryonic day 11.5 |
|
Note: |
Expressed in the distal. |
Specimen Label: |
S7l E11.5 |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6506496 |
Assay Type: |
RNA in situ |
Annotation Date: |
2021-02-17 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:2760524 |
|
Stage: |
TS24 |
Assay Id: |
MGI:6506663 |
Age: |
embryonic day 16.5 |
|
|
Specimen Label: |
not shown |
Detected: |
false |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6450207 |
Assay Type: |
RNA in situ |
Annotation Date: |
2020-08-18 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1724819 |
Pattern: |
Regionally restricted |
Stage: |
TS19 |
Assay Id: |
MGI:6450524 |
Age: |
embryonic day 11.5 |
|
Note: |
Expressed in the distal. |
Specimen Label: |
S7l E11.5 |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
Publication |
First Author: |
Georgia S |
Year: |
2006 |
Journal: |
Diabetes |
Title: |
p27 Regulates the transition of beta-cells from quiescence to proliferation. |
Volume: |
55 |
Issue: |
11 |
Pages: |
2950-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Desanlis I |
Year: |
2020 |
Journal: |
J Dev Biol |
Title: |
Transcriptional Trajectories in Mouse Limb Buds Reveal the Transition from Anterior-Posterior to Proximal-Distal Patterning at Early Limb Bud Stage. |
Volume: |
8 |
Issue: |
4 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Cao J |
Year: |
2019 |
Journal: |
Nature |
Title: |
The single-cell transcriptional landscape of mammalian organogenesis. |
Volume: |
566 |
Issue: |
7745 |
Pages: |
496-502 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wells JM |
Year: |
2007 |
Journal: |
BMC Dev Biol |
Title: |
Wnt/beta-catenin signaling is required for development of the exocrine pancreas. |
Volume: |
7 |
|
Pages: |
4 |
|
•
•
•
•
•
|
Publication |
First Author: |
Valtat B |
Year: |
2011 |
Journal: |
Diabetologia |
Title: |
Genetic evidence of the programming of beta cell mass and function by glucocorticoids in mice. |
Volume: |
54 |
Issue: |
2 |
Pages: |
350-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hale MA |
Year: |
2014 |
Journal: |
Development |
Title: |
The nuclear hormone receptor family member NR5A2 controls aspects of multipotent progenitor cell formation and acinar differentiation during pancreatic organogenesis. |
Volume: |
141 |
Issue: |
16 |
Pages: |
3123-33 |
|
•
•
•
•
•
|
Publication |
First Author: |
Martinez-Ramirez AS |
Year: |
2022 |
Journal: |
Gastro Hep Adv |
Title: |
Specific Temporal Requirement of Prox1 Activity During Pancreatic Acinar Cell Development. |
Volume: |
1 |
Issue: |
5 |
Pages: |
807-823 |
|
•
•
•
•
•
|
Publication |
First Author: |
Scavuzzo MA |
Year: |
2018 |
Journal: |
Nat Commun |
Title: |
Endocrine lineage biases arise in temporally distinct endocrine progenitors during pancreatic morphogenesis. |
Volume: |
9 |
Issue: |
1 |
Pages: |
3356 |
|
•
•
•
•
•
|
Publication |
First Author: |
Rutledge EA |
Year: |
2017 |
Journal: |
Development |
Title: |
Cellular heterogeneity in the ureteric progenitor niche and distinct profiles of branching morphogenesis in organ development. |
Volume: |
144 |
Issue: |
17 |
Pages: |
3177-3188 |
|
•
•
•
•
•
|
Publication |
First Author: |
Shanghai Model Organisms Center |
Year: |
2017 |
Journal: |
MGI Direct Data Submission |
Title: |
Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Dickinson ME |
Year: |
2016 |
Journal: |
Nature |
Title: |
High-throughput discovery of novel developmental phenotypes. |
Volume: |
537 |
Issue: |
7621 |
Pages: |
508-514 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2003 |
|
Title: |
Data Curation Using Mouse Genome Assembly |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Koscielny G |
Year: |
2014 |
Journal: |
Nucleic Acids Res |
Title: |
The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. |
Volume: |
42 |
Issue: |
Database issue |
Pages: |
D802-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
International Knockout Mouse Consortium |
Year: |
2014 |
Journal: |
Database Download |
Title: |
MGI download of modified allele data from IKMC and creation of new knockout alleles |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
International Mouse Strain Resource |
Year: |
2014 |
Journal: |
Database Download |
Title: |
MGI download of germline transmission data for alleles from IMSR strain data |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC) |
Year: |
2014 |
Journal: |
Database Release |
Title: |
Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Helmholtz Zentrum Muenchen GmbH |
Year: |
2010 |
Journal: |
MGI Direct Data Submission |
Title: |
Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu) |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
UniProt-GOA |
Year: |
2012 |
|
Title: |
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2003 |
|
Title: |
MGI Sequence Curation Reference |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Adams DJ |
Year: |
2024 |
Journal: |
Nature |
Title: |
Genetic determinants of micronucleus formation in vivo. |
Volume: |
627 |
Issue: |
8002 |
Pages: |
130-136 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zambrowicz BP |
Year: |
2003 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. |
Volume: |
100 |
Issue: |
24 |
Pages: |
14109-14 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI) |
Year: |
2008 |
Journal: |
Database Download |
Title: |
Mouse Gene Trap Data Load from dbGSS |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators |
Year: |
2011 |
|
Title: |
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
UniProt-GOA |
Year: |
2012 |
|
Title: |
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
GOA curators |
Year: |
2016 |
|
Title: |
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
The Gene Ontology Consortium |
Year: |
2010 |
|
Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
MGI Genome Annotation Group and UniGene Staff |
Year: |
2015 |
Journal: |
Database Download |
Title: |
MGI-UniGene Interconnection Effort |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
Year: |
2010 |
|
Title: |
Annotation inferences using phylogenetic trees |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
Year: |
2000 |
Journal: |
Database Release |
Title: |
Entrez Gene Load |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Allen Institute for Brain Science |
Year: |
2004 |
Journal: |
Allen Institute |
Title: |
Allen Brain Atlas: mouse riboprobes |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
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|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Group |
Year: |
2003 |
Journal: |
Database Procedure |
Title: |
Automatic Encodes (AutoE) Reference |
|
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|
|
•
•
•
•
•
|
Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
|
|
|
|
•
•
•
•
•
|
Allele |
Name: |
carboxypeptidase A2, pancreatic; endonuclease-mediated mutation 1, Shanghai Model Organisms Center |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
Strain |
Attribute String: |
coisogenic, endonuclease-mediated mutation, mutant strain |
|
•
•
•
•
•
|
Publication |
First Author: |
Chintapalli VR |
Year: |
2015 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Transport proteins NHA1 and NHA2 are essential for survival, but have distinct transport modalities. |
Volume: |
112 |
Issue: |
37 |
Pages: |
11720-5 |
|
•
•
•
•
•
|
Publication |
First Author: |
Holling T |
Year: |
2023 |
Journal: |
J Bone Miner Res |
Title: |
TMCO3, a Putative K(+) :Proton Antiporter at the Golgi Apparatus, Is Important for Longitudinal Growth in Mice and Humans. |
Volume: |
38 |
Issue: |
9 |
Pages: |
1334-1349 |
|
•
•
•
•
•
|
Publication |
First Author: |
Liu Q |
Year: |
2000 |
Journal: |
Mol Biol Rep |
Title: |
Cloning, tissue expression pattern and genomic organization of latexin, a human homologue of rat carboxypeptidase A inhibitor. |
Volume: |
27 |
Issue: |
4 |
Pages: |
241-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Uratani Y |
Year: |
2000 |
Journal: |
Biochem J |
Title: |
Latexin, a carboxypeptidase A inhibitor, is expressed in rat peritoneal mast cells and is associated with granular structures distinct from secretory granules and lysosomes. |
Volume: |
346 Pt 3 |
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Pages: |
817-26 |
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•
•
•
•
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Publication |
First Author: |
Hincke MT |
Year: |
2003 |
Journal: |
Connect Tissue Res |
Title: |
Purification of ovocalyxin-32, a novel chicken eggshell matrix protein. |
Volume: |
44 Suppl 1 |
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Pages: |
16-9 |
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•
•
•
•
•
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Publication |
First Author: |
Jing C |
Year: |
2002 |
Journal: |
J Natl Cancer Inst |
Title: |
Tazarotene-induced gene 1 (TIG1) expression in prostate carcinomas and its relationship to tumorigenicity. |
Volume: |
94 |
Issue: |
7 |
Pages: |
482-90 |
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•
•
•
•
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Publication |
First Author: |
Bakker EP |
Year: |
1987 |
Journal: |
J Bacteriol |
Title: |
High-affinity potassium uptake system in Bacillus acidocaldarius showing immunological cross-reactivity with the Kdp system from Escherichia coli. |
Volume: |
169 |
Issue: |
9 |
Pages: |
4342-8 |
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•
•
•
•
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Publication |
First Author: |
Waser M |
Year: |
1992 |
Journal: |
J Biol Chem |
Title: |
Cloning and disruption of a putative NaH-antiporter gene of Enterococcus hirae. |
Volume: |
267 |
Issue: |
8 |
Pages: |
5396-400 |
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•
•
•
•
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Publication |
First Author: |
Reizer J |
Year: |
1992 |
Journal: |
FEMS Microbiol Lett |
Title: |
The putative Na+/H+ antiporter (NapA) of Enterococcus hirae is homologous to the putative K+/H+ antiporter (KefC) of Escherichia coli. |
Volume: |
73 |
Issue: |
1-2 |
Pages: |
161-3 |
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•
•
•
•
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Publication |
First Author: |
Ferguson GP |
Year: |
1993 |
Journal: |
Mol Microbiol |
Title: |
Activation of potassium channels during metabolite detoxification in Escherichia coli. |
Volume: |
9 |
Issue: |
6 |
Pages: |
1297-303 |
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•
•
•
•
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Publication |
First Author: |
Ferguson GP |
Year: |
1997 |
Journal: |
J Bacteriol |
Title: |
Survival during exposure to the electrophilic reagent N-ethylmaleimide in Escherichia coli: role of KefB and KefC potassium channels. |
Volume: |
179 |
Issue: |
4 |
Pages: |
1007-12 |
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•
•
•
•
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Publication |
First Author: |
MacLean MJ |
Year: |
1998 |
Journal: |
Mol Microbiol |
Title: |
The role of glyoxalase I in the detoxification of methylglyoxal and in the activation of the KefB K+ efflux system in Escherichia coli. |
Volume: |
27 |
Issue: |
3 |
Pages: |
563-71 |
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•
•
•
•
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Protein Domain |
Type: |
Family |
Description: |
This family consists of several animal specific latexin and proteins related to latexin that belong to MEROPS proteinase inhibitor family I47, clan I- []. Latexin, a protein possessing inhibitory activity against rat carboxypeptidase A1 (CPA1) and CPA2 (MEROPS peptidase family M14A), is expressed in a neuronal subset in the cerebral cortexand cells in other neural and non-neural tissues of rat [, ]. OCX-32, the 32kDa eggshell matrix protein, is present at high levels in the uterine fluid during the terminal phase of eggshell formation, and is localised predominantly in the outer eggshell. The timing of OCX-32 secretion into the uterine fluid suggests that it may play a role in the termination of mineral deposition []. OCX-32 protein possesses limited identity (32%) to two unrelated proteins: latexin and to a skin protein that is encoded by a retinoic acid receptor-responsive gene, TIG1. Tazarotene Induced Gene 1 (TIG1) is a putative 228 transmembrane protein with a small N-terminal intracellular region, a single membrane-spanning hydrophobic region, and a large C-terminal extracellular region containing a glycosylation signal. TIG1 is up-regulated by retinoic acid receptor but not by retinoid X receptor-specific synthetic retinoids []. TIG1 may be a tumour suppressor gene whose diminished expression is involved in the malignant progression of prostate cancer []. |
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Protein Domain |
Type: |
Family |
Description: |
The CPA2 family is a moderately large family (over 100 sequenced members) from bacteria, archaea and eukaryotes. Among the functionally well-characterised members of the family are (1) the KefB/KefC K+ efflux proteins of Escherichia coli which may be capable of catalysing both K+/H+ antiport and K+ uniport, depending on conditions [, ], (2) the Na+/H+ antiporter of Enterococcus hirae []and (3) the K+/H+ antiporter of Saccharomyces cerevisiae. It has been proposed that under normal physiological conditions, these proteins may function by essentially the same mechanism [].KefC and KefB of E. coli are responsible for glutathione-gated K+ efflux [, ]. Each of these proteins consists of a transmembrane hydrophobic N-terminal domain, and a less well-conserved C-terminal hydrophilic domain. Each protein interacts with a second protein encoded by genes that overlap the gene encoding the primary transporter. The KefB ancillary protein is YheR. The ancillary proteins stimulate transport activity about 10-fold []. They are important for cell survival during exposure to toxic metabolites, possibly because they can release K+, allowing H+ uptake. Activation of the KefB or KefC K+ efflux system only occurs in the presence of glutathione and a reactive electrophile such as methylglyoxal or N-ethylmaleimide. Formation of the methylglyoxal-glutathione conjugate, S-lactoylglutathione, is catalysed by glyoxalase I, and S-lactoylglutathione activates KefB and KefC []. H+ uptake (acidification of the cytoplasm) accompanying or following K+ efflux may serve as a further protective mechanism against electrophile toxicity [, ]. Inhibition of transport by glutathione is enhanced by NADH []. This entry represents the Glutathione-regulated potassium-efflux system protein KefB. |
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Publication |
First Author: |
Nagpal S |
Year: |
1996 |
Journal: |
J Invest Dermatol |
Title: |
Tazarotene-induced gene 1 (TIG1), a novel retinoic acid receptor-responsive gene in skin. |
Volume: |
106 |
Issue: |
2 |
Pages: |
269-74 |
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•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
222
 |
Fragment?: |
false |
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•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
283
 |
Fragment?: |
false |
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•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
319
 |
Fragment?: |
true |
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•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
222
 |
Fragment?: |
false |
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•
•
•
•
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Publication |
First Author: |
Fujisawa M |
Year: |
2007 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Three two-component transporters with channel-like properties have monovalent cation/proton antiport activity. |
Volume: |
104 |
Issue: |
33 |
Pages: |
13289-94 |
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•
•
•
•
•
|
Publication |
First Author: |
Miller S |
Year: |
2000 |
Journal: |
J Bacteriol |
Title: |
Identification of an ancillary protein, YabF, required for activity of the KefC glutathione-gated potassium efflux system in Escherichia coli. |
Volume: |
182 |
Issue: |
22 |
Pages: |
6536-40 |
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•
•
•
•
•
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Publication |
First Author: |
Munro AW |
Year: |
1991 |
Journal: |
Mol Microbiol |
Title: |
The cloning and DNA sequence of the gene for the glutathione-regulated potassium-efflux system KefC of Escherichia coli. |
Volume: |
5 |
Issue: |
3 |
Pages: |
607-16 |
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•
•
•
•
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