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Search results 1 to 100 out of 219 for Crlf2

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Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: chicken
Gene
Type: gene
Organism: zebrafish
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: frog, western clawed
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: dog, domestic
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Publication      
First Author: Junco JJ
Year: 2022
Journal: Exp Hematol
Title: CRLF2 overexpression results in reduced B-cell differentiation and upregulated E2F signaling in the Dp16 mouse model of Down syndrome.
Protein
Organism: Mus musculus/domesticus
Length: 354  
Fragment?: false
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Park LS
Year: 2000
Journal: J Exp Med
Title: Cloning of the murine thymic stromal lymphopoietin (TSLP) receptor: Formation of a functional heteromeric complex requires interleukin 7 receptor.
Volume: 192
Issue: 5
Pages: 659-70
Publication
First Author: Pandey A
Year: 2000
Journal: Nat Immunol
Title: Cloning of a receptor subunit required for signaling by thymic stromal lymphopoietin.
Volume: 1
Issue: 1
Pages: 59-64
Publication
First Author: Malinczak CA
Year: 2024
Journal: Am J Physiol Lung Cell Mol Physiol
Title: Early-life pulmonary viral infection leads to long-term functional and lower airway structural changes in the lungs.
Volume: 326
Issue: 3
Pages: L280-L291
Publication
First Author: Zhou B
Year: 2005
Journal: Nat Immunol
Title: Thymic stromal lymphopoietin as a key initiator of allergic airway inflammation in mice.
Volume: 6
Issue: 10
Pages: 1047-53
Publication
First Author: Astrakhan A
Year: 2007
Journal: Nat Immunol
Title: Local increase in thymic stromal lymphopoietin induces systemic alterations in B cell development.
Volume: 8
Issue: 5
Pages: 522-31
Publication
First Author: Nishiura H
Year: 2012
Journal: J Immunol
Title: Increased susceptibility to autoimmune gastritis in thymic stromal lymphopoietin receptor-deficient mice.
Volume: 188
Issue: 1
Pages: 190-7
Publication  
First Author: Zhu Z
Year: 2011
Journal: Sci Rep
Title: The Role of TSLP in IL-13-induced atopic march.
Volume: 1
Pages: 23
Publication
First Author: Ragonnaud E
Year: 2019
Journal: Cancer Res
Title: Tumor-Derived Thymic Stromal Lymphopoietin Expands Bone Marrow B-cell Precursors in Circulation to Support Metastasis.
Volume: 79
Issue: 22
Pages: 5826-5838
Publication
First Author: Lay MK
Year: 2015
Journal: Eur J Immunol
Title: Human metapneumovirus infection activates the TSLP pathway that drives excessive pulmonary inflammation and viral replication in mice.
Volume: 45
Issue: 6
Pages: 1680-95
Publication  
First Author: Boieri M
Year: 2022
Journal: Front Cell Dev Biol
Title: Thymic stromal lymphopoietin-stimulated CD4(+) T cells induce senescence in advanced breast cancer.
Volume: 10
Pages: 1002692
Publication
First Author: Oh MH
Year: 2011
Journal: J Immunol
Title: IL-13 induces skin fibrosis in atopic dermatitis by thymic stromal lymphopoietin.
Volume: 186
Issue: 12
Pages: 7232-42
Publication  
First Author: Ye L
Year: 2021
Journal: Front Immunol
Title: Interferon-λ Improves the Efficacy of Intranasally or Rectally Administered Influenza Subunit Vaccines by a Thymic Stromal Lymphopoietin-Dependent Mechanism.
Volume: 12
Pages: 749325
Publication
First Author: Wikman L
Year: 2005
Journal: Mol Immunol
Title: The murine thymic stromal lymphopoietin receptor is partially expressed with an extracellular C-terminus.
Volume: 42
Issue: 1
Pages: 49-54
Publication
First Author: Blagoev B
Year: 2002
Journal: Gene
Title: Cloning of rat thymic stromal lymphopoietin receptor (TSLPR) and characterization of genomic structure of murine Tslpr gene.
Volume: 284
Issue: 1-2
Pages: 161-8
GXD Expression    
Probe: MGI:5001517
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Male
Emaps: EMAPS:2769723
Stage: TS23
Assay Id: MGI:5542071
Age: embryonic day 15.5
Image: GUDMAP:8510
Specimen Label: GUDMAP:8510
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:5001517
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Female
Emaps: EMAPS:2769723
Stage: TS23
Assay Id: MGI:5542071
Age: embryonic day 15.5
Image: GUDMAP:8684
Specimen Label: GUDMAP:8684
Detected: false
Specimen Num: 2
GXD Expression    
Probe: MGI:5001517
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Male
Emaps: EMAPS:2853323
Stage: TS23
Assay Id: MGI:5542071
Age: embryonic day 15.5
Image: GUDMAP:8510
Specimen Label: GUDMAP:8510
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:5001517
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Male
Emaps: EMAPS:2845723
Stage: TS23
Assay Id: MGI:5542071
Age: embryonic day 15.5
Image: GUDMAP:8510
Specimen Label: GUDMAP:8510
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:5001517
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Female
Emaps: EMAPS:2845723
Stage: TS23
Assay Id: MGI:5542071
Age: embryonic day 15.5
Image: GUDMAP:8684
Specimen Label: GUDMAP:8684
Detected: false
Specimen Num: 2
GXD Expression    
Probe: MGI:5001517
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Male
Emaps: EMAPS:1795023
Stage: TS23
Assay Id: MGI:5542071
Age: embryonic day 15.5
Image: GUDMAP:8510
Specimen Label: GUDMAP:8510
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:5001517
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Female
Emaps: EMAPS:1795023
Stage: TS23
Assay Id: MGI:5542071
Age: embryonic day 15.5
Image: GUDMAP:8684
Specimen Label: GUDMAP:8684
Detected: false
Specimen Num: 2
GXD Expression    
Probe: MGI:5001517
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Male
Emaps: EMAPS:1869223
Stage: TS23
Assay Id: MGI:5542071
Age: embryonic day 15.5
Image: GUDMAP:8510
Specimen Label: GUDMAP:8510
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:5001517
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Female
Emaps: EMAPS:2854023
Stage: TS23
Assay Id: MGI:5542071
Age: embryonic day 15.5
Image: GUDMAP:8684
Specimen Label: GUDMAP:8684
Detected: false
Specimen Num: 2
GXD Expression    
Probe: MGI:5001517
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Male
Emaps: EMAPS:2762123
Stage: TS23
Assay Id: MGI:5542071
Age: embryonic day 15.5
Image: GUDMAP:8510
Specimen Label: GUDMAP:8510
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:5001517
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Female
Emaps: EMAPS:2762123
Stage: TS23
Assay Id: MGI:5542071
Age: embryonic day 15.5
Image: GUDMAP:8684
Specimen Label: GUDMAP:8684
Detected: false
Specimen Num: 2
GXD Expression    
Probe: MGI:5001517
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Male
Emaps: EMAPS:1797223
Stage: TS23
Assay Id: MGI:5542071
Age: embryonic day 15.5
Image: GUDMAP:8510
Specimen Label: GUDMAP:8510
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:5001517
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Male
Emaps: EMAPS:1832123
Stage: TS23
Assay Id: MGI:5542071
Age: embryonic day 15.5
Image: GUDMAP:8510
Specimen Label: GUDMAP:8510
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:5001517
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Female
Emaps: EMAPS:1832123
Stage: TS23
Assay Id: MGI:5542071
Age: embryonic day 15.5
Image: GUDMAP:8684
Specimen Label: GUDMAP:8684
Detected: false
Specimen Num: 2
GXD Expression    
Probe: MGI:5001517
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Male
Emaps: EMAPS:2851823
Stage: TS23
Assay Id: MGI:5542071
Age: embryonic day 15.5
Image: GUDMAP:8510
Specimen Label: GUDMAP:8510
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:5001517
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Female
Emaps: EMAPS:2851823
Stage: TS23
Assay Id: MGI:5542071
Age: embryonic day 15.5
Image: GUDMAP:8684
Specimen Label: GUDMAP:8684
Detected: false
Specimen Num: 2
GXD Expression    
Probe: MGI:5001517
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Male
Emaps: EMAPS:2760523
Stage: TS23
Assay Id: MGI:5542071
Age: embryonic day 15.5
Image: GUDMAP:8510
Specimen Label: GUDMAP:8510
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:5001517
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Female
Emaps: EMAPS:2760523
Stage: TS23
Assay Id: MGI:5542071
Age: embryonic day 15.5
Image: GUDMAP:8684
Specimen Label: GUDMAP:8684
Detected: false
Specimen Num: 2
GXD Expression  
Probe: MGI:4416041
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1801023
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4824060
Age: embryonic day 14.5
Image: euxassay_010413_03
Specimen Label: euxassay_010413_03
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:4416041
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1801023
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4824060
Age: embryonic day 14.5
Image: euxassay_010413_04
Specimen Label: euxassay_010413_04
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:4416041
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1801023
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4824060
Age: embryonic day 14.5
Image: euxassay_010413_05
Specimen Label: euxassay_010413_05
Detected: true
Specimen Num: 3
GXD Expression  
Probe: MGI:4416041
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1801023
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4824060
Age: embryonic day 14.5
Image: euxassay_010413_16
Specimen Label: euxassay_010413_16
Detected: true
Specimen Num: 4
GXD Expression  
Probe: MGI:4416041
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1801023
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4824060
Age: embryonic day 14.5
Image: euxassay_010413_17
Specimen Label: euxassay_010413_17
Detected: true
Specimen Num: 5
GXD Expression  
Probe: MGI:4416041
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1801023
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4824060
Age: embryonic day 14.5
Image: euxassay_010413_18
Specimen Label: euxassay_010413_18
Detected: true
Specimen Num: 6
GXD Expression  
Probe: MGI:4416041
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1801023
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4824060
Age: embryonic day 14.5
Image: euxassay_010413_19
Specimen Label: euxassay_010413_19
Detected: true
Specimen Num: 7
GXD Expression  
Probe: MGI:4416041
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1801023
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4824060
Age: embryonic day 14.5
Image: euxassay_010413_20
Specimen Label: euxassay_010413_20
Detected: true
Specimen Num: 8
GXD Expression  
Probe: MGI:4416041
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1801023
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4824060
Age: embryonic day 14.5
Image: euxassay_010413_21
Specimen Label: euxassay_010413_21
Detected: true
Specimen Num: 9
GXD Expression    
Probe: MGI:5001517
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Male
Emaps: EMAPS:2852723
Stage: TS23
Assay Id: MGI:5542071
Age: embryonic day 15.5
Image: GUDMAP:8510
Specimen Label: GUDMAP:8510
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:5001517
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Female
Emaps: EMAPS:2852723
Stage: TS23
Assay Id: MGI:5542071
Age: embryonic day 15.5
Image: GUDMAP:8684
Specimen Label: GUDMAP:8684
Detected: false
Specimen Num: 2
GXD Expression    
Probe: MGI:5001517
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Female
Emaps: EMAPS:2874723
Stage: TS23
Assay Id: MGI:5542071
Age: embryonic day 15.5
Image: GUDMAP:8684
Specimen Label: GUDMAP:8684
Detected: false
Specimen Num: 2
GXD Expression    
Probe: MGI:5001517
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Male
Emaps: EMAPS:2850023
Stage: TS23
Assay Id: MGI:5542071
Age: embryonic day 15.5
Image: GUDMAP:8510
Specimen Label: GUDMAP:8510
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:5001517
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Female
Emaps: EMAPS:2850023
Stage: TS23
Assay Id: MGI:5542071
Age: embryonic day 15.5
Image: GUDMAP:8684
Specimen Label: GUDMAP:8684
Detected: false
Specimen Num: 2
GXD Expression    
Probe: MGI:5001517
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Female
Emaps: EMAPS:1796223
Stage: TS23
Assay Id: MGI:5542071
Age: embryonic day 15.5
Image: GUDMAP:8684
Specimen Label: GUDMAP:8684
Detected: false
Specimen Num: 2
Publication
First Author: Verstraete K
Year: 2014
Journal: Nat Struct Mol Biol
Title: Structural basis of the proinflammatory signaling complex mediated by TSLP.
Volume: 21
Issue: 4
Pages: 375-82
Publication
First Author: Zhang Y
Year: 2012
Journal: Eur J Immunol
Title: DC-derived TSLP promotes Th2 polarization in LPS-primed allergic airway inflammation.
Volume: 42
Issue: 7
Pages: 1735-43
Publication
First Author: Shane HL
Year: 2014
Journal: J Immunol
Title: A direct and nonredundant role for thymic stromal lymphopoietin on antiviral CD8 T cell responses in the respiratory mucosa.
Volume: 192
Issue: 5
Pages: 2261-70
Publication
First Author: Noti M
Year: 2013
Journal: Nat Med
Title: Thymic stromal lymphopoietin-elicited basophil responses promote eosinophilic esophagitis.
Volume: 19
Issue: 8
Pages: 1005-13
Publication      
First Author: Brandt EB
Year: 2023
Journal: J Allergy Clin Immunol
Title: Thymic stromal lymphopoietin rather than IL-33 drives food allergy after epicutaneous sensitization to food allergen.
Publication
First Author: Taylor BC
Year: 2009
Journal: J Exp Med
Title: TSLP regulates intestinal immunity and inflammation in mouse models of helminth infection and colitis.
Volume: 206
Issue: 3
Pages: 655-67
Publication
First Author: Noti M
Year: 2014
Journal: J Allergy Clin Immunol
Title: Exposure to food allergens through inflamed skin promotes intestinal food allergy through the thymic stromal lymphopoietin-basophil axis.
Volume: 133
Issue: 5
Pages: 1390-9, 1399.e1-6
Publication
First Author: Larson RP
Year: 2010
Journal: J Immunol
Title: Dibutyl phthalate-induced thymic stromal lymphopoietin is required for Th2 contact hypersensitivity responses.
Volume: 184
Issue: 6
Pages: 2974-84
Publication  
First Author: Li S
Year: 2019
Journal: JCI Insight
Title: TSLP protects against liver I/R injury via activation of the PI3K/Akt pathway.
Volume: 4
Issue: 22
Publication
First Author: Rochman Y
Year: 2008
Journal: J Immunol
Title: The role of thymic stromal lymphopoietin in CD8+ T cell homeostasis.
Volume: 181
Issue: 11
Pages: 7699-705
Publication
First Author: Olkhanud PB
Year: 2011
Journal: J Immunol
Title: Thymic stromal lymphopoietin is a key mediator of breast cancer progression.
Volume: 186
Issue: 10
Pages: 5656-62
Publication
First Author: Ochiai S
Year: 2018
Journal: Proc Natl Acad Sci U S A
Title: Thymic stromal lymphopoietin drives the development of IL-13+ Th2 cells.
Volume: 115
Issue: 5
Pages: 1033-1038
Publication
First Author: He R
Year: 2008
Journal: Proc Natl Acad Sci U S A
Title: TSLP acts on infiltrating effector T cells to drive allergic skin inflammation.
Volume: 105
Issue: 33
Pages: 11875-80
Publication
First Author: Ramalingam TR
Year: 2009
Journal: J Immunol
Title: Regulation of helminth-induced Th2 responses by thymic stromal lymphopoietin.
Volume: 182
Issue: 10
Pages: 6452-9
Publication
First Author: Lai JF
Year: 2020
Journal: J Allergy Clin Immunol
Title: TSLP drives acute TH2-cell differentiation in lungs.
Volume: 146
Issue: 6
Pages: 1406-1418.e7
Publication
First Author: Hiroyama T
Year: 2000
Journal: Biochem Biophys Res Commun
Title: Molecular cloning and characterization of CRLM-2, a novel type I cytokine receptor preferentially expressed in hematopoietic cells.
Volume: 272
Issue: 1
Pages: 224-9
Publication
First Author: Han H
Year: 2014
Journal: J Clin Invest
Title: Thymic stromal lymphopoietin-mediated epicutaneous inflammation promotes acute diarrhea and anaphylaxis.
Volume: 124
Issue: 12
Pages: 5442-52
Publication
First Author: Piliponsky AM
Year: 2016
Journal: Am J Respir Cell Mol Biol
Title: Thymic Stromal Lymphopoietin Improves Survival and Reduces Inflammation in Sepsis.
Volume: 55
Issue: 2
Pages: 264-74
Publication
First Author: Carpino N
Year: 2004
Journal: Mol Cell Biol
Title: Absence of an essential role for thymic stromal lymphopoietin receptor in murine B-cell development.
Volume: 24
Issue: 6
Pages: 2584-92
Publication    
First Author: Walsh CM
Year: 2019
Journal: Elife
Title: Neutrophils promote CXCR3-dependent itch in the development of atopic dermatitis.
Volume: 8
Publication
First Author: Siracusa MC
Year: 2013
Journal: Immunity
Title: Thymic stromal lymphopoietin-mediated extramedullary hematopoiesis promotes allergic inflammation.
Volume: 39
Issue: 6
Pages: 1158-70
Publication
First Author: Larson RP
Year: 2013
Journal: J Immunol
Title: Cutting edge: allergen-specific CD4 T cells respond indirectly to thymic stromal lymphopoietin to promote allergic responses in the skin.
Volume: 190
Issue: 9
Pages: 4474-7
Publication
First Author: Zaph C
Year: 2007
Journal: Nature
Title: Epithelial-cell-intrinsic IKK-beta expression regulates intestinal immune homeostasis.
Volume: 446
Issue: 7135
Pages: 552-6
Publication
First Author: Yao W
Year: 2013
Journal: Immunity
Title: Interleukin-9 is required for allergic airway inflammation mediated by the cytokine TSLP.
Volume: 38
Issue: 2
Pages: 360-72
Publication  
First Author: Wu C
Year: 2014
Journal: J Mol Cell Cardiol
Title: TSLPR deficiency attenuates atherosclerotic lesion development associated with the inhibition of TH17 cells and the promotion of regulator T cells in ApoE-deficient mice.
Volume: 76
Pages: 33-45