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Search results 1 to 100 out of 168 for Crybb2

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0.046s
Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: dog, domestic
Gene
Type: gene
Organism: chimpanzee
Gene
Type: gene
Organism: chicken
Gene
Type: gene
Organism: zebrafish
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: frog, western clawed
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: hamster, golden
Gene
Type: gene
Organism: rat
Protein Domain
Type: Family
Description: Beta-crystallins are the most abundant water-soluble proteins in the eye lens. Beta-crystallin B2 was first described as a structural protein of the ocular lens. Mutations in the beta-crystallin B2 gene (CRYBB2) are associated with congenital cataracts [, ]. However, beta-crystallin B2 is also expressed in several regions of the mammalian brain and has a role in hippocampal function and behavioral phenotypes in mice [].
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Publication
First Author: Sun M
Year: 2013
Journal: Mamm Genome
Title: Crybb2 coding for βB2-crystallin affects sensorimotor gating and hippocampal function.
Volume: 24
Issue: 9-10
Pages: 333-48
Publication
First Author: Litt M
Year: 1997
Journal: Hum Mol Genet
Title: Autosomal dominant cerulean cataract is associated with a chain termination mutation in the human beta-crystallin gene CRYBB2.
Volume: 6
Issue: 5
Pages: 665-8
Publication
First Author: Gao Q
Year: 2014
Journal: Biochem Biophys Res Commun
Title: Crybb2 deficiency impairs fertility in female mice.
Volume: 453
Issue: 1
Pages: 37-42
Publication      
First Author: Heermann T
Year: 2018
Journal: Mol Neurobiol
Title: Crybb2 Mutations Consistently Affect Schizophrenia Endophenotypes in Mice.
Publication
First Author: Sun M
Year: 2018
Journal: Biochem Biophys Res Commun
Title: Crybb2 associates with Tmsb4X and is crucial for dendrite morphogenesis.
Volume: 503
Issue: 1
Pages: 123-130
Publication
First Author: Chen W
Year: 2013
Journal: PLoS One
Title: A missense mutation in CRYBB2 leads to progressive congenital membranous cataract by impacting the solubility and function of βB2-crystallin.
Volume: 8
Issue: 11
Pages: e81290
Publication
First Author: Ganguly K
Year: 2008
Journal: Invest Ophthalmol Vis Sci
Title: Novel allele of crybb2 in the mouse and its expression in the brain.
Volume: 49
Issue: 4
Pages: 1533-41
Publication
First Author: Kerscher S
Year: 1995
Journal: Genomics
Title: Mapping of four mouse genes encoding eye lens-specific structural, gap junction, and integral membrane proteins: Cryba1 (crystallin beta A3/A1), Crybb2 (crystallin beta B2), Gja8 (MP70), and Lim2 (MP19).
Volume: 29
Issue: 2
Pages: 445-50
Protein
Organism: Mus musculus/domesticus
Length: 205  
Fragment?: false
Publication
First Author: Zhang J
Year: 2008
Journal: Invest Ophthalmol Vis Sci
Title: Targeted knockout of the mouse betaB2-crystallin gene (Crybb2) induces age-related cataract.
Volume: 49
Issue: 12
Pages: 5476-83
Publication
First Author: Xiang F
Year: 2012
Journal: Int J Mol Med
Title: Decreased levels of Ca²⁺-calmodulin-dependent protein kinase IV in the testis as a contributing factor to reduced fertility in male Crybb2⁻/⁻ mice.
Volume: 30
Issue: 5
Pages: 1145-51
Publication
First Author: Graw J
Year: 2001
Journal: Invest Ophthalmol Vis Sci
Title: Aey2, a new mutation in the betaB2-crystallin-encoding gene of the mouse.
Volume: 42
Issue: 7
Pages: 1574-80
Publication
First Author: Gao Q
Year: 2016
Journal: Mol Med Rep
Title: Long non-coding RNAs regulate effects of β-crystallin B2 on mouse ovary development.
Volume: 14
Issue: 5
Pages: 4223-4231
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Chambers C
Year: 1991
Journal: J Biol Chem
Title: Deletion mutation in an eye lens beta-crystallin. An animal model for inherited cataracts.
Volume: 266
Issue: 11
Pages: 6742-6
Publication      
First Author: Hawes NL
Year: 2012
Journal: MGI Direct Data Submission
Title: Lens opacity 19, a spontaneous dominant mutation in beta 2 crystallin
Publication
First Author: Kador PF
Year: 1980
Journal: Exp Eye Res
Title: Philly mouse: a new model of hereditary cataract.
Volume: 30
Issue: 1
Pages: 59-68
Publication
First Author: Carper D
Year: 1986
Journal: Dev Biol
Title: Immunocytochemical localization of the 27K beta-crystallin polypeptide in the mouse lens during development using a specific monoclonal antibody: implications for cataract formation in the Philly mouse.
Volume: 113
Issue: 1
Pages: 104-9
Publication
First Author: Piatigorsky J
Year: 1980
Journal: Exp Eye Res
Title: Differential synthesis and degradation of protein in the hereditary Philly mouse cataract.
Volume: 30
Issue: 1
Pages: 69-78
Publication  
First Author: Duprey KM
Year: 2007
Journal: Mol Vis
Title: Subfertility in mice harboring a mutation in betaB2-crystallin.
Volume: 13
Pages: 366-73
Publication  
First Author: Zhang J
Year: 2006
Journal: Acad J Sec Mil Med Univ
Title: Establishment of a betaB2crystallin gene knockout mice model.
Volume: 27
Pages: 1246-1248
Publication
First Author: Magabo KS
Year: 2000
Journal: Invest Ophthalmol Vis Sci
Title: Expression of betaB(2)-crystallin mRNA and protein in retina, brain, and testis.
Volume: 41
Issue: 10
Pages: 3056-60
Publication
First Author: Zarbalis K
Year: 1996
Journal: Gene
Title: Sequence analysis of the beta B2-crystallin cDNA of hamster containing a domain conserved among vertebrates.
Volume: 174
Issue: 1
Pages: 181-4
GXD Expression    
Probe: MGI:2149571
Assay Type: RT-PCR
Annotation Date: 2001-09-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1619825
Stage: TS25
Assay Id: MGI:2149583
Age: embryonic day 17.5
Image: 4
Specimen Label: betaB2 E17.5 +/+ 1
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:2149571
Assay Type: RT-PCR
Annotation Date: 2001-09-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1619825
Stage: TS25
Assay Id: MGI:2149583
Age: embryonic day 17.5
Image: 4
Specimen Label: betaB2 E17.5 -/- 1
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:2149571
Assay Type: RT-PCR
Annotation Date: 2001-09-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1619825
Stage: TS25
Assay Id: MGI:2149583
Age: embryonic day 17.5
Image: 4
Specimen Label: betaB2 E17.5 +/- 1
Detected: true
Specimen Num: 7
GXD Expression      
Probe: MGI:2149571
Assay Type: RT-PCR
Annotation Date: 2009-05-27
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1619819
Stage: TS19
Assay Id: MGI:3845611
Age: embryonic day 11.5
Specimen Label: None
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:2149571
Assay Type: RT-PCR
Annotation Date: 2009-05-27
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1619819
Stage: TS19
Assay Id: MGI:3845611
Age: embryonic day 11.5
Specimen Label: None
Detected: false
Specimen Num: 2
GXD Expression      
Probe: MGI:2149571
Assay Type: RT-PCR
Annotation Date: 2009-05-27
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1619819
Stage: TS19
Assay Id: MGI:3845611
Age: embryonic day 11.5
Specimen Label: None
Detected: false
Specimen Num: 3
GXD Expression      
Probe: MGI:2149571
Assay Type: RT-PCR
Annotation Date: 2001-09-11
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:1619825
Stage: TS25
Assay Id: MGI:2149583
Age: embryonic day 17.5
Image: 4
Specimen Label: betaB2 E17.5 +/+ 1/10
Specimen Num: 2
GXD Expression      
Probe: MGI:2149571
Assay Type: RT-PCR
Annotation Date: 2001-09-11
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:1619825
Stage: TS25
Assay Id: MGI:2149583
Age: embryonic day 17.5
Image: 4
Specimen Label: betaB2 E17.5 +/+ 1/100
Specimen Num: 3
GXD Expression      
Probe: MGI:2149571
Assay Type: RT-PCR
Annotation Date: 2001-09-11
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:1619825
Stage: TS25
Assay Id: MGI:2149583
Age: embryonic day 17.5
Image: 4
Specimen Label: betaB2 E17.5 -/- 1/10
Specimen Num: 5
GXD Expression      
Probe: MGI:2149571
Assay Type: RT-PCR
Annotation Date: 2001-09-11
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:1619825
Stage: TS25
Assay Id: MGI:2149583
Age: embryonic day 17.5
Image: 4
Specimen Label: betaB2 E17.5 -/- 1/100
Specimen Num: 6
GXD Expression      
Probe: MGI:2149571
Assay Type: RT-PCR
Annotation Date: 2001-09-11
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:1619825
Stage: TS25
Assay Id: MGI:2149583
Age: embryonic day 17.5
Image: 4
Specimen Label: betaB2 E17.5 +/- 1/10
Specimen Num: 8
GXD Expression      
Probe: MGI:2149571
Assay Type: RT-PCR
Annotation Date: 2001-09-11
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:1619825
Stage: TS25
Assay Id: MGI:2149583
Age: embryonic day 17.5
Image: 4
Specimen Label: betaB2 E17.5 +/- 1/100
Specimen Num: 9
GXD Expression      
Probe: MGI:6402255
Assay Type: RT-PCR
Annotation Date: 2020-03-31
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1783828
Stage: TS28
Assay Id: MGI:6402257
Age: postnatal
Specimen Label: C3H Lens
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:6402255
Assay Type: RT-PCR
Annotation Date: 2020-03-31
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1783828
Stage: TS28
Assay Id: MGI:6402257
Age: postnatal
Specimen Label: O377 Lens
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:6402242
Assay Type: Western blot
Annotation Date: 2020-03-31
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1783828
Stage: TS28
Assay Id: MGI:6402260
Age: postnatal
Specimen Label: C3H Lens
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:7423676
Assay Type: RT-PCR
Annotation Date: 2023-01-09
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:1783826
Stage: TS26
Assay Id: MGI:7423682
Age: embryonic day 18.0
Image: 6
Specimen Label: E18
Specimen Num: 1
GXD Expression    
Probe: MGI:7423676
Assay Type: RT-PCR
Annotation Date: 2023-01-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1783827
Stage: TS27
Assay Id: MGI:7423682
Age: postnatal day 0
Image: 6
Specimen Label: P0
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:7423676
Assay Type: RT-PCR
Annotation Date: 2023-01-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1783827
Stage: TS27
Assay Id: MGI:7423682
Age: postnatal day 3
Image: 6
Specimen Label: P3
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:7423676
Assay Type: RT-PCR
Annotation Date: 2023-01-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1783828
Stage: TS28
Assay Id: MGI:7423682
Age: postnatal day 6
Image: 6
Specimen Label: P6
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:7423676
Assay Type: RT-PCR
Annotation Date: 2023-01-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1783828
Stage: TS28
Assay Id: MGI:7423682
Age: postnatal day 9
Image: 6
Specimen Label: P9
Detected: true
Specimen Num: 5
GXD Expression    
Probe: MGI:7423676
Assay Type: RT-PCR
Annotation Date: 2023-01-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1783828
Stage: TS28
Assay Id: MGI:7423682
Age: postnatal day 12
Image: 6
Specimen Label: P12
Detected: true
Specimen Num: 6
GXD Expression    
Probe: MGI:7423676
Assay Type: RT-PCR
Annotation Date: 2023-01-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1783828
Stage: TS28
Assay Id: MGI:7423682
Age: postnatal day 14
Image: 6
Specimen Label: P14
Detected: true
Specimen Num: 7
GXD Expression    
Probe: MGI:7423676
Assay Type: RT-PCR
Annotation Date: 2023-01-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1783828
Stage: TS28
Assay Id: MGI:7423682
Age: postnatal day 21
Image: 6
Specimen Label: P21
Detected: true
Specimen Num: 8
GXD Expression    
Probe: MGI:7423676
Assay Type: RT-PCR
Annotation Date: 2023-01-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1783828
Stage: TS28
Assay Id: MGI:7423682
Age: postnatal day 28
Image: 6
Specimen Label: P28
Detected: true
Specimen Num: 9
GXD Expression    
Probe: MGI:7423676
Assay Type: RT-PCR
Annotation Date: 2023-01-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1783828
Stage: TS28
Assay Id: MGI:7423682
Age: postnatal day 28
Image: 6
Specimen Label: P42
Detected: true
Specimen Num: 10
GXD Expression    
Probe: MGI:7423676
Assay Type: RT-PCR
Annotation Date: 2023-01-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1783828
Stage: TS28
Assay Id: MGI:7423682
Age: postnatal day 28
Image: 6
Specimen Label: P56
Detected: true
Specimen Num: 11
GXD Expression      
Probe: MGI:6402255
Assay Type: RT-PCR
Annotation Date: 2020-03-31
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:6402257
Age: postnatal
Specimen Label: C3H Brain
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:6402255
Assay Type: RT-PCR
Annotation Date: 2020-03-31
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:6402257
Age: postnatal
Specimen Label: O377 Brain
Detected: true
Specimen Num: 5
GXD Expression      
Probe: MGI:6402242
Assay Type: Western blot
Annotation Date: 2020-03-31
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:6402260
Age: postnatal
Specimen Label: C3H Brain
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:6402242
Assay Type: Western blot
Annotation Date: 2020-03-31
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:6402260
Age: postnatal
Specimen Label: O377 Lens
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:6402242
Assay Type: Western blot
Annotation Date: 2020-03-31
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:6402260
Age: postnatal
Specimen Label: O377 Brain
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:6402255
Assay Type: RT-PCR
Annotation Date: 2020-03-31
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689427
Stage: TS27
Assay Id: MGI:6402264
Age: postnatal day 1
Specimen Label: P1
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:6402255
Assay Type: RT-PCR
Annotation Date: 2020-03-31
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:6402264
Age: postnatal day 7
Specimen Label: P7
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:6402255
Assay Type: RT-PCR
Annotation Date: 2020-03-31
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:6402264
Age: postnatal day 14
Specimen Label: P14
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:6402255
Assay Type: RT-PCR
Annotation Date: 2020-03-31
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:6402264
Age: postnatal day 21
Specimen Label: P21
Detected: true
Specimen Num: 5
GXD Expression      
Probe: MGI:6402255
Assay Type: RT-PCR
Annotation Date: 2020-03-31
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:6402264
Age: postnatal day 28
Specimen Label: P28
Detected: true
Specimen Num: 6
GXD Expression      
Probe: MGI:6402255
Assay Type: RT-PCR
Annotation Date: 2020-03-31
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:6402264
Age: postnatal week 6
Specimen Label: 6wk
Detected: true
Specimen Num: 7
GXD Expression      
Probe: MGI:6402255
Assay Type: RT-PCR
Annotation Date: 2020-03-31
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:6402264
Age: postnatal month 8
Specimen Label: 8m
Detected: false
Specimen Num: 8
GXD Expression      
Probe: MGI:6402255
Assay Type: RT-PCR
Annotation Date: 2020-03-31
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689427
Stage: TS27
Assay Id: MGI:6402266
Age: postnatal day 1
Specimen Label: P1
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:6402255
Assay Type: RT-PCR
Annotation Date: 2020-03-31
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:6402266
Age: postnatal day 7
Specimen Label: P7
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:6402255
Assay Type: RT-PCR
Annotation Date: 2020-03-31
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:6402266
Age: postnatal day 14
Specimen Label: P14
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:6402255
Assay Type: RT-PCR
Annotation Date: 2020-03-31
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:6402266
Age: postnatal day 21
Specimen Label: P21
Detected: true
Specimen Num: 5
GXD Expression      
Probe: MGI:6402255
Assay Type: RT-PCR
Annotation Date: 2020-03-31
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:6402266
Age: postnatal day 28
Specimen Label: P28
Detected: true
Specimen Num: 6
GXD Expression      
Probe: MGI:6402255
Assay Type: RT-PCR
Annotation Date: 2020-03-31
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:6402266
Age: postnatal week 6
Specimen Label: 6wk
Detected: true
Specimen Num: 7
GXD Expression      
Probe: MGI:6402255
Assay Type: RT-PCR
Annotation Date: 2020-03-31
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:6402266
Age: postnatal month 8
Specimen Label: 8m
Detected: false
Specimen Num: 8
GXD Expression    
Probe: MGI:6402242
Assay Type: Immunohistochemistry
Annotation Date: 2020-03-31
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3519628
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6402244
Age: postnatal week 3
Specimen Label: 5K
Detected: true
Specimen Num: 7
GXD Expression    
Probe: MGI:6402242
Assay Type: Immunohistochemistry
Annotation Date: 2020-03-31
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3519628
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6402244
Age: postnatal week 3
Specimen Label: 5L
Detected: true
Specimen Num: 8