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Search results 1 to 97 out of 97 for Ctc1

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Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: chicken
Gene
Type: gene
Organism: zebrafish
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: frog, western clawed
Protein Domain
Type: Family
Description: In animals and plants, CTC1 is a component of the CST complex (consists of Ten1, Stn1 and CTC1), a complex that binds to single-stranded DNA and is required to protect telomeres from DNA degradation []. Two distinct telomere capping complexes have evolved: CST complex in budding yeast and shelterin complex in vertebrates. Budding yeast CST is composed of Cdc13, Ten1 and Stn1 []. The homologues of Ten1 and Stn1 have been identified in vertebrates and plants. The vertebrate CST complex does not appear to play a primary role in telomere protection, but may complement the function of shelterin complex []. The mammalian CST complex may have both telomeric and non-telomeric function [].In plants, the contribution of the CST components to chromosome end protection, telomeric DNA replication or both processes remains to be determined [].
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: dog, domestic
Gene
Type: gene
Organism: chimpanzee
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Publication
First Author: Miyake Y
Year: 2009
Journal: Mol Cell
Title: RPA-like mammalian Ctc1-Stn1-Ten1 complex binds to single-stranded DNA and protects telomeres independently of the Pot1 pathway.
Volume: 36
Issue: 2
Pages: 193-206
Protein
Organism: Mus musculus/domesticus
Length: 965  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 1212  
Fragment?: false
Publication
First Author: Gu P
Year: 2012
Journal: EMBO J
Title: CTC1 deletion results in defective telomere replication, leading to catastrophic telomere loss and stem cell exhaustion.
Volume: 31
Issue: 10
Pages: 2309-21
Publication
First Author: Price CM
Year: 2010
Journal: Cell Cycle
Title: Evolution of CST function in telomere maintenance.
Volume: 9
Issue: 16
Pages: 3157-65
Publication
First Author: Casteel DE
Year: 2009
Journal: J Biol Chem
Title: A DNA polymerase-{alpha}{middle dot}primase cofactor with homology to replication protein A-32 regulates DNA replication in mammalian cells.
Volume: 284
Issue: 9
Pages: 5807-18
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
GXD Expression    
Probe: MGI:2453444
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Male
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:5538953
Age: postnatal day 84
Image: GUDMAP:14741
Specimen Label: GUDMAP:14741
Detected: false
Specimen Num: 1
GXD Expression  
Probe: MGI:5000990
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1674417
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:5541548
Age: embryonic day 10.5
Image: GUDMAP:10090
Specimen Label: GUDMAP:10090
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:5000990
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1636717
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:5541548
Age: embryonic day 10.5
Image: GUDMAP:10090
Specimen Label: GUDMAP:10090
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:5000990
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Ambiguous
Sex: Not Specified
Emaps: EMAPS:1674517
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:5541548
Age: embryonic day 10.5
Image: GUDMAP:10090
Note: expression uncertain
Specimen Label: GUDMAP:10090
Specimen Num: 1
GXD Expression  
Probe: MGI:5000990
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1674717
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:5541548
Age: embryonic day 10.5
Image: GUDMAP:10090
Specimen Label: GUDMAP:10090
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:5000990
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:2759917
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:5541548
Age: embryonic day 10.5
Image: GUDMAP:10090
Specimen Label: GUDMAP:10090
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:5000990
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Ambiguous
Sex: Not Specified
Emaps: EMAPS:1737517
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:5541548
Age: embryonic day 10.5
Image: GUDMAP:10090
Note: expression uncertain
Specimen Label: GUDMAP:10090
Specimen Num: 1
Publication
First Author: Lin Q
Year: 2006
Journal: Nucleic Acids Res
Title: Mutagenesis of diploid mammalian genes by gene entrapment.
Volume: 34
Issue: 20
Pages: e139
Publication      
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
Publication
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
Publication
First Author: Stryke D
Year: 2003
Journal: Nucleic Acids Res
Title: BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Volume: 31
Issue: 1
Pages: 278-81
Publication      
First Author: International Knockout Mouse Consortium
Year: 2014
Journal: Database Download
Title: MGI download of modified allele data from IKMC and creation of new knockout alleles
Publication      
First Author: International Mouse Strain Resource
Year: 2014
Journal: Database Download
Title: MGI download of germline transmission data for alleles from IMSR strain data
Publication      
First Author: Wellcome Trust Sanger Institute
Year: 2009
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute
Publication      
First Author: GUDMAP Consortium
Year: 2004
Journal: www.gudmap.org
Title: GUDMAP: the GenitoUrinary Development Molecular Anatomy Project
Publication      
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
Publication
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
Publication
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
Publication
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
Publication      
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
Publication        
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
Publication
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
Publication        
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
Publication
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2000
Title: Gene Ontology Annotation by electronic association of SwissProt Keywords with GO terms
Publication
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
Publication
First Author: Gaudet P
Year: 2011
Journal: Brief Bioinform
Title: Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.
Volume: 12
Issue: 5
Pages: 449-62
Publication      
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
Publication      
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
Publication      
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
Publication      
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
Publication      
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
Publication      
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
UniProt Feature
Begin: 1
Description: CST complex subunit CTC1
Type: chain
End: 1212
Protein
Organism: Mus musculus/domesticus
Length: 966  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 1211  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 67  
Fragment?: false
Allele
Name: CTS telomere maintenance complex component 1; endonuclease-mediated mutation 2, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
Publication
First Author: Wu P
Year: 2012
Journal: Cell
Title: Telomeric 3' overhangs derive from resection by Exo1 and Apollo and fill-in by POT1b-associated CST.
Volume: 150
Issue: 1
Pages: 39-52
Allele
Name: CTS telomere maintenance complex component 1; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, No functional change
Protein Domain
Type: Family
Description: In animals and plants, CTC1 is a component of the CST complex (consists of Ten1, Stn1 and CTC1), a complex that binds to single-stranded DNA and is required to protect telomeres from DNA degradation []. Two distinct telomere capping complexes have evolved: CST complex in budding yeast and shelterin complex in vertebrates. Budding yeast CST is composed of Cdc13, Ten1 and Stn1 []. The homologues of Ten1 and Stn1 have been identified in vertebrates and plants. The vertebrate CST complex does not appear to play a primary role in telomere protection, but may complement the function of shelterin complex []. The mammalian CST complex may have both telomeric and non-telomeric function [].In plants, the contribution of the CST components to chromosome end protection, telomeric DNA replication or both processes remains to be determined [].
Protein Domain
Type: Homologous_superfamily
Description: Stn1 is a component of the CST complex, a complex that binds to single-stranded DNA and is required to protect telomeres from DNA degradation. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. In addition to telomere protection, the CST complex has probably a more general role in DNA metabolism at non-telomeric sites [, ]. The C-terminal domain of Stn1 has two winged helix-turn-helix (wHTH) motifs, wHTH1 and wHTH2. This superfamily represents the wHTH1 motif, which is structurally similar to that in RPA32 with an additional large insertion between helices α2 and α3, unique to Stn1 [, ]. This additional wHTH1 motif may allow interaction with a different set of proteins that function at telomeres such as Ctc1 [].
Protein Domain
Type: Domain
Description: Stn1 is a component of the CST complex, a complex that binds to single-stranded DNA and is required to protect telomeres from DNA degradation. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. In addition to telomere protection, the CST complex has probably a more general role in DNA metabolism at non-telomeric sites [, ]. This entry represents the C-terminal domain of Stn1, which has two winged helix-turn-helix (wHTH) motifs, wHTH1 and wHTH2 [, ]. wHTH1 is structurally similar to that in RPA32 with an additional large insertion between helices alpha2 and alpha3, unique to Stn1, and it may allow interaction with a different set of proteins that function at telomeres such as Ctc1 []. wHTH2 is most similar to the DNA-binding wHTH motifs of the pur operon repressor and RepE replication initiator, but it does not bind double-stranded DNA [].
Publication
First Author: Bryan C
Year: 2013
Journal: PLoS One
Title: Structure of the human telomeric Stn1-Ten1 capping complex.
Volume: 8
Issue: 6
Pages: e66756
Publication
First Author: Zhang T
Year: 2020
Journal: PLoS Genet
Title: High-throughput discovery of genetic determinants of circadian misalignment.
Volume: 16
Issue: 1
Pages: e1008577
Publication
First Author: Wan M
Year: 2009
Journal: J Biol Chem
Title: OB fold-containing protein 1 (OBFC1), a human homolog of yeast Stn1, associates with TPP1 and is implicated in telomere length regulation.
Volume: 284
Issue: 39
Pages: 26725-31
Publication
First Author: Sun J
Year: 2009
Journal: Genes Dev
Title: Stn1-Ten1 is an Rpa2-Rpa3-like complex at telomeres.
Volume: 23
Issue: 24
Pages: 2900-14
Protein
Organism: Mus musculus/domesticus
Length: 351  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 84  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 378  
Fragment?: false
Publication
First Author: Gerhard DS
Year: 2004
Journal: Genome Res
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Volume: 14
Issue: 10B
Pages: 2121-7
Publication
First Author: Huttlin EL
Year: 2010
Journal: Cell
Title: A tissue-specific atlas of mouse protein phosphorylation and expression.
Volume: 143
Issue: 7
Pages: 1174-89
Publication
First Author: Church DM
Year: 2009
Journal: PLoS Biol
Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.
Volume: 7
Issue: 5
Pages: e1000112