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Search results 1 to 100 out of 494 for Ctla4

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Hits by Pathway

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Hits by Strain

Type Details Score
Gene
1493 | CTLA4
Type: gene
Organism: human
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Gene
100493714 | ctla4
Type: gene
Organism: frog, western clawed
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Gene
281732 | CTLA4
Type: gene
Organism: cattle
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Gene
key_81969 | CTLA4
Type: gene
Organism: cat, domestic
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Gene
key_23260 | CTLA4
Type: gene
Organism: rabbit, European
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Gene
63835 | Ctla4
Type: gene
Organism: rat
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Gene
403696 | CTLA4
Type: gene
Organism: dog, domestic
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Gene
470619 | CTLA4
Type: gene
Organism: chimpanzee
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Gene
424106 | CTLA4
Type: gene
Organism: chicken
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Gene
705673 | CTLA4
Type: gene
Organism: macaque, rhesus
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Protein Coding Gene
MGI:88556 | Ctla4
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Domain
IPR008096 | CTLA4
Type: Family
Description: T cell-dependent immune processes require cell-surface interactions thatmediate the initiation, modulation and the ultimate course of the response.The specificity of T cell recognition is determined by the engagement of theT cell receptor (TCR) on T cells with cognate peptide-MHC complexes presented by antigen presenting cells (APCs). Additional signals arerequired to sustain and enhance T cell activity, the most important of whichis provided by the engagement of CD28 on T cells with its ligands B7-1(CD80) and B7-2 (CD86). By contrast, the interaction of B7 isoformswith cytotoxic T lymphocyte-associated molecule-4 CTLA-4, a CD28 homologue receptor on T cells (31% identity), provides inhibitory signals requiredfor down-regulation of the response, while it may also prevent T cell activation by weak TCR signals[, , , , ].Unlike CD28, which is not expressed on resting T cells, CTLA-4 is not detected on the cell surface until 24 hours after activation. In fact, Tcell activation leads to both increased CTLA4 gene expression andtrafficking of CTLA4 protein to the cell surface. In addition, CTLA-4exhibits an affinity for the B7 isoforms that is 10 to 100 times that forCD28. Covalent dimerisation of CTLA4 is required for its high bindingavidity, but each monomeric subunit also contains a binding site for CD80and CD86. It is likely that CTLA-4 directly competes with CD28 for bindingB7 and also directs the assembly of inhibitory signalling complexes thatlead to quiescence or anergy. Thus the balance between the opposing signals elicited by CD28 and CTLA-4 is central to the regulation of T cellresponsiveness and homeostasis. One mechanism by which CTLA-4 may performthis function is by regulating cell-cycle progression; by contrast with CD28, which down-regulates the cell-cycle inhibitor p27kip1, CTLA-4 prevents this degradation[, , ].Sequence comparison between human CTLA-4 and CD28 proteins suggests they arehomologous, with the highest of degree of similarity being in the juxta-membrane and cytoplasmic regions. In addition, the cytoplasmic domainsof human and murine CTLA-4 are identical, suggesting that this region hasimportant functional properties [].Typically, activation of T cells by TCR-engaging peptide-MHC is dramatically enhanced by interaction of the CD28 co-stimulatory receptor with its ligands CD80 (B7-1) and CD86 (B7-2) on the APC surface. Interestingly, CTLA-4 is transported from intracellular stores toward the region of the cell surface receiving activation signals. This suggests that binding of CD28 to its ligand may occur primarily at the centre of the mature immunological synapse, and that CTLA-4 may be transported to this site under certain circumstancesto block or reverse this effect.
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Publication
9600957 | J:47908
First Author: Zheng P
Year: 1998
Journal: Proc Natl Acad Sci U S A
Title: B7-CTLA4 interaction enhances both production of antitumor cytotoxic T lymphocytes and resistance to tumor challenge.
Volume: 95
Issue: 11
Pages: 6284-9
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Publication
11052947 | J:65436
First Author: Ostrov DA
Year: 2000
Journal: Science
Title: Structure of murine CTLA-4 and its role in modulating T cell responsiveness.
Volume: 290
Issue: 5492
Pages: 816-9
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Publication
11807776 | J:74753
First Author: Greenwald RJ
Year: 2002
Journal: Eur J Immunol
Title: CTLA-4 regulates cell cycle progression during a primary immune response.
Volume: 32
Issue: 2
Pages: 366-73
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Protein
P09793
Organism: Mus musculus/domesticus
Length: 223  
Fragment?: false
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Publication
29463898 | J:350766
First Author: Du X
Year: 2018
Journal: Cell Res
Title: Uncoupling therapeutic from immunotherapy-related adverse effects for safer and effective anti-CTLA-4 antibodies in CTLA4 humanized mice.
Volume: 28
Issue: 4
Pages: 433-447
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Publication
16037385 | J:123940
First Author: Lute KD
Year: 2005
Journal: Blood
Title: Human CTLA4 knock-in mice unravel the quantitative link between tumor immunity and autoimmunity induced by anti-CTLA-4 antibodies.
Volume: 106
Issue: 9
Pages: 3127-33
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Publication
25329329 | J:227811
First Author: Schubert D
Year: 2014
Journal: Nat Med
Title: Autosomal dominant immune dysregulation syndrome in humans with CTLA4 mutations.
Volume: 20
Issue: 12
Pages: 1410-1416
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Publication
16443792 | J:106844
First Author: Lundholm M
Year: 2006
Journal: Diabetes
Title: Defective induction of CTLA-4 in the NOD mouse is controlled by the NOD allele of Idd3/IL-2 and a novel locus (Ctex) telomeric on chromosome 1.
Volume: 55
Issue: 2
Pages: 538-44
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QTL
MGI:3639484 | Ctex
Type: QTL
Organism: mouse, laboratory
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Publication
12724780 | J:83656
First Author: Ueda H
Year: 2003
Journal: Nature
Title: Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease.
Volume: 423
Issue: 6939
Pages: 506-11
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Publication
32872393 | J:313309
 
First Author: Poels K
Year: 2020
Journal: Cells
Title: Antibody-Mediated Inhibition of CTLA4 Aggravates Atherosclerotic Plaque Inflammation and Progression in Hyperlipidemic Mice.
Volume: 9
Issue: 9
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Publication
15308325 | J:91985
First Author: Mao Y
Year: 2004
Journal: Exp Hematol
Title: Overexpression of a mutant CTLA4 inhibits T-cell activation and homeostasis-driven expansion.
Volume: 32
Issue: 8
Pages: 735-47
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Publication
7504059 | J:15724
First Author: Freeman GJ
Year: 1993
Journal: J Exp Med
Title: Murine B7-2, an alternative CTLA4 counter-receptor that costimulates T cell proliferation and interleukin 2 production.
Volume: 178
Issue: 6
Pages: 2185-92
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Publication
29374027 | J:257732
First Author: Miska J
Year: 2018
Journal: J Exp Med
Title: Initiation of inflammatory tumorigenesis by CTLA4 insufficiency due to type 2 cytokines.
Volume: 215
Issue: 3
Pages: 841-858
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Publication
18641318 | J:139249
First Author: Tang AL
Year: 2008
Journal: J Immunol
Title: CTLA4 expression is an indicator and regulator of steady-state CD4+ FoxP3+ T cell homeostasis.
Volume: 181
Issue: 3
Pages: 1806-13
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Publication
10493833 | J:57945
First Author: Ling V
Year: 1999
Journal: Genomics
Title: Complete sequence determination of the mouse and human CTLA4 gene loci: cross-species DNA sequence similarity beyond exon borders.
Volume: 60
Issue: 3
Pages: 341-55
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Publication
1714933 | -
First Author: Linsley PS
Year: 1991
Journal: J Exp Med
Title: CTLA-4 is a second receptor for the B cell activation antigen B7.
Volume: 174
Issue: 3
Pages: 561-9
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Publication
11841692 | -
First Author: Wang XB
Year: 2002
Journal: Scand J Immunol
Title: Expression of CTLA-4 by human monocytes.
Volume: 55
Issue: 1
Pages: 53-60
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Publication
33419761 | J:305678
First Author: Dovedi SJ
Year: 2021
Journal: Cancer Discov
Title: Design and Efficacy of a Monovalent Bispecific PD-1/CTLA4 Antibody That Enhances CTLA4 Blockade on PD-1+ Activated T Cells.
Volume: 11
Issue: 5
Pages: 1100-1117
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Protein
Q8CH94
Organism: Mus musculus/domesticus
Length: 102  
Fragment?: false
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Protein
Q7TMX1
Organism: Mus musculus/domesticus
Length: 223  
Fragment?: false
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Protein
Q6GTR6
Organism: Mus musculus/domesticus
Length: 223  
Fragment?: false
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Protein
Q5SSM0
Organism: Mus musculus/domesticus
Length: 174  
Fragment?: false
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Publication
8244464 | J:14550
First Author: Lane P
Year: 1993
Journal: Immunology
Title: Expression and functional properties of mouse B7/BB1 using a fusion protein between mouse CTLA4 and human gamma 1.
Volume: 80
Issue: 1
Pages: 56-61
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Publication
15210771 | J:90924
First Author: Wicker LS
Year: 2004
Journal: J Immunol
Title: Fine mapping, gene content, comparative sequencing, and expression analyses support Ctla4 and Nramp1 as candidates for Idd5.1 and Idd5.2 in the nonobese diabetic mouse.
Volume: 173
Issue: 1
Pages: 164-73
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Allele
Ctex<NOD> | MGI:3639487
 
Name: Ctla4 expression QTL; NOD
Allele Type: QTL
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Publication
- | J:265263
     
First Author: Zhong X
Year: 2018
Journal: MGI Direct Data Submission
Title: Mutagenetix entry for complementary.
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Publication
10955330 | J:71276
First Author: Brayer J
Year: 2000
Journal: J Rheumatol
Title: Alleles from chromosomes 1 and 3 of NOD mice combine to influence Sjögren's syndrome-like autoimmune exocrinopathy.
Volume: 27
Issue: 8
Pages: 1896-904
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Publication
17060611 | J:115599
First Author: Chen Z
Year: 2006
Journal: Proc Natl Acad Sci U S A
Title: Modeling CTLA4-linked autoimmunity with RNA interference in mice.
Volume: 103
Issue: 44
Pages: 16400-5
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Publication
30910862 | J:274899
First Author: Do P
Year: 2019
Journal: J Immunol
Title: Leukemic B Cell CTLA-4 Suppresses Costimulation of T Cells.
Volume: 202
Issue: 9
Pages: 2806-2816
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Publication
38055819 | J:358258
First Author: Turnbull C
Year: 2023
Journal: Sci Adv
Title: DECTIN-1: A modifier protein in CTLA-4 haploinsufficiency.
Volume: 9
Issue: 49
Pages: eadi9566
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Publication
37827154 | J:350457
First Author: Bailey C
Year: 2023
Journal: Cell Rep Med
Title: Genetic and pharmaceutical targeting of HIF1α allows combo-immunotherapy to boost graft vs. leukemia without exacerbation graft vs. host disease.
Volume: 4
Issue: 11
Pages: 101236
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Publication
10975832 | J:64561
First Author: Vaughan AN
Year: 2000
Journal: J Immunol
Title: Porcine CTLA4-Ig lacks a MYPPPY motif, binds inefficiently to human B7 and specifically suppresses human CD4+ T cell responses costimulated by pig but not human B7.
Volume: 165
Issue: 6
Pages: 3175-81
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Publication
19783679 | J:153599
First Author: Araki M
Year: 2009
Journal: J Immunol
Title: Genetic evidence that the differential expression of the ligand-independent isoform of CTLA-4 is the molecular basis of the Idd5.1 type 1 diabetes region in nonobese diabetic mice.
Volume: 183
Issue: 8
Pages: 5146-57
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Publication
18056379 | J:143549
First Author: Hunter K
Year: 2007
Journal: J Immunol
Title: Interactions between Idd5.1/Ctla4 and other type 1 diabetes genes.
Volume: 179
Issue: 12
Pages: 8341-9
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Publication
21602513 | J:186752
First Author: Gerold KD
Year: 2011
Journal: Diabetes
Title: The soluble CTLA-4 splice variant protects from type 1 diabetes and potentiates regulatory T-cell function.
Volume: 60
Issue: 7
Pages: 1955-63
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Publication
26450994 | J:247241
First Author: Jakubczik F
Year: 2016
Journal: Diabetes
Title: A SNP in the Immunoregulatory Molecule CTLA-4 Controls mRNA Splicing In Vivo but Does Not Alter Diabetes Susceptibility in the NOD Mouse.
Volume: 65
Issue: 1
Pages: 120-8
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Publication
33257470 | J:303822
First Author: Wei SC
Year: 2021
Journal: Cancer Discov
Title: A Genetic Mouse Model Recapitulates Immune Checkpoint Inhibitor-Associated Myocarditis and Supports a Mechanism-Based Therapeutic Intervention.
Volume: 11
Issue: 3
Pages: 614-625
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Publication
25377239 | J:289996
First Author: Noyes H
Year: 2015
Journal: Parasitology
Title: Evidence for genes controlling resistance to Heligmosomoides bakeri on mouse chromosome 1.
Volume: 142
Issue: 4
Pages: 566-75
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Publication
23203389 | J:312061
First Author: Ichinose K
Year: 2013
Journal: Arthritis Rheum
Title: Brief report: increased expression of a short splice variant of CTLA-4 exacerbates lupus in MRL/lpr mice.
Volume: 65
Issue: 3
Pages: 764-9
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Publication
22777737 | J:188006
First Author: Miska J
Year: 2012
Journal: Eur J Immunol
Title: Autoimmunity-mediated antitumor immunity: tumor as an immunoprivileged self.
Volume: 42
Issue: 10
Pages: 2584-96
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Publication
7544393 | J:28279
First Author: Fargeas CA
Year: 1995
Journal: J Exp Med
Title: Identification of residues in the V domain of CD80 (B7-1) implicated in functional interactions with CD28 and CTLA4.
Volume: 182
Issue: 3
Pages: 667-75
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Publication
37746718 | J:357407
First Author: Ma P
Year: 2024
Journal: Circulation
Title: Expansion of Pathogenic Cardiac Macrophages in Immune Checkpoint Inhibitor Myocarditis.
Volume: 149
Issue: 1
Pages: 48-66
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Publication
22124121 | J:180821
First Author: Liu SM
Year: 2012
Journal: J Immunol
Title: Overexpression of the Ctla-4 isoform lacking exons 2 and 3 causes autoimmunity.
Volume: 188
Issue: 1
Pages: 155-62
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Publication
7515723 | J:18764
First Author: Blazar BR
Year: 1994
Journal: Blood
Title: In vivo blockade of CD28/CTLA4: B7/BB1 interaction with CTLA4-Ig reduces lethal murine graft-versus-host disease across the major histocompatibility complex barrier in mice.
Volume: 83
Issue: 12
Pages: 3815-25
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Publication
11723074 | J:72900
First Author: Lamhamedi-Cherradi SE
Year: 2001
Journal: Diabetes
Title: Further mapping of the Idd5.1 locus for autoimmune diabetes in NOD mice.
Volume: 50
Issue: 12
Pages: 2874-8
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Publication
26371185 | J:266026
First Author: Paterson AM
Year: 2015
Journal: J Exp Med
Title: Deletion of CTLA-4 on regulatory T cells during adulthood leads to resistance to autoimmunity.
Volume: 212
Issue: 10
Pages: 1603-21
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Publication
28581446 | J:244075
First Author: Alissafi T
Year: 2017
Journal: J Clin Invest
Title: Tregs restrain dendritic cell autophagy to ameliorate autoimmunity.
Volume: 127
Issue: 7
Pages: 2789-2804
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Protein Coding Gene
MGP_CAROLIEiJ_G0014192 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0016080 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0016063 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0016019 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0016018 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0015850 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_88556 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0016471 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0015432 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0015822 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0015923 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0015925 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0015995 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0015945 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0016518 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0015219 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0015495 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0027430 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0014999 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
3496540 | J:8775
First Author: Brunet JF
Year: 1987
Journal: Nature
Title: A new member of the immunoglobulin superfamily--CTLA-4.
Volume: 328
Issue: 6127
Pages: 267-70
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Publication
11279501 | J:68436
First Author: Schwartz JC
Year: 2001
Journal: Nature
Title: Structural basis for co-stimulation by the human CTLA-4/B7-2 complex.
Volume: 410
Issue: 6828
Pages: 604-8
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Publication
11035773 | J:109887
First Author: Luhder F
Year: 2000
Journal: Proc Natl Acad Sci U S A
Title: Pinpointing when T cell costimulatory receptor CTLA-4 must be engaged to dampen diabetogenic T cells.
Volume: 97
Issue: 22
Pages: 12204-9
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Publication
7584144 | J:30393
First Author: Tivol EA
Year: 1995
Journal: Immunity
Title: Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4.
Volume: 3
Issue: 5
Pages: 541-7
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Publication
16931720 | J:112894
First Author: Schneider H
Year: 2006
Journal: Science
Title: Reversal of the TCR stop signal by CTLA-4.
Volume: 313
Issue: 5795
Pages: 1972-5
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Publication
15468055 | J:93847
First Author: Tang Q
Year: 2004
Journal: Eur J Immunol
Title: Distinct roles of CTLA-4 and TGF-beta in CD4+CD25+ regulatory T cell function.
Volume: 34
Issue: 11
Pages: 2996-3005
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Publication
9164923 | J:40627
First Author: Tivol EA
Year: 1997
Journal: J Immunol
Title: CTLA4Ig prevents lymphoproliferation and fatal multiorgan tissue destruction in CTLA-4-deficient mice.
Volume: 158
Issue: 11
Pages: 5091-4
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Publication
22403258 | J:184989
First Author: Tai X
Year: 2012
Journal: Blood
Title: Basis of CTLA-4 function in regulatory and conventional CD4(+) T cells.
Volume: 119
Issue: 22
Pages: 5155-63
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Publication
19109158 | J:142898
First Author: Schmidt EM
Year: 2009
Journal: J Immunol
Title: Ctla-4 controls regulatory T cell peripheral homeostasis and is required for suppression of pancreatic islet autoimmunity.
Volume: 182
Issue: 1
Pages: 274-82
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Publication
10229811 | J:76907
First Author: Khattri R
Year: 1999
Journal: J Immunol
Title: Lymphoproliferative disorder in CTLA-4 knockout mice is characterized by CD28-regulated activation of Th2 responses.
Volume: 162
Issue: 10
Pages: 5784-91
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Publication
22753931 | J:189776
First Author: Wang CJ
Year: 2012
Journal: J Immunol
Title: Cutting edge: cell-extrinsic immune regulation by CTLA-4 expressed on conventional T cells.
Volume: 189
Issue: 3
Pages: 1118-22
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Publication
12165509 | J:120704
First Author: Tivol EA
Year: 2002
Journal: J Immunol
Title: Re-establishing peripheral tolerance in the absence of CTLA-4: complementation by wild-type T cells points to an indirect role for CTLA-4.
Volume: 169
Issue: 4
Pages: 1852-8
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Publication
23267099 | J:193282
First Author: Verhagen J
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: CTLA-4 controls the thymic development of both conventional and regulatory T cells through modulation of the TCR repertoire.
Volume: 110
Issue: 3
Pages: E221-30
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Publication
7481803 | J:29652
First Author: Waterhouse P
Year: 1995
Journal: Science
Title: Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4.
Volume: 270
Issue: 5238
Pages: 985-8
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Publication
9295023 | J:42659
First Author: Waterhouse P
Year: 1997
Journal: Eur J Immunol
Title: Normal thymic selection, normal viability and decreased lymphoproliferation in T cell receptor-transgenic CTLA-4-deficient mice.
Volume: 27
Issue: 8
Pages: 1887-92
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Publication
11673499 | J:131512
First Author: Frauwirth KA
Year: 2001
Journal: J Immunol
Title: CTLA-4 is not required for induction of CD8(+) T cell anergy in vivo.
Volume: 167
Issue: 9
Pages: 4936-41
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Publication
15557155 | J:94356
First Author: Kwon H
Year: 2004
Journal: J Immunol
Title: Role of CTLA-4 in the activation of single- and double-positive thymocytes.
Volume: 173
Issue: 11
Pages: 6645-53
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Publication
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First Author: Katz G
Year: 2014
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Title: T cell receptor stimulation impairs IL-7 receptor signaling by inducing expression of the microRNA miR-17 to target Janus kinase 1.
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First Author: Harlin H
Year: 2002
Journal: Eur J Immunol
Title: CTLA-4 engagement regulates NF-kappaB activation in vivo.
Volume: 32
Issue: 8
Pages: 2095-104
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11238634 | J:126159
First Author: Gajewski TF
Year: 2001
Journal: J Immunol
Title: Absence of CTLA-4 lowers the activation threshold of primed CD8+ TCR-transgenic T cells: lack of correlation with Src homology domain 2-containing protein tyrosine phosphatase.
Volume: 166
Issue: 6
Pages: 3900-7
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First Author: Chambers CA
Year: 1997
Journal: Proc Natl Acad Sci U S A
Title: Thymocyte development is normal in CTLA-4-deficient mice.
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