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Search results 1 to 11 out of 11 for Ctps

0.017s

Type

Details

Score

Publication

- | J:63390

First Author:	Eggington JM
Year:	2000
Journal:	MGI Direct Data Submission
Title:	Mapping of Ctps to mouse Chromosome 4

•

Publication

34022203 | J:307740

First Author:	Peng M
Year:	2021
Journal:	Exp Cell Res
Title:	CTPS and IMPDH form cytoophidia in developmental thymocytes.
Volume:	405
Issue:	1
Pages:	112662

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Protein

P70698

Organism:	Mus musculus/domesticus
Length:	591
Fragment?:	false

•

Protein Coding Gene

MGI:1858304 | Ctps1

Type:	protein_coding_gene
Organism:	mouse, laboratory

•

Publication

15157079 | -

First Author:	Endrizzi JA
Year:	2004
Journal:	Biochemistry
Title:	Crystal structure of Escherichia coli cytidine triphosphate synthetase, a nucleotide-regulated glutamine amidotransferase/ATP-dependent amidoligase fusion protein and homologue of anticancer and antiparasitic drug targets.
Volume:	43
Issue:	21
Pages:	6447-63

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Protein Domain

IPR033828 | GATase1_CTP_Synthase

Type:

Domain

Description:

This entry represents the type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase (CTP). CTP is involved in pyrimidine ribonucleotide/ribonucleoside metabolism. CTPs produce CTP from UTP and glutamine and regulate intracellular CTP levels through interactions with four ribonucleotide triphosphates. The enzyme exists as a dimer of identical chains that aggregates as a tetramer [].CTP is derived form UTP in three separate steps involving two active sites. In one active site, the UTP O4 oxygen is activated by Mg-ATP-dependent phosphorylation, followed by displacement of the resulting 4-phosphate moiety by ammonia. At a separate site, ammonia is generated via rate limiting glutamine hydrolysis (glutaminase) activity []. A gated channel that spans between the glutamine hydrolysis and amidoligase active sites provides a path for ammonia diffusion. CTPs belong to the triad family of amidotransferases having a conserved Cys-His-Glu catalytic triad in the glutaminase active site [].

•

Publication

26303200 | J:233379

First Author:	Chang CC
Year:	2015
Journal:	J Cell Sci
Title:	Cytoophidium assembly reflects upregulation of IMPDH activity.
Volume:	128
Issue:	19
Pages:	3550-5

•

Publication

36563716 | J:334388

First Author:	Bie M
Year:	2023
Journal:	Bone
Title:	HIF-1α mediates osteoclast-induced disuse osteoporosis via cytoophidia in the femur of mice.
Volume:	168

Pages:	116648

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Protein

P70303

Organism:	Mus musculus/domesticus
Length:	586
Fragment?:	false

•

Publication

3298209 | -

First Author:	Weng ML
Year:	1987
Journal:	J Bacteriol
Title:	Structural role for a conserved region in the CTP synthetase glutamine amide transfer domain.
Volume:	169
Issue:	7
Pages:	3023-8

•

Publication

10387030 | -

First Author:	Raushel FM
Year:	1999
Journal:	Biochemistry
Title:	The amidotransferase family of enzymes: molecular machines for the production and delivery of ammonia.
Volume:	38
Issue:	25
Pages:	7891-9

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