Type |
Details |
Score |
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
frog, western clawed |
|
•
•
•
•
•
|
Gene |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chimpanzee |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
cattle |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
dog, domestic |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chicken |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
zebrafish |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
This entry includes budding yeast RNA polymerase-associated protein Ctr9 and its homologues from other yeasts, animals and plants. The homologue in fission yeast is known as tetratricopeptide repeat protein 1 (Tpr1) [].Budding yeast Ctr9 is part of the Paf1 complex, an RNA polymerase II-associated protein complex containing Paf1, Cdc73, Ctr9, Rtf1 and Leo1 []. Paf1 complex is involved in histone modifications, transcription elongation and other gene expression processes that include transcript site selection []. Human Paf1 complex (Paf1C) consists of Paf1, Cdc73, Ctr9, Rtf1, Leo1 and Wdr61 (Ski8). As in yeast, the human Paf1C has a central role in co-transcriptional histone modifications [].Arabidopsis Paf1C related proteins such as VIP4 (Leo1), VIP5 (Rtf1), ELF7 (Paf1), ELF8 (Ctr9) and ATXR7 (Set1) are required for the induction of seed dormancy. They control both germination and flowering time []. |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
82
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
939
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
936
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1173
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Yoo HS |
Year: |
2014 |
Journal: |
J Immunol |
Title: |
Transcriptional regulator CTR9 inhibits Th17 differentiation via repression of IL-17 expression. |
Volume: |
192 |
Issue: |
4 |
Pages: |
1440-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mbogning J |
Year: |
2013 |
Journal: |
PLoS Genet |
Title: |
The PAF complex and Prf1/Rtf1 delineate distinct Cdk9-dependent pathways regulating transcription elongation in fission yeast. |
Volume: |
9 |
Issue: |
12 |
Pages: |
e1004029 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mueller CL |
Year: |
2002 |
Journal: |
Mol Cell Biol |
Title: |
Ctr9, Rtf1, and Leo1 are components of the Paf1/RNA polymerase II complex. |
Volume: |
22 |
Issue: |
7 |
Pages: |
1971-80 |
|
•
•
•
•
•
|
Publication |
First Author: |
Isom H |
Year: |
1991 |
Journal: |
Cancer Res |
Title: |
Workshop report from the Division of Research Grants, National Institutes of Health. The role of chromosome rearrangements, deletions, and point mutations in cancer--a Pathology B Study Section workshop. |
Volume: |
51 |
Issue: |
19 |
Pages: |
5440-4 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kim J |
Year: |
2010 |
Journal: |
Cell |
Title: |
The human PAF1 complex acts in chromatin transcription elongation both independently and cooperatively with SII/TFIIS. |
Volume: |
140 |
Issue: |
4 |
Pages: |
491-503 |
|
•
•
•
•
•
|
Publication |
First Author: |
Liu Y |
Year: |
2011 |
Journal: |
PLoS One |
Title: |
Identification of the Arabidopsis REDUCED DORMANCY 2 gene uncovers a role for the polymerase associated factor 1 complex in seed dormancy. |
Volume: |
6 |
Issue: |
7 |
Pages: |
e22241 |
|
•
•
•
•
•
|
Publication |
First Author: |
Youn MY |
Year: |
2007 |
Journal: |
J Biol Chem |
Title: |
hCTR9, a component of Paf1 complex, participates in the transcription of interleukin 6-responsive genes through regulation of STAT3-DNA interactions. |
Volume: |
282 |
Issue: |
48 |
Pages: |
34727-34 |
|
•
•
•
•
•
|
Publication |
First Author: |
Malek SN |
Year: |
1996 |
Journal: |
J Biol Chem |
Title: |
p150TSP, a conserved nuclear phosphoprotein that contains multiple tetratricopeptide repeats and binds specifically to SH2 domains. |
Volume: |
271 |
Issue: |
12 |
Pages: |
6952-62 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5636732 |
Assay Type: |
Western blot |
Annotation Date: |
2015-05-22 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1754421 |
|
Stage: |
TS21 |
Assay Id: |
MGI:5636787 |
Age: |
embryonic day 13.0 |
|
|
Specimen Label: |
E13 |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5636732 |
Assay Type: |
Western blot |
Annotation Date: |
2015-05-22 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1754426 |
|
Stage: |
TS26 |
Assay Id: |
MGI:5636787 |
Age: |
embryonic day 19.0 |
|
|
Specimen Label: |
E19 |
Detected: |
true |
Specimen Num: |
5 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5636732 |
Assay Type: |
Western blot |
Annotation Date: |
2015-05-22 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1754428 |
|
Stage: |
TS28 |
Assay Id: |
MGI:5636787 |
Age: |
postnatal adult |
|
|
Specimen Label: |
adult |
Detected: |
true |
Specimen Num: |
8 |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus caroli |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus pahari |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus spretus |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5636732 |
Assay Type: |
Western blot |
Annotation Date: |
2015-05-22 |
Strength: |
Not Specified |
Sex: |
Not Specified |
Emaps: |
EMAPS:1691018 |
|
Stage: |
TS18 |
Assay Id: |
MGI:5636787 |
Age: |
embryonic day 11.0 |
|
|
Specimen Label: |
E11 |
|
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5636732 |
Assay Type: |
Western blot |
Annotation Date: |
2015-05-22 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1754423 |
|
Stage: |
TS23 |
Assay Id: |
MGI:5636787 |
Age: |
embryonic day 15.0 |
|
|
Specimen Label: |
E15 |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5636732 |
Assay Type: |
Western blot |
Annotation Date: |
2015-05-22 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1754425 |
|
Stage: |
TS25 |
Assay Id: |
MGI:5636787 |
Age: |
embryonic day 17.0 |
|
|
Specimen Label: |
E17 |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5636732 |
Assay Type: |
Western blot |
Annotation Date: |
2015-05-22 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1754427 |
|
Stage: |
TS27 |
Assay Id: |
MGI:5636787 |
Age: |
postnatal day 0 |
|
|
Specimen Label: |
P0 |
Detected: |
true |
Specimen Num: |
6 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5636732 |
Assay Type: |
Western blot |
Annotation Date: |
2015-05-22 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1754428 |
|
Stage: |
TS28 |
Assay Id: |
MGI:5636787 |
Age: |
postnatal day 5 |
|
|
Specimen Label: |
P5 |
Detected: |
true |
Specimen Num: |
7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lee H |
Year: |
2016 |
Journal: |
Am J Physiol Renal Physiol |
Title: |
Cln 3-requiring 9 is a negative regulator of Th17 pathway-driven inflammation in anti-glomerular basement membrane glomerulonephritis. |
Volume: |
311 |
Issue: |
3 |
Pages: |
F505-19 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ding L |
Year: |
2009 |
Journal: |
Cell Stem Cell |
Title: |
A genome-scale RNAi screen for Oct4 modulators defines a role of the Paf1 complex for embryonic stem cell identity. |
Volume: |
4 |
Issue: |
5 |
Pages: |
403-15 |
|
•
•
•
•
•
|
Publication |
First Author: |
Strikoudis A |
Year: |
2016 |
Journal: |
Nat Cell Biol |
Title: |
Regulation of transcriptional elongation in pluripotency and cell differentiation by the PHD-finger protein Phf5a. |
Volume: |
18 |
Issue: |
11 |
Pages: |
1127-1138 |
|
•
•
•
•
•
|
Publication |
First Author: |
Osipovich AB |
Year: |
2016 |
Journal: |
Development |
Title: |
Setd5 is essential for mammalian development and the co-transcriptional regulation of histone acetylation. |
Volume: |
143 |
Issue: |
24 |
Pages: |
4595-4607 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhang K |
Year: |
2013 |
Journal: |
Dev Biol |
Title: |
CTR9/PAF1c regulates molecular lineage identity, histone H3K36 trimethylation and genomic imprinting during preimplantation development. |
Volume: |
383 |
Issue: |
1 |
Pages: |
15-27 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhang C |
Year: |
2013 |
Journal: |
Neuron |
Title: |
The X-linked intellectual disability protein PHF6 associates with the PAF1 complex and regulates neuronal migration in the mammalian brain. |
Volume: |
78 |
Issue: |
6 |
Pages: |
986-93 |
|
•
•
•
•
•
|
Publication |
First Author: |
Burbelo PD |
Year: |
1999 |
Journal: |
Gene |
Title: |
Cloning, central nervous system expression and chromosomal mapping of the mouse PAK-1 and PAK-3 genes. |
Volume: |
232 |
Issue: |
2 |
Pages: |
209-15 |
|
•
•
•
•
•
|
Publication |
First Author: |
Cui W |
Year: |
2016 |
Journal: |
Sci Rep |
Title: |
Towards Functional Annotation of the Preimplantation Transcriptome: An RNAi Screen in Mammalian Embryos. |
Volume: |
6 |
|
Pages: |
37396 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kozak CA |
Year: |
1999 |
Journal: |
Mamm Genome |
Title: |
Identification and genetic mapping of differentially expressed genes in mice differing at the If1 interferon regulatory locus. |
Volume: |
10 |
Issue: |
9 |
Pages: |
853-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Dickinson ME |
Year: |
2016 |
Journal: |
Nature |
Title: |
High-throughput discovery of novel developmental phenotypes. |
Volume: |
537 |
Issue: |
7621 |
Pages: |
508-514 |
|
•
•
•
•
•
|
Publication |
First Author: |
International Knockout Mouse Consortium |
Year: |
2014 |
Journal: |
Database Download |
Title: |
MGI download of modified allele data from IKMC and creation of new knockout alleles |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Ingham NJ |
Year: |
2019 |
Journal: |
PLoS Biol |
Title: |
Mouse screen reveals multiple new genes underlying mouse and human hearing loss. |
Volume: |
17 |
Issue: |
4 |
Pages: |
e3000194 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wellcome Trust Sanger Institute |
Year: |
2010 |
Journal: |
MGI Direct Data Submission |
Title: |
Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
International Mouse Strain Resource |
Year: |
2014 |
Journal: |
Database Download |
Title: |
MGI download of germline transmission data for alleles from IMSR strain data |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC) |
Year: |
2014 |
Journal: |
Database Release |
Title: |
Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Adams DJ |
Year: |
2024 |
Journal: |
Nature |
Title: |
Genetic determinants of micronucleus formation in vivo. |
Volume: |
627 |
Issue: |
8002 |
Pages: |
130-136 |
|
•
•
•
•
•
|
Publication |
First Author: |
Carninci P |
Year: |
2005 |
Journal: |
Science |
Title: |
The transcriptional landscape of the mammalian genome. |
Volume: |
309 |
Issue: |
5740 |
Pages: |
1559-63 |
|
•
•
•
•
•
|
Publication |
First Author: |
Skarnes WC |
Year: |
2011 |
Journal: |
Nature |
Title: |
A conditional knockout resource for the genome-wide study of mouse gene function. |
Volume: |
474 |
Issue: |
7351 |
Pages: |
337-42 |
|
•
•
•
•
•
|
Publication |
First Author: |
GemPharmatech |
Year: |
2020 |
|
Title: |
GemPharmatech Website. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
UniProt-GOA |
Year: |
2012 |
|
Title: |
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2003 |
|
Title: |
MGI Sequence Curation Reference |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators |
Year: |
2011 |
|
Title: |
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
UniProt-GOA |
Year: |
2012 |
|
Title: |
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
GOA curators |
Year: |
2016 |
|
Title: |
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI) |
Year: |
2008 |
Journal: |
Database Download |
Title: |
Mouse Gene Trap Data Load from dbGSS |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
MGD Nomenclature Committee |
Year: |
1995 |
|
Title: |
Nomenclature Committee Use |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
The Jackson Laboratory Mouse Radiation Hybrid Database |
Year: |
2004 |
Journal: |
Database Release |
Title: |
Mouse T31 Radiation Hybrid Data Load |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Okazaki Y |
Year: |
2002 |
Journal: |
Nature |
Title: |
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. |
Volume: |
420 |
Issue: |
6915 |
Pages: |
563-73 |
|
•
•
•
•
•
|
Publication |
First Author: |
The Gene Ontology Consortium |
Year: |
2010 |
|
Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Diez-Roux G |
Year: |
2011 |
Journal: |
PLoS Biol |
Title: |
A high-resolution anatomical atlas of the transcriptome in the mouse embryo. |
Volume: |
9 |
Issue: |
1 |
Pages: |
e1000582 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2). |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
MGI Genome Annotation Group and UniGene Staff |
Year: |
2015 |
Journal: |
Database Download |
Title: |
MGI-UniGene Interconnection Effort |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
|
Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
Year: |
2010 |
|
Title: |
Annotation inferences using phylogenetic trees |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Allen Institute for Brain Science |
Year: |
2004 |
Journal: |
Allen Institute |
Title: |
Allen Brain Atlas: mouse riboprobes |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
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Publication |
First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
Year: |
2000 |
Journal: |
Database Release |
Title: |
Entrez Gene Load |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
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Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
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Publication |
First Author: |
Mouse Genome Informatics Group |
Year: |
2003 |
Journal: |
Database Procedure |
Title: |
Automatic Encodes (AutoE) Reference |
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Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
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Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
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Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
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UniProt Feature |
Begin: |
1 |
Description: |
RNA polymerase-associated protein CTR9 homolog |
Type: |
chain |
End: |
1173 |
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Gene |
Type: |
gene |
Organism: |
frog, African clawed |
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Gene |
Type: |
gene |
Organism: |
frog, African clawed |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1090
 |
Fragment?: |
false |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
721
 |
Fragment?: |
false |
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Allele |
Name: |
CTR9 homolog, Paf1/RNA polymerase II complex component; wild type |
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