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Search results 1 to 100 out of 364 for Ctsd

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0.063s
Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: chimpanzee
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: chicken
Gene
Type: gene
Organism: zebrafish
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: frog, western clawed
Gene
Type: gene
Organism: sheep
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: dog, domestic
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein
Organism: Mus musculus/domesticus
Length: 217  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 87  
Fragment?: false
Publication
First Author: Shevtsova Z
Year: 2010
Journal: Am J Pathol
Title: CNS-expressed cathepsin D prevents lymphopenia in a murine model of congenital neuronal ceroid lipofuscinosis.
Volume: 177
Issue: 1
Pages: 271-9
Publication
First Author: del Cerro-Vadillo E
Year: 2006
Journal: J Immunol
Title: Cutting edge: a novel nonoxidative phagosomal mechanism exerted by cathepsin-D controls Listeria monocytogenes intracellular growth.
Volume: 176
Issue: 3
Pages: 1321-5
Publication
First Author: Ketterer S
Year: 2020
Journal: Nat Commun
Title: Cathepsin D deficiency in mammary epithelium transiently stalls breast cancer by interference with mTORC1 signaling.
Volume: 11
Issue: 1
Pages: 5133
Publication
First Author: Cheng S
Year: 2017
Journal: J Neurochem
Title: Haplodeficiency of Cathepsin D does not affect cerebral amyloidosis and autophagy in APP/PS1 transgenic mice.
Volume: 142
Issue: 2
Pages: 297-304
Publication  
First Author: Liu J
Year: 2022
Journal: Neurobiol Dis
Title: Intravitreal gene therapy restores the autophagy-lysosomal pathway and attenuates retinal degeneration in cathepsin D-deficient mice.
Volume: 164
Pages: 105628
Publication
First Author: Mutka AL
Year: 2010
Journal: J Neurochem
Title: Murine cathepsin D deficiency is associated with dysmyelination/myelin disruption and accumulation of cholesteryl esters in the brain.
Volume: 112
Issue: 1
Pages: 193-203
Publication  
First Author: Zhou R
Year: 2015
Journal: Prog Neuropsychopharmacol Biol Psychiatry
Title: Mice heterozygous for cathepsin D deficiency exhibit mania-related behavior and stress-induced depression.
Volume: 63
Pages: 110-8
Publication  
First Author: Qin S
Year: 1987
Journal: Cytogenet Cell Genet
Title: Mapping FSHB, CAT, and CTSB to specific sites on 11p
Volume: 46
Pages: 678 (Abstr.)
Publication
First Author: Iwama H
Year: 2021
Journal: Sci Rep
Title: Cathepsin B and D deficiency in the mouse pancreas induces impaired autophagy and chronic pancreatitis.
Volume: 11
Issue: 1
Pages: 6596
Publication  
First Author: Gallwitz L
Year: 2022
Journal: Neurobiol Dis
Title: Cathepsin D: Analysis of its potential role as an amyloid beta degrading protease.
Volume: 175
Pages: 105919
Publication  
First Author: Ketscher A
Year: 2016
Journal: Biochimie
Title: Neuroectoderm-specific deletion of cathepsin D in mice models human inherited neuronal ceroid lipofuscinosis type 10.
Volume: 122
Pages: 219-26
Publication
First Author: Prieto Huarcaya S
Year: 2022
Journal: Autophagy
Title: Recombinant pro-CTSD (cathepsin D) enhances SNCA/α-Synuclein degradation in α-Synucleinopathy models.
Volume: 18
Issue: 5
Pages: 1127-1151
Publication
First Author: Marques ARA
Year: 2020
Journal: Autophagy
Title: Enzyme replacement therapy with recombinant pro-CTSD (cathepsin D) corrects defective proteolysis and autophagy in neuronal ceroid lipofuscinosis.
Volume: 16
Issue: 5
Pages: 811-825
Publication
First Author: Beel S
Year: 2017
Journal: Hum Mol Genet
Title: Progranulin functions as a cathepsin D chaperone to stimulate axonal outgrowth in vivo.
Volume: 26
Issue: 15
Pages: 2850-2863
Publication
First Author: Houben T
Year: 2017
Journal: Sci Rep
Title: Cathepsin D regulates lipid metabolism in murine steatohepatitis.
Volume: 7
Issue: 1
Pages: 3494
Publication
First Author: Koike M
Year: 2017
Journal: Am J Pathol
Title: Purkinje Cells Are More Vulnerable to the Specific Depletion of Cathepsin D Than to That of Atg7.
Volume: 187
Issue: 7
Pages: 1586-1600
Publication
First Author: Aghdassi AA
Year: 2018
Journal: J Biol Chem
Title: Cathepsin D regulates cathepsin B activation and disease severity predominantly in inflammatory cells during experimental pancreatitis.
Volume: 293
Issue: 3
Pages: 1018-1029
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Diedrich JF
Year: 1990
Journal: Nucleic Acids Res
Title: Nucleotide sequence of a cDNA encoding mouse cathepsin D.
Volume: 18
Issue: 23
Pages: 7184
Publication
First Author: Grusby MJ
Year: 1990
Journal: Nucleic Acids Res
Title: Molecular cloning of mouse cathepsin D.
Volume: 18
Issue: 13
Pages: 4008
Publication
First Author: Koike M
Year: 2000
Journal: J Neurosci
Title: Cathepsin D deficiency induces lysosomal storage with ceroid lipofuscin in mouse CNS neurons.
Volume: 20
Issue: 18
Pages: 6898-906
Publication
First Author: Saftig P
Year: 1995
Journal: EMBO J
Title: Mice deficient for the lysosomal proteinase cathepsin D exhibit progressive atrophy of the intestinal mucosa and profound destruction of lymphoid cells.
Volume: 14
Issue: 15
Pages: 3599-608
Publication
First Author: Yamamoto-Nonaka K
Year: 2016
Journal: J Am Soc Nephrol
Title: Cathepsin D in Podocytes Is Important in the Pathogenesis of Proteinuria and CKD.
Volume: 27
Issue: 9
Pages: 2685-700
Publication      
First Author: Harris BS
Year: 2016
Journal: MGI Direct Data Submission
Title: A spontaneous model for neuronal ceroid lipofuscinosis 10
Publication
First Author: Di Spiezio A
Year: 2021
Journal: Biochim Biophys Acta Mol Basis Dis
Title: Analysis of cathepsin B and cathepsin L treatment to clear toxic lysosomal protein aggregates in neuronal ceroid lipofuscinosis.
Volume: 1867
Issue: 10
Pages: 166205
Publication
First Author: Tulone C
Year: 2011
Journal: PLoS One
Title: Differential requirement for cathepsin D for processing of the full length and C-terminal fragment of the malaria antigen MSP1.
Volume: 6
Issue: 10
Pages: e24886
Publication
First Author: Shimizu T
Year: 2005
Journal: J Neurochem
Title: Proteolytic degradation of glutamate decarboxylase mediates disinhibition of hippocampal CA3 pyramidal cells in cathepsin D-deficient mice.
Volume: 94
Issue: 3
Pages: 680-90
Publication  
First Author: Koch S
Year: 2013
Journal: Neurobiol Dis
Title: Cathepsin D deficiency induces cytoskeletal changes and affects cell migration pathways in the brain.
Volume: 50
Pages: 107-19
Publication  
First Author: Bassal M
Year: 2021
Journal: Cells
Title: Rapid and Progressive Loss of Multiple Retinal Cell Types in Cathepsin D-Deficient Mice-An Animal Model of CLN10 Disease.
Volume: 10
Issue: 3
Publication  
First Author: Crabtree D
Year: 2013
Journal: Neurosci Lett
Title: Dopamine and its metabolites in cathepsin D heterozygous mice before and after MPTP administration.
Volume: 538
Pages: 3-8
Publication
First Author: Yamasaki R
Year: 2007
Journal: Mol Cell Neurosci
Title: Involvement of lysosomal storage-induced p38 MAP kinase activation in the overproduction of nitric oxide by microglia in cathepsin D-deficient mice.
Volume: 35
Issue: 4
Pages: 573-84
Publication  
First Author: Okada R
Year: 2015
Journal: Mol Cell Neurosci
Title: Cathepsin D deficiency induces oxidative damage in brain pericytes and impairs the blood-brain barrier.
Volume: 64
Pages: 51-60
Publication
First Author: Zhou W
Year: 2006
Journal: Neuroscience
Title: Cathepsin D-mediated proteolysis of apolipoprotein E: possible role in Alzheimer's disease.
Volume: 143
Issue: 3
Pages: 689-701
Publication
First Author: Tyynelä J
Year: 2000
Journal: EMBO J
Title: A mutation in the ovine cathepsin D gene causes a congenital lysosomal storage disease with profound neurodegeneration.
Volume: 19
Issue: 12
Pages: 2786-92
Publication  
First Author: Journet A
Year: 1999
Journal: J Cell Sci
Title: Characterization of Dictyostelium discoideum cathepsin D.
Volume: 112 ( Pt 21)
Pages: 3833-43
Publication
First Author: Cho JH
Year: 2002
Journal: FASEB J
Title: Cathepsin D produces antimicrobial peptide parasin I from histone H2A in the skin mucosa of fish.
Volume: 16
Issue: 3
Pages: 429-31
Publication
First Author: Zhang D
Year: 2005
Journal: Invest Ophthalmol Vis Sci
Title: Correlation between inactive cathepsin D expression and retinal changes in mcd2/mcd2 transgenic mice.
Volume: 46
Issue: 9
Pages: 3031-8
Publication
First Author: Moss CX
Year: 2005
Journal: Eur J Immunol
Title: Destructive potential of the aspartyl protease cathepsin D in MHC class II-restricted antigen processing.
Volume: 35
Issue: 12
Pages: 3442-51
Publication
First Author: Boland B
Year: 2008
Journal: J Neurosci
Title: Autophagy induction and autophagosome clearance in neurons: relationship to autophagic pathology in Alzheimer's disease.
Volume: 28
Issue: 27
Pages: 6926-37
Publication
First Author: Singh CR
Year: 2006
Journal: J Immunol
Title: Processing and presentation of a mycobacterial antigen 85B epitope by murine macrophages is dependent on the phagosomal acquisition of vacuolar proton ATPase and in situ activation of cathepsin D.
Volume: 177
Issue: 5
Pages: 3250-9
GXD Expression    
Probe: MGI:1353061
Assay Type: Northern blot
Annotation Date: 2001-02-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1605911
Stage: TS11
Assay Id: MGI:1929712
Age: embryonic day 7.5
Image: 1
Specimen Label: d7.5
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:1353061
Assay Type: Northern blot
Annotation Date: 2001-02-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1605913
Stage: TS13
Assay Id: MGI:1929712
Age: embryonic day 8.5
Image: 1
Specimen Label: d8.5
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:1353061
Assay Type: Northern blot
Annotation Date: 2001-02-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3568928
Stage: TS28
Assay Id: MGI:1929712
Age: embryonic day 9.5
Image: 1
Specimen Label: d9.5
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:1353061
Assay Type: Northern blot
Annotation Date: 2001-02-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3568928
Stage: TS28
Assay Id: MGI:1929712
Age: embryonic day 10.5
Image: 1
Specimen Label: d10.5
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:1353061
Assay Type: Northern blot
Annotation Date: 2001-02-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3568928
Stage: TS28
Assay Id: MGI:1929712
Age: embryonic day 11.5
Image: 1
Specimen Label: d11.5
Detected: true
Specimen Num: 5
GXD Expression    
Probe: MGI:1353061
Assay Type: Northern blot
Annotation Date: 2001-02-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1606613
Stage: TS13
Assay Id: MGI:1929712
Age: embryonic day 8.5
Image: 1
Specimen Label: d8.5 Prim. TB
Detected: true
Specimen Num: 6
GXD Expression    
Probe: MGI:1929687
Assay Type: Western blot
Annotation Date: 2001-02-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1605911
Stage: TS11
Assay Id: MGI:1929719
Age: embryonic day 7.5
Image: 2
Specimen Label: d7.5
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:1929687
Assay Type: Western blot
Annotation Date: 2001-02-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3568928
Stage: TS28
Assay Id: MGI:1929719
Age: embryonic day 9.5
Image: 2
Specimen Label: d9.5
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:1929687
Assay Type: Western blot
Annotation Date: 2001-02-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3568928
Stage: TS28
Assay Id: MGI:1929719
Age: embryonic day 11.5
Image: 2
Specimen Label: d11.5
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:1929687
Assay Type: Western blot
Annotation Date: 2001-02-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1606613
Stage: TS13
Assay Id: MGI:1929719
Age: embryonic day 8.5
Image: 2
Specimen Label: d8.5 Prim. TB
Detected: true
Specimen Num: 4
GXD Expression
Probe: MGI:3700695
Assay Type: RNA in situ
Annotation Date: 2014-10-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1667819
Pattern: Single cells
Stage: TS19
Assay Id: MGI:5588136
Age: embryonic day 11.5
Image: 5B
Note: Expression is in the ventral region.
Specimen Label: 5B
Detected: true
Specimen Num: 12
GXD Expression
Probe: MGI:3700695
Assay Type: RNA in situ
Annotation Date: 2014-10-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1667820
Pattern: Single cells
Stage: TS20
Assay Id: MGI:5588136
Age: embryonic day 12.0
Image: 5D
Note: Expression is in the ventral region.
Specimen Label: 5D
Detected: true
Specimen Num: 13
GXD Expression
Probe: MGI:3700695
Assay Type: RNA in situ
Annotation Date: 2014-10-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1667822
Pattern: Single cells
Stage: TS22
Assay Id: MGI:5588136
Age: embryonic day 14.0
Image: 5F
Note: Labeled cells almost disappeared at this age.
Specimen Label: 5F
Detected: true
Specimen Num: 14
GXD Expression
Probe: MGI:4886004
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1691619
Pattern: Regionally restricted
Stage: TS19
Assay Id: MGI:4945717
Age: embryonic day 11.5
Image: g01313 E11.5
Note: Expression was region specific and scattered.
Specimen Label: g01313 E11.5
Detected: true
Specimen Num: 1
GXD Expression
Probe: MGI:4886004
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1691623
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4945717
Age: embryonic day 15.5
Image: g01313 E15.5
Note: Expression was region specific and scattered.
Specimen Label: g01313 E15.5
Detected: true
Specimen Num: 2
GXD Expression
Probe: MGI:4886004
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:3284223
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4945717
Age: embryonic day 15.5
Image: g01313 E15.5
Note: Expression was region specific and scattered.
Specimen Label: g01313 E15.5
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:3700695
Assay Type: RNA in situ
Annotation Date: 2014-10-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1902728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:5588136
Age: postnatal day 8
Image: 3E
Specimen Label: 3E
Detected: true
Specimen Num: 8
GXD Expression
Probe: MGI:7334873
Assay Type: Immunohistochemistry
Annotation Date: 2022-09-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:2828128
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:7334882
Age: postnatal adult
Image: 4B
Note: Expression in lysosomes distributed in middle region of cells.
Specimen Label: 4B
Detected: true
Specimen Num: 1
GXD Expression
Probe: MGI:3700695
Assay Type: RNA in situ
Annotation Date: 2014-10-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1619818
Pattern: Single cells
Stage: TS18
Assay Id: MGI:5588136
Age: embryonic day 11.0
Image: 1B
Note: Expression is in the mesenchyme between the cornea and the lens.
Specimen Label: 1B
Detected: true
Specimen Num: 3
GXD Expression
Probe: MGI:3700695
Assay Type: RNA in situ
Annotation Date: 2014-10-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1619818
Pattern: Single cells
Stage: TS18
Assay Id: MGI:5588136
Age: embryonic day 11.0
Image: 1A
Note: Expression is in the mesenchyme between the cornea and the lens.
Specimen Label: 1A
Detected: true
Specimen Num: 2
GXD Expression
Probe: MGI:4886004
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:3267828
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:4945717
Age: postnatal day 7
Image: g01313 P7
Note: Expression was region specific and scattered.
Specimen Label: g01313 P7
Detected: true
Specimen Num: 3
GXD Expression
Probe: MGI:4886004
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:3267828
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:4945717
Age: postnatal day 42
Image: g01313 Adult
Note: Expression was region specific and scattered.
Specimen Label: g01313 Adult
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:3700695
Assay Type: RNA in situ
Annotation Date: 2014-10-16
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3574428
Stage: TS28
Assay Id: MGI:5588136
Age: postnatal day 8
Image: 3E
Specimen Label: 3E
Detected: false
Specimen Num: 8
GXD Expression  
Probe: MGI:1353061
Assay Type: RNA in situ
Annotation Date: 2001-02-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3568928
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:1929725
Age: embryonic day 9.5
Note: Expression is detected in the primary giant cells and the placental secondary giant cells.
Specimen Label: E9.5
Detected: true
Specimen Num: 1
GXD Expression
Probe: MGI:1353061
Assay Type: RNA in situ
Annotation Date: 2001-02-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3568928
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:1929725
Age: embryonic day 11.5
Image: 3. g.
Note: Expression is detected in the placental secondary giant cells and the spongiotrophoblast layer.
Specimen Label: 3. g.
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:1929687
Assay Type: Immunohistochemistry
Annotation Date: 2001-02-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3568928
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:1929733
Age: embryonic day 9.5
Note: Expression is detected in the cytoplasmic vesicles of the primary giant cells and the secondary giant cells of the developing placental rudiment.
Specimen Label: 4. d.
Detected: true
Specimen Num: 2
GXD Expression
Probe: MGI:1929687
Assay Type: Immunohistochemistry
Annotation Date: 2001-02-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3568928
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:1929733
Age: embryonic day 11.5
Image: 4. g.
Note: Expression is detected in the placental secondary giant cells and the spongiotrophoblast layer.
Specimen Label: 4. g.
Detected: true
Specimen Num: 3
GXD Expression  
Probe: MGI:3700695
Assay Type: RNA in situ
Annotation Date: 2014-10-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1717218
Pattern: Single cells
Stage: TS18
Assay Id: MGI:5588136
Age: embryonic day 11.0
Image: 1A
Specimen Label: 1A
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:3700695
Assay Type: RNA in situ
Annotation Date: 2014-10-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1717220
Pattern: Not Specified
Stage: TS20
Assay Id: MGI:5588136
Age: embryonic day 12.5
Image: 2A
Specimen Label: 2A
Detected: true
Specimen Num: 4