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Search results 1 to 100 out of 457 for Ctsk

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Hits by Pathway

Hits by Strain

Hits by Category

Type Details Score
Gene
key_979890 | Ctsk
Type: gene
Organism: Not Specified
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Gene
1513 | CTSK
Type: gene
Organism: human
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Gene
513038 | CTSK
Type: gene
Organism: cattle
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Gene
395818 | CTSK
Type: gene
Organism: chicken
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Gene
550475 | ctsk
Type: gene
Organism: zebrafish
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Gene
574112 | CTSK
Type: gene
Organism: macaque, rhesus
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Gene
779889 | ctsk
Type: gene
Organism: frog, western clawed
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Gene
key_29936 | CTSK
Type: gene
Organism: rabbit, European
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Gene
29175 | Ctsk
Type: gene
Organism: rat
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Gene
608843 | CTSK
Type: gene
Organism: dog, domestic
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Gene
457278 | CTSK
Type: gene
Organism: chimpanzee
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Protein Coding Gene
MGI:107823 | Ctsk
Type: protein_coding_gene
Organism: mouse, laboratory
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GXD Expression
GXD Expression
 
Probe: MGI:7546861
Assay Type: Immunohistochemistry
Annotation Date: 2023-11-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1914327
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:7546923
Age: postnatal day 0
Image: 3D Ctsk WT
Specimen Label: 3D Ctsk WT
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:7546861
Assay Type: Immunohistochemistry
Annotation Date: 2023-11-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1914327
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:7546923
Age: postnatal day 0
Image: 3D Ctsk CKO
Specimen Label: 3D Ctsk CKO
Detected: true
Specimen Num: 2
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Publication
32212276 | J:311501
First Author: Li Q
Year: 2020
Journal: J Bone Miner Res
Title: Ubiquitin-Specific Protease 34 Inhibits Osteoclast Differentiation by Regulating NF-κB Signaling.
Volume: 35
Issue: 8
Pages: 1597-1608
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Publication
25958043 | J:225929
 
First Author: Sinnesael M
Year: 2015
Journal: Mol Cell Endocrinol
Title: The androgen receptor has no direct antiresorptive actions in mouse osteoclasts.
Volume: 411
Pages: 198-206
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Publication
25896020 | J:221174
First Author: Hao L
Year: 2015
Journal: FEBS Lett
Title: Deficiency of cathepsin K prevents inflammation and bone erosion in rheumatoid arthritis and periodontitis and reveals its shared osteoimmune role.
Volume: 589
Issue: 12
Pages: 1331-1339
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Publication
20230792 | J:159232
First Author: Zenger S
Year: 2010
Journal: Biochem Biophys Res Commun
Title: Long bone osteoclasts display an augmented osteoclast phenotype compared to calvarial osteoclasts.
Volume: 394
Issue: 3
Pages: 743-9
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Publication
17668061 | J:129317
First Author: Funicello M
Year: 2007
Journal: PLoS One
Title: Cathepsin K null mice show reduced adiposity during the rapid accumulation of fat stores.
Volume: 2
Issue: 8
Pages: e683
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Publication
31065924 | J:294308
First Author: Zhao R
Year: 2019
Journal: Cell Mol Neurobiol
Title: Cathepsin K Knockout Exacerbates Haemorrhagic Transformation Induced by Recombinant Tissue Plasminogen Activator After Focal Cerebral Ischaemia in Mice.
Volume: 39
Issue: 6
Pages: 823-831
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Publication
23321671 | J:194492
First Author: Lotinun S
Year: 2013
Journal: J Clin Invest
Title: Osteoclast-specific cathepsin K deletion stimulates S1P-dependent bone formation.
Volume: 123
Issue: 2
Pages: 666-81
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Publication
31112135 | J:289620
First Author: Lotinun S
Year: 2019
Journal: J Clin Invest
Title: Cathepsin K-deficient osteocytes prevent lactation-induced bone loss and parathyroid hormone suppression.
Volume: 129
Issue: 8
Pages: 3058-3071
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Publication
28095448 | J:248530
First Author: Jiang T
Year: 2017
Journal: PLoS One
Title: Distribution of Cathepsin K in Late Stage of Tooth Germ Development and Its Function in Degrading Enamel Matrix Proteins in Mouse.
Volume: 12
Issue: 1
Pages: e0169857
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Publication
30850734 | J:298399
First Author: Li R
Year: 2019
Journal: Cell Death Differ
Title: Gut microbiota-stimulated cathepsin K secretion mediates TLR4-dependent M2 macrophage polarization and promotes tumor metastasis in colorectal cancer.
Volume: 26
Issue: 11
Pages: 2447-2463
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Publication
15664014 | J:95525
First Author: Kiviranta R
Year: 2005
Journal: Bone
Title: Impaired bone resorption in cathepsin K-deficient mice is partially compensated for by enhanced osteoclastogenesis and increased expression of other proteases via an increased RANKL/OPG ratio.
Volume: 36
Issue: 1
Pages: 159-72
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Publication
16753017 | J:128098
First Author: Li CY
Year: 2006
Journal: J Bone Miner Res
Title: Mice lacking cathepsin K maintain bone remodeling but develop bone fragility despite high bone mass.
Volume: 21
Issue: 6
Pages: 865-75
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Publication
29880809 | J:314812
First Author: Guo R
Year: 2018
Journal: Cell Death Dis
Title: Cardiomyocyte-specific disruption of Cathepsin K protects against doxorubicin-induced cardiotoxicity.
Volume: 9
Issue: 6
Pages: 692
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Publication
34183355 | J:310826
First Author: Khan IZ
Year: 2021
Journal: Cancer Res
Title: The CD200-CD200R Axis Promotes Squamous Cell Carcinoma Metastasis via Regulation of Cathepsin K.
Volume: 81
Issue: 19
Pages: 5021-5032
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Publication
10372556 | J:55345
First Author: Rantakokko J
Year: 1999
Journal: Matrix Biol
Title: Complete genomic structure of the mouse cathepsin K gene (Ctsk) and its localization next to the Arnt gene on mouse chromosome 3.
Volume: 18
Issue: 2
Pages: 155-61
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Publication
36147479 | J:329286
First Author: Zhu G
Year: 2022
Journal: Int J Biol Sci
Title: Knockout and Double Knockout of Cathepsin K and Mmp9 reveals a novel function of Cathepsin K as a regulator of osteoclast gene expression and bone homeostasis.
Volume: 18
Issue: 14
Pages: 5522-5538
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Publication
34742737 | J:334709
First Author: Yu J
Year: 2021
Journal: J Biol Chem
Title: Hairy and enhancer of split 1 is a primary effector of NOTCH2 signaling and induces osteoclast differentiation and function.
Volume: 297
Issue: 6
Pages: 101376
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Publication
31134061 | J:284399
 
First Author: Csete D
Year: 2019
Journal: Front Immunol
Title: Hematopoietic or Osteoclast-Specific Deletion of Syk Leads to Increased Bone Mass in Experimental Mice.
Volume: 10
Pages: 937
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Publication
30075049 | J:325973
First Author: Pohl S
Year: 2018
Journal: J Bone Miner Res
Title: The Lysosomal Protein Arylsulfatase B Is a Key Enzyme Involved in Skeletal Turnover.
Volume: 33
Issue: 12
Pages: 2186-2201
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Publication
21447555 | J:171274
First Author: Combs MD
Year: 2011
Journal: Development
Title: NFATC1 promotes epicardium-derived cell invasion into myocardium.
Volume: 138
Issue: 9
Pages: 1747-57
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Publication
19661463 | J:169972
First Author: Combs MD
Year: 2009
Journal: Circ Res
Title: VEGF and RANKL regulation of NFATc1 in heart valve development.
Volume: 105
Issue: 6
Pages: 565-74
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Publication
16680826 | J:109487
First Author: Lange AW
Year: 2006
Journal: Dev Biol
Title: NFATc1 expression in the developing heart valves is responsive to the RANKL pathway and is required for endocardial expression of cathepsin K.
Volume: 292
Issue: 2
Pages: 407-17
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Publication
12652657 | J:106181
First Author: Chiellini C
Year: 2003
Journal: J Cell Physiol
Title: Identification of cathepsin K as a novel marker of adiposity in white adipose tissue.
Volume: 195
Issue: 2
Pages: 309-21
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Protein Coding Gene
MGP_CAROLIEiJ_G0025344 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0027585 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0027544 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0027511 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0027556 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0027289 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_107823 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0028004 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0026739 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0027266 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0027405 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0027376 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0027514 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0027403 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0028058 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0026467 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0026821 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0026788 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0026288 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
8814310 | J:35370
First Author: Rantakokko J
Year: 1996
Journal: FEBS Lett
Title: Mouse cathepsin K: cDNA cloning and predominant expression of the gene in osteoclasts, and in some hypertrophying chondrocytes during mouse development.
Volume: 393
Issue: 2-3
Pages: 307-13
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Publication
15826870 | J:99669
First Author: Morko J
Year: 2005
Journal: Bone
Title: Differential turnover of cortical and trabecular bone in transgenic mice overexpressing cathepsin K.
Volume: 36
Issue: 5
Pages: 854-65
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Publication
17210673 | J:117870
First Author: Chen W
Year: 2007
Journal: Hum Mol Genet
Title: Novel pycnodysostosis mouse model uncovers cathepsin K function as a potential regulator of osteoclast apoptosis and senescence.
Volume: 16
Issue: 4
Pages: 410-23
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Publication
24894568 | J:274177
 
First Author: Jiang H
Year: 2014
Journal: Nat Commun
Title: Cathepsin K-mediated Notch1 activation contributes to neovascularization in response to hypoxia.
Volume: 5
Pages: 3838
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Publication
21718816 | J:176984
First Author: Leung P
Year: 2011
Journal: Bone
Title: The effects of the cathepsin K inhibitor odanacatib on osteoclastic bone resorption and vesicular trafficking.
Volume: 49
Issue: 4
Pages: 623-35
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Publication
25692548 | J:222030
First Author: Hua Y
Year: 2015
Journal: Aging Cell
Title: Cathepsin K knockout alleviates aging-induced cardiac dysfunction.
Volume: 14
Issue: 3
Pages: 345-51
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Publication
21968827 | J:233286
First Author: Kozawa E
Year: 2012
Journal: Arthritis Rheum
Title: Osteoarthritic change is delayed in a Ctsk-knockout mouse model of osteoarthritis.
Volume: 64
Issue: 2
Pages: 454-64
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Publication
23069627 | J:208613
First Author: Hua Y
Year: 2013
Journal: Diabetes
Title: Cathepsin K knockout mitigates high-fat diet-induced cardiac hypertrophy and contractile dysfunction.
Volume: 62
Issue: 2
Pages: 498-509
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Publication
28821796 | J:255813
First Author: Guo R
Year: 2017
Journal: Sci Rep
Title: Cathepsin K knockout protects against cardiac dysfunction in diabetic mice.
Volume: 7
Issue: 1
Pages: 8703
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Publication
24343118 | J:280766
First Author: Hu L
Year: 2014
Journal: Hypertension
Title: Cathepsin K activity controls injury-related vascular repair in mice.
Volume: 63
Issue: 3
Pages: 607-15
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Publication
15161653 | J:109717
First Author: Bühling F
Year: 2004
Journal: Am J Pathol
Title: Pivotal role of cathepsin K in lung fibrosis.
Volume: 164
Issue: 6
Pages: 2203-16
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Publication
23529168 | J:268788
First Author: Hua Y
Year: 2013
Journal: Hypertension
Title: Cathepsin K knockout alleviates pressure overload-induced cardiac hypertrophy.
Volume: 61
Issue: 6
Pages: 1184-92
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Publication
31808010 | J:332715
First Author: Dauth S
Year: 2020
Journal: Cell Mol Neurobiol
Title: Function of Cathepsin K in the Central Nervous System of Male Mice is Independent of Its Role in the Thyroid Gland.
Volume: 40
Issue: 5
Pages: 695-710
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Publication
24928497 | J:215505
 
First Author: Gentile MA
Year: 2014
Journal: Bone
Title: Increased fracture callus mineralization and strength in cathepsin K knockout mice.
Volume: 66
Pages: 72-81
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Publication
22484689 | J:186212
First Author: Hayami T
Year: 2012
Journal: Bone
Title: Inhibition of cathepsin K reduces cartilage degeneration in the anterior cruciate ligament transection rabbit and murine models of osteoarthritis.
Volume: 50
Issue: 6
Pages: 1250-9
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Publication
23152408 | J:320786
First Author: Arampatzidou M
Year: 2012
Journal: Biol Chem
Title: Effects of cathepsin K deficiency on intercellular junction proteins, luminal mucus layers, and extracellular matrix constituents in the mouse colon.
Volume: 393
Issue: 12
Pages: 1391-403
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Publication
29800693 | J:266619
 
First Author: Yang P
Year: 2018
Journal: Bone
Title: Preservation of type H vessels and osteoblasts by enhanced preosteoclast platelet-derived growth factor type BB attenuates glucocorticoid-induced osteoporosis in growing mice.
Volume: 114
Pages: 1-13
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Publication
21817099 | J:194802
First Author: Sun J
Year: 2012
Journal: Arterioscler Thromb Vasc Biol
Title: Cathepsin K deficiency reduces elastase perfusion-induced abdominal aortic aneurysms in mice.
Volume: 32
Issue: 1
Pages: 15-23
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Publication
18845279 | J:146026
First Author: Pennypacker B
Year: 2009
Journal: Bone
Title: Bone density, strength, and formation in adult cathepsin K (-/-) mice.
Volume: 44
Issue: 2
Pages: 199-207
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Publication
26460818 | J:309069
First Author: Moriya S
Year: 2016
Journal: J Cell Physiol
Title: Cathepsin K Deficiency Suppresses Disuse-Induced Bone Loss.
Volume: 231
Issue: 5
Pages: 1163-70
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Publication
24590570 | J:234751
First Author: Jacome-Galarza C
Year: 2014
Journal: J Cell Biochem
Title: Altered hematopoietic stem cell and osteoclast precursor frequency in cathepsin K null mice.
Volume: 115
Issue: 8
Pages: 1449-57
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Publication
23269702 | J:194359
First Author: Yang C
Year: 2013
Journal: Cancer Discov
Title: Antagonism of inhibitor of apoptosis proteins increases bone metastasis via unexpected osteoclast activation.
Volume: 3
Issue: 2
Pages: 212-23
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Publication
34327196 | J:321400
 
First Author: Pánczél Á
Year: 2021
Journal: Front Cell Dev Biol
Title: Fluorescence-Based Real-Time Analysis of Osteoclast Development.
Volume: 9
Pages: 657935
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Publication
25951977 | J:228464
First Author: Rahman MM
Year: 2015
Journal: Biochem Biophys Res Commun
Title: Secretion of PDGF isoforms during osteoclastogenesis and its modulation by anti-osteoclast drugs.
Volume: 462
Issue: 2
Pages: 159-64
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Publication
37948912 | J:343371
 
First Author: Yamaguchi H
Year: 2023
Journal: Biochem Biophys Res Commun
Title: Enhanced BMP signaling in Cathepsin K-positive tendon progenitors induces heterotopic ossification.
Volume: 688
Pages: 149147
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Publication
11082042 | J:66887
 
First Author: Tepel C
Year: 2000
Journal: J Cell Sci
Title: Cathepsin K in thyroid epithelial cells: sequence, localization and possible function in extracellular proteolysis of thyroglobulin.
Volume: 113 Pt 24
Pages: 4487-98
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Publication
8703060 | J:47500
First Author: Gelb BD
Year: 1996
Journal: Science
Title: Pycnodysostosis, a lysosomal disease caused by cathepsin K deficiency.
Volume: 273
Issue: 5279
Pages: 1236-8
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Publication
8986645 | J:38441
First Author: Gelb BD
Year: 1996
Journal: Biochem Mol Med
Title: Cathepsin K: isolation and characterization of the murine cDNA and genomic sequence, the homologue of the human pycnodysostosis gene.
Volume: 59
Issue: 2
Pages: 200-6
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Publication
9556067 | J:47097
First Author: Dodds RA
Year: 1998
Journal: J Bone Miner Res
Title: Cathepsin K mRNA detection is restricted to osteoclasts during fetal mouse development.
Volume: 13
Issue: 4
Pages: 673-82
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Publication
10234569 | J:54282
First Author: Li YP
Year: 1999
Journal: J Bone Miner Res
Title: Characterization of mouse cathepsin K gene, the gene promoter, and the gene expression.
Volume: 14
Issue: 4
Pages: 487-99
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Publication
15265002 | J:94063
First Author: Godat E
Year: 2004
Journal: Biochem J
Title: Cathepsin K: a cysteine protease with unique kinin-degrading properties.
Volume: 383
Issue: Pt. 3
Pages: 501-6
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Publication
16329095 | J:133863
First Author: Morko J
Year: 2005
Journal: Arthritis Rheum
Title: Spontaneous development of synovitis and cartilage degeneration in transgenic mice overexpressing cathepsin K.
Volume: 52
Issue: 12
Pages: 3713-7
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Publication
19700761 | J:153118
First Author: Podgorski I
Year: 2009
Journal: Am J Pathol
Title: Bone marrow-derived cathepsin K cleaves SPARC in bone metastasis.
Volume: 175
Issue: 3
Pages: 1255-69
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Publication
32853181 | J:309035
First Author: Feng H
Year: 2020
Journal: J Clin Invest
Title: Tendon-derived cathepsin K-expressing progenitor cells activate Hedgehog signaling to drive heterotopic ossification.
Volume: 130
Issue: 12
Pages: 6354-6365
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GXD Expression
GXD Expression
     
Probe: MGI:3653432
Assay Type: Northern blot
Annotation Date: 2006-09-05
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:3653440
Age: postnatal
Specimen Label: wt Li
Detected: false
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:3653432
Assay Type: Northern blot
Annotation Date: 2006-09-05
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:3653440
Age: postnatal
Specimen Label: db Li
Detected: false
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:3653432
Assay Type: Northern blot
Annotation Date: 2006-09-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1672828
Stage: TS28
Assay Id: MGI:3653440
Age: postnatal
Specimen Label: wt Lu
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
     
Probe: MGI:3653432
Assay Type: Northern blot
Annotation Date: 2006-09-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1672828
Stage: TS28
Assay Id: MGI:3653440
Age: postnatal
Specimen Label: db Lu
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
     
Probe: MGI:3653432
Assay Type: Northern blot
Annotation Date: 2006-09-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3557728
Stage: TS28
Assay Id: MGI:3653440
Age: postnatal
Specimen Label: wt M
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
     
Probe: MGI:3653432
Assay Type: Northern blot
Annotation Date: 2006-09-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3557728
Stage: TS28
Assay Id: MGI:3653440
Age: postnatal
Specimen Label: db M
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
     
Probe: MGI:3653432
Assay Type: Northern blot
Annotation Date: 2006-09-05
Strength: Present
Sex: Male
Emaps: EMAPS:1797228
Stage: TS28
Assay Id: MGI:3653440
Age: postnatal
Specimen Label: wt T
Detected: true
Specimen Num: 7
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:3653432
Assay Type: Northern blot
Annotation Date: 2006-09-05
Strength: Present
Sex: Male
Emaps: EMAPS:1797228
Stage: TS28
Assay Id: MGI:3653440
Age: postnatal
Specimen Label: db T
Detected: true
Specimen Num: 8
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:3653431
Assay Type: RT-PCR
Annotation Date: 2006-09-05
Strength: Present
Sex: Male
Emaps: EMAPS:1797228
Stage: TS28
Assay Id: MGI:3653494
Age: postnatal adult
Specimen Label: testis
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:3653431
Assay Type: RT-PCR
Annotation Date: 2006-09-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:3653494
Age: postnatal adult
Specimen Label: liver
Detected: true
Specimen Num: 2
•
•
•
•
•




MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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