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Search results 1 to 100 out of 118 for Ctsz

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0.044s
Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: chicken
Gene
Type: gene
Organism: zebrafish
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: frog, western clawed
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: dog, domestic
Gene
Type: gene
Organism: chimpanzee
Gene
Type: gene
Organism: rat
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Domain
Type: Family
Description: Cathepsin Z (also known as Cathepsin X , and MEROPS identifier C01.013) is predominantly a cysteine-type carboxypeptidase with limited endopeptidase or dipeptidyl-peptidase activity, mainly against synthetic substrates [, ]. The substrate specificity has been examined by peptide scanning and shows that proline is not tolerated in the P1 or P1' positions and poorly accepted in P2, and Tyr, Met and Cys are marginally prefered in P2, P1 and P1' [, ].Cathepsin X is synthesized as an inactive zymogen, but the propeptide lacks the ERFNIN motif characteristic of lysosomal cysteine peptidases. A disulfide bridge can be formed between the proregion and the enzyme which leads to inactivation of the zymogen by the formation of a reversible covalent bond with the active site residue []. From the crystal structure of the mature enzyme, a short, five-residue 'mini-loop' which includes the motif His-Xaa-Xaa-Xaa-Tyr restricts access to the S2' binding pocket, and it is the histidine that confers carboxypeptidase activity []. Rotation of the histidine ring permits dipeptidyl-peptidase substrates to bind. The presence of an exposed RGD motif allows binding to beta3-integrin []and the enzyme may have a role in cell signalling. Cathepsin X deficiency leads to accelerated cell senescence []. Cathepsin X also regulates the immune response to Helicobacter pylori infection [, ].
GXD Expression
Probe: MGI:3713678
Assay Type: RNA in situ
Annotation Date: 2007-07-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:160587
Pattern: Regionally restricted
Stage: TS07
Assay Id: MGI:3713786
Age: embryonic day 5.5
Image: 2 Ctsz E5.5
Note: Expression in visceral endoderm mainly within the proximal or 'extraembryonic' part of the egg cylinder.
Specimen Label: 2 Ctsz E5.5
Detected: true
Specimen Num: 1
GXD Expression
Probe: MGI:3713678
Assay Type: RNA in situ
Annotation Date: 2007-07-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:160589
Pattern: Regionally restricted
Stage: TS09
Assay Id: MGI:3713786
Age: embryonic day 6.5
Image: 2 Ctsz E6.5
Note: Expression in visceral endoderm mainly within the proximal or 'extraembryonic' part of the egg cylinder.
Specimen Label: 2 Ctsz E6.5
Detected: true
Specimen Num: 2
Protein
Organism: Mus musculus/domesticus
Length: 306  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 307  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 306  
Fragment?: false
Publication
First Author: Sivaraman J
Year: 2000
Journal: J Mol Biol
Title: Crystal structure of human procathepsin X: a cysteine protease with the proregion covalently linked to the active site cysteine.
Volume: 295
Issue: 4
Pages: 939-51
Publication
First Author: Guncar G
Year: 2000
Journal: Structure
Title: Crystal structure of cathepsin X: a flip-flop of the ring of His23 allows carboxy-monopeptidase and carboxy-dipeptidase activity of the protease.
Volume: 8
Issue: 3
Pages: 305-13
Publication
First Author: Nägler DK
Year: 1999
Journal: Biochemistry
Title: Human cathepsin X: A cysteine protease with unique carboxypeptidase activity.
Volume: 38
Issue: 39
Pages: 12648-54
Publication
First Author: Klemencic I
Year: 2000
Journal: Eur J Biochem
Title: Biochemical characterization of human cathepsin X revealed that the enzyme is an exopeptidase, acting as carboxymonopeptidase or carboxydipeptidase.
Volume: 267
Issue: 17
Pages: 5404-12
Publication
First Author: Devanathan G
Year: 2005
Journal: Biochem Biophys Res Commun
Title: Carboxy-monopeptidase substrate specificity of human cathepsin X.
Volume: 329
Issue: 2
Pages: 445-52
Publication
First Author: Puzer L
Year: 2005
Journal: Biol Chem
Title: Recombinant human cathepsin X is a carboxymonopeptidase only: a comparison with cathepsins B and L.
Volume: 386
Issue: 11
Pages: 1191-5
Publication
First Author: Obermajer N
Year: 2006
Journal: Exp Cell Res
Title: Carboxypeptidase cathepsin X mediates beta2-integrin-dependent adhesion of differentiated U-937 cells.
Volume: 312
Issue: 13
Pages: 2515-27
Publication
First Author: Kraus S
Year: 2011
Journal: Eur J Cell Biol
Title: Cellular senescence induced by cathepsin X downregulation.
Volume: 90
Issue: 8
Pages: 678-86
Publication
First Author: Krueger S
Year: 2005
Journal: J Pathol
Title: Up-regulation of cathepsin X in Helicobacter pylori gastritis and gastric cancer.
Volume: 207
Issue: 1
Pages: 32-42
Publication
First Author: Obermajer N
Year: 2009
Journal: Eur J Cell Biol
Title: Cathepsin X prevents an effective immune response against Helicobacter pylori infection.
Volume: 88
Issue: 8
Pages: 461-71
Publication
First Author: Akkari L
Year: 2014
Journal: Genes Dev
Title: Distinct functions of macrophage-derived and cancer cell-derived cathepsin Z combine to promote tumor malignancy via interactions with the extracellular matrix.
Volume: 28
Issue: 19
Pages: 2134-50
Publication
First Author: Krueger S
Year: 2013
Journal: PLoS One
Title: Induction of premalignant host responses by cathepsin x/z-deficiency in Helicobacter pylori-infected mice.
Volume: 8
Issue: 7
Pages: e70242
Publication
First Author: Sevenich L
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: Synergistic antitumor effects of combined cathepsin B and cathepsin Z deficiencies on breast cancer progression and metastasis in mice.
Volume: 107
Issue: 6
Pages: 2497-502
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
GXD Expression      
Probe: MGI:1331793
Assay Type: RT-PCR
Annotation Date: 1999-03-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603911
Stage: TS11
Assay Id: MGI:1331794
Age: embryonic day 7.5
Specimen Label: 1x
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:1331793
Assay Type: RT-PCR
Annotation Date: 1999-03-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603911
Stage: TS11
Assay Id: MGI:1331794
Age: embryonic day 7.5
Specimen Label: 10x
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:1331793
Assay Type: RT-PCR
Annotation Date: 1999-03-18
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1603911
Stage: TS11
Assay Id: MGI:1331794
Age: embryonic day 7.5
Specimen Label: 100x
Detected: false
Specimen Num: 3
GXD Expression      
Probe: MGI:1331793
Assay Type: RT-PCR
Annotation Date: 1999-03-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1604211
Stage: TS11
Assay Id: MGI:1331794
Age: embryonic day 7.5
Specimen Label: 1x
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:1331793
Assay Type: RT-PCR
Annotation Date: 1999-03-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1604211
Stage: TS11
Assay Id: MGI:1331794
Age: embryonic day 7.5
Specimen Label: 10x
Detected: true
Specimen Num: 5
GXD Expression      
Probe: MGI:1331793
Assay Type: RT-PCR
Annotation Date: 1999-03-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1604211
Stage: TS11
Assay Id: MGI:1331794
Age: embryonic day 7.5
Specimen Label: 100x
Detected: true
Specimen Num: 6
GXD Expression    
Probe: MGI:3711972
Assay Type: RT-PCR
Annotation Date: 2007-06-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603915
Stage: TS15
Assay Id: MGI:3712102
Age: embryonic day 9.5
Image: 2D
Specimen Label: WT
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:3711972
Assay Type: RT-PCR
Annotation Date: 2007-06-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603915
Stage: TS15
Assay Id: MGI:3712102
Age: embryonic day 9.5
Image: 2D
Specimen Label: ADNP-/-
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:3060248
Assay Type: RNA in situ
Annotation Date: 2022-11-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3286620
Pattern: Not Specified
Stage: TS20
Assay Id: MGI:7378774
Age: embryonic day 12.0
Image: 2D
Specimen Label: 2D
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:6170542
Assay Type: RNA in situ
Annotation Date: 2023-11-28
Strength: Present
Sex: Male
Emaps: EMAPS:3583128
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:7561555
Age: postnatal day 56
Image: S3
Specimen Label: S3
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:3060248
Assay Type: RNA in situ
Annotation Date: 2022-11-07
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:3286020
Pattern: Not Specified
Stage: TS20
Assay Id: MGI:7378774
Age: embryonic day 12.0
Image: 2D
Specimen Label: 2D
Detected: true
Specimen Num: 1
Publication    
First Author: Shi GP
Year: 2000
Journal: GenBank Submission
Title: Mus musculus strain C57BL/6 cathepsin Z (Ctsz) mRNA, complete cds
Pages: AF197479
Publication    
First Author: Strausberg R
Year: 2001
Journal: GenBank Submission
Title: Mus musculus, cathepsin Z, clone MGC: 5694, mRNA, complete cds
Pages: BC008619
Publication  
First Author: Bühler A
Year: 2013
Journal: Exp Eye Res
Title: Cathepsin proteases promote angiogenic sprouting and laser-induced choroidal neovascularisation in mice.
Volume: 115
Pages: 73-8
Publication
First Author: Bernhardt A
Year: 2010
Journal: J Biol Chem
Title: Cathepsin X-deficient gastric epithelial cells in co-culture with macrophages: characterization of cytokine response and migration capability after Helicobacter pylori infection.
Volume: 285
Issue: 44
Pages: 33691-700
Publication
First Author: Bhutani N
Year: 2012
Journal: J Biol Chem
Title: Cathepsins L and Z are critical in degrading polyglutamine-containing proteins within lysosomes.
Volume: 287
Issue: 21
Pages: 17471-82
Publication
First Author: Schwenck J
Year: 2019
Journal: Theranostics
Title: Cysteine-type cathepsins promote the effector phase of acute cutaneous delayed-type hypersensitivity reactions.
Volume: 9
Issue: 13
Pages: 3903-3917
Publication
First Author: Akkari L
Year: 2016
Journal: Genes Dev
Title: Combined deletion of cathepsin protease family members reveals compensatory mechanisms in cancer.
Volume: 30
Issue: 2
Pages: 220-32
Publication
First Author: Miller G
Year: 2011
Journal: FASEB J
Title: Asparagine endopeptidase is required for normal kidney physiology and homeostasis.
Volume: 25
Issue: 5
Pages: 1606-17
Publication
First Author: Campden RI
Year: 2022
Journal: J Biol Chem
Title: Extracellular cathepsin Z signals through the α5 integrin and augments NLRP3 inflammasome activation.
Volume: 298
Issue: 1
Pages: 101459
Publication
First Author: Deu E
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Ferrous iron-dependent drug delivery enables controlled and selective release of therapeutic agents in vivo.
Volume: 110
Issue: 45
Pages: 18244-9
Publication
First Author: Deussing J
Year: 2000
Journal: Biochim Biophys Acta
Title: Murine and human cathepsin Z: cDNA-cloning, characterization of the genes and chromosomal localization.
Volume: 1491
Issue: 1-3
Pages: 93-106
Publication  
First Author: Frankenberg S
Year: 2007
Journal: BMC Dev Biol
Title: Novel gene expression patterns along the proximo-distal axis of the mouse embryo before gastrulation.
Volume: 7
Pages: 8
Publication
First Author: Zhou X
Year: 2017
Journal: Mol Neurodegener
Title: Lysosomal processing of progranulin.
Volume: 12
Issue: 1
Pages: 62
Publication
First Author: Tisljar K
Year: 1999
Journal: FEBS Lett
Title: Cathepsin J, a novel murine cysteine protease of the papain family with a placenta-restricted expression.
Volume: 459
Issue: 3
Pages: 299-304
Publication
First Author: Sol-Church K
Year: 2000
Journal: Biochim Biophys Acta
Title: Mouse cathepsin M, a placenta-specific lysosomal cysteine protease related to cathepsins L and P.
Volume: 1491
Issue: 1-3
Pages: 289-94
Publication
First Author: Prudova A
Year: 2016
Journal: Cell Rep
Title: TAILS N-Terminomics and Proteomics Show Protein Degradation Dominates over Proteolytic Processing by Cathepsins in Pancreatic Tumors.
Volume: 16
Issue: 6
Pages: 1762-1773
Publication
First Author: Lü J
Year: 2007
Journal: J Biol Chem
Title: Cathespin H is an Fgf10 target involved in Bmp4 degradation during lung branching morphogenesis.
Volume: 282
Issue: 30
Pages: 22176-84
Publication
First Author: Orlowski GM
Year: 2017
Journal: J Leukoc Biol
Title: Frontline Science: Multiple cathepsins promote inflammasome-independent, particle-induced cell death during NLRP3-dependent IL-1β activation.
Volume: 102
Issue: 1
Pages: 7-17
Publication
First Author: Zhang B
Year: 2011
Journal: Blood
Title: Mice deficient in LMAN1 exhibit FV and FVIII deficiencies and liver accumulation of α1-antitrypsin.
Volume: 118
Issue: 12
Pages: 3384-91
Publication
First Author: Mandel S
Year: 2007
Journal: Dev Biol
Title: Activity-dependent neuroprotective protein (ADNP) differentially interacts with chromatin to regulate genes essential for embryogenesis.
Volume: 303
Issue: 2
Pages: 814-24
Publication
First Author: Yan D
Year: 2016
Journal: Cell Rep
Title: STAT3 and STAT6 Signaling Pathways Synergize to Promote Cathepsin Secretion from Macrophages via IRE1α Activation.
Volume: 16
Issue: 11
Pages: 2914-2927
Publication  
First Author: Naba A
Year: 2017
Journal: Sci Rep
Title: Quantitative proteomic profiling of the extracellular matrix of pancreatic islets during the angiogenic switch and insulinoma progression.
Volume: 7
Pages: 40495
Publication
First Author: Ko MS
Year: 1998
Journal: Hum Mol Genet
Title: Genome-wide mapping of unselected transcripts from extraembryonic tissue of 7.5-day mouse embryos reveals enrichment in the t-complex and under-representation on the X chromosome.
Volume: 7
Issue: 12
Pages: 1967-78
Publication
First Author: Miller JA
Year: 2013
Journal: Development
Title: Conserved molecular signatures of neurogenesis in the hippocampal subgranular zone of rodents and primates.
Volume: 140
Issue: 22
Pages: 4633-44
Publication      
First Author: The Jackson Laboratory Backcross DNA Panel Mapping Resource
Year: 1999
Journal: Database Release
Title: JAX BSS Panel Mapping Data
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: RIKEN Data Curation in Mouse Genome Informatics
Publication
First Author: Ko MS
Year: 2000
Journal: Development
Title: Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development.
Volume: 127
Issue: 8
Pages: 1737-49
Publication
First Author: Hansen J
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.
Volume: 100
Issue: 17
Pages: 9918-22
Publication      
First Author: MGI and IMPC
Year: 2018
Journal: Database Release
Title: MGI Load of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC)
Publication      
First Author: Lennon G
Year: 1999
Journal: Database Download
Title: WashU-HHMI Mouse EST Project
Publication      
First Author: Helmholtz Zentrum Muenchen GmbH
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu)
Publication        
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
Publication      
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
Publication        
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Publication        
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Rat to Mouse ISO GO annotation transfer
Publication
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
Publication
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
Publication        
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
Publication      
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
Publication      
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load