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Search results 1 to 100 out of 120 for Ctsz

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Categories

Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
Gene
1522 | CTSZ
Type: gene
Organism: human
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Gene
100127597 | ctsz
Type: gene
Organism: frog, western clawed
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Gene
404187 | CTSZ
Type: gene
Organism: cattle
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Gene
611983 | CTSZ
Type: gene
Organism: dog, domestic
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Gene
736240 | CTSZ
Type: gene
Organism: chimpanzee
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Gene
252929 | Ctsz
Type: gene
Organism: rat
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Gene
419311 | CTSZ
Type: gene
Organism: chicken
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Gene
450022 | ctsz
Type: gene
Organism: zebrafish
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Gene
694157 | CTSZ
Type: gene
Organism: macaque, rhesus
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Protein Coding Gene
MGI:1891190 | Ctsz
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Domain
IPR033157 | CTSZ
Type: Family
Description: Cathepsin Z (also known as Cathepsin X , and MEROPS identifier C01.013) is predominantly a cysteine-type carboxypeptidase with limited endopeptidase or dipeptidyl-peptidase activity, mainly against synthetic substrates [, ]. The substrate specificity has been examined by peptide scanning and shows that proline is not tolerated in the P1 or P1' positions and poorly accepted in P2, and Tyr, Met and Cys are marginally prefered in P2, P1 and P1' [, ].Cathepsin X is synthesized as an inactive zymogen, but the propeptide lacks the ERFNIN motif characteristic of lysosomal cysteine peptidases. A disulfide bridge can be formed between the proregion and the enzyme which leads to inactivation of the zymogen by the formation of a reversible covalent bond with the active site residue []. From the crystal structure of the mature enzyme, a short, five-residue 'mini-loop' which includes the motif His-Xaa-Xaa-Xaa-Tyr restricts access to the S2' binding pocket, and it is the histidine that confers carboxypeptidase activity []. Rotation of the histidine ring permits dipeptidyl-peptidase substrates to bind. The presence of an exposed RGD motif allows binding to beta3-integrin []and the enzyme may have a role in cell signalling. Cathepsin X deficiency leads to accelerated cell senescence []. Cathepsin X also regulates the immune response to Helicobacter pylori infection [, ].
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GXD Expression
GXD Expression
Probe: MGI:3713678
Assay Type: RNA in situ
Annotation Date: 2007-07-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:160587
Pattern: Regionally restricted
Stage: TS07
Assay Id: MGI:3713786
Age: embryonic day 5.5
Image: 2 Ctsz E5.5
Note: Expression in visceral endoderm mainly within the proximal or 'extraembryonic' part of the egg cylinder.
Specimen Label: 2 Ctsz E5.5
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
Probe: MGI:3713678
Assay Type: RNA in situ
Annotation Date: 2007-07-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:160589
Pattern: Regionally restricted
Stage: TS09
Assay Id: MGI:3713786
Age: embryonic day 6.5
Image: 2 Ctsz E6.5
Note: Expression in visceral endoderm mainly within the proximal or 'extraembryonic' part of the egg cylinder.
Specimen Label: 2 Ctsz E6.5
Detected: true
Specimen Num: 2
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Protein
Q9WUU7
Organism: Mus musculus/domesticus
Length: 306  
Fragment?: false
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Protein
Q9ES94
Organism: Mus musculus/domesticus
Length: 307  
Fragment?: false
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Protein
Q545I6
Organism: Mus musculus/domesticus
Length: 306  
Fragment?: false
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Publication
10656802 | -
First Author: Sivaraman J
Year: 2000
Journal: J Mol Biol
Title: Crystal structure of human procathepsin X: a cysteine protease with the proregion covalently linked to the active site cysteine.
Volume: 295
Issue: 4
Pages: 939-51
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Publication
10745011 | -
First Author: Guncar G
Year: 2000
Journal: Structure
Title: Crystal structure of cathepsin X: a flip-flop of the ring of His23 allows carboxy-monopeptidase and carboxy-dipeptidase activity of the protease.
Volume: 8
Issue: 3
Pages: 305-13
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Publication
10504234 | -
First Author: Nägler DK
Year: 1999
Journal: Biochemistry
Title: Human cathepsin X: A cysteine protease with unique carboxypeptidase activity.
Volume: 38
Issue: 39
Pages: 12648-54
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Publication
10951198 | -
First Author: Klemencic I
Year: 2000
Journal: Eur J Biochem
Title: Biochemical characterization of human cathepsin X revealed that the enzyme is an exopeptidase, acting as carboxymonopeptidase or carboxydipeptidase.
Volume: 267
Issue: 17
Pages: 5404-12
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Publication
15737607 | -
First Author: Devanathan G
Year: 2005
Journal: Biochem Biophys Res Commun
Title: Carboxy-monopeptidase substrate specificity of human cathepsin X.
Volume: 329
Issue: 2
Pages: 445-52
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Publication
16307485 | -
First Author: Puzer L
Year: 2005
Journal: Biol Chem
Title: Recombinant human cathepsin X is a carboxymonopeptidase only: a comparison with cathepsins B and L.
Volume: 386
Issue: 11
Pages: 1191-5
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Publication
16774752 | -
First Author: Obermajer N
Year: 2006
Journal: Exp Cell Res
Title: Carboxypeptidase cathepsin X mediates beta2-integrin-dependent adhesion of differentiated U-937 cells.
Volume: 312
Issue: 13
Pages: 2515-27
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Publication
21616554 | -
First Author: Kraus S
Year: 2011
Journal: Eur J Cell Biol
Title: Cellular senescence induced by cathepsin X downregulation.
Volume: 90
Issue: 8
Pages: 678-86
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Publication
16025436 | -
First Author: Krueger S
Year: 2005
Journal: J Pathol
Title: Up-regulation of cathepsin X in Helicobacter pylori gastritis and gastric cancer.
Volume: 207
Issue: 1
Pages: 32-42
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Publication
19446361 | -
First Author: Obermajer N
Year: 2009
Journal: Eur J Cell Biol
Title: Cathepsin X prevents an effective immune response against Helicobacter pylori infection.
Volume: 88
Issue: 8
Pages: 461-71
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Publication
25274726 | J:217440
First Author: Akkari L
Year: 2014
Journal: Genes Dev
Title: Distinct functions of macrophage-derived and cancer cell-derived cathepsin Z combine to promote tumor malignancy via interactions with the extracellular matrix.
Volume: 28
Issue: 19
Pages: 2134-50
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Publication
23936173 | J:203265
First Author: Krueger S
Year: 2013
Journal: PLoS One
Title: Induction of premalignant host responses by cathepsin x/z-deficiency in Helicobacter pylori-infected mice.
Volume: 8
Issue: 7
Pages: e70242
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Publication
20133781 | J:157541
First Author: Sevenich L
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: Synergistic antitumor effects of combined cathepsin B and cathepsin Z deficiencies on breast cancer progression and metastasis in mice.
Volume: 107
Issue: 6
Pages: 2497-502
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Protein Coding Gene
MGP_CAROLIEiJ_G0024759 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0026967 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0026934 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0026905 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0026943 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0026685 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1891190 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0027390 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0026144 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0026662 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0026800 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0026766 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0026901 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0026785 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0027447 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0025880 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0026216 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0026201 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0025680 | -
Type: protein_coding_gene
Organism: Mus spretus
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GXD Expression
GXD Expression
     
Probe: MGI:1331793
Assay Type: RT-PCR
Annotation Date: 1999-03-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603911
Stage: TS11
Assay Id: MGI:1331794
Age: embryonic day 7.5
Specimen Label: 1x
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:1331793
Assay Type: RT-PCR
Annotation Date: 1999-03-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603911
Stage: TS11
Assay Id: MGI:1331794
Age: embryonic day 7.5
Specimen Label: 10x
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:1331793
Assay Type: RT-PCR
Annotation Date: 1999-03-18
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1603911
Stage: TS11
Assay Id: MGI:1331794
Age: embryonic day 7.5
Specimen Label: 100x
Detected: false
Specimen Num: 3
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GXD Expression
GXD Expression
     
Probe: MGI:1331793
Assay Type: RT-PCR
Annotation Date: 1999-03-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1604211
Stage: TS11
Assay Id: MGI:1331794
Age: embryonic day 7.5
Specimen Label: 1x
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
     
Probe: MGI:1331793
Assay Type: RT-PCR
Annotation Date: 1999-03-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1604211
Stage: TS11
Assay Id: MGI:1331794
Age: embryonic day 7.5
Specimen Label: 10x
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
     
Probe: MGI:1331793
Assay Type: RT-PCR
Annotation Date: 1999-03-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1604211
Stage: TS11
Assay Id: MGI:1331794
Age: embryonic day 7.5
Specimen Label: 100x
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
   
Probe: MGI:3711972
Assay Type: RT-PCR
Annotation Date: 2007-06-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603915
Stage: TS15
Assay Id: MGI:3712102
Age: embryonic day 9.5
Image: 2D
Specimen Label: WT
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:3711972
Assay Type: RT-PCR
Annotation Date: 2007-06-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603915
Stage: TS15
Assay Id: MGI:3712102
Age: embryonic day 9.5
Image: 2D
Specimen Label: ADNP-/-
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:3060248
Assay Type: RNA in situ
Annotation Date: 2022-11-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3286620
Pattern: Not Specified
Stage: TS20
Assay Id: MGI:7378774
Age: embryonic day 12.0
Image: 2D
Specimen Label: 2D
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:6170542
Assay Type: RNA in situ
Annotation Date: 2023-11-28
Strength: Present
Sex: Male
Emaps: EMAPS:3583128
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:7561555
Age: postnatal day 56
Image: S3
Specimen Label: S3
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:3060248
Assay Type: RNA in situ
Annotation Date: 2022-11-07
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:3286020
Pattern: Not Specified
Stage: TS20
Assay Id: MGI:7378774
Age: embryonic day 12.0
Image: 2D
Specimen Label: 2D
Detected: true
Specimen Num: 1
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Publication
- | J:69699
   
First Author: Strausberg R
Year: 2001
Journal: GenBank Submission
Title: Mus musculus, cathepsin Z, clone MGC: 5694, mRNA, complete cds
Pages: BC008619
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Publication
- | J:66763
   
First Author: Shi GP
Year: 2000
Journal: GenBank Submission
Title: Mus musculus strain C57BL/6 cathepsin Z (Ctsz) mRNA, complete cds
Pages: AF197479
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Publication
20736174 | J:166782
First Author: Bernhardt A
Year: 2010
Journal: J Biol Chem
Title: Cathepsin X-deficient gastric epithelial cells in co-culture with macrophages: characterization of cytokine response and migration capability after Helicobacter pylori infection.
Volume: 285
Issue: 44
Pages: 33691-700
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Publication
23800510 | J:210411
 
First Author: Bühler A
Year: 2013
Journal: Exp Eye Res
Title: Cathepsin proteases promote angiogenic sprouting and laser-induced choroidal neovascularisation in mice.
Volume: 115
Pages: 73-8
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Publication
22451661 | J:185626
First Author: Bhutani N
Year: 2012
Journal: J Biol Chem
Title: Cathepsins L and Z are critical in degrading polyglutamine-containing proteins within lysosomes.
Volume: 287
Issue: 21
Pages: 17471-82
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Publication
31281521 | J:295407
First Author: Schwenck J
Year: 2019
Journal: Theranostics
Title: Cysteine-type cathepsins promote the effector phase of acute cutaneous delayed-type hypersensitivity reactions.
Volume: 9
Issue: 13
Pages: 3903-3917
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Publication
26773004 | J:229457
First Author: Akkari L
Year: 2016
Journal: Genes Dev
Title: Combined deletion of cathepsin protease family members reveals compensatory mechanisms in cancer.
Volume: 30
Issue: 2
Pages: 220-32
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Publication
21292981 | J:172774
First Author: Miller G
Year: 2011
Journal: FASEB J
Title: Asparagine endopeptidase is required for normal kidney physiology and homeostasis.
Volume: 25
Issue: 5
Pages: 1606-17
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Publication
34864055 | J:325372
First Author: Campden RI
Year: 2022
Journal: J Biol Chem
Title: Extracellular cathepsin Z signals through the α5 integrin and augments NLRP3 inflammasome activation.
Volume: 298
Issue: 1
Pages: 101459
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Publication
10526153 | J:58089
First Author: Tisljar K
Year: 1999
Journal: FEBS Lett
Title: Cathepsin J, a novel murine cysteine protease of the papain family with a placenta-restricted expression.
Volume: 459
Issue: 3
Pages: 299-304
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Publication
24145449 | J:202911
First Author: Deu E
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Ferrous iron-dependent drug delivery enables controlled and selective release of therapeutic agents in vivo.
Volume: 110
Issue: 45
Pages: 18244-9
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Publication
10760573 | J:65737
First Author: Deussing J
Year: 2000
Journal: Biochim Biophys Acta
Title: Murine and human cathepsin Z: cDNA-cloning, characterization of the genes and chromosomal localization.
Volume: 1491
Issue: 1-3
Pages: 93-106
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Publication
17302988 | J:120097
 
First Author: Frankenberg S
Year: 2007
Journal: BMC Dev Biol
Title: Novel gene expression patterns along the proximo-distal axis of the mouse embryo before gastrulation.
Volume: 7
Pages: 8
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Publication
28835281 | J:269551
First Author: Zhou X
Year: 2017
Journal: Mol Neurodegener
Title: Lysosomal processing of progranulin.
Volume: 12
Issue: 1
Pages: 62
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Publication
10760593 | J:65735
First Author: Sol-Church K
Year: 2000
Journal: Biochim Biophys Acta
Title: Mouse cathepsin M, a placenta-specific lysosomal cysteine protease related to cathepsins L and P.
Volume: 1491
Issue: 1-3
Pages: 289-94
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Publication
27477282 | J:238979
First Author: Prudova A
Year: 2016
Journal: Cell Rep
Title: TAILS N-Terminomics and Proteomics Show Protein Degradation Dominates over Proteolytic Processing by Cathepsins in Pancreatic Tumors.
Volume: 16
Issue: 6
Pages: 1762-1773
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Publication
17500053 | J:124592
First Author: Lü J
Year: 2007
Journal: J Biol Chem
Title: Cathespin H is an Fgf10 target involved in Bmp4 degradation during lung branching morphogenesis.
Volume: 282
Issue: 30
Pages: 22176-84
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Publication
28087651 | J:243148
First Author: Orlowski GM
Year: 2017
Journal: J Leukoc Biol
Title: Frontline Science: Multiple cathepsins promote inflammasome-independent, particle-induced cell death during NLRP3-dependent IL-1β activation.
Volume: 102
Issue: 1
Pages: 7-17
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Publication
21795745 | J:177067
First Author: Zhang B
Year: 2011
Journal: Blood
Title: Mice deficient in LMAN1 exhibit FV and FVIII deficiencies and liver accumulation of α1-antitrypsin.
Volume: 118
Issue: 12
Pages: 3384-91
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Publication
17222401 | J:119141
First Author: Mandel S
Year: 2007
Journal: Dev Biol
Title: Activity-dependent neuroprotective protein (ADNP) differentially interacts with chromatin to regulate genes essential for embryogenesis.
Volume: 303
Issue: 2
Pages: 814-24
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Publication
27626662 | J:238995
First Author: Yan D
Year: 2016
Journal: Cell Rep
Title: STAT3 and STAT6 Signaling Pathways Synergize to Promote Cathepsin Secretion from Macrophages via IRE1α Activation.
Volume: 16
Issue: 11
Pages: 2914-2927
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Publication
28071719 | J:265607
 
First Author: Naba A
Year: 2017
Journal: Sci Rep
Title: Quantitative proteomic profiling of the extracellular matrix of pancreatic islets during the angiogenic switch and insulinoma progression.
Volume: 7
Pages: 40495
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Publication
9811942 | J:50869
First Author: Ko MS
Year: 1998
Journal: Hum Mol Genet
Title: Genome-wide mapping of unselected transcripts from extraembryonic tissue of 7.5-day mouse embryos reveals enrichment in the t-complex and under-representation on the X chromosome.
Volume: 7
Issue: 12
Pages: 1967-78
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Publication
24154525 | J:205051
First Author: Miller JA
Year: 2013
Journal: Development
Title: Conserved molecular signatures of neurogenesis in the hippocampal subgranular zone of rodents and primates.
Volume: 140
Issue: 22
Pages: 4633-44
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Publication
- | J:24194
     
First Author: The Jackson Laboratory Backcross DNA Panel Mapping Resource
Year: 1999
Journal: Database Release
Title: JAX BSS Panel Mapping Data
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Publication
- | J:68100
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: RIKEN Data Curation in Mouse Genome Informatics
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Publication
10725249 | J:60984
First Author: Ko MS
Year: 2000
Journal: Development
Title: Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development.
Volume: 127
Issue: 8
Pages: 1737-49
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Publication
- | J:72245
       
First Author: GOA curators, MGI curators
Year: 2001
Title: Gene Ontology annotation based on Enzyme Commission mapping
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Publication
12904583 | J:85162
First Author: Hansen J
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.
Volume: 100
Issue: 17
Pages: 9918-22
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Publication
- | J:265051
     
First Author: MGI and IMPC
Year: 2018
Journal: Database Release
Title: MGI Load of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC)
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Publication
- | J:57656
     
First Author: Lennon G
Year: 1999
Journal: Database Download
Title: WashU-HHMI Mouse EST Project
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Publication
- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
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Publication
- | J:157065
     
First Author: Helmholtz Zentrum Muenchen GmbH
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu)
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Publication
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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