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Search results 1 to 100 out of 148 for Cul4b

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Categories

Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
Gene
8450 | CUL4B
Type: gene
Organism: human
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Gene
100151714 | cul4b
Type: gene
Organism: frog, western clawed
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Gene
302502 | Cul4b
Type: gene
Organism: rat
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Gene
492102 | CUL4B
Type: gene
Organism: dog, domestic
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Gene
465835 | CUL4B
Type: gene
Organism: chimpanzee
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Gene
539668 | CUL4B
Type: gene
Organism: cattle
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Gene
422364 | CUL4B
Type: gene
Organism: chicken
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Gene
560313 | cul4b
Type: gene
Organism: zebrafish
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Gene
696410 | CUL4B
Type: gene
Organism: macaque, rhesus
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Protein Domain
IPR033044 | CUL4B
Type: Family
Description: Cullin-4B (CUL4B) is a core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. CUL4B may act within the complex as a scaffold protein, contributing to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme [, ]. Mutations in the CUL4B gene cause X-linked mental retardation [].Cullins are a family of hydrophobic proteins that act as scaffolds for ubiquitin ligases (E3). Cullins are found throughout eukaryotes. Humans express seven cullins (Cul1, 2, 3, 4A, 4B, 5 and 7), each forming part of a multi-subunit ubiquitin complex.
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Protein Coding Gene
MGI:1919834 | Cul4b
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
22118460 | J:320034
First Author: Fischer ES
Year: 2011
Journal: Cell
Title: The molecular basis of CRL4DDB2/CSA ubiquitin ligase architecture, targeting, and activation.
Volume: 147
Issue: 5
Pages: 1024-39
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Publication
25945838 | J:295016
First Author: Yuan J
Year: 2015
Journal: Oncotarget
Title: Accelerated hepatocellular carcinoma development in CUL4B transgenic mice.
Volume: 6
Issue: 17
Pages: 15209-21
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Publication
23479742 | J:196602
First Author: Zou Y
Year: 2013
Journal: J Cell Biol
Title: CUL4B promotes replication licensing by up-regulating the CDK2-CDC6 cascade.
Volume: 200
Issue: 6
Pages: 743-56
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Publication
26846852 | J:232429
First Author: Yin Y
Year: 2016
Journal: J Biol Chem
Title: Cell Autonomous and Nonautonomous Function of CUL4B in Mouse Spermatogenesis.
Volume: 291
Issue: 13
Pages: 6923-35
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Publication
27899484 | J:246625
First Author: Li P
Year: 2017
Journal: Diabetes
Title: Lack of CUL4B in Adipocytes Promotes PPARγ-Mediated Adipose Tissue Expansion and Insulin Sensitivity.
Volume: 66
Issue: 2
Pages: 300-313
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Publication
37224018 | J:337914
First Author: Jin S
Year: 2023
Journal: Cell Rep
Title: Depletion of CUL4B in macrophages ameliorates diabetic kidney disease via miR-194-5p/ITGA9 axis.
Volume: 42
Issue: 6
Pages: 112550
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Publication
25464270 | J:255504
 
First Author: Wei Z
Year: 2015
Journal: Free Radic Biol Med
Title: CUL4B impedes stress-induced cellular senescence by dampening a p53-reactive oxygen species positive feedback loop.
Volume: 79
Pages: 1-13
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Publication
22453236 | J:199210
First Author: Liu L
Year: 2012
Journal: Cell Res
Title: Essential role of the CUL4B ubiquitin ligase in extra-embryonic tissue development during mouse embryogenesis.
Volume: 22
Issue: 8
Pages: 1258-69
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Publication
26832838 | J:251405
 
First Author: Lin CY
Year: 2016
Journal: Sci Rep
Title: Human X-linked Intellectual Disability Factor CUL4B Is Required for Post-meiotic Sperm Development and Male Fertility.
Volume: 6
Pages: 20227
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Publication
23357576 | J:199037
First Author: He F
Year: 2013
Journal: Biochim Biophys Acta
Title: X-linked intellectual disability gene CUL4B targets Jab1/CSN5 for degradation and regulates bone morphogenetic protein signaling.
Volume: 1832
Issue: 5
Pages: 595-605
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Publication
38761506 | J:352616
 
First Author: Guo B
Year: 2024
Journal: Neoplasia
Title: Enhanced Apc(Min/+) adenoma formation after epithelial CUL4B deletion by recruitment of myeloid-derived suppressor cells.
Volume: 53
Pages: 101005
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Publication
23348097 | J:199040
First Author: Wang HL
Year: 2013
Journal: Biochim Biophys Acta
Title: XLID CUL4B mutants are defective in promoting TSC2 degradation and positively regulating mTOR signaling in neocortical neurons.
Volume: 1832
Issue: 4
Pages: 585-93
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Publication
37653114 | J:342127
First Author: Liu X
Year: 2023
Journal: Oncogene
Title: CUL4B functions as a tumor suppressor in KRAS-driven lung tumors by inhibiting the recruitment of myeloid-derived suppressor cells.
Volume: 42
Issue: 42
Pages: 3113-3126
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Publication
22763239 | J:187403
First Author: Chen CY
Year: 2012
Journal: Hum Mol Genet
Title: Rescue of the genetically engineered Cul4b mutant mouse as a potential model for human X-linked mental retardation.
Volume: 21
Issue: 19
Pages: 4270-85
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Publication
31260508 | J:277240
First Author: Chen CY
Year: 2019
Journal: PLoS One
Title: Embryonic Cul4b is important for epiblast growth and location of primitive streak layer cells.
Volume: 14
Issue: 7
Pages: e0219221
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Publication
33524014 | J:305161
First Author: Dar AA
Year: 2021
Journal: PLoS Biol
Title: The E3 ubiquitin ligase Cul4b promotes CD4+ T cell expansion by aiding the repair of damaged DNA.
Volume: 19
Issue: 2
Pages: e3001041
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Publication
26025376 | J:223924
First Author: Zhao W
Year: 2015
Journal: Hum Mol Genet
Title: Lack of CUL4B leads to increased abundance of GFAP-positive cells that is mediated by PTGDS in mouse brain.
Volume: 24
Issue: 16
Pages: 4686-97
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Publication
25189618 | -
First Author: Ji Q
Year: 2014
Journal: J Cell Sci
Title: CRL4B interacts with and coordinates the SIN3A-HDAC complex to repress CDKN1A and drive cell cycle progression.
Volume: 127
Issue: Pt 21
Pages: 4679-91
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Publication
17273978 | -
First Author: Zou Y
Year: 2007
Journal: Am J Hum Genet
Title: Mutation in CUL4B, which encodes a member of cullin-RING ubiquitin ligase complex, causes X-linked mental retardation.
Volume: 80
Issue: 3
Pages: 561-6
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Protein
J3QJX0
Organism: Mus musculus/domesticus
Length: 552  
Fragment?: false
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Protein
Q3TP81
Organism: Mus musculus/domesticus
Length: 119  
Fragment?: true
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Protein
A2A432
Organism: Mus musculus/domesticus
Length: 970  
Fragment?: false
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Protein
Q9CW15
Organism: Mus musculus/domesticus
Length: 205  
Fragment?: true
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Protein
E9PXY1
Organism: Mus musculus/domesticus
Length: 896  
Fragment?: false
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Publication
38265261 | J:360909
First Author: Dar AA
Year: 2024
Journal: J Immunol
Title: CRL4b Inhibition Ameliorates Experimental Autoimmune Encephalomyelitis Progression.
Volume: 212
Issue: 6
Pages: 982-991
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Publication
26450912 | J:226767
First Author: Qian Y
Year: 2015
Journal: Cancer Res
Title: The CUL4B/AKT/β-Catenin Axis Restricts the Accumulation of Myeloid-Derived Suppressor Cells to Prohibit the Establishment of a Tumor-Permissive Microenvironment.
Volume: 75
Issue: 23
Pages: 5070-83
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Publication
34161765 | J:306626
First Author: Wang X
Year: 2021
Journal: Cell Rep
Title: DDB1 binds histone reader BRWD3 to activate the transcriptional cascade in adipogenesis and promote onset of obesity.
Volume: 35
Issue: 12
Pages: 109281
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Publication
31235785 | J:278172
First Author: Xu Z
Year: 2019
Journal: Oncogene
Title: Upregulation of IL-6 in CUL4B-deficient myeloid-derived suppressive cells increases the aggressiveness of cancer cells.
Volume: 38
Issue: 30
Pages: 5860-5872
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Publication
31653699 | J:283071
First Author: Dou H
Year: 2019
Journal: J Biol Chem
Title: Aryl hydrocarbon receptor (AhR) regulates adipocyte differentiation by assembling CRL4B ubiquitin ligase to target PPARγ for proteasomal degradation.
Volume: 294
Issue: 48
Pages: 18504-18515
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Publication
22262661 | J:181301
First Author: Pfeiffer JR
Year: 2012
Journal: J Immunol
Title: Cullin 4B is recruited to tristetraprolin-containing messenger ribonucleoproteins and regulates TNF-α mRNA polysome loading.
Volume: 188
Issue: 4
Pages: 1828-39
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Publication
35197566 | J:328106
First Author: Fan Y
Year: 2022
Journal: Cell Death Differ
Title: Cullin 4b-RING ubiquitin ligase targets IRGM1 to regulate Wnt signaling and intestinal homeostasis.
Volume: 29
Issue: 9
Pages: 1673-1688
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Publication
19056892 | J:142037
First Author: Miranda-Carboni GA
Year: 2008
Journal: Genes Dev
Title: A functional link between Wnt signaling and SKP2-independent p27 turnover in mammary tumors.
Volume: 22
Issue: 22
Pages: 3121-34
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Publication
22606329 | J:199139
First Author: Jiang B
Year: 2012
Journal: PLoS One
Title: Lack of Cul4b, an E3 ubiquitin ligase component, leads to embryonic lethality and abnormal placental development.
Volume: 7
Issue: 5
Pages: e37070
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Publication
30992047 | J:291732
First Author: Lin Y
Year: 2019
Journal: Epigenetics Chromatin
Title: Abnormal level of CUL4B-mediated histone H2A ubiquitination causes disruptive HOX gene expression.
Volume: 12
Issue: 1
Pages: 22
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Publication
34685710 | J:312461
 
First Author: Yin Y
Year: 2021
Journal: Cells
Title: Cullin4 E3 Ubiquitin Ligases Regulate Male Gonocyte Migration, Proliferation and Blood-Testis Barrier Homeostasis.
Volume: 10
Issue: 10
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Protein Coding Gene
MGP_CAROLIEiJ_G0033018 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0035666 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0035651 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0035568 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0035635 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0035339 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1919834 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0036166 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0034630 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0035313 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0035467 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0035416 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0035555 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0035454 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0036182 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0034331 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0034776 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0031564 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0034176 | -
Type: protein_coding_gene
Organism: Mus spretus
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GXD Expression
GXD Expression
   
Probe: MGI:6154377
Assay Type: Western blot
Annotation Date: 2018-05-04
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1684625
Stage: TS25
Assay Id: MGI:6154589
Age: embryonic day 17.0
Image: 4
Specimen Label: E17
Detected: false
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:6154377
Assay Type: Western blot
Annotation Date: 2018-05-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684627
Stage: TS27
Assay Id: MGI:6154589
Age: postnatal day 1
Image: 4
Specimen Label: 1 day
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:6154377
Assay Type: Western blot
Annotation Date: 2018-05-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:6154589
Age: postnatal week 1
Image: 4
Specimen Label: 1 wk
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:6154377
Assay Type: Western blot
Annotation Date: 2018-05-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:6154589
Age: postnatal week 2
Image: 4
Specimen Label: 2 wks
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
   
Probe: MGI:6154377
Assay Type: Western blot
Annotation Date: 2018-05-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:6154589
Age: postnatal week 4
Image: 4
Specimen Label: 4 wks
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
   
Probe: MGI:6154377
Assay Type: Western blot
Annotation Date: 2018-05-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:6154589
Age: postnatal week 10
Image: 4
Specimen Label: 10 wks
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
   
Probe: MGI:6488216
Assay Type: Western blot
Annotation Date: 2020-12-23
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689421
Stage: TS21
Assay Id: MGI:6488223
Age: embryonic day 13.5
Image: 5
Specimen Label: Normal
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:7281823
Assay Type: Immunohistochemistry
Annotation Date: 2022-06-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754423
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:7282012
Age: embryonic day 15.5
Image: 10C
Specimen Label: 10C
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
Probe: MGI:7281823
Assay Type: Immunohistochemistry
Annotation Date: 2022-06-03
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1754723
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:7282012
Age: embryonic day 15.5
Image: 10C
Note: Strongest expression is along the ventricular surface.
Specimen Label: 10C
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:6488216
Assay Type: Immunohistochemistry
Annotation Date: 2020-12-23
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689421
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:6488224
Age: embryonic day 13.5
Image: 5d - Normal
Specimen Label: 5d - Normal
Detected: true
Specimen Num: 1
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Publication
- | J:72748
   
First Author: Strausberg R
Year: 2001
Journal: GenBank Submission
Title: Mus musculus, clone MGC: 12054 IMAGE: 3707849, mRNA, complete cds
Pages: BC010347
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Publication
21525980 | J:172274
First Author: Xu B
Year: 2011
Journal: PLoS One
Title: Replication stress induces micronuclei comprising of aggregated DNA double-strand breaks.
Volume: 6
Issue: 4
Pages: e18618
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Publication
26711351 | J:273532
First Author: Badertscher L
Year: 2015
Journal: Cell Rep
Title: Genome-wide RNAi Screening Identifies Protein Modules Required for 40S Subunit Synthesis in Human Cells.
Volume: 13
Issue: 12
Pages: 2879-91
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Publication
28604389 | J:244997
First Author: Li Q
Year: 2017
Journal: J Clin Invest
Title: A cullin 4B-RING E3 ligase complex fine-tunes pancreatic δ cell paracrine interactions.
Volume: 127
Issue: 7
Pages: 2631-2646
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Publication
18602923 | J:142027
First Author: Dooley S
Year: 2008
Journal: Gastroenterology
Title: Hepatocyte-specific Smad7 expression attenuates TGF-beta-mediated fibrogenesis and protects against liver damage.
Volume: 135
Issue: 2
Pages: 642-59
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Publication
34233190 | J:321419
First Author: Tang WS
Year: 2021
Journal: Cell Rep
Title: The Mediator subunit MED20 organizes the early adipogenic complex to promote development of adipose tissues and diet-induced obesity.
Volume: 36
Issue: 1
Pages: 109314
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Publication
37390815 | J:338217
First Author: Su Y
Year: 2023
Journal: Mol Cell
Title: Glucose-induced CRL4(COP1)-p53 axis amplifies glycometabolism to drive tumorigenesis.
Volume: 83
Issue: 13
Pages: 2316-2331.e7
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Publication
25970626 | J:235324
First Author: Sjögren B
Year: 2015
Journal: PLoS One
Title: FBXO44-Mediated Degradation of RGS2 Protein Uniquely Depends on a Cullin 4B/DDB1 Complex.
Volume: 10
Issue: 5
Pages: e0123581
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Publication
33911083 | J:317457
First Author: Lin H
Year: 2021
Journal: Nat Commun
Title: IP6-assisted CSN-COP1 competition regulates a CRL4-ETV5 proteolytic checkpoint to safeguard glucose-induced insulin secretion.
Volume: 12
Issue: 1
Pages: 2461
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Publication
30442713 | J:331350
First Author: Zhang C
Year: 2019
Journal: J Biol Chem
Title: Proteolysis of methylated SOX2 protein is regulated by L3MBTL3 and CRL4DCAF5 ubiquitin ligase.
Volume: 294
Issue: 2
Pages: 476-489
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Publication
28178526 | J:254519
First Author: Li G
Year: 2017
Journal: Cell Rep
Title: CRL4DCAF8 Ubiquitin Ligase Targets Histone H3K79 and Promotes H3K9 Methylation in the Liver.
Volume: 18
Issue: 6
Pages: 1499-1511
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Publication
34518307 | J:314180
First Author: Matsuki T
Year: 2021
Journal: J Neurosci
Title: STK25 and MST3 Have Overlapping Roles to Regulate Rho GTPases during Cortical Development.
Volume: 41
Issue: 43
Pages: 8887-8903
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Publication
36414375 | J:331366
 
First Author: Song Y
Year: 2023
Journal: Life Sci Alliance
Title: Loss of circSRY reduces γH2AX level in germ cells and impairs mouse spermatogenesis.
Volume: 6
Issue: 2
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Publication
23011808 | J:244654
First Author: Leduc MS
Year: 2012
Journal: Mol Genet Genomics
Title: A major X-linked locus affects kidney function in mice.
Volume: 287
Issue: 11-12
Pages: 845-54
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Publication
26471094 | J:226978
First Author: Tateossian H
Year: 2015
Journal: Dis Model Mech
Title: Interactions between the otitis media gene, Fbxo11, and p53 in the mouse embryonic lung.
Volume: 8
Issue: 12
Pages: 1531-42
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Publication
17182866 | J:116773
First Author: Oda M
Year: 2006
Journal: Genes Dev
Title: DNA methylation regulates long-range gene silencing of an X-linked homeobox gene cluster in a lineage-specific manner.
Volume: 20
Issue: 24
Pages: 3382-94
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Publication
23754746 | J:204566
First Author: Gendrel AV
Year: 2013
Journal: Mol Cell Biol
Title: Epigenetic functions of smchd1 repress gene clusters on the inactive X chromosome and on autosomes.
Volume: 33
Issue: 16
Pages: 3150-65
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Publication
24357321 | J:205485
First Author: Yu C
Year: 2013
Journal: Science
Title: CRL4 complex regulates mammalian oocyte survival and reprogramming by activation of TET proteins.
Volume: 342
Issue: 6165
Pages: 1518-21
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Publication
20548051 | J:163340
First Author: Cox BJ
Year: 2010
Journal: Genome Res
Title: Phenotypic annotation of the mouse X chromosome.
Volume: 20
Issue: 8
Pages: 1154-64
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Publication
- | J:160967
     
First Author: Cox BJ
Year: 2010
Journal: MGI Direct Data Submission
Title: Phenotypic annotation of the mouse X chromosome
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Publication
- | J:342607
       
First Author: Birgit Meldal and Sandra Orchard (1). (1) European Bioinformatics Institute (EBI), Hinxton, Cambridgeshire, United Kingdom
Year: 2023
Title: Manual transfer of experimentally-verified manual GO annotation data to homologous complexes by curator judgment of sequence, composition and function similarity
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Publication
- | J:68100
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: RIKEN Data Curation in Mouse Genome Informatics
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Publication
- | J:73065
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Gene Ontology Annotation by the MGI Curatorial Staff
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Publication
12904583 | J:85162
First Author: Hansen J
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.
Volume: 100
Issue: 17
Pages: 9918-22
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Publication
17967808 | J:152068
First Author: Friedel RH
Year: 2007
Journal: Brief Funct Genomic Proteomic
Title: EUCOMM--the European conditional mouse mutagenesis program.
Volume: 6
Issue: 3
Pages: 180-5
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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