| Type |
Details |
Score |
| Gene |
| Type: |
gene |
| Organism: |
human |
|
•
•
•
•
•
|
| Gene |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
dog, domestic |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
chimpanzee |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
cattle |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
chicken |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
human |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ryu YC |
| Year: |
2023 |
| Journal: |
Cells |
| Title: |
CXXC5 Mediates DHT-Induced Androgenetic Alopecia via PGD(2). |
| Volume: |
12 |
| Issue: |
4 |
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Seo SH |
| Year: |
2022 |
| Journal: |
Clin Transl Med |
| Title: |
Inhibition of CXXC5 function reverses obesity-related metabolic diseases. |
| Volume: |
12 |
| Issue: |
4 |
| Pages: |
e742 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ma L |
| Year: |
2024 |
| Journal: |
Cell Commun Signal |
| Title: |
CXXC5 mitigates P. gingivalis-inhibited cementogenesis by influencing mitochondrial biogenesis. |
| Volume: |
22 |
| Issue: |
1 |
| Pages: |
4 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Lee SH |
| Year: |
2015 |
| Journal: |
J Exp Med |
| Title: |
The Dishevelled-binding protein CXXC5 negatively regulates cutaneous wound healing. |
| Volume: |
212 |
| Issue: |
7 |
| Pages: |
1061-80 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Choi S |
| Year: |
2019 |
| Journal: |
Life Sci Alliance |
| Title: |
CXXC5 mediates growth plate senescence and is a target for enhancement of longitudinal bone growth. |
| Volume: |
2 |
| Issue: |
2 |
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ma S |
| Year: |
2017 |
| Journal: |
J Exp Med |
| Title: |
Epigenetic regulator CXXC5 recruits DNA demethylase Tet2 to regulate TLR7/9-elicited IFN response in pDCs. |
| Volume: |
214 |
| Issue: |
5 |
| Pages: |
1471-1491 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kim HY |
| Year: |
2015 |
| Journal: |
Cell Death Differ |
| Title: |
CXXC5 is a negative-feedback regulator of the Wnt/β-catenin pathway involved in osteoblast differentiation. |
| Volume: |
22 |
| Issue: |
6 |
| Pages: |
912-20 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Yoon M |
| Year: |
2023 |
| Journal: |
Pharmacol Res |
| Title: |
Inhibition of CXXC5 function rescues Alzheimer's disease phenotypes by restoring Wnt/β-catenin signaling pathway. |
| Volume: |
194 |
|
| Pages: |
106836 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kim MY |
| Year: |
2016 |
| Journal: |
Glia |
| Title: |
CXXC5 plays a role as a transcription activator for myelin genes on oligodendrocyte differentiation. |
| Volume: |
64 |
| Issue: |
3 |
| Pages: |
350-62 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Lee SH |
| Year: |
2017 |
| Journal: |
J Invest Dermatol |
| Title: |
Targeting of CXXC5 by a Competing Peptide Stimulates Hair Regrowth and Wound-Induced Hair Neogenesis. |
| Volume: |
137 |
| Issue: |
11 |
| Pages: |
2260-2269 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kim E |
| Year: |
2023 |
| Journal: |
Exp Mol Med |
| Title: |
Inhibiting the cytosolic function of CXXC5 accelerates diabetic wound healing by enhancing angiogenesis and skin repair. |
| Volume: |
55 |
| Issue: |
8 |
| Pages: |
1770-1782 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kim HY |
| Year: |
2014 |
| Journal: |
FASEB J |
| Title: |
CXXC5 is a transcriptional activator of Flk-1 and mediates bone morphogenic protein-induced endothelial cell differentiation and vessel formation. |
| Volume: |
28 |
| Issue: |
2 |
| Pages: |
615-26 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Seo SH |
| Year: |
2022 |
| Journal: |
Exp Mol Med |
| Title: |
Metabolic improvement and liver regeneration by inhibiting CXXC5 function for non-alcoholic steatohepatitis treatment. |
| Volume: |
54 |
| Issue: |
9 |
| Pages: |
1511-1523 |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
Mus caroli |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
Mus pahari |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
Mus spretus |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Stoddart A |
| Year: |
2016 |
| Journal: |
Haematologica |
| Title: |
Retroviral insertional mutagenesis identifies the del(5q) genes, CXXC5, TIFAB and ETF1, as well as the Wnt pathway, as potential targets in del(5q) myeloid neoplasms. |
| Volume: |
101 |
| Issue: |
6 |
| Pages: |
e232-6 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ravichandran M |
| Year: |
2019 |
| Journal: |
Cell Rep |
| Title: |
Rinf Regulates Pluripotency Network Genes and Tet Enzymes in Embryonic Stem Cells. |
| Volume: |
28 |
| Issue: |
8 |
| Pages: |
1993-2003.e5 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Abou-Jaoude A |
| Year: |
2022 |
| Journal: |
Stem Cell Res |
| Title: |
Idax and Rinf facilitate expression of Tet enzymes to promote neural and suppress trophectodermal programs during differentiation of embryonic stem cells. |
| Volume: |
61 |
|
| Pages: |
102770 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Galazo MJ |
| Year: |
2023 |
| Journal: |
Cell Rep |
| Title: |
Tle4 controls both developmental acquisition and early post-natal maturation of corticothalamic projection neuron identity. |
| Volume: |
42 |
| Issue: |
8 |
| Pages: |
112957 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Galazo MJ |
| Year: |
2016 |
| Journal: |
Neuron |
| Title: |
Corticothalamic Projection Neuron Development beyond Subtype Specification: Fog2 and Intersectional Controls Regulate Intraclass Neuronal Diversity. |
| Volume: |
91 |
| Issue: |
1 |
| Pages: |
90-106 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2002 |
|
| Title: |
FANTOM2 Data Curation in Mouse Genome Informatics |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Velocigene |
| Year: |
2008 |
| Journal: |
MGI Direct Data Submission |
| Title: |
Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals) |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wellcome Trust Sanger Institute |
| Year: |
2010 |
| Journal: |
MGI Direct Data Submission |
| Title: |
Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Helmholtz Zentrum Muenchen GmbH |
| Year: |
2010 |
| Journal: |
MGI Direct Data Submission |
| Title: |
Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu) |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2002 |
|
| Title: |
Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Carninci P |
| Year: |
2005 |
| Journal: |
Science |
| Title: |
The transcriptional landscape of the mammalian genome. |
| Volume: |
309 |
| Issue: |
5740 |
| Pages: |
1559-63 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kawai J |
| Year: |
2001 |
| Journal: |
Nature |
| Title: |
Functional annotation of a full-length mouse cDNA collection. |
| Volume: |
409 |
| Issue: |
6821 |
| Pages: |
685-90 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Zambrowicz BP |
| Year: |
2003 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. |
| Volume: |
100 |
| Issue: |
24 |
| Pages: |
14109-14 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Skarnes WC |
| Year: |
2011 |
| Journal: |
Nature |
| Title: |
A conditional knockout resource for the genome-wide study of mouse gene function. |
| Volume: |
474 |
| Issue: |
7351 |
| Pages: |
337-42 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI) |
| Year: |
2008 |
| Journal: |
Database Download |
| Title: |
Mouse Gene Trap Data Load from dbGSS |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Cyagen Biosciences Inc. |
| Year: |
2022 |
|
| Title: |
Cyagen Biosciences Website. |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators |
| Year: |
2011 |
|
| Title: |
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
GOA curators |
| Year: |
2016 |
|
| Title: |
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Okazaki Y |
| Year: |
2002 |
| Journal: |
Nature |
| Title: |
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. |
| Volume: |
420 |
| Issue: |
6915 |
| Pages: |
563-73 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
The Gene Ontology Consortium |
| Year: |
2010 |
|
| Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2002 |
|
| Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2010 |
| Journal: |
Database Download |
| Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2). |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
MGI Genome Annotation Group and UniGene Staff |
| Year: |
2015 |
| Journal: |
Database Download |
| Title: |
MGI-UniGene Interconnection Effort |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
| Year: |
2010 |
|
| Title: |
Annotation inferences using phylogenetic trees |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
| Year: |
2000 |
| Journal: |
Database Release |
| Title: |
Entrez Gene Load |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Allen Institute for Brain Science |
| Year: |
2004 |
| Journal: |
Allen Institute |
| Title: |
Allen Brain Atlas: mouse riboprobes |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2009 |
| Journal: |
Database Download |
| Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
| Year: |
2010 |
| Journal: |
Database Download |
| Title: |
Consensus CDS project |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Group |
| Year: |
2003 |
| Journal: |
Database Procedure |
| Title: |
Automatic Encodes (AutoE) Reference |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Bairoch A |
| Year: |
1999 |
| Journal: |
Database Release |
| Title: |
SWISS-PROT Annotated protein sequence database |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2005 |
|
| Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics |
| Year: |
2010 |
| Journal: |
Database Release |
| Title: |
Protein Ontology Association Load. |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2005 |
|
| Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2009 |
| Journal: |
Database Download |
| Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Andersson T |
| Year: |
2009 |
| Journal: |
J Biol Chem |
| Title: |
CXXC5 is a novel BMP4-regulated modulator of Wnt signaling in neural stem cells. |
| Volume: |
284 |
| Issue: |
6 |
| Pages: |
3672-81 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Joshi HR |
| Year: |
2020 |
| Journal: |
J Leukoc Biol |
| Title: |
Frontline Science: Cxxc5 expression alters cell cycle and myeloid differentiation of mouse hematopoietic stem and progenitor cells. |
| Volume: |
108 |
| Issue: |
2 |
| Pages: |
469-484 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Astori A |
| Year: |
2013 |
| Journal: |
Oncotarget |
| Title: |
CXXC5 (retinoid-inducible nuclear factor, RINF) is a potential therapeutic target in high-risk human acute myeloid leukemia. |
| Volume: |
4 |
| Issue: |
9 |
| Pages: |
1438-48 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Fang L |
| Year: |
2018 |
| Journal: |
Oncol Lett |
| Title: |
Overexpression of CXXC5 is a strong poor prognostic factor in ER+ breast cancer. |
| Volume: |
16 |
| Issue: |
1 |
| Pages: |
395-401 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Aras S |
| Year: |
2013 |
| Journal: |
Nucleic Acids Res |
| Title: |
Oxygen-dependent expression of cytochrome c oxidase subunit 4-2 gene expression is mediated by transcription factors RBPJ, CXXC5 and CHCHD2. |
| Volume: |
41 |
| Issue: |
4 |
| Pages: |
2255-66 |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
205
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
151
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
211
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
222
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Lu H |
| Year: |
2013 |
| Journal: |
Cell Death Dis |
| Title: |
Enhancer of zeste homolog 2 activates wnt signaling through downregulating CXXC finger protein 4. |
| Volume: |
4 |
|
| Pages: |
e776 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Lu H |
| Year: |
2014 |
| Journal: |
FEBS Lett |
| Title: |
New tumor suppressor CXXC finger protein 4 inactivates mitogen activated protein kinase signaling. |
| Volume: |
588 |
| Issue: |
18 |
| Pages: |
3322-6 |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Family |
| Description: |
This entry represents CXXC-type zinc finger proteins CXXC4 and CXXC5. CXXC4 is a potential tumour suppressor directly regulated by EZH2 []. It has been shown to inactivate mitogen activated protein kinase signaling []. CXXC5 is a retinoid-inducible nuclear factor (RINF) involved in normal myelopoiesis []. It has been associated with various malignant tumours []. |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Katoh M |
| Year: |
2004 |
| Journal: |
Int J Mol Med |
| Title: |
Identification and characterization of FBXL19 gene in silico. |
| Volume: |
14 |
| Issue: |
6 |
| Pages: |
1109-14 |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
198
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
317
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
366
 |
| Fragment?: |
false |
|
•
•
•
•
•
|