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Search results 1 to 100 out of 746 for Cyp11a1

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0.044s
Type Details Score
Gene
Type: gene
Organism: Not Specified
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: chicken
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: frog, western clawed
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: dog, domestic
Gene
Type: gene
Organism: chimpanzee
Protein Domain
Type: Family
Description: CYP11A1 is involved in the C21-steroid hormone metabolism. It catalyses the side-chain cleavage reaction of cholesterol to pregnenolone []. Mutations in the CYP11A1 gene cause adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR), a rare disorder that can present as acute adrenal insufficiency in infancy or childhood [, ].
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Gene
Type: gene
Organism: human
Publication
First Author: Strushkevich N
Year: 2011
Journal: Proc Natl Acad Sci U S A
Title: Structural basis for pregnenolone biosynthesis by the mitochondrial monooxygenase system.
Volume: 108
Issue: 25
Pages: 10139-43
Publication
First Author: Tajima T
Year: 2001
Journal: J Clin Endocrinol Metab
Title: Heterozygous mutation in the cholesterol side chain cleavage enzyme (p450scc) gene in a patient with 46,XY sex reversal and adrenal insufficiency.
Volume: 86
Issue: 8
Pages: 3820-5
Publication
First Author: Katsumata N
Year: 2002
Journal: J Clin Endocrinol Metab
Title: Compound heterozygous mutations in the cholesterol side-chain cleavage enzyme gene (CYP11A) cause congenital adrenal insufficiency in humans.
Volume: 87
Issue: 8
Pages: 3808-13
Publication
First Author: Chien Y
Year: 2013
Journal: Biol Reprod
Title: Misregulated progesterone secretion and impaired pregnancy in Cyp11a1 transgenic mice.
Volume: 89
Issue: 4
Pages: 91
Protein
Organism: Mus musculus/domesticus
Length: 115  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 279  
Fragment?: true
Publication  
First Author: Schedel M
Year: 2016
Journal: Nat Commun
Title: 1,25D3 prevents CD8(+)Tc2 skewing and asthma development through VDR binding changes to the Cyp11a1 promoter.
Volume: 7
Pages: 10213
Protein
Organism: Mus musculus/domesticus
Length: 526  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 526  
Fragment?: false
Publication
First Author: Jia Y
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Steroidogenic enzyme Cyp11a1 regulates Type 2 CD8+ T cell skewing in allergic lung disease.
Volume: 110
Issue: 20
Pages: 8152-7
Publication
First Author: Teplyuk NM
Year: 2009
Journal: Mol Endocrinol
Title: The osteogenic transcription factor runx2 controls genes involved in sterol/steroid metabolism, including CYP11A1 in osteoblasts.
Volume: 23
Issue: 6
Pages: 849-61
Publication
First Author: Shih MC
Year: 2008
Journal: Mol Endocrinol
Title: Mutation of mouse Cyp11a1 promoter caused tissue-specific reduction of gene expression and blunted stress response without affecting reproduction.
Volume: 22
Issue: 4
Pages: 915-23
Publication
First Author: O'Hara L
Year: 2014
Journal: PLoS One
Title: Targeting of GFP-Cre to the mouse Cyp11a1 locus both drives cre recombinase expression in steroidogenic cells and permits generation of Cyp11a1 knock out mice.
Volume: 9
Issue: 1
Pages: e84541
HT Experiment  
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: GEO
Publication
First Author: Hu MC
Year: 2002
Journal: Mol Endocrinol
Title: Steroid deficiency syndromes in mice with targeted disruption of Cyp11a1.
Volume: 16
Issue: 8
Pages: 1943-50
Publication  
First Author: Kothandapani A
Year: 2021
Journal: Mol Cell Endocrinol
Title: Distinctive functioning of STARD1 in the fetal Leydig cells compared to adult Leydig and adrenal cells. Impact of Hedgehog signaling via the primary cilium.
Volume: 531
Pages: 111265
Publication
First Author: Wang W
Year: 2019
Journal: Endocrinology
Title: Tissue-Specific Ablation of ACSL4 Results in Disturbed Steroidogenesis.
Volume: 160
Issue: 11
Pages: 2517-2528
Publication  
First Author: Janjetovic Z
Year: 2021
Journal: Endocrinology
Title: Antifibrogenic Activities of CYP11A1-derived Vitamin D3-hydroxyderivatives Are Dependent on RORγ.
Volume: 162
Issue: 1
Publication  
First Author: Li Z
Year: 2023
Journal: Int J Mol Sci
Title: FXR Maintains the Intestinal Barrier and Stemness by Regulating CYP11A1-Mediated Corticosterone Synthesis in Biliary Obstruction Diseases.
Volume: 24
Issue: 17
Publication
First Author: Buaas FW
Year: 2012
Journal: Development
Title: In vivo evidence for the crucial role of SF1 in steroid-producing cells of the testis, ovary and adrenal gland.
Volume: 139
Issue: 24
Pages: 4561-70
Publication
First Author: Park SY
Year: 2005
Journal: Development
Title: Nuclear receptors Sf1 and Dax1 function cooperatively to mediate somatic cell differentiation during testis development.
Volume: 132
Issue: 10
Pages: 2415-23
Publication
First Author: Karpova T
Year: 2015
Journal: Biol Reprod
Title: Steroidogenic factor 1 differentially regulates fetal and adult leydig cell development in male mice.
Volume: 93
Issue: 4
Pages: 83
Publication
First Author: Huang CC
Year: 2012
Journal: Endocrinology
Title: Fetal glucocorticoid synthesis is required for development of fetal adrenal medulla and hypothalamus feedback suppression.
Volume: 153
Issue: 10
Pages: 4749-56
Publication
First Author: Val P
Year: 2006
Journal: Dev Biol
Title: Identification of a novel population of adrenal-like cells in the mammalian testis.
Volume: 299
Issue: 1
Pages: 250-6
Publication  
First Author: Monica Shih MC
Year: 2021
Journal: Endocrinology
Title: Embryonic Steroids Control Developmental Programming of Energy Balance.
Volume: 162
Issue: 12
Publication
First Author: Sarraj MA
Year: 2010
Journal: Biol Reprod
Title: Fetal testis dysgenesis and compromised Leydig cell function in Tgfbr3 (beta glycan) knockout mice.
Volume: 82
Issue: 1
Pages: 153-62
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Mahata B
Year: 2020
Journal: Nat Commun
Title: Tumors induce de novo steroid biosynthesis in T cells to evade immunity.
Volume: 11
Issue: 1
Pages: 3588
Publication
First Author: Rice DA
Year: 1990
Journal: J Biol Chem
Title: Analysis of the promoter region of the gene encoding mouse cholesterol side-chain cleavage enzyme.
Volume: 265
Issue: 20
Pages: 11713-20
Publication
First Author: Schiff R
Year: 1993
Journal: Endocrinology
Title: Expression and cellular localization of uterine side-chain cleavage cytochrome P450 messenger ribonucleic acid during early pregnancy in mice.
Volume: 133
Issue: 2
Pages: 529-37
GXD Expression    
Probe: MGI:2653740
Assay Type: RT-PCR
Annotation Date: 2003-04-07
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:360464
Stage: TS04
Assay Id: MGI:2653783
Age: embryonic day 3.5
Image: 4
Specimen Label: +
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:2653740
Assay Type: RT-PCR
Annotation Date: 2003-04-07
Strength: Present
Sex: Female
Emaps: EMAPS:1796228
Stage: TS28
Assay Id: MGI:2653785
Age: postnatal adult
Image: 4
Specimen Label: +
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:2663782
Assay Type: RT-PCR
Annotation Date: 2003-06-25
Strength: Present
Sex: Male
Emaps: EMAPS:1797226
Stage: TS26
Assay Id: MGI:2663799
Age: embryonic day 18.0
Specimen Label: 1
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:3053302
Assay Type: RT-PCR
Annotation Date: 2004-10-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:1603910
Stage: TS10
Assay Id: MGI:3053361
Age: embryonic day 7.0
Specimen Label: E7
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:3053302
Assay Type: RT-PCR
Annotation Date: 2004-10-01
Strength: Absent
Sex: Pooled
Emaps: EMAPS:1603918
Stage: TS18
Assay Id: MGI:3053361
Age: embryonic day 11.0
Specimen Label: E11
Detected: false
Specimen Num: 2
GXD Expression      
Probe: MGI:3053302
Assay Type: RT-PCR
Annotation Date: 2004-10-01
Strength: Absent
Sex: Pooled
Emaps: EMAPS:1603923
Stage: TS23
Assay Id: MGI:3053361
Age: embryonic day 15.0
Specimen Label: E15
Detected: false
Specimen Num: 3
GXD Expression      
Probe: MGI:3053302
Assay Type: RT-PCR
Annotation Date: 2004-10-01
Strength: Absent
Sex: Pooled
Emaps: EMAPS:1603925
Stage: TS25
Assay Id: MGI:3053361
Age: embryonic day 17.0
Specimen Label: E17
Detected: false
Specimen Num: 4
GXD Expression      
Probe: MGI:3053302
Assay Type: RT-PCR
Annotation Date: 2004-10-01
Strength: Absent
Sex: Male
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:3053361
Age: postnatal week 8-12
Specimen Label: Heart
Detected: false
Specimen Num: 5
GXD Expression      
Probe: MGI:3053302
Assay Type: RT-PCR
Annotation Date: 2004-10-01
Strength: Absent
Sex: Male
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:3053361
Age: postnatal week 8-12
Specimen Label: Brain
Detected: false
Specimen Num: 6
GXD Expression      
Probe: MGI:3053302
Assay Type: RT-PCR
Annotation Date: 2004-10-01
Strength: Absent
Sex: Male
Emaps: EMAPS:1876728
Stage: TS28
Assay Id: MGI:3053361
Age: postnatal week 8-12
Specimen Label: Spleen
Detected: false
Specimen Num: 7
GXD Expression      
Probe: MGI:3053302
Assay Type: RT-PCR
Annotation Date: 2004-10-01
Strength: Absent
Sex: Male
Emaps: EMAPS:1672828
Stage: TS28
Assay Id: MGI:3053361
Age: postnatal week 8-12
Specimen Label: Lung
Detected: false
Specimen Num: 8
GXD Expression      
Probe: MGI:3053302
Assay Type: RT-PCR
Annotation Date: 2004-10-01
Strength: Absent
Sex: Male
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:3053361
Age: postnatal week 8-12
Specimen Label: Liver
Detected: false
Specimen Num: 9
GXD Expression      
Probe: MGI:3053302
Assay Type: RT-PCR
Annotation Date: 2004-10-01
Strength: Absent
Sex: Male
Emaps: EMAPS:3598828
Stage: TS28
Assay Id: MGI:3053361
Age: postnatal week 8-12
Specimen Label: S.M.
Detected: false
Specimen Num: 10
GXD Expression      
Probe: MGI:3053302
Assay Type: RT-PCR
Annotation Date: 2004-10-01
Strength: Present
Sex: Male
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:3053361
Age: postnatal week 8-12
Specimen Label: Kidney
Detected: true
Specimen Num: 11
GXD Expression      
Probe: MGI:3053302
Assay Type: RT-PCR
Annotation Date: 2004-10-01
Strength: Present
Sex: Male
Emaps: EMAPS:1797228
Stage: TS28
Assay Id: MGI:3053361
Age: postnatal week 8-12
Specimen Label: Testis
Detected: true
Specimen Num: 12
GXD Expression      
Probe: MGI:3510932
Assay Type: RT-PCR
Annotation Date: 2004-12-15
Strength: Absent
Sex: Female
Emaps: EMAPS:1685718
Stage: TS18
Assay Id: MGI:3511046
Age: embryonic day 11.0
Specimen Label: E10.5 XX
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:3510932
Assay Type: RT-PCR
Annotation Date: 2004-12-15
Strength: Absent
Sex: Female
Emaps: EMAPS:1674418
Stage: TS18
Assay Id: MGI:3511046
Age: embryonic day 11.0
Specimen Label: E10.5 XX
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:3510932
Assay Type: RT-PCR
Annotation Date: 2004-12-15
Strength: Absent
Sex: Male
Emaps: EMAPS:1685718
Stage: TS18
Assay Id: MGI:3511046
Age: embryonic day 11.0
Specimen Label: E10.5 XY
Detected: false
Specimen Num: 2
GXD Expression      
Probe: MGI:3510932
Assay Type: RT-PCR
Annotation Date: 2004-12-15
Strength: Absent
Sex: Male
Emaps: EMAPS:1674418
Stage: TS18
Assay Id: MGI:3511046
Age: embryonic day 11.0
Specimen Label: E10.5 XY
Detected: false
Specimen Num: 2
GXD Expression      
Probe: MGI:3510932
Assay Type: RT-PCR
Annotation Date: 2004-12-15
Strength: Absent
Sex: Female
Emaps: EMAPS:2890920
Stage: TS20
Assay Id: MGI:3511046
Age: embryonic day 12.0
Specimen Label: E11.5 XX
Detected: false
Specimen Num: 3
GXD Expression      
Probe: MGI:3510932
Assay Type: RT-PCR
Annotation Date: 2004-12-15
Strength: Absent
Sex: Female
Emaps: EMAPS:1796220
Stage: TS20
Assay Id: MGI:3511046
Age: embryonic day 12.0
Specimen Label: E11.5 XX
Detected: false
Specimen Num: 3
GXD Expression      
Probe: MGI:3510932
Assay Type: RT-PCR
Annotation Date: 2004-12-15
Strength: Absent
Sex: Male
Emaps: EMAPS:2913820
Stage: TS20
Assay Id: MGI:3511046
Age: embryonic day 12.0
Specimen Label: E11.5 XY
Detected: false
Specimen Num: 4
GXD Expression      
Probe: MGI:3510932
Assay Type: RT-PCR
Annotation Date: 2004-12-15
Strength: Absent
Sex: Male
Emaps: EMAPS:1797220
Stage: TS20
Assay Id: MGI:3511046
Age: embryonic day 12.0
Specimen Label: E11.5 XY
Detected: false
Specimen Num: 4
GXD Expression      
Probe: MGI:3510932
Assay Type: RT-PCR
Annotation Date: 2004-12-15
Strength: Absent
Sex: Female
Emaps: EMAPS:1796220
Stage: TS20
Assay Id: MGI:3511046
Age: embryonic day 12.5
Specimen Label: E12.0 XX gonad
Detected: false
Specimen Num: 5
GXD Expression      
Probe: MGI:3510932
Assay Type: RT-PCR
Annotation Date: 2004-12-15
Strength: Absent
Sex: Female
Emaps: EMAPS:2890920
Stage: TS20
Assay Id: MGI:3511046
Age: embryonic day 12.5
Specimen Label: E12.0 XX mesonephros
Detected: false
Specimen Num: 6
GXD Expression      
Probe: MGI:3510932
Assay Type: RT-PCR
Annotation Date: 2004-12-15
Strength: Absent
Sex: Male
Emaps: EMAPS:1797220
Stage: TS20
Assay Id: MGI:3511046
Age: embryonic day 12.5
Specimen Label: E12.0 XY gonad
Detected: false
Specimen Num: 7
GXD Expression      
Probe: MGI:3510932
Assay Type: RT-PCR
Annotation Date: 2004-12-15
Strength: Absent
Sex: Male
Emaps: EMAPS:2913820
Stage: TS20
Assay Id: MGI:3511046
Age: embryonic day 12.5
Specimen Label: E12.0 XY mesonephros
Detected: false
Specimen Num: 8
GXD Expression      
Probe: MGI:3510932
Assay Type: RT-PCR
Annotation Date: 2004-12-15
Strength: Absent
Sex: Female
Emaps: EMAPS:1796221
Stage: TS21
Assay Id: MGI:3511046
Age: embryonic day 13.0
Specimen Label: E12.5 XX gonad
Detected: false
Specimen Num: 9
GXD Expression      
Probe: MGI:3510932
Assay Type: RT-PCR
Annotation Date: 2004-12-15
Strength: Present
Sex: Female
Emaps: EMAPS:2890921
Stage: TS21
Assay Id: MGI:3511046
Age: embryonic day 13.0
Specimen Label: E12.5 XX mesonephros
Detected: true
Specimen Num: 10
GXD Expression      
Probe: MGI:3510932
Assay Type: RT-PCR
Annotation Date: 2004-12-15
Strength: Present
Sex: Female
Emaps: EMAPS:3559021
Stage: TS21
Assay Id: MGI:3511046
Age: embryonic day 13.0
Specimen Label: E12.5 XX mesonephros
Detected: true
Specimen Num: 10
GXD Expression      
Probe: MGI:3510932
Assay Type: RT-PCR
Annotation Date: 2004-12-15
Strength: Present
Sex: Female
Emaps: EMAPS:3566021
Stage: TS21
Assay Id: MGI:3511046
Age: embryonic day 13.0
Specimen Label: E12.5 XX mesonephros
Detected: true
Specimen Num: 10
GXD Expression      
Probe: MGI:3510932
Assay Type: RT-PCR
Annotation Date: 2004-12-15
Strength: Present
Sex: Male
Emaps: EMAPS:1797221
Stage: TS21
Assay Id: MGI:3511046
Age: embryonic day 13.0
Specimen Label: E12.5 XY gonad
Detected: true
Specimen Num: 11
GXD Expression      
Probe: MGI:3510932
Assay Type: RT-PCR
Annotation Date: 2004-12-15
Strength: Present
Sex: Male
Emaps: EMAPS:1797021
Stage: TS21
Assay Id: MGI:3511046
Age: embryonic day 13.0
Specimen Label: E12.5 XY mesonephros
Detected: true
Specimen Num: 12
GXD Expression      
Probe: MGI:3510932
Assay Type: RT-PCR
Annotation Date: 2004-12-15
Strength: Present
Sex: Male
Emaps: EMAPS:3559121
Stage: TS21
Assay Id: MGI:3511046
Age: embryonic day 13.0
Specimen Label: E12.5 XY mesonephros
Detected: true
Specimen Num: 12
GXD Expression      
Probe: MGI:3510932
Assay Type: RT-PCR
Annotation Date: 2004-12-15
Strength: Present
Sex: Male
Emaps: EMAPS:2913821
Stage: TS21
Assay Id: MGI:3511046
Age: embryonic day 13.0
Specimen Label: E12.5 XY mesonephros
Detected: true
Specimen Num: 12
GXD Expression      
Probe: MGI:3510932
Assay Type: RT-PCR
Annotation Date: 2004-12-15
Strength: Absent
Sex: Female
Emaps: EMAPS:1796221
Stage: TS21
Assay Id: MGI:3511046
Age: embryonic day 13.5
Specimen Label: E13.0 XX gonad
Detected: false
Specimen Num: 13
GXD Expression      
Probe: MGI:3510932
Assay Type: RT-PCR
Annotation Date: 2004-12-15
Strength: Present
Sex: Female
Emaps: EMAPS:2890921
Stage: TS21
Assay Id: MGI:3511046
Age: embryonic day 13.5
Specimen Label: E13.0 XX mesonephros
Detected: true
Specimen Num: 14
GXD Expression      
Probe: MGI:3510932
Assay Type: RT-PCR
Annotation Date: 2004-12-15
Strength: Present
Sex: Female
Emaps: EMAPS:3559021
Stage: TS21
Assay Id: MGI:3511046
Age: embryonic day 13.5
Specimen Label: E13.0 XX mesonephros
Detected: true
Specimen Num: 14
GXD Expression      
Probe: MGI:3510932
Assay Type: RT-PCR
Annotation Date: 2004-12-15
Strength: Present
Sex: Female
Emaps: EMAPS:3566021
Stage: TS21
Assay Id: MGI:3511046
Age: embryonic day 13.5
Specimen Label: E13.0 XX mesonephros
Detected: true
Specimen Num: 14
GXD Expression      
Probe: MGI:3510932
Assay Type: RT-PCR
Annotation Date: 2004-12-15
Strength: Present
Sex: Male
Emaps: EMAPS:1797221
Stage: TS21
Assay Id: MGI:3511046
Age: embryonic day 13.5
Specimen Label: E13.0 XY gonad
Detected: true
Specimen Num: 15