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Search results 1 to 100 out of 369 for Cyp1a2

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Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: chimpanzee
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: chicken
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: hamster, Chinese
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: dog, domestic
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: human
Publication
First Author: Gorman N
Year: 2002
Journal: Hepatology
Title: Uroporphyria in mice: thresholds for hepatic CYP1A2 and iron.
Volume: 35
Issue: 4
Pages: 912-21
Publication
First Author: Nemoto N
Year: 1993
Journal: Jpn J Cancer Res
Title: Cell-density-dependent expression of Cyp1a2 gene in monolayer-cultured adult mouse hepatocytes.
Volume: 84
Issue: 3
Pages: 265-71
Publication
First Author: Diliberto JJ
Year: 1997
Journal: Biochem Biophys Res Commun
Title: Role of CYP1A2 in hepatic sequestration of dioxin: studies using CYP1A2 knock-out mice.
Volume: 236
Issue: 2
Pages: 431-3
Publication
First Author: Shertzer HG
Year: 2004
Journal: Free Radic Biol Med
Title: Cyp1a2 protects against reactive oxygen production in mouse liver microsomes.
Volume: 36
Issue: 5
Pages: 605-17
Publication
First Author: Zaher H
Year: 1998
Journal: Toxicol Appl Pharmacol
Title: Protection against acetaminophen toxicity in CYP1A2 and CYP2E1 double-null mice.
Volume: 152
Issue: 1
Pages: 193-9
Publication
First Author: Tonge RP
Year: 1998
Journal: Toxicol Appl Pharmacol
Title: Role of CYP1A2 in the hepatotoxicity of acetaminophen: investigations using Cyp1a2 null mice.
Volume: 153
Issue: 1
Pages: 102-8
Publication
First Author: Kapelyukh Y
Year: 2019
Journal: Drug Metab Dispos
Title: Defining the Contribution of CYP1A1 and CYP1A2 to Drug Metabolism Using Humanized CYP1A1/1A2 and Cyp1a1/Cyp1a2 Knockout Mice.
Volume: 47
Issue: 8
Pages: 907-918
Publication
First Author: Sinclair PR
Year: 2000
Journal: Toxicol Appl Pharmacol
Title: CYP1A2 is essential in murine uroporphyria caused by hexachlorobenzene and iron.
Volume: 162
Issue: 1
Pages: 60-7
Publication
First Author: Peters JM
Year: 1999
Journal: Toxicol Sci
Title: Role of CYP1A2 in the toxicity of long-term phenacetin feeding in mice.
Volume: 50
Issue: 1
Pages: 82-9
Publication
First Author: Mikhailova ON
Year: 2007
Journal: Mutat Res
Title: Enhancer elements in the mouse CYP1A2 gene: a comparative sequencing among different inbred mouse strains.
Volume: 632
Issue: 1-2
Pages: 99-103
Publication
First Author: Zaccaro C
Year: 2001
Journal: Biochem Pharmacol
Title: Role of cytochrome P450 1A2 in bilirubin degradation Studies in Cyp1a2 (-/-) mutant mice.
Volume: 61
Issue: 7
Pages: 843-9
Publication
First Author: Nemoto N
Year: 1993
Journal: Jpn J Cancer Res
Title: Activation of Cyp1a1 and Cyp1a2 genes in adult mouse hepatocytes in primary culture.
Volume: 84
Issue: 3
Pages: 272-8
Publication
First Author: Ryu DY
Year: 1995
Journal: Chem Biol Interact
Title: Regulation of cytochrome P-450 isozymes CYP1A1, CYP1A2 and CYP2B10 by three benzodioxole compounds.
Volume: 96
Issue: 3
Pages: 235-47
Publication
First Author: Diliberto JJ
Year: 1999
Journal: Toxicol Appl Pharmacol
Title: Effects of CYP1A2 on disposition of 2,3,7, 8-tetrachlorodibenzo-p-dioxin, 2,3,4,7,8-pentachlorodibenzofuran, and 2,2',4,4',5,5'-hexachlorobiphenyl in CYP1A2 knockout and parental (C57BL/6N and 129/Sv) strains of mice.
Volume: 159
Issue: 1
Pages: 52-64
Publication
First Author: Nemoto N
Year: 1994
Journal: Arch Biochem Biophys
Title: Elevated expression of the Cyp1a2 gene in the presence of nicotinamide by adult mouse hepatocytes in primary culture.
Volume: 308
Issue: 1
Pages: 292-8
Publication
First Author: Chaloupka K
Year: 1994
Journal: Carcinogenesis
Title: Aryl hydrocarbon (Ah) receptor-independent induction of Cyp1a2 gene expression by acenaphthylene and related compounds in B6C3F1 mice.
Volume: 15
Issue: 12
Pages: 2835-40
Publication
First Author: Casley WL
Year: 1997
Journal: Pharmacogenetics
Title: Increased basal expression of hepatic Cyp1a1 and Cyp1a2 genes in inbred mice selected for susceptibility to acetaminophen-induced hepatotoxicity.
Volume: 7
Issue: 4
Pages: 283-93
Publication
First Author: Dragin N
Year: 2006
Journal: J Biol Chem
Title: For dioxin-induced birth defects, mouse or human CYP1A2 in maternal liver protects whereas mouse CYP1A1 and CYP1B1 are inconsequential.
Volume: 281
Issue: 27
Pages: 18591-600
Publication
First Author: Kondraganti SR
Year: 2002
Journal: J Pharmacol Exp Ther
Title: Differential regulation of expression of hepatic and pulmonary cytochrome P4501A enzymes by 3-methylcholanthrene in mice lacking the CYP1A2 gene.
Volume: 303
Issue: 3
Pages: 945-51
Publication
First Author: McAvoy M
Year: 1996
Journal: Exp Eye Res
Title: In situ hybridization of Cyp1a1, Cyp1a2 and Ah receptor mRNAs expressed in murine ocular tissues.
Volume: 62
Issue: 4
Pages: 449-52
Publication
First Author: Nukaya M
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: The role of the dioxin-responsive element cluster between the Cyp1a1 and Cyp1a2 loci in aryl hydrocarbon receptor biology.
Volume: 106
Issue: 12
Pages: 4923-8
Publication
First Author: Hakk H
Year: 2009
Journal: Toxicol Appl Pharmacol
Title: The effect of dose on 2,3,7,8-TCDD tissue distribution, metabolism and elimination in CYP1A2 (-/-) knockout and C57BL/6N parental strains of mice.
Volume: 241
Issue: 1
Pages: 119-26
Publication
First Author: Curran CP
Year: 2011
Journal: Toxicol Sci
Title: In utero and lactational exposure to a complex mixture of polychlorinated biphenyls: toxicity in pups dependent on the Cyp1a2 and Ahr genotypes.
Volume: 119
Issue: 1
Pages: 189-208
Publication
First Author: Raffalli-Mathieu F
Year: 1997
Journal: Eur J Biochem
Title: Characterization of two nuclear proteins that interact with cytochrome P-450 1A2 mRNA. Regulation of RNA binding and possible role in the expression of the Cyp1a2 gene.
Volume: 245
Issue: 1
Pages: 17-24
Publication
First Author: Curran CP
Year: 2011
Journal: Environ Health Perspect
Title: In utero and lactational exposure to PCBs in mice: adult offspring show altered learning and memory depending on Cyp1a2 and Ahr genotypes.
Volume: 119
Issue: 9
Pages: 1286-93
Publication    
First Author: Nemoto N
Year: 1994
Journal: Cytochrome P450 8th Int Conf
Title: Activation and regulation of aromatic hydrocarbon- inducible cyp1a1 and cyp1a2 gene expression in mouse hepatocytes in primary culture.
Pages: 757-760
Publication
First Author: Klinefelter K
Year: 2018
Journal: Mamm Genome
Title: Genetic differences in the aryl hydrocarbon receptor and CYP1A2 affect sensitivity to developmental polychlorinated biphenyl exposure in mice: relevance to studies of human neurological disorders.
Volume: 29
Issue: 1-2
Pages: 112-127
Publication
First Author: Cheung C
Year: 2011
Journal: Carcinogenesis
Title: Rapid induction of colon carcinogenesis in CYP1A-humanized mice by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and dextran sodium sulfate.
Volume: 32
Issue: 2
Pages: 233-9
Publication
First Author: Jiang Z
Year: 2005
Journal: Hum Mutat
Title: Toward the evaluation of function in genetic variability: characterizing human SNP frequencies and establishing BAC-transgenic mice carrying the human CYP1A1_CYP1A2 locus.
Volume: 25
Issue: 2
Pages: 196-206
Publication
First Author: Dalton TP
Year: 2000
Journal: Biochem Biophys Res Commun
Title: Targeted knockout of Cyp1a1 gene does not alter hepatic constitutive expression of other genes in the mouse [Ah] battery.
Volume: 267
Issue: 1
Pages: 184-9
Publication
First Author: Shi Z
Year: 2008
Journal: Biochem Biophys Res Commun
Title: Generation of a 'humanized' hCYP1A1_1A2_Cyp1a1/1a2(-/-)_Ahrd mouse line harboring the poor-affinity aryl hydrocarbon receptor.
Volume: 376
Issue: 4
Pages: 775-80
Publication  
First Author: Sinclair PR
Year: 1998
Journal: Biochem J
Title: Uroporphyria produced in mice by iron and 5-aminolaevulinic acid does not occur in Cyp1a2(-/-) null mutant mice.
Volume: 330 ( Pt 1)
Pages: 149-53
Publication
First Author: Greaves P
Year: 2005
Journal: Biochem Biophys Res Commun
Title: Uroporphyria and hepatic carcinogenesis induced by polychlorinated biphenyls-iron interaction: absence in the Cyp1a2(-/-) knockout mouse.
Volume: 331
Issue: 1
Pages: 147-52
Publication
First Author: Stiborová M
Year: 2012
Journal: Toxicol Sci
Title: Bioactivation versus detoxication of the urothelial carcinogen aristolochic acid I by human cytochrome P450 1A1 and 1A2.
Volume: 125
Issue: 2
Pages: 345-58
Publication
First Author: Levova K
Year: 2012
Journal: Toxicol Appl Pharmacol
Title: NAD(P)H:quinone oxidoreductase expression in Cyp1a-knockout and CYP1A-humanized mouse lines and its effect on bioactivation of the carcinogen aristolochic acid I.
Volume: 265
Issue: 3
Pages: 360-7
Publication
First Author: Dragin N
Year: 2007
Journal: Biochem Biophys Res Commun
Title: Generation of 'humanized' hCYP1A1_1A2_Cyp1a1/1a2(-/-) mouse line.
Volume: 359
Issue: 3
Pages: 635-42
Publication
First Author: Casley WL
Year: 1999
Journal: Drug Metab Dispos
Title: Detection of quantitative trait loci affecting caffeine metabolism by interval mapping in a genome-wide scan of C3H/HeJ x APN F(2) mice.
Volume: 27
Issue: 12
Pages: 1375-80
Publication
First Author: Aitchison KJ
Year: 2000
Journal: J Psychopharmacol
Title: Clozapine pharmacokinetics and pharmacodynamics studied with Cyp1A2-null mice.
Volume: 14
Issue: 4
Pages: 353-9
Publication
First Author: Liang HC
Year: 1996
Journal: Proc Natl Acad Sci U S A
Title: Cyp1a2(-/-) null mutant mice develop normally but show deficient drug metabolism.
Volume: 93
Issue: 4
Pages: 1671-6
Publication
First Author: Smith AG
Year: 2001
Journal: Toxicol Appl Pharmacol
Title: Protection of the Cyp1a2(-/-) null mouse against uroporphyria and hepatic injury following exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin.
Volume: 173
Issue: 2
Pages: 89-98
Publication
First Author: Wang S
Year: 2015
Journal: Toxicol Sci
Title: N-hydroxylation of 4-aminobiphenyl by CYP2E1 produces oxidative stress in a mouse model of chemically induced liver cancer.
Volume: 144
Issue: 2
Pages: 393-405
Publication
First Author: Genter MB
Year: 2006
Journal: Biochem Biophys Res Commun
Title: Naphthalene toxicity in mice and aryl hydrocarbon receptor-mediated CYPs.
Volume: 348
Issue: 1
Pages: 120-3
Publication
First Author: Pineau T
Year: 1995
Journal: Proc Natl Acad Sci U S A
Title: Neonatal lethality associated with respiratory distress in mice lacking cytochrome P450 1A2.
Volume: 92
Issue: 11
Pages: 5134-8
Publication  
First Author: Lingappan K
Year: 2015
Journal: Toxicology
Title: Sex-specific differences in hyperoxic lung injury in mice: role of cytochrome P450 (CYP)1A.
Volume: 331
Pages: 14-23
Publication
First Author: Gastelum G
Year: 2020
Journal: Toxicol Sci
Title: Polycyclic Aromatic Hydrocarbon-induced Pulmonary Carcinogenesis in Cytochrome P450 (CYP)1A1- and 1A2-Null Mice: Roles of CYP1A1 and CYP1A2.
Volume: 177
Issue: 2
Pages: 347-361
Publication
First Author: Curran CP
Year: 2012
Journal: Neurotoxicology
Title: Ahrd Cyp1a2(-/-) mice show increased susceptibility to PCB-induced developmental neurotoxicity.
Volume: 33
Issue: 6
Pages: 1436-42
Publication
First Author: Uno S
Year: 2004
Journal: Toxicol Appl Pharmacol
Title: Cyp1a1(-/-) male mice: protection against high-dose TCDD-induced lethality and wasting syndrome, and resistance to intrahepatocyte lipid accumulation and uroporphyria.
Volume: 196
Issue: 3
Pages: 410-21
Publication  
First Author: Wang L
Year: 2015
Journal: Free Radic Biol Med
Title: Disruption of cytochrome P4501A2 in mice leads to increased susceptibility to hyperoxic lung injury.
Volume: 82
Pages: 147-59
Publication
First Author: Tsyrlov IB
Year: 1993
Journal: Arch Biochem Biophys
Title: Enzyme-kinetic and immunochemical characteristics of mouse cDNA-expressed, microsomal, and purified CYP1A1 and CYP1A2.
Volume: 307
Issue: 2
Pages: 259-66
Publication
First Author: Nemoto N
Year: 1992
Journal: Carcinogenesis
Title: Differences in regulation of gene expression between Cyp1a-1 and Cyp1a-2 in adult mouse hepatocytes in primary culture.
Volume: 13
Issue: 12
Pages: 2249-54
Publication
First Author: Brooks RA
Year: 1994
Journal: Cancer Res
Title: 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine is a potent mutagen in the mouse small intestine.
Volume: 54
Issue: 7
Pages: 1665-71
Publication
First Author: Liang HC
Year: 1997
Journal: Biochem Pharmacol
Title: Sensitivity of CYP1A1 mRNA inducibility by dioxin is the same in Cyp1a2(+/+) wild-type and Cyp1a2(-/-) null mutant mice.
Volume: 54
Issue: 10
Pages: 1127-31
Publication
First Author: Abu-Bakar A
Year: 2005
Journal: Biochem Pharmacol
Title: Evidence for induced microsomal bilirubin degradation by cytochrome P450 2A5.
Volume: 70
Issue: 10
Pages: 1527-35
Publication
First Author: Uno S
Year: 2003
Journal: Biochem Biophys Res Commun
Title: Balancer-Cre transgenic mouse germ cells direct the incomplete resolution of a tri-loxP-targeted Cyp1a1 allele, producing a conditional knockout allele.
Volume: 312
Issue: 2
Pages: 494-9
Publication
First Author: Zhang W
Year: 2004
Journal: Toxicol Sci
Title: A Cyp1a2-luciferase transgenic CD-1 mouse model: responses to aryl hydrocarbons similar to the humanized AhR mice.
Volume: 82
Issue: 1
Pages: 297-307
Publication  
First Author: Stading R
Year: 2021
Journal: Semin Cancer Biol
Title: Molecular mechanisms of pulmonary carcinogenesis by polycyclic aromatic hydrocarbons (PAHs): Implications for human lung cancer.
Volume: 76
Pages: 3-16
Publication
First Author: Bansal S
Year: 2014
Journal: J Biol Chem
Title: Mitochondrial targeting of cytochrome P450 (CYP) 1B1 and its role in polycyclic aromatic hydrocarbon-induced mitochondrial dysfunction.
Volume: 289
Issue: 14
Pages: 9936-51
Publication
First Author: Divanovic S
Year: 2013
Journal: J Immunol
Title: Contributions of the three CYP1 monooxygenases to pro-inflammatory and inflammation-resolution lipid mediator pathways.
Volume: 191
Issue: 6
Pages: 3347-57
Publication  
First Author: Stading R
Year: 2024
Journal: Free Radic Biol Med
Title: Prenatal exposure to polycyclic aromatic hydrocarbons (PAHs) augments neonatal hyperoxic lung injury: Role of cytochrome P450 (CYP)1A1, 1A2, and 1B1.
Volume: 211
Pages: 35-46
Publication
First Author: Uno S
Year: 2008
Journal: Free Radic Biol Med
Title: Basal and inducible CYP1 mRNA quantitation and protein localization throughout the mouse gastrointestinal tract.
Volume: 44
Issue: 4
Pages: 570-83
Publication
First Author: Shertzer HG
Year: 2007
Journal: Carcinogenesis
Title: 7H-dibenzo[c,g]carbazole metabolism by the mouse and human CYP1 family of enzymes.
Volume: 28
Issue: 6
Pages: 1371-8
Publication
First Author: Iqbal J
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Smoke carcinogens cause bone loss through the aryl hydrocarbon receptor and induction of Cyp1 enzymes.
Volume: 110
Issue: 27
Pages: 11115-20
Publication
First Author: Roe AL
Year: 1999
Journal: Int J Obes Relat Metab Disord
Title: Characterization of cytochrome P450 and glutathione S-transferase activity and expression in male and female ob/ob mice.
Volume: 23
Issue: 1
Pages: 48-53
Publication
First Author: Petersen DD
Year: 1989
Journal: Proc Natl Acad Sci U S A
Title: Marked increases in hepatic NAD(P)H:oxidoreductase gene transcription and mRNA levels correlated with a mouse chromosome 7 deletion.
Volume: 86
Issue: 17
Pages: 6699-703
Publication
First Author: Choudhary D
Year: 2003
Journal: Arch Biochem Biophys
Title: Comparative expression profiling of 40 mouse cytochrome P450 genes in embryonic and adult tissues.
Volume: 414
Issue: 1
Pages: 91-100
Publication
First Author: Henderson CJ
Year: 2019
Journal: Drug Metab Dispos
Title: An Extensively Humanized Mouse Model to Predict Pathways of Drug Disposition and Drug/Drug Interactions, and to Facilitate Design of Clinical Trials.
Volume: 47
Issue: 6
Pages: 601-615
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Kimura S
Year: 1984
Journal: Nucleic Acids Res
Title: Mouse cytochrome P3-450: complete cDNA and amino acid sequence.
Volume: 12
Issue: 6
Pages: 2917-28
Publication
First Author: Kimura S
Year: 1986
Journal: Nucleic Acids Res
Title: cDNA and complete amino acid sequence of mouse P2(450): allelic variant of mouse P3(450) gene.
Volume: 14
Issue: 16
Pages: 6765-6
Publication
First Author: Ohyama T
Year: 1984
Journal: J Biol Chem
Title: Isosafrole-induced cytochrome P2-450 in DBA/2N mouse liver. Characterization and genetic control of induction.
Volume: 259
Issue: 4
Pages: 2675-82
GXD Expression      
Probe: MGI:3053272
Assay Type: RT-PCR
Annotation Date: 2004-10-01
Strength: Absent
Sex: Pooled
Emaps: EMAPS:1603910
Stage: TS10
Assay Id: MGI:3053326
Age: embryonic day 7.0
Specimen Label: E7
Detected: false
Specimen Num: 1