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Search results 1 to 57 out of 57 for Cyp2j8

0.493s
Type Details Score
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Publication
First Author: Graves JP
Year: 2015
Journal: Drug Metab Dispos
Title: Quantitative Polymerase Chain Reaction Analysis of the Mouse Cyp2j Subfamily: Tissue Distribution and Regulation.
Volume: 43
Issue: 8
Pages: 1169-80
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication        
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
Publication        
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
Publication        
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
Publication
First Author: Gaudet P
Year: 2011
Journal: Brief Bioinform
Title: Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.
Volume: 12
Issue: 5
Pages: 449-62
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
Publication      
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
Publication      
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
Publication      
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
Publication      
First Author: Mouse Genome Informatics and VEGA Genome Database Project
Year: 2006
Journal: Database Release
Title: Collaboration to Associate VEGA (Vertebrate Genome Annotation) Mouse Gene Models with MGI Markers
Publication    
First Author: Ma J
Year: 2002
Journal: GenBank Submission
Title: Mus musculus cytochrome P450 (Cyp2j8) gene sequence
Pages: AF218857
Publication
First Author: Aiba I
Year: 2006
Journal: Steroids
Title: Characterization of rat and human CYP2J enzymes as Vitamin D 25-hydroxylases.
Volume: 71
Issue: 10
Pages: 849-56
Publication
First Author: Zhang QY
Year: 1998
Journal: Arch Biochem Biophys
Title: Characterization of the cytochrome P450 CYP2J4: expression in rat small intestine and role in retinoic acid biotransformation from retinal.
Volume: 353
Issue: 2
Pages: 257-64
Publication
First Author: Ma J
Year: 2004
Journal: Mol Pharmacol
Title: Regulation of mouse renal CYP2J5 expression by sex hormones.
Volume: 65
Issue: 3
Pages: 730-43
Publication
First Author: Lee CA
Year: 2010
Journal: Drug Metab Dispos
Title: Identification of novel substrates for human cytochrome P450 2J2.
Volume: 38
Issue: 2
Pages: 347-56
Protein Domain
Type: Family
Description: Cytochrome P450 enzymes are a superfamily of haem-containing mono-oxygenases that are found in all kingdoms of life, and which show extraordinary diversity in their reaction chemistry. In mammals, these proteins are found primarily in microsomes of hepatocytes and other cell types, where they oxidise steroids, fatty acids and xenobiotics, and are important for the detoxification and clearance of various compounds, as well as for hormone synthesis and breakdown, cholesterol synthesis and vitamin D metabolism. In plants, these proteins are important for the biosynthesis of several compounds such as hormones, defensive compounds and fatty acids. In bacteria, they are important for several metabolic processes, such as the biosynthesis of antibiotic erythromycin in Saccharopolyspora erythraea (Streptomyces erythraeus).Cytochrome P450 enzymes use haem to oxidise their substrates, using protons derived from NADH or NADPH to split the oxygen so a single atom can be added to a substrate. They also require electrons, which they receive from a variety of redox partners. In certain cases, cytochrome P450 can be fused to its redox partner to produce a bi-functional protein, such as with P450BM-3 from Bacillus megaterium [], which has haem and flavin domains.Organisms produce many different cytochrome P450 enzymes (at least 58 in humans), which together with alternative splicing can provide a wide array of enzymes with different substrate and tissue specificities. Individual cytochrome P450 proteins follow the nomenclature: CYP, followed by a number (family), then a letter (subfamily), and another number (protein); e.g. CYP3A4 is the fourth protein in family 3, subfamily A. In general, family members should share >40% identity, while subfamily members should share >55% identity.Cytochrome P450 proteins can also be grouped by two different schemes. One scheme was based on a taxonomic split: class I (prokaryotic/mitochondrial) and class II (eukaryotic microsomes). The other scheme was based on the number of components in the system: class B (3-components) and class E (2-components). These classes merge to a certain degree. Most prokaryotes and mitochondria (and fungal CYP55) have 3-component systems (class I/class B) - a FAD-containing flavoprotein (NAD(P)H-dependent reductase), an iron-sulphur protein and P450. Most eukaryotic microsomes have 2-component systems (class II/class E) - NADPH:P450 reductase (FAD and FMN-containing flavoprotein) and P450. There are exceptions to this scheme, such as 1-component systems that resemble class E enzymes [, , ]. The class E enzymes can be further subdivided into five sequence clusters, groups I-V, each of which may contain more than one cytochrome P450 family (eg, CYP1 and CYP2 are both found in group I). The divergence of the cytochrome P450 superfamily into B- and E-classes, and further divergence into stable clusters within the E-class, appears to be very ancient, occurring before the appearance of eukaryotes.This entry represents the CYP2J family from group I, class E, cytochrome P450 proteins, as well as other CYP2 family proteins. The CYP2 family comprises 15 subfamilies (A-H, J-N, P and Q). The first five (A-E) are present in mammalian liver, but in differing amounts and with different inducibilities. These five subfamilies show varied substrate specificities, with some degree of overlap. Several CYP2J isoforms have been reported, including rabbit CYP2J1; human CYP2J2, the only member of the human CYP2J subfamily known for its role as arachidonic acid epoxygenase and antihistamine drugs are also substrates of it []; rat CYP2J3 and CYP2J4; mouse CYP2J5, CYP2J6, CYP2J7, CYP2J8 and CYP2J9; and rat CYP2J10. Both rat CYP2J3 and human CYP2J2 catalyse vitamin D 25-hydroxylase, but with distinct preferences: rat for vitamin D3 and human for vitamin D2 []. Rat CYP2J4 is expressed in the intestine, where it is active towards all-trans and 9-cis-retinal, producing the corresponding retinoic acids []. Mouse CYP2J5 is abundant in the kidney, where it is active in the metabolism of arachidonic acid to epoxyeicosatrienoic acids, and may be influenced by sex hormones [].
Protein
Organism: Mus musculus/domesticus
Length: 501  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 501  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 374  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 501  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 504  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 502  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 503  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 504  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 503  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 433  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 502  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 501  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 501  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 374  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 504  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 529  
Fragment?: true
Publication
First Author: McLean KJ
Year: 2005
Journal: Biochem Soc Trans
Title: Biodiversity of cytochrome P450 redox systems.
Volume: 33
Issue: Pt 4
Pages: 796-801
Publication
First Author: Munro AW
Year: 2007
Journal: Biochim Biophys Acta
Title: Cytochrome P450--redox partner fusion enzymes.
Volume: 1770
Issue: 3
Pages: 345-59
Publication
First Author: Nelson DR
Year: 2004
Journal: Pharmacogenetics
Title: Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants.
Volume: 14
Issue: 1
Pages: 1-18
Publication
First Author: Degtyarenko KN
Year: 1995
Journal: Protein Eng
Title: Structural domains of P450-containing monooxygenase systems.
Volume: 8
Issue: 8
Pages: 737-47