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Search results 1 to 100 out of 111 for Cyp46a1

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0.066s
Type Details Score
Gene
Type: gene
Organism: Homo sapiens
Gene
Type: gene
Organism: Rattus norvegicus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Domain
Type: Family
Description: Cholesterol 24-hydroxylase (CYP46A1) is the neuronal-specific and rate-limiting enzyme for cholesterol conversion to 24S-hydroxycholesterol (24S-OHC) [, ]. It has a neuroprotective effect in Huntington's disease, a genetic disease that leads to many cellular dysfunctions, including abnormalities in cholesterol metabolism [, ].
Publication
First Author: Lund EG
Year: 1999
Journal: Proc Natl Acad Sci U S A
Title: cDNA cloning of cholesterol 24-hydroxylase, a mediator of cholesterol homeostasis in the brain.
Volume: 96
Issue: 13
Pages: 7238-43
Publication      
First Author: Boussicault L
Year: 2018
Journal: Biochimie
Title: CYP46A1 protects against NMDA-mediated excitotoxicity in Huntington's disease: Analysis of lipid raft content.
Protein
Organism: Mus musculus
Length: 500  
Fragment?: false
Protein
Organism: Mus musculus
Length: 500  
Fragment?: false
Protein
Organism: Mus musculus
Length: 112  
Fragment?: true
Publication
First Author: Björkhem I
Year: 2004
Journal: Arterioscler Thromb Vasc Biol
Title: Brain cholesterol: long secret life behind a barrier.
Volume: 24
Issue: 5
Pages: 806-15
Publication
First Author: Boussicault L
Year: 2016
Journal: Brain
Title: CYP46A1, the rate-limiting enzyme for cholesterol degradation, is neuroprotective in Huntington's disease.
Volume: 139
Issue: Pt 3
Pages: 953-70
Publication  
First Author: Mast N
Year: 2017
Journal: Neuropharmacology
Title: Cholesterol-metabolizing enzyme cytochrome P450 46A1 as a pharmacologic target for Alzheimer's disease.
Volume: 123
Pages: 465-476
Publication
First Author: Mast N
Year: 2017
Journal: PLoS One
Title: Transcriptional and post-translational changes in the brain of mice deficient in cholesterol removal mediated by cytochrome P450 46A1 (CYP46A1).
Volume: 12
Issue: 10
Pages: e0187168
Publication
First Author: Saadane A
Year: 2019
Journal: Am J Pathol
Title: Retinal Vascular Abnormalities and Microglia Activation in Mice with Deficiency in Cytochrome P450 46A1-Mediated Cholesterol Removal.
Volume: 189
Issue: 2
Pages: 405-425
Publication
First Author: Mast N
Year: 2017
Journal: J Biol Chem
Title: Cytochrome P450 27A1 Deficiency and Regional Differences in Brain Sterol Metabolism Cause Preferential Cholestanol Accumulation in the Cerebellum.
Volume: 292
Issue: 12
Pages: 4913-4924
Publication
First Author: Sodero AO
Year: 2012
Journal: EMBO J
Title: Cholesterol loss during glutamate-mediated excitotoxicity.
Volume: 31
Issue: 7
Pages: 1764-73
Publication
First Author: Quan G
Year: 2003
Journal: Brain Res Dev Brain Res
Title: Ontogenesis and regulation of cholesterol metabolism in the central nervous system of the mouse.
Volume: 146
Issue: 1-2
Pages: 87-98
Publication
First Author: Lorbek G
Year: 2012
Journal: FEBS J
Title: Cytochrome P450s in the synthesis of cholesterol and bile acids--from mouse models to human diseases.
Volume: 279
Issue: 9
Pages: 1516-33
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Halford RW
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: Reduction of cholesterol synthesis in the mouse brain does not affect amyloid formation in Alzheimer's disease, but does extend lifespan.
Volume: 106
Issue: 9
Pages: 3502-6
Publication
First Author: Lund EG
Year: 2003
Journal: J Biol Chem
Title: Knockout of the cholesterol 24-hydroxylase gene in mice reveals a brain-specific mechanism of cholesterol turnover.
Volume: 278
Issue: 25
Pages: 22980-8
Publication
First Author: Sun MY
Year: 2017
Journal: PLoS One
Title: 24S-hydroxycholesterol and 25-hydroxycholesterol differentially impact hippocampal neuronal survival following oxygen-glucose deprivation.
Volume: 12
Issue: 3
Pages: e0174416
Publication
First Author: Ramirez DM
Year: 2008
Journal: J Comp Neurol
Title: Neuronal expression and subcellular localization of cholesterol 24-hydroxylase in the mouse brain.
Volume: 507
Issue: 5
Pages: 1676-93
Publication
First Author: Xie C
Year: 2003
Journal: J Lipid Res
Title: Quantitation of two pathways for cholesterol excretion from the brain in normal mice and mice with neurodegeneration.
Volume: 44
Issue: 9
Pages: 1780-9
GXD Expression      
Probe: MGI:3053314
Assay Type: RT-PCR
Annotation Date: 2004-10-01
Strength: Present
Sex: Male
Emaps: EMAPS:1672828
Stage: TS28
Assay Id: MGI:3053374
Age: postnatal week 8-12
Detected: true
Specimen Num: 8
GXD Expression      
Probe: MGI:3053314
Assay Type: RT-PCR
Annotation Date: 2004-10-01
Strength: Present
Sex: Male
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:3053374
Age: postnatal week 8-12
Detected: true
Specimen Num: 5
GXD Expression      
Probe: MGI:3053314
Assay Type: RT-PCR
Annotation Date: 2004-10-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:1603925
Stage: TS25
Assay Id: MGI:3053374
Age: embryonic day 17.0
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:3053314
Assay Type: RT-PCR
Annotation Date: 2004-10-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:1603923
Stage: TS23
Assay Id: MGI:3053374
Age: embryonic day 15.0
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:3053314
Assay Type: RT-PCR
Annotation Date: 2004-10-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:1603918
Stage: TS18
Assay Id: MGI:3053374
Age: embryonic day 11.0
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:3053314
Assay Type: RT-PCR
Annotation Date: 2004-10-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:1603910
Stage: TS10
Assay Id: MGI:3053374
Age: embryonic day 7.0
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:3691304
Assay Type: RT-PCR
Annotation Date: 2006-12-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689426
Stage: TS26
Assay Id: MGI:3691309
Age: embryonic day 20.5
Image: 4
Detected: true
Specimen Num: 8
GXD Expression    
Probe: MGI:3691304
Assay Type: RT-PCR
Annotation Date: 2006-12-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689426
Stage: TS26
Assay Id: MGI:3691309
Age: embryonic day 20.5
Image: 4
Detected: true
Specimen Num: 7
GXD Expression    
Probe: MGI:3691304
Assay Type: RT-PCR
Annotation Date: 2006-12-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689419
Stage: TS19
Assay Id: MGI:3691309
Age: embryonic day 11.5
Image: 4
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:3691304
Assay Type: RT-PCR
Annotation Date: 2006-12-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689419
Stage: TS19
Assay Id: MGI:3691309
Age: embryonic day 11.5
Image: 4
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:3691304
Assay Type: RT-PCR
Annotation Date: 2006-12-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689426
Stage: TS26
Assay Id: MGI:3691309
Age: embryonic day 18.5
Image: 4
Detected: true
Specimen Num: 6
GXD Expression    
Probe: MGI:3691304
Assay Type: RT-PCR
Annotation Date: 2006-12-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689426
Stage: TS26
Assay Id: MGI:3691309
Age: embryonic day 18.5
Image: 4
Detected: true
Specimen Num: 5
GXD Expression    
Probe: MGI:3691304
Assay Type: RT-PCR
Annotation Date: 2006-12-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689421
Stage: TS21
Assay Id: MGI:3691309
Age: embryonic day 13.5
Image: 4
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:3691304
Assay Type: RT-PCR
Annotation Date: 2006-12-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689421
Stage: TS21
Assay Id: MGI:3691309
Age: embryonic day 13.5
Image: 4
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:3053314
Assay Type: RT-PCR
Annotation Date: 2004-10-01
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:3053374
Age: postnatal week 8-12
Detected: true
Specimen Num: 6
GXD Expression      
Probe: MGI:3053314
Assay Type: RT-PCR
Annotation Date: 2004-10-01
Strength: Present
Sex: Male
Emaps: EMAPS:1876728
Stage: TS28
Assay Id: MGI:3053374
Age: postnatal week 8-12
Detected: true
Specimen Num: 7
GXD Expression      
Probe: MGI:3053314
Assay Type: RT-PCR
Annotation Date: 2004-10-01
Strength: Present
Sex: Male
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:3053374
Age: postnatal week 8-12
Detected: true
Specimen Num: 11
GXD Expression      
Probe: MGI:3053314
Assay Type: RT-PCR
Annotation Date: 2004-10-01
Strength: Absent
Sex: Male
Emaps: EMAPS:3598828
Stage: TS28
Assay Id: MGI:3053374
Age: postnatal week 8-12
Detected: false
Specimen Num: 10
GXD Expression      
Probe: MGI:3053314
Assay Type: RT-PCR
Annotation Date: 2004-10-01
Strength: Present
Sex: Male
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:3053374
Age: postnatal week 8-12
Detected: true
Specimen Num: 9
GXD Expression      
Probe: MGI:3053314
Assay Type: RT-PCR
Annotation Date: 2004-10-01
Strength: Present
Sex: Male
Emaps: EMAPS:1797228
Stage: TS28
Assay Id: MGI:3053374
Age: postnatal week 8-12
Detected: true
Specimen Num: 12
GXD Expression  
Probe: MGI:3585205
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1647028
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3586061
Age: postnatal day 6
Note: Expression was widespread.
Detected: true
Specimen Num: 7
GXD Expression  
Probe: MGI:3585205
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Male
Emaps: EMAPS:1915728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3586061
Age: postnatal adult
Image: Adult
Detected: true
Specimen Num: 6
GXD Expression  
Probe: MGI:3585205
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1915728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3586061
Age: postnatal day 8-10
Image: P8/10
Detected: true
Specimen Num: 5
GXD Expression  
Probe: MGI:3585205
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1915728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3586061
Age: postnatal day 6-7
Image: P6/7
Detected: true
Specimen Num: 4
GXD Expression
Probe: MGI:3585205
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1915728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3586061
Age: postnatal day 4-5
Image: P4/5
Note: Expression was detected in the outer neuroblastic layer.
Detected: true
Specimen Num: 3
GXD Expression  
Probe: MGI:3585205
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1915727
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:3586061
Age: postnatal day 2-3
Note: Expression was detected in the outer neuroblastic layer.
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:3585205
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1915727
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:3586061
Age: postnatal day 0-1
Note: Expression was detected in the outer neuroblastic layer.
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:3585205
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Male
Emaps: EMAPS:1915528
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3586061
Age: postnatal adult
Image: Adult
Detected: true
Specimen Num: 6
GXD Expression  
Probe: MGI:3585205
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1915528
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3586061
Age: postnatal day 8-10
Image: P8/10
Detected: true
Specimen Num: 5
GXD Expression  
Probe: MGI:3585205
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1915528
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3586061
Age: postnatal day 6-7
Image: P6/7
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:3585205
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1603924
Stage: TS24
Assay Id: MGI:3586061
Age: embryonic day 16.0
Detected: false
Specimen Num: 8
Publication
First Author: Saadane A
Year: 2014
Journal: Am J Pathol
Title: Retinal and nonocular abnormalities in Cyp27a1(-/-)Cyp46a1(-/-) mice with dysfunctional metabolism of cholesterol.
Volume: 184
Issue: 9
Pages: 2403-19
Publication
First Author: Kotti T
Year: 2008
Journal: Proc Natl Acad Sci U S A
Title: Biphasic requirement for geranylgeraniol in hippocampal long-term potentiation.
Volume: 105
Issue: 32
Pages: 11394-9
Publication
First Author: Saadane A
Year: 2016
Journal: J Biol Chem
Title: Retinal Hypercholesterolemia Triggers Cholesterol Accumulation and Esterification in Photoreceptor Cells.
Volume: 291
Issue: 39
Pages: 20427-39
Publication
First Author: Kotti TJ
Year: 2006
Journal: Proc Natl Acad Sci U S A
Title: Brain cholesterol turnover required for geranylgeraniol production and learning in mice.
Volume: 103
Issue: 10
Pages: 3869-74
Publication
First Author: Tint GS
Year: 2006
Journal: J Lipid Res
Title: The use of the Dhcr7 knockout mouse to accurately determine the origin of fetal sterols.
Volume: 47
Issue: 7
Pages: 1535-41
Publication
First Author: Buchovecky CM
Year: 2013
Journal: Nat Genet
Title: A suppressor screen in Mecp2 mutant mice implicates cholesterol metabolism in Rett syndrome.
Volume: 45
Issue: 9
Pages: 1013-20
Publication
First Author: Togashi T
Year: 2004
Journal: Biochem Biophys Res Commun
Title: Two distinct methods analyzing chromatin structure using centrifugation and antibodies to modified histone H3: both provide similar chromatin states of the Rit1/Bcl11b gene.
Volume: 313
Issue: 3
Pages: 489-95
Publication
First Author: La Fata G
Year: 2014
Journal: Nat Neurosci
Title: FMRP regulates multipolar to bipolar transition affecting neuronal migration and cortical circuitry.
Volume: 17
Issue: 12
Pages: 1693-700
Publication
First Author: Bojanic DD
Year: 2010
Journal: J Lipid Res
Title: Differential expression and function of ABCG1 and ABCG4 during development and aging.
Volume: 51
Issue: 1
Pages: 169-81
Publication
First Author: Choudhary D
Year: 2003
Journal: Arch Biochem Biophys
Title: Comparative expression profiling of 40 mouse cytochrome P450 genes in embryonic and adult tissues.
Volume: 414
Issue: 1
Pages: 91-100
Publication
First Author: Blackshaw S
Year: 2004
Journal: PLoS Biol
Title: Genomic analysis of mouse retinal development.
Volume: 2
Issue: 9
Pages: E247
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Mouse Synonym Curation
Publication
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
Publication
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
Publication          
First Author: MGD Nomenclature Committee
Year: 1995
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
Publication
First Author: Gaudet P
Year: 2011
Journal: Brief Bioinform
Title: Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.
Volume: 12
Issue: 5
Pages: 449-62
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Gene Ontology Annotation by the MGI Curatorial Staff
Publication      
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2000
Title: Gene Ontology Annotation by electronic association of SwissProt Keywords with GO terms
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
Publication      
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
Publication      
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
Publication      
First Author: Mouse Genome Informatics, the Protein Information Resource and the Protein Ontology Consortium
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load