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Search results 1 to 100 out of 251 for Cyp7a1

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Hits by Pathway

Hits by Strain

Hits by Category

Type Details Score
Gene
1581 | CYP7A1
Type: gene
Organism: human
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Gene
510507 | CYP7A1
Type: gene
Organism: cattle
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Gene
414834 | CYP7A1
Type: gene
Organism: chicken
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Gene
394148 | cyp7a1
Type: gene
Organism: zebrafish
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Gene
698127 | CYP7A1
Type: gene
Organism: macaque, rhesus
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Gene
100488670 | cyp7a1
Type: gene
Organism: frog, western clawed
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Gene
key_78994 | CYP7A1
Type: gene
Organism: hamster, Chinese
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Gene
25428 | Cyp7a1
Type: gene
Organism: rat
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Gene
486962 | CYP7A1
Type: gene
Organism: dog, domestic
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Gene
464191 | CYP7A1
Type: gene
Organism: chimpanzee
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Protein Coding Gene
MGI:106091 | Cyp7a1
Type: protein_coding_gene
Organism: mouse, laboratory
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Gene
110596866 | LOC110596866
Type: gene
Organism: human
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Publication
16609145 | J:112052
First Author: Ratliff EP
Year: 2006
Journal: J Lipid Res
Title: Transgenic expression of CYP7A1 in LDL receptor-deficient mice blocks diet-induced hypercholesterolemia.
Volume: 47
Issue: 7
Pages: 1513-20
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Publication
12202481 | J:80051
First Author: Chen JY
Year: 2002
Journal: J Biol Chem
Title: Mice expressing the human CYP7A1 gene in the mouse CYP7A1 knock-out background lack induction of CYP7A1 expression by cholesterol feeding and have increased hypercholesterolemia when fed a high fat diet.
Volume: 277
Issue: 45
Pages: 42588-95
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Publication
19101514 | J:144522
First Author: Kojima M
Year: 2009
Journal: Biochem Biophys Res Commun
Title: IL-1 regulates the Cyp7a1 gene and serum total cholesterol level at steady state in mice.
Volume: 379
Issue: 2
Pages: 239-42
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Publication
19056864 | J:144235
First Author: Zhang L
Year: 2009
Journal: Mol Endocrinol
Title: Significance and mechanism of CYP7a1 gene regulation during the acute phase of liver regeneration.
Volume: 23
Issue: 2
Pages: 137-45
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Publication
28843503 | J:253883
First Author: Lee EA
Year: 2018
Journal: Biochim Biophys Acta
Title: Cyp7a1 is continuously increased with disrupted Fxr-mediated feedback inhibition in hypercholesterolemic TALLYHO/Jng mice.
Volume: 1863
Issue: 1
Pages: 20-25
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Publication
24365583 | J:323205
First Author: Chow EC
Year: 2014
Journal: Gastroenterology
Title: Vitamin D receptor activation down-regulates the small heterodimer partner and increases CYP7A1 to lower cholesterol.
Volume: 146
Issue: 4
Pages: 1048-59
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Publication
17636037 | J:125929
First Author: Ponugoti B
Year: 2007
Journal: Mol Endocrinol
Title: Functional interaction of hepatic nuclear factor-4 and peroxisome proliferator-activated receptor-gamma coactivator 1alpha in CYP7A1 regulation is inhibited by a key lipogenic activator, sterol regulatory element-binding protein-1c.
Volume: 21
Issue: 11
Pages: 2698-712
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Publication
9077551 | J:38473
First Author: Machleder D
Year: 1997
Journal: J Clin Invest
Title: Complex genetic control of HDL levels in mice in response to an atherogenic diet. Coordinate regulation of HDL levels and bile acid metabolism.
Volume: 99
Issue: 6
Pages: 1406-19
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QTL
MGI:3514364 | C7mlq
Type: QTL
Organism: mouse, laboratory
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Publication
11323427 | J:70134
First Author: Miyake JH
Year: 2001
Journal: J Biol Chem
Title: Increased production of apolipoprotein B-containing lipoproteins in the absence of hyperlipidemia in transgenic mice expressing cholesterol 7alpha-hydroxylase.
Volume: 276
Issue: 26
Pages: 23304-11
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Publication
23536474 | J:340665
First Author: Li T
Year: 2013
Journal: Hepatology
Title: Regulation of cholesterol and bile acid homeostasis by the cholesterol 7α-hydroxylase/steroid response element-binding protein 2/microRNA-33a axis in mice.
Volume: 58
Issue: 3
Pages: 1111-21
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Publication
8088795 | J:18307
First Author: Tzung KW
Year: 1994
Journal: Genomics
Title: Structure of the mouse cholesterol 7 alpha-hydroxylase gene.
Volume: 21
Issue: 1
Pages: 244-7
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Publication
12588950 | J:83458
First Author: Erickson SK
Year: 2003
Journal: J Lipid Res
Title: Hypercholesterolemia and changes in lipid and bile acid metabolism in male and female cyp7A1-deficient mice.
Volume: 44
Issue: 5
Pages: 1001-9
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Publication
14962946 | J:102144
First Author: Post SM
Year: 2004
Journal: Arterioscler Thromb Vasc Biol
Title: Cholesterol 7alpha-hydroxylase deficiency in mice on an APOE*3-Leiden background impairs very-low-density lipoprotein production.
Volume: 24
Issue: 4
Pages: 768-74
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Publication
14762172 | J:88391
First Author: Tiemann M
Year: 2004
Journal: Proc Natl Acad Sci U S A
Title: Cholesterol feeding of mice expressing cholesterol 7alpha-hydroxylase increases bile acid pool size despite decreased enzyme activity.
Volume: 101
Issue: 7
Pages: 1846-51
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Publication
11967256 | J:77084
First Author: Agellon LB
Year: 2002
Journal: J Biol Chem
Title: Dietary cholesterol fails to stimulate the human cholesterol 7alpha-hydroxylase gene (CYP7A1) in transgenic mice.
Volume: 277
Issue: 23
Pages: 20131-4
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Publication
10777541 | J:61828
First Author: Cheema SK
Year: 2000
Journal: J Biol Chem
Title: The murine and human cholesterol 7alpha-hydroxylase gene promoters are differentially responsive to regulation by fatty acids mediated via peroxisome proliferator-activated receptor alpha.
Volume: 275
Issue: 17
Pages: 12530-6
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Publication
27534992 | J:236079
First Author: Liu H
Year: 2016
Journal: J Lipid Res
Title: Cholesterol 7α-hydroxylase protects the liver from inflammation and fibrosis by maintaining cholesterol homeostasis.
Volume: 57
Issue: 10
Pages: 1831-1844
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Publication
36868469 | J:345560
First Author: Chen PC
Year: 2023
Journal: Am J Pathol
Title: miR-194 Up-Regulates Cholesterol 7 Alpha-Hydroxylase Expression via β-Catenin Signaling and Aggravates Cholestatic Liver Diseases.
Volume: 193
Issue: 6
Pages: 755-768
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Publication
12393855 | J:100206
First Author: Li-Hawkins J
Year: 2002
Journal: J Clin Invest
Title: Cholic acid mediates negative feedback regulation of bile acid synthesis in mice.
Volume: 110
Issue: 8
Pages: 1191-200
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Publication
11590215 | J:72319
First Author: Schwarz M
Year: 2001
Journal: J Lipid Res
Title: Alternate pathways of bile acid synthesis in the cholesterol 7alpha-hydroxylase knockout mouse are not upregulated by either cholesterol or cholestyramine feeding.
Volume: 42
Issue: 10
Pages: 1594-603
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Publication
28039331 | J:239685
First Author: Liu X
Year: 2017
Journal: J Lipid Res
Title: Hepatic deletion of X-box binding protein 1 impairs bile acid metabolism in mice.
Volume: 58
Issue: 3
Pages: 504-511
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Publication
11042130 | J:114186
 
First Author: Patel DD
Year: 2000
Journal: Biochem J
Title: The effect of peroxisome-proliferator-activated receptor-alpha on the activity of the cholesterol 7 alpha-hydroxylase gene.
Volume: 351 Pt 3
Pages: 747-53
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Publication
17623664 | J:124949
First Author: Kurosu H
Year: 2007
Journal: J Biol Chem
Title: Tissue-specific expression of betaKlotho and fibroblast growth factor (FGF) receptor isoforms determines metabolic activity of FGF19 and FGF21.
Volume: 282
Issue: 37
Pages: 26687-95
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Publication
17008588 | J:128088
First Author: Post SM
Year: 2006
Journal: Arterioscler Thromb Vasc Biol
Title: Cholesterol 7alpha-hydroxylase deficiency in mice on an APOE*3-Leiden background increases hepatic ABCA1 mRNA expression and HDL-cholesterol.
Volume: 26
Issue: 12
Pages: 2724-30
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Publication
27131506 | J:253293
First Author: Krishnamurthy K
Year: 2016
Journal: Cardiovasc Res
Title: Heat shock factor-1 knockout enhances cholesterol 7α-hydroxylase (CYP7A1) and multidrug transporter (MDR1) gene expressions to attenuate atherosclerosis.
Volume: 111
Issue: 1
Pages: 74-83
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Publication
22144677 | J:180806
First Author: Li T
Year: 2012
Journal: J Biol Chem
Title: Glucose and insulin induction of bile acid synthesis: mechanisms and implication in diabetes and obesity.
Volume: 287
Issue: 3
Pages: 1861-73
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Publication
19386592 | J:151211
First Author: Xie Y
Year: 2009
Journal: J Biol Chem
Title: Decreased expression of cholesterol 7alpha-hydroxylase and altered bile acid metabolism in Apobec-1-/- mice lead to increased gallstone susceptibility.
Volume: 284
Issue: 25
Pages: 16860-71
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Publication
23747249 | J:199245
First Author: Vergnes L
Year: 2013
Journal: Cell Metab
Title: Diet1 functions in the FGF15/19 enterohepatic signaling axis to modulate bile acid and lipid levels.
Volume: 17
Issue: 6
Pages: 916-28
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Publication
23880190 | J:318171
First Author: Lan T
Year: 2013
Journal: Atherosclerosis
Title: Inhibition of ileal apical but not basolateral bile acid transport reduces atherosclerosis in apoE⁻/⁻ mice.
Volume: 229
Issue: 2
Pages: 374-80
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Publication
15014077 | J:91695
First Author: Paré JF
Year: 2004
Journal: J Biol Chem
Title: The fetoprotein transcription factor (FTF) gene is essential to embryogenesis and cholesterol homeostasis and is regulated by a DR4 element.
Volume: 279
Issue: 20
Pages: 21206-16
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Protein Coding Gene
MGP_CAROLIEiJ_G0025791 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0028034 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0027992 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0027958 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0028004 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0027734 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_106091 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0028447 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0027187 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0027709 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0027849 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0027816 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0027960 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0027849 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0028506 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0026909 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0027267 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0023914 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0026739 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
8663429 | J:34342
First Author: Ishibashi S
Year: 1996
Journal: J Biol Chem
Title: Disruption of cholesterol 7alpha-hydroxylase gene in mice. I. Postnatal lethality reversed by bile acid and vitamin supplementation.
Volume: 271
Issue: 30
Pages: 18017-23
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Publication
26683664 | J:229683
First Author: McMillin M
Year: 2016
Journal: Am J Pathol
Title: Bile Acid Signaling Is Involved in the Neurological Decline in a Murine Model of Acute Liver Failure.
Volume: 186
Issue: 2
Pages: 312-23
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Publication
9741696 | J:120425
First Author: Schwarz M
Year: 1998
Journal: J Lipid Res
Title: Marked reduction in bile acid synthesis in cholesterol 7alpha-hydroxylase-deficient mice does not lead to diminished tissue cholesterol turnover or to hypercholesterolemia.
Volume: 39
Issue: 9
Pages: 1833-43
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Publication
8663430 | J:34870
First Author: Schwarz M
Year: 1996
Journal: J Biol Chem
Title: Disruption of cholesterol 7alpha-hydroxylase gene in mice. II. Bile acid deficiency is overcome by induction of oxysterol 7alpha-hydroxylase.
Volume: 271
Issue: 30
Pages: 18024-31
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Publication
9371693 | J:44626
 
First Author: Agellon LB
Year: 1997
Journal: Biochem J
Title: The 3'-untranslated region of the mouse cholesterol 7alpha-hydroxylase mRNA contains elements responsive to post-transcriptional regulation by bile acids.
Volume: 328 ( Pt 2)
Pages: 393-9
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GXD Expression
GXD Expression
   
Probe: MGI:5792579
Assay Type: RT-PCR
Annotation Date: 2016-09-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684626
Stage: TS26
Assay Id: MGI:5792665
Age: embryonic day 19.0
Image: 2
Specimen Label: p57+/+,p57+/-p
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:5792579
Assay Type: RT-PCR
Annotation Date: 2016-09-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684626
Stage: TS26
Assay Id: MGI:5792665
Age: embryonic day 19.0
Image: 2
Specimen Label: p57-/-,p57+/-m
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:6510494
Assay Type: RT-PCR
Annotation Date: 2021-03-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:6510532
Age: postnatal
Specimen Label: B6J
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:6510494
Assay Type: RT-PCR
Annotation Date: 2021-03-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:6510532
Age: postnatal
Specimen Label: B6By
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:6510494
Assay Type: RT-PCR
Annotation Date: 2021-03-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:6510558
Age: postnatal
Specimen Label: B6J
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:6510494
Assay Type: RT-PCR
Annotation Date: 2021-03-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:6510558
Age: postnatal
Specimen Label: B6By
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:7510218
Assay Type: RT-PCR
Annotation Date: 2023-07-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:7511501
Age: postnatal week 3-4
Image: S4
Specimen Label: Control
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:7510218
Assay Type: RT-PCR
Annotation Date: 2023-07-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:7511501
Age: postnatal week 3-4
Image: S4
Specimen Label: DKO
Detected: true
Specimen Num: 2
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Publication
22111624 | J:196553
First Author: Lorbek G
Year: 2012
Journal: FEBS J
Title: Cytochrome P450s in the synthesis of cholesterol and bile acids--from mouse models to human diseases.
Volume: 279
Issue: 9
Pages: 1516-33
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Publication
12746876 | J:83644
First Author: Faust PL
Year: 2003
Journal: J Comp Neurol
Title: Abnormal cerebellar histogenesis in PEX2 Zellweger mice reflects multiple neuronal defects induced by peroxisome deficiency.
Volume: 461
Issue: 3
Pages: 394-413
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Publication
11368757 | J:114411
First Author: Voshol PJ
Year: 2001
Journal: Biochem J
Title: Down-regulation of intestinal scavenger receptor class B, type I (SR-BI) expression in rodents under conditions of deficient bile delivery to the intestine.
Volume: 356
Issue: Pt 2
Pages: 317-25
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Publication
9797378 | J:51019
First Author: Arnon R
Year: 1998
Journal: Gastroenterology
Title: Cholesterol 7-hydroxylase knockout mouse: a model for monohydroxy bile acid-related neonatal cholestasis.
Volume: 115
Issue: 5
Pages: 1223-8
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Publication
12933663 | J:85596
First Author: Hewitt KN
Year: 2003
Journal: Endocrinology
Title: The aromatase knockout mouse presents with a sexually dimorphic disruption to cholesterol homeostasis.
Volume: 144
Issue: 9
Pages: 3895-903
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Publication
15845870 | J:101230
First Author: Wu MK
Year: 2005
Journal: Am J Physiol Gastrointest Liver Physiol
Title: Altered hepatic cholesterol metabolism compensates for disruption of phosphatidylcholine transfer protein in mice.
Volume: 289
Issue: 3
Pages: G456-61
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Publication
14517541 | J:85796
First Author: Woodruff ML
Year: 2003
Journal: Nat Genet
Title: Spontaneous activity of opsin apoprotein is a cause of Leber congenital amaurosis.
Volume: 35
Issue: 2
Pages: 158-64
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Publication
12114517 | J:78952
First Author: Hyogo H
Year: 2002
Journal: J Biol Chem
Title: Leptin promotes biliary cholesterol elimination during weight loss in ob/ob mice by regulating the enterohepatic circulation of bile salts.
Volume: 277
Issue: 37
Pages: 34117-24
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Publication
10551403 | J:59685
First Author: Smith AJ
Year: 1999
Journal: J Hepatol
Title: Liver gene disruptions: winners by KO?
Volume: 31
Issue: 4
Pages: 752-9
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Publication
14701919 | J:88732
First Author: Lyons MA
Year: 2004
Journal: Physiol Genomics
Title: Quantitative trait loci that determine lipoprotein cholesterol levels in an intercross of 129S1/SvImJ and CAST/Ei inbred mice.
Volume: 17
Issue: 1
Pages: 60-8
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Publication
11090130 | J:65994
First Author: Repa JJ
Year: 2000
Journal: Genes Dev
Title: Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRalpha and LXRbeta.
Volume: 14
Issue: 22
Pages: 2819-30
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Publication
26165599 | J:226930
First Author: Yanagida A
Year: 2015
Journal: Dev Biol
Title: Liver maturation deficiency in p57(Kip2)-/- mice occurs in a hepatocytic p57(Kip2) expression-independent manner.
Volume: 407
Issue: 2
Pages: 331-43
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Publication
11279518 | J:68661
First Author: Shih DQ
Year: 2001
Journal: Nat Genet
Title: Hepatocyte nuclear factor-1alpha is an essential regulator of bile acid and plasma cholesterol metabolism.
Volume: 27
Issue: 4
Pages: 375-82
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Publication
27197076 | J:256166
First Author: Creasy KT
Year: 2016
Journal: Gene Expr
Title: Zinc Fingers and Homeoboxes 2 (Zhx2) Regulates Sexually Dimorphic Cyp Gene Expression in the Adult Mouse Liver.
Volume: 17
Issue: 1
Pages: 7-17
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Publication
26655896 | J:259735
First Author: Rocha AS
Year: 2015
Journal: Cell Rep
Title: The Angiocrine Factor Rspondin3 Is a Key Determinant of Liver Zonation.
Volume: 13
Issue: 9
Pages: 1757-64
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Publication
27358050 | J:240786
 
First Author: Lee DH
Year: 2016
Journal: Nat Commun
Title: LATS-YAP/TAZ controls lineage specification by regulating TGFβ signaling and Hnf4α expression during liver development.
Volume: 7
Pages: 11961
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Publication
26508642 | J:227474
First Author: Fonseca TL
Year: 2015
Journal: Proc Natl Acad Sci U S A
Title: Perinatal deiodinase 2 expression in hepatocytes defines epigenetic susceptibility to liver steatosis and obesity.
Volume: 112
Issue: 45
Pages: 14018-23
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Publication
35293576 | J:324687
 
First Author: Pantasis S
Year: 2022
Journal: J Cell Sci
Title: Vertebrate lonesome kinase modulates the hepatocyte secretome to prevent perivascular liver fibrosis and inflammation.
Volume: 135
Issue: 7
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Publication
27146480 | J:233745
First Author: Ferrell JM
Year: 2016
Journal: J Lipid Res
Title: Cholesterol 7α-hydroxylase-deficient mice are protected from high-fat/high-cholesterol diet-induced metabolic disorders.
Volume: 57
Issue: 7
Pages: 1144-54
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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