Type |
Details |
Score |
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
dog, domestic |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chimpanzee |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
cattle |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chicken |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Publication |
First Author: |
Barajas-Espinosa A |
Year: |
2012 |
Journal: |
FASEB J |
Title: |
The cysteinyl leukotriene 2 receptor mediates retinal edema and pathological neovascularization in a murine model of oxygen-induced retinopathy. |
Volume: |
26 |
Issue: |
3 |
Pages: |
1100-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Moos MP |
Year: |
2008 |
Journal: |
FASEB J |
Title: |
Cysteinyl leukotriene 2 receptor-mediated vascular permeability via transendothelial vesicle transport. |
Volume: |
22 |
Issue: |
12 |
Pages: |
4352-62 |
|
•
•
•
•
•
|
Publication |
First Author: |
Jiang W |
Year: |
2008 |
Journal: |
Am J Pathol |
Title: |
Endothelial cysteinyl leukotriene 2 receptor expression mediates myocardial ischemia-reperfusion injury. |
Volume: |
172 |
Issue: |
3 |
Pages: |
592-602 |
|
•
•
•
•
•
|
Publication |
First Author: |
Duah E |
Year: |
2019 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Cysteinyl leukotriene 2 receptor promotes endothelial permeability, tumor angiogenesis, and metastasis. |
Volume: |
116 |
Issue: |
1 |
Pages: |
199-204 |
|
•
•
•
•
•
|
Publication |
First Author: |
Voisin T |
Year: |
2021 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
The CysLT2R receptor mediates leukotriene C4-driven acute and chronic itch. |
Volume: |
118 |
Issue: |
13 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Liu T |
Year: |
2018 |
Journal: |
J Immunol |
Title: |
Type 2 Cysteinyl Leukotriene Receptors Drive IL-33-Dependent Type 2 Immunopathology and Aspirin Sensitivity. |
Volume: |
200 |
Issue: |
3 |
Pages: |
915-927 |
|
•
•
•
•
•
|
Publication |
First Author: |
Qi L |
Year: |
2024 |
Journal: |
Cell |
Title: |
A mouse DRG genetic toolkit reveals morphological and physiological diversity of somatosensory neuron subtypes. |
Volume: |
187 |
Issue: |
6 |
Pages: |
1508-1526.e16 |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus caroli |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus pahari |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus spretus |
|
•
•
•
•
•
|
Publication |
First Author: |
Beller TC |
Year: |
2004 |
Journal: |
J Biol Chem |
Title: |
Targeted gene disruption reveals the role of the cysteinyl leukotriene 2 receptor in increased vascular permeability and in bleomycin-induced pulmonary fibrosis in mice. |
Volume: |
279 |
Issue: |
44 |
Pages: |
46129-34 |
|
•
•
•
•
•
|
Publication |
First Author: |
Barajas-Espinosa A |
Year: |
2011 |
Journal: |
Am J Pathol |
Title: |
Characterization of the cysteinyl leukotriene 2 receptor in novel expression sites of the gastrointestinal tract. |
Volume: |
178 |
Issue: |
6 |
Pages: |
2682-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kawakami Y |
Year: |
2014 |
Journal: |
Biochim Biophys Acta |
Title: |
Neutralization of leukotriene C4 and D4 activity by monoclonal and single-chain antibodies. |
Volume: |
1840 |
Issue: |
6 |
Pages: |
1625-33 |
|
•
•
•
•
•
|
Publication |
First Author: |
Liu T |
Year: |
2019 |
Journal: |
Mucosal Immunol |
Title: |
Cysteinyl leukotriene receptor 2 drives lung immunopathology through a platelet and high mobility box 1-dependent mechanism. |
Volume: |
12 |
Issue: |
3 |
Pages: |
679-690 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ogasawara H |
Year: |
2002 |
Journal: |
J Biol Chem |
Title: |
Characterization of mouse cysteinyl leukotriene receptors mCysLT1 and mCysLT2: differential pharmacological properties and tissue distribution. |
Volume: |
277 |
Issue: |
21 |
Pages: |
18763-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Maekawa A |
Year: |
2008 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Functional recognition of a distinct receptor preferential for leukotriene E4 in mice lacking the cysteinyl leukotriene 1 and 2 receptors. |
Volume: |
105 |
Issue: |
43 |
Pages: |
16695-700 |
|
•
•
•
•
•
|
Publication |
First Author: |
Jiang Y |
Year: |
2007 |
Journal: |
Blood |
Title: |
CysLT2 receptors interact with CysLT1 receptors and down-modulate cysteinyl leukotriene dependent mitogenic responses of mast cells. |
Volume: |
110 |
Issue: |
9 |
Pages: |
3263-70 |
|
•
•
•
•
•
|
Publication |
First Author: |
Barrett NA |
Year: |
2012 |
Journal: |
J Immunol |
Title: |
Cysteinyl leukotriene 2 receptor on dendritic cells negatively regulates ligand-dependent allergic pulmonary inflammation. |
Volume: |
189 |
Issue: |
9 |
Pages: |
4556-65 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hui Y |
Year: |
2001 |
Journal: |
J Biol Chem |
Title: |
The murine cysteinyl leukotriene 2 (CysLT2) receptor. cDNA and genomic cloning, alternative splicing, and in vitro characterization. |
Volume: |
276 |
Issue: |
50 |
Pages: |
47489-95 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kanaoka Y |
Year: |
2013 |
Journal: |
J Biol Chem |
Title: |
Identification of GPR99 protein as a potential third cysteinyl leukotriene receptor with a preference for leukotriene E4 ligand. |
Volume: |
288 |
Issue: |
16 |
Pages: |
10967-72 |
|
•
•
•
•
•
|
Publication |
First Author: |
Jiang Y |
Year: |
2006 |
Journal: |
J Immunol |
Title: |
Cutting edge: Interleukin 4-dependent mast cell proliferation requires autocrine/intracrine cysteinyl leukotriene-induced signaling. |
Volume: |
177 |
Issue: |
5 |
Pages: |
2755-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lund SJ |
Year: |
2017 |
Journal: |
J Immunol |
Title: |
Leukotriene C4 Potentiates IL-33-Induced Group 2 Innate Lymphoid Cell Activation and Lung Inflammation. |
Volume: |
199 |
Issue: |
3 |
Pages: |
1096-1104 |
|
•
•
•
•
•
|
Publication |
First Author: |
Paruchuri S |
Year: |
2009 |
Journal: |
J Exp Med |
Title: |
Leukotriene E4-induced pulmonary inflammation is mediated by the P2Y12 receptor. |
Volume: |
206 |
Issue: |
11 |
Pages: |
2543-55 |
|
•
•
•
•
•
|
Publication |
First Author: |
Oyoshi MK |
Year: |
2012 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Eosinophil-derived leukotriene C4 signals via type 2 cysteinyl leukotriene receptor to promote skin fibrosis in a mouse model of atopic dermatitis. |
Volume: |
109 |
Issue: |
13 |
Pages: |
4992-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Shi WZ |
Year: |
2012 |
Journal: |
Neurosci Bull |
Title: |
Aggravated inflammation and increased expression of cysteinyl leukotriene receptors in the brain after focal cerebral ischemia in AQP4-deficient mice. |
Volume: |
28 |
Issue: |
6 |
Pages: |
680-92 |
|
•
•
•
•
•
|
Publication |
First Author: |
Tang SS |
Year: |
2014 |
Journal: |
Neurobiol Aging |
Title: |
Involvement of cysteinyl leukotriene receptor 1 in Aβ1-42-induced neurotoxicity in vitro and in vivo. |
Volume: |
35 |
Issue: |
3 |
Pages: |
590-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bankova LG |
Year: |
2016 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Leukotriene E4 elicits respiratory epithelial cell mucin release through the G-protein-coupled receptor, GPR99. |
Volume: |
113 |
Issue: |
22 |
Pages: |
6242-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Cummings HE |
Year: |
2013 |
Journal: |
J Immunol |
Title: |
Cutting edge: Leukotriene C4 activates mouse platelets in plasma exclusively through the type 2 cysteinyl leukotriene receptor. |
Volume: |
191 |
Issue: |
12 |
Pages: |
5807-10 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sasaki F |
Year: |
2019 |
Journal: |
Int Immunol |
Title: |
The leukotriene receptors as therapeutic targets of inflammatory diseases. |
Volume: |
31 |
Issue: |
9 |
Pages: |
607-615 |
|
•
•
•
•
•
|
Publication |
First Author: |
Queto T |
Year: |
2010 |
Journal: |
J Leukoc Biol |
Title: |
Cysteinyl-leukotriene type 1 receptors transduce a critical signal for the up-regulation of eosinophilopoiesis by interleukin-13 and eotaxin in murine bone marrow. |
Volume: |
87 |
Issue: |
5 |
Pages: |
885-93 |
|
•
•
•
•
•
|
Publication |
First Author: |
von Moltke J |
Year: |
2017 |
Journal: |
J Exp Med |
Title: |
Leukotrienes provide an NFAT-dependent signal that synergizes with IL-33 to activate ILC2s. |
Volume: |
214 |
Issue: |
1 |
Pages: |
27-37 |
|
•
•
•
•
•
|
Publication |
First Author: |
Florsheim EB |
Year: |
2023 |
Journal: |
Nature |
Title: |
Immune sensing of food allergens promotes avoidance behaviour. |
Volume: |
620 |
Issue: |
7974 |
Pages: |
643-650 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ualiyeva S |
Year: |
2021 |
Journal: |
Sci Immunol |
Title: |
Tuft cell-produced cysteinyl leukotrienes and IL-25 synergistically initiate lung type 2 inflammation. |
Volume: |
6 |
Issue: |
66 |
Pages: |
eabj0474 |
|
•
•
•
•
•
|
Publication |
First Author: |
McGinty JW |
Year: |
2020 |
Journal: |
Immunity |
Title: |
Tuft-Cell-Derived Leukotrienes Drive Rapid Anti-helminth Immunity in the Small Intestine but Are Dispensable for Anti-protist Immunity. |
Volume: |
52 |
Issue: |
3 |
Pages: |
528-541.e7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Qi L |
Year: |
2017 |
Journal: |
J Neurosci |
Title: |
Hierarchical Specification of Pruriceptors by Runt-Domain Transcription Factor Runx1. |
Volume: |
37 |
Issue: |
22 |
Pages: |
5549-5561 |
|
•
•
•
•
•
|
Publication |
First Author: |
Cao Z |
Year: |
2022 |
Journal: |
Front Mol Neurosci |
Title: |
Meis1 Regulates Nociceptor Development and Behavioral Response to Tactile Stimuli. |
Volume: |
15 |
|
Pages: |
901466 |
|
•
•
•
•
•
|
Publication |
First Author: |
The Jackson Laboratory |
Year: |
2005 |
Journal: |
Unpublished |
Title: |
Information obtained from The Jackson Laboratory, Bar Harbor, ME |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Shanghai Model Organisms Center |
Year: |
2017 |
Journal: |
MGI Direct Data Submission |
Title: |
Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Database and National Center for Biotechnology Information Editorial Staff Collaboration |
Year: |
2001 |
|
Title: |
LocusLink Collaboration |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2001 |
|
Title: |
RIKEN Data Curation in Mouse Genome Informatics |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
MGI and IMPC |
Year: |
2018 |
Journal: |
Database Release |
Title: |
MGI Load of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC) |
|
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|
|
•
•
•
•
•
|
Publication |
First Author: |
The Gene Ontology Consortium |
Year: |
2016 |
|
Title: |
Automatic assignment of GO terms using logical inference, based on on inter-ontology links |
|
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•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC) |
Year: |
2014 |
Journal: |
Database Release |
Title: |
Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database |
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•
•
•
•
•
|
Publication |
First Author: |
Helmholtz Zentrum Muenchen GmbH |
Year: |
2010 |
Journal: |
MGI Direct Data Submission |
Title: |
Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu) |
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|
•
•
•
•
•
|
Publication |
First Author: |
The Gene Ontology Consortium |
Year: |
2014 |
|
Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs |
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•
•
•
•
•
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Publication |
First Author: |
UniProt-GOA |
Year: |
2012 |
|
Title: |
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt |
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•
•
•
•
•
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Publication |
First Author: |
Magdaleno S |
Year: |
2006 |
Journal: |
PLoS Biol |
Title: |
BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. |
Volume: |
4 |
Issue: |
4 |
Pages: |
e86 |
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•
•
•
•
•
|
Publication |
First Author: |
Kawai J |
Year: |
2001 |
Journal: |
Nature |
Title: |
Functional annotation of a full-length mouse cDNA collection. |
Volume: |
409 |
Issue: |
6821 |
Pages: |
685-90 |
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•
•
•
•
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Publication |
First Author: |
Adams DJ |
Year: |
2024 |
Journal: |
Nature |
Title: |
Genetic determinants of micronucleus formation in vivo. |
Volume: |
627 |
Issue: |
8002 |
Pages: |
130-136 |
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•
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Publication |
First Author: |
GemPharmatech |
Year: |
2020 |
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Title: |
GemPharmatech Website. |
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Publication |
First Author: |
Cyagen Biosciences Inc. |
Year: |
2022 |
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Title: |
Cyagen Biosciences Website. |
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Publication |
First Author: |
GOA curators |
Year: |
2016 |
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Title: |
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara |
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Publication |
First Author: |
Okazaki Y |
Year: |
2002 |
Journal: |
Nature |
Title: |
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. |
Volume: |
420 |
Issue: |
6915 |
Pages: |
563-73 |
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Publication |
First Author: |
Diez-Roux G |
Year: |
2011 |
Journal: |
PLoS Biol |
Title: |
A high-resolution anatomical atlas of the transcriptome in the mouse embryo. |
Volume: |
9 |
Issue: |
1 |
Pages: |
e1000582 |
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Publication |
First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
Year: |
2010 |
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Title: |
Annotation inferences using phylogenetic trees |
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Publication |
First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
Year: |
2000 |
Journal: |
Database Release |
Title: |
Entrez Gene Load |
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•
•
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•
•
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Publication |
First Author: |
Allen Institute for Brain Science |
Year: |
2004 |
Journal: |
Allen Institute |
Title: |
Allen Brain Atlas: mouse riboprobes |
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•
•
•
•
•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
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•
•
•
•
•
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Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
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•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Group |
Year: |
2003 |
Journal: |
Database Procedure |
Title: |
Automatic Encodes (AutoE) Reference |
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•
•
•
•
•
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Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
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•
•
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•
•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
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Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
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•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
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•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
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Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
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•
•
•
•
•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
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•
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
309
 |
Fragment?: |
false |
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Allele |
Name: |
cysteinyl leukotriene receptor 2; endonuclease-mediated mutation 2, Shanghai Model Organisms Center |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Null/knockout |
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Allele |
Name: |
transgene insertion 4, Colin D Funk |
Allele Type: |
Transgenic |
Attribute String: |
Inserted expressed sequence |
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Strain |
Attribute String: |
transgenic, congenic |
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Publication |
First Author: |
Hui Y |
Year: |
2004 |
Journal: |
Circulation |
Title: |
Directed vascular expression of human cysteinyl leukotriene 2 receptor modulates endothelial permeability and systemic blood pressure. |
Volume: |
110 |
Issue: |
21 |
Pages: |
3360-6 |
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Strain |
Attribute String: |
coisogenic, endonuclease-mediated mutation, mutant strain |
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Genotype |
Symbol: |
Tg(Tek-CYSLTR2)4Fun/? |
Background: |
B6.Cg-Tg(Tek-CYSLTR2)4Fun |
Zygosity: |
ot |
Has Mutant Allele: |
true |
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Allele |
Name: |
cysteinyl leukotriene receptor 2; endonuclease-mediated mutation 1, Shanghai Model Organisms Center |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Conditional ready, No functional change |
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Allele |
Name: |
cysteinyl leukotriene receptor 2; endonuclease-mediated mutation 1, David D Ginty |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Recombinase |
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Strain |
Attribute String: |
coisogenic, endonuclease-mediated mutation, mutant strain |
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Strain |
Attribute String: |
mutant stock, endonuclease-mediated mutation |
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