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Search results 1101 to 1200 out of 1388 for Dab1

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Type Details Score
Publication
14681479 | J:122989
First Author: Visel A
Year: 2004
Journal: Nucleic Acids Res
Title: GenePaint.org: an atlas of gene expression patterns in the mouse embryo.
Volume: 32
Issue: Database issue
Pages: D552-6
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Publication
- | J:57656
     
First Author: Lennon G
Year: 1999
Journal: Database Download
Title: WashU-HHMI Mouse EST Project
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Publication
- | J:157065
     
First Author: Helmholtz Zentrum Muenchen GmbH
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu)
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Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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Publication
- | J:171409
     
First Author: GUDMAP Consortium
Year: 2004
Journal: www.gudmap.org
Title: GUDMAP: the GenitoUrinary Development Molecular Anatomy Project
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Publication
- | J:155856
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Rat to Mouse ISO GO annotation transfer
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Publication
16602821 | J:162220
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
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Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Allele
Dab1<tm1Cpr> | MGI:1861918
Name: disabled 1; targeted mutation 1, Jonathan A Cooper
Allele Type: Targeted
Attribute String: Null/knockout
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Publication
21534960 | J:175582
First Author: Minami SS
Year: 2011
Journal: J Neurochem
Title: Fyn kinase regulates the association between amyloid precursor protein and Dab1 by promoting their localization to detergent-resistant membranes.
Volume: 118
Issue: 5
Pages: 879-90
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GXD Expression
GXD Expression
 
Probe: MGI:6295196
Assay Type: Immunohistochemistry
Annotation Date: 2019-05-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754723
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:6295390
Age: embryonic day 15.5
Note: Co-localization of staining with Dab1 was noted.
Specimen Label: 3B
Detected: true
Specimen Num: 1
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Interaction Experiment
Chen K (2004)
Description: Interaction between Dab1 and CrkII is promoted by Reelin signaling.
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GXD Expression
GXD Expression
 
Probe: MGI:3763264
Assay Type: In situ reporter (knock in)
Annotation Date: 2020-08-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754623
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:6451022
Age: embryonic day 15.5
Note: Co-expression with Dab1 in some neurons in the marginal zone.
Specimen Label: 6D/F
Detected: true
Specimen Num: 4
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Interaction Experiment
Feng L (2007)
Description: Cullin 5 regulates Dab1 protein levels and neuron positioning during cortical development.
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Interaction Experiment
Assadi AH (2008)
Description: Pafah1b2 mutations suppress the development of hydrocephalus in compound Pafah1b1; Reln and Pafah1b1; Dab1 mutant mice.
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Publication
15316068 | -
First Author: Chen K
Year: 2004
Journal: J Cell Sci
Title: Interaction between Dab1 and CrkII is promoted by Reelin signaling.
Volume: 117
Issue: Pt 19
Pages: 4527-36
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GXD Expression
GXD Expression
 
Probe: MGI:5749732
Assay Type: Immunohistochemistry
Annotation Date: 2020-05-28
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1915528
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:6430465
Age: postnatal day 21
Note: Removing one copy of Dab1 rescued rod bipolar cell displacement in the conditional mutant.
Specimen Label: not shown P21 Rbx2cKO-Nes;Dab1+/-
Detected: true
Specimen Num: 11
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GXD Expression
GXD Expression
 
Probe: MGI:6430205
Assay Type: Immunohistochemistry
Annotation Date: 2020-05-28
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1915528
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:6430451
Age: postnatal day 21
Note: Removing one copy of Dab1 rescued rod bipolar cell displacement in the conditional mutant.
Specimen Label: not shown P21 Rbx2cKO-Nes;Dab1+/-
Detected: true
Specimen Num: 11
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Interaction Experiment
Herrick TM (2004)
Description: High affinity binding of Dab1 to Reelin receptors promotes normal positioning of upper layer cortical plate neurons.
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DO Term
DOID:0050984 | spinocerebellar ataxia type 37
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Publication
17974915 | -
First Author: Feng L
Year: 2007
Journal: Genes Dev
Title: Cullin 5 regulates Dab1 protein levels and neuron positioning during cortical development.
Volume: 21
Issue: 21
Pages: 2717-30
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Allele
Dab1<scm-6J> | MGI:5573136
Name: disabled 1; scrambler 6 Jackson
Allele Type: Spontaneous
Attribute String: Not Specified
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Allele
Dab1<scm-4J> | MGI:4360102
 
Name: disabled 1; scrambler 4 Jackson
Allele Type: Spontaneous
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GXD Expression
GXD Expression
Probe: MGI:6195063
Assay Type: Immunohistochemistry
Annotation Date: 2020-05-28
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3574228
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:6430500
Age: postnatal day 20
Image: S4B
Note: Expression was detected in ectopic cone cells. A reduction in the Dab1 level in the mutant did not rescue cone displacement.
Specimen Label: S4B
Detected: true
Specimen Num: 19
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Strain
MGI:4361836 | CBA/J-Dab1<scm-4J>/GrsrJ
Attribute String: coisogenic, mutant strain, spontaneous mutation
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Genotype
Genotype
Symbol: Dab1/Dab1
Background: CBA/J-Dab1/GrsrJ
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Dab1/Dab1
Background: involves: C57BL/6
Zygosity: hm
Has Mutant Allele: true
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HT Experiment
GSE94896 | Expression data from 3 different Reeler mouse models
 
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: GEO
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HT Experiment
E-GEOD-22758 | Wild type vs. Nova2 KO mouse E14.5 cortex RNA
Series Id: GSE22758
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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Allele
Dab1<scm> | MGI:1856801
 
Name: disabled 1; scrambler
Allele Type: Spontaneous
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Strain
MGI:5650693 | (BALB/cByJ x Dab1<scm>)F1-Dab1<scm>
Attribute String: F1 hybrid, mutant stock
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Strain
MGI:5650739 | (DC/Le-Dab1<scm> x C57BL/6 +/+)F1
Attribute String: F1 hybrid, mutant stock
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Strain
MGI:2164549 | C3FeLe.DC-Dab1<scm>
Attribute String: congenic, spontaneous mutation
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Strain
MGI:5651130 | (BALB/cByJ x Dab1<scm>)F1
Attribute String: F1 hybrid, mutant stock
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Strain
MGI:2161428 | STOCK Dab1<scm>
Attribute String: mutant stock
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Strain
MGI:2164240 | STOCK A/A-Dab1<scm>/J
Attribute String: mutant stock, spontaneous mutation
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Strain
MGI:2161387 | DC/Le-Dab1<scm>
Attribute String: mutant strain
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Genotype
Genotype
Symbol: Dab1/Dab1
Background: involves: C3H * C57BL/6J
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Dab1/Dab1
Background: involves: C3HeB/FeJ * DC/Le
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Dab1/Dab1
Background: involves: C3HeB/FeJ * DC/LeJ
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Dab1/Dab1
Background: involves: DC/Le
Zygosity: hm
Has Mutant Allele: true
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Publication
12805222 | J:83951
First Author: Hocevar BA
Year: 2003
Journal: EMBO J
Title: Regulation of the Wnt signaling pathway by disabled-2 (Dab2).
Volume: 22
Issue: 12
Pages: 3084-94
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Publication
16984970 | J:188901
First Author: Maurer ME
Year: 2006
Journal: J Cell Sci
Title: The adaptor protein Dab2 sorts LDL receptors into coated pits independently of AP-2 and ARH.
Volume: 119
Issue: Pt 20
Pages: 4235-46
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Publication
9671493 | -
First Author: Le N
Year: 1998
Journal: Mol Cell Biol
Title: Disabled is a putative adaptor protein that functions during signaling by the sevenless receptor tyrosine kinase.
Volume: 18
Issue: 8
Pages: 4844-54
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Publication
16267015 | -
First Author: Zhoul J
Year: 2005
Journal: Cancer Res
Title: The role of DOC-2/DAB2 in modulating androgen receptor-mediated cell growth via the nongenomic c-Src-mediated pathway in normal prostatic epithelium and cancer.
Volume: 65
Issue: 21
Pages: 9906-13
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Publication
11387212 | -
First Author: Hocevar BA
Year: 2001
Journal: EMBO J
Title: The adaptor molecule Disabled-2 links the transforming growth factor beta receptors to the Smad pathway.
Volume: 20
Issue: 11
Pages: 2789-801
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Publication
7680635 | -
First Author: Gertler FB
Year: 1993
Journal: Genes Dev
Title: Dosage-sensitive modifiers of Drosophila abl tyrosine kinase function: prospero, a regulator of axonal outgrowth, and disabled, a novel tyrosine kinase substrate.
Volume: 7
Issue: 3
Pages: 441-53
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Protein Domain
IPR028761 | Dab
Type: Family
Description: This entry represents the protein disabled (DAB) and related proteins. It includes DAB from Drosophila melanogaster and its mammlian homologues, DAB1 and DAB2 (also known as DOC1 and DOC2). This group of proteins are adapter proteins that play roles in development. In Drosophila melanogaster, DAB acts as an adapter protein for SH2-domain containing proteins in the sevenless (sev) signalling pathway []. Together with Abl, it is involved in embryonic neural development []. In mammals, DAB1 is implicated in neuronal development []. In humans, DAB2 is an adapter protein that functions as clathrin-associated sorting protein (CLASP) required for clathrin-mediated endocytosis of selected cargo proteins []. It is involved in several signalling pathways and plays an important part in cell growth and development [, , ].
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Strain
MGI:2161295 | STOCK Tyrp1<b> +/+ Dab1<scm>
Attribute String: mutant stock
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Publication
19903888 | J:154743
First Author: Xie D
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: DAB2IP coordinates both PI3K-Akt and ASK1 pathways for cell survival and apoptosis.
Volume: 106
Issue: 47
Pages: 19878-83
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Publication
21444365 | -
First Author: Harrison SC
Year: 2012
Journal: Eur Heart J
Title: Association of a sequence variant in DAB2IP with coronary heart disease.
Volume: 33
Issue: 7
Pages: 881-8
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Publication
15310755 | -
First Author: Zhang H
Year: 2004
Journal: J Biol Chem
Title: AIP1/DAB2IP, a novel member of the Ras-GAP family, transduces TRAF2-induced ASK1-JNK activation.
Volume: 279
Issue: 43
Pages: 44955-65
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Publication
18073375 | -
First Author: Duggan D
Year: 2007
Journal: J Natl Cancer Inst
Title: Two genome-wide association studies of aggressive prostate cancer implicate putative prostate tumor suppressor gene DAB2IP.
Volume: 99
Issue: 24
Pages: 1836-44
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Publication
20622881 | -
First Author: Gretarsdottir S
Year: 2010
Journal: Nat Genet
Title: Genome-wide association study identifies a sequence variant within the DAB2IP gene conferring susceptibility to abdominal aortic aneurysm.
Volume: 42
Issue: 8
Pages: 692-7
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Protein Domain
IPR030403 | DAB2IP
Type: Family
Description: DAB-2 interacting protein (Dab2IP) is a GTPase activating protein involved in the regulation of multiple signalling pathways. Dab2IP regulates PI3K-AKT signalling and functions as a tumour suppressor. It modulates the balance between phosphatidylinositol 3-kinase (PI3K) mediated cell survival and ASK1 mediated apoptosis [, ]. Besides its function as a tumour suppressor, Dab2IP is also highly expressed in the brain, where it interacts with Dab1 (Disabled homologue 1), a key mediator of the Reelin pathway that controls several aspects of brain development and function [, , ]. It also functions as an inhibitor in VEGFR2-mediated adaptative angiogenesis [].Dab2IP has been associated with metastatic prostate cancer [], abdominal aortic aneurysms []and coronary heart disease [].
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Publication
17913789 | J:126335
First Author: Hack I
Year: 2007
Journal: Development
Title: Divergent roles of ApoER2 and Vldlr in the migration of cortical neurons.
Volume: 134
Issue: 21
Pages: 3883-91
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Publication
18946489 | J:143787
First Author: Blake SM
Year: 2008
Journal: EMBO J
Title: Thrombospondin-1 binds to ApoER2 and VLDL receptor and functions in postnatal neuronal migration.
Volume: 27
Issue: 22
Pages: 3069-80
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Publication
29691400 | J:264763
First Author: Lanjakornsiripan D
Year: 2018
Journal: Nat Commun
Title: Layer-specific morphological and molecular differences in neocortical astrocytes and their dependence on neuronal layers.
Volume: 9
Issue: 1
Pages: 1623
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Publication
37188781 | J:341134
First Author: Lopera F
Year: 2023
Journal: Nat Med
Title: Resilience to autosomal dominant Alzheimer's disease in a Reelin-COLBOS heterozygous man.
Volume: 29
Issue: 5
Pages: 1243-1252
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Publication
11137154 | J:66167
First Author: Bar I
Year: 2000
Journal: Trends Neurosci
Title: The evolution of cortical development. An hypothesis based on the role of the Reelin signaling pathway.
Volume: 23
Issue: 12
Pages: 633-8
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Publication
10328932 | J:54649
First Author: Lambert de Rouvroit C
Year: 1999
Journal: Exp Neurol
Title: Evolutionarily conserved, alternative splicing of reelin during brain development.
Volume: 156
Issue: 2
Pages: 229-38
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Publication
17548821 | J:248288
First Author: Yasui N
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: Structure of a receptor-binding fragment of reelin and mutational analysis reveal a recognition mechanism similar to endocytic receptors.
Volume: 104
Issue: 24
Pages: 9988-93
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Publication
25128699 | J:217773
 
First Author: Mota SI
Year: 2014
Journal: Exp Neurol
Title: Impaired Src signaling and post-synaptic actin polymerization in Alzheimer's disease mice hippocampus--linking NMDA receptors and the reelin pathway.
Volume: 261
Pages: 698-709
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Publication
26503265 | J:239271
First Author: Lawrenson ID
Year: 2017
Journal: Cereb Cortex
Title: Cortical Layer Inversion and Deregulation of Reelin Signaling in the Absence of SOCS6 and SOCS7.
Volume: 27
Issue: 1
Pages: 576-588
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Publication
26635527 | J:245046
 
First Author: Brai E
Year: 2015
Journal: Front Cell Neurosci
Title: Notch1 Regulates Hippocampal Plasticity Through Interaction with the Reelin Pathway, Glutamatergic Transmission and CREB Signaling.
Volume: 9
Pages: 447
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Publication
19074029 | J:143049
First Author: Park TJ
Year: 2008
Journal: J Neurosci
Title: Crk and Crk-like play essential overlapping roles downstream of disabled-1 in the Reelin pathway.
Volume: 28
Issue: 50
Pages: 13551-62
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Publication
25788693 | J:220151
First Author: Kohno T
Year: 2015
Journal: J Neurosci
Title: Importance of Reelin C-terminal region in the development and maintenance of the postnatal cerebral cortex and its regulation by specific proteolysis.
Volume: 35
Issue: 11
Pages: 4776-87
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Publication
27726110 | J:339400
First Author: Mata A
Year: 2017
Journal: Mol Neurobiol
Title: Reelin Expression in Creutzfeldt-Jakob Disease and Experimental Models of Transmissible Spongiform Encephalopathies.
Volume: 54
Issue: 8
Pages: 6412-6425
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Publication
23209795 | J:225068
First Author: Hellwig S
Year: 2012
Journal: PLoS One
Title: Reelin together with ApoER2 regulates interneuron migration in the olfactory bulb.
Volume: 7
Issue: 11
Pages: e50646
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Publication
28484035 | J:242292
First Author: Jakob B
Year: 2017
Journal: Proc Natl Acad Sci U S A
Title: Intersectin 1 is a component of the Reelin pathway to regulate neuronal migration and synaptic plasticity in the hippocampus.
Volume: 114
Issue: 21
Pages: 5533-5538
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Publication
11835672 | J:74540
First Author: Park C
Year: 2002
Journal: Genesis
Title: The cerebellar deficient folia (cdf) gene acts intrinsically in Purkinje cell migrations.
Volume: 32
Issue: 1
Pages: 32-41
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Publication
14645539 | J:86862
First Author: Arnaud L
Year: 2003
Journal: Mol Cell Biol
Title: Regulation of protein tyrosine kinase signaling by substrate degradation during brain development.
Volume: 23
Issue: 24
Pages: 9293-302
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Publication
14724251 | J:87733
First Author: Jossin Y
Year: 2004
Journal: J Neurosci
Title: The central fragment of Reelin, generated by proteolytic processing in vivo, is critical to its function during cortical plate development.
Volume: 24
Issue: 2
Pages: 514-21
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Publication
23976984 | J:205842
First Author: Sharaf A
Year: 2013
Journal: PLoS One
Title: ApoER2 and VLDLr are required for mediating reelin signalling pathway for normal migration and positioning of mesencephalic dopaminergic neurons.
Volume: 8
Issue: 8
Pages: e71091
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Publication
23326475 | J:195873
First Author: Qiao S
Year: 2013
Journal: PLoS One
Title: Dab2IP GTPase activating protein regulates dendrite development and synapse number in cerebellum.
Volume: 8
Issue: 1
Pages: e53635
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Publication
19033661 | J:144734
First Author: Zhang H
Year: 2008
Journal: J Clin Invest
Title: AIP1 functions as an endogenous inhibitor of VEGFR2-mediated signaling and inflammatory angiogenesis in mice.
Volume: 118
Issue: 12
Pages: 3904-16
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Protein
F6Y0W2
Organism: Mus musculus/domesticus
Length: 97  
Fragment?: true
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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