Type |
Details |
Score |
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chimpanzee |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
cattle |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chicken |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
frog, western clawed |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
pig, domestic |
|
•
•
•
•
•
|
Gene |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
dog, domestic |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
D-Amino acid oxidase (DAO or DAAO) is a flavin adenine dinucleotide (FAD)-containing flavoproteins that catalyse the oxidative deamination of d-amino acids with oxygen to generate the corresponding 2-oxo acids along with hydrogen peroxide and ammonia. It displays broad substrate specificity and acts on several neutral and basic d-amino acids, such as d-Ser and d-Ala []. |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
249
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
182
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
345
|
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Dao MA |
Year: |
2000 |
Journal: |
Leukemia |
Title: |
CD34: to select or not to select? That is the question. |
Volume: |
14 |
Issue: |
5 |
Pages: |
773-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Dao M |
Year: |
2022 |
Journal: |
Neuropsychopharmacology |
Title: |
The role of orphan receptor GPR139 in neuropsychiatric behavior. |
Volume: |
47 |
Issue: |
4 |
Pages: |
902-913 |
|
•
•
•
•
•
|
Publication |
First Author: |
Dao DY |
Year: |
2010 |
Journal: |
J Orthop Res |
Title: |
Axin2 regulates chondrocyte maturation and axial skeletal development. |
Volume: |
28 |
Issue: |
1 |
Pages: |
89-95 |
|
•
•
•
•
•
|
Publication |
First Author: |
Dao T |
Year: |
2004 |
Journal: |
Eur J Immunol |
Title: |
Development of CD1d-restricted NKT cells in the mouse thymus. |
Volume: |
34 |
Issue: |
12 |
Pages: |
3542-52 |
|
•
•
•
•
•
|
Publication |
First Author: |
Dao DQ |
Year: |
2014 |
Journal: |
J Neurosci |
Title: |
Nicotine enhances excitability of medial habenular neurons via facilitation of neurokinin signaling. |
Volume: |
34 |
Issue: |
12 |
Pages: |
4273-84 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
341
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
82
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
158
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
182
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
167
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
341
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
133
|
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
345
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
174
|
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Saitoh Y |
Year: |
2012 |
Journal: |
Mol Cell Biol |
Title: |
Spatiotemporal localization of D-amino acid oxidase and D-aspartate oxidases during development in Caenorhabditis elegans. |
Volume: |
32 |
Issue: |
10 |
Pages: |
1967-83 |
|
•
•
•
•
•
|
Publication |
First Author: |
Dao KH |
Year: |
2012 |
Journal: |
Blood |
Title: |
FANCL ubiquitinates β-catenin and enhances its nuclear function. |
Volume: |
120 |
Issue: |
2 |
Pages: |
323-34 |
|
•
•
•
•
•
|
Publication |
First Author: |
Dao D |
Year: |
1998 |
Journal: |
Hum Mol Genet |
Title: |
IMPT1, an imprinted gene similar to polyspecific transporter and multi-drug resistance genes. |
Volume: |
7 |
Issue: |
4 |
Pages: |
597-608 |
|
•
•
•
•
•
|
Publication |
First Author: |
Dao DY |
Year: |
2012 |
Journal: |
J Bone Miner Res |
Title: |
Cartilage-specific β-catenin signaling regulates chondrocyte maturation, generation of ossification centers, and perichondrial bone formation during skeletal development. |
Volume: |
27 |
Issue: |
8 |
Pages: |
1680-94 |
|
•
•
•
•
•
|
Publication |
First Author: |
Dao T |
Year: |
2001 |
Journal: |
J Immunol |
Title: |
Involvement of CD1 in peripheral deletion of T lymphocytes is independent of NK T cells. |
Volume: |
166 |
Issue: |
5 |
Pages: |
3090-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Dao V |
Year: |
2016 |
Journal: |
Cancer Res |
Title: |
Immune-Stimulatory Effects of Rapamycin Are Mediated by Stimulation of Antitumor γδ T Cells. |
Volume: |
76 |
Issue: |
20 |
Pages: |
5970-5982 |
|
•
•
•
•
•
|
Publication |
First Author: |
Dao D |
Year: |
1999 |
Journal: |
Hum Mol Genet |
Title: |
Multipoint analysis of human chromosome 11p15/mouse distal chromosome 7: inclusion of H19/IGF2 in the minimal WT2 region, gene specificity of H19 silencing in Wilms' tumorigenesis and methylation hyper-dependence of H19 imprinting. |
Volume: |
8 |
Issue: |
7 |
Pages: |
1337-52 |
|
•
•
•
•
•
|
Publication |
First Author: |
Dao TT |
Year: |
2011 |
Journal: |
Phytochem Rev |
Title: |
Chalcone synthase and its functions in plant resistance. |
Volume: |
10 |
Issue: |
3 |
Pages: |
397-412 |
|
•
•
•
•
•
|
Publication |
First Author: |
Dao DT |
Year: |
2010 |
Journal: |
Biol Psychiatry |
Title: |
Mood disorder susceptibility gene CACNA1C modifies mood-related behaviors in mice and interacts with sex to influence behavior in mice and diagnosis in humans. |
Volume: |
68 |
Issue: |
9 |
Pages: |
801-10 |
|
•
•
•
•
•
|
Publication |
First Author: |
Dao D |
Year: |
2016 |
Journal: |
MGI Direct Data Submission |
Title: |
Mutagenetix entry for Long_lost |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Dao D |
Year: |
2015 |
Journal: |
MGI Direct Data Submission |
Title: |
Mutagenetix entry for Houstonian |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Dao D |
Year: |
2018 |
Journal: |
MGI Direct Data Submission |
Title: |
Mutagenetix entry for newhome. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Hashimoto A |
Year: |
1993 |
Journal: |
Neurosci Lett |
Title: |
Free D-serine, D-aspartate and D-alanine in central nervous system and serum in mutant mice lacking D-amino acid oxidase. |
Volume: |
152 |
Issue: |
1-2 |
Pages: |
33-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mellink CH |
Year: |
1993 |
Journal: |
Cytogenet Cell Genet |
Title: |
Localization of four new markers to pig chromosomes 1, 6, and 14 by radioactive in situ hybridization. |
Volume: |
64 |
Issue: |
3-4 |
Pages: |
256-60 |
|
•
•
•
•
•
|
Publication |
First Author: |
Almond SL |
Year: |
2006 |
Journal: |
Mol Cell Neurosci |
Title: |
Behavioral and biochemical characterization of a mutant mouse strain lacking D-amino acid oxidase activity and its implications for schizophrenia. |
Volume: |
32 |
Issue: |
4 |
Pages: |
324-34 |
|
•
•
•
•
•
|
Publication |
First Author: |
Holmes RS |
Year: |
1976 |
Journal: |
Biochem Genet |
Title: |
Genetics of peroxisomal enzymes in the mouse: nonlinkage of D-amino acid oxidase locus (Dao) to catalase (Cs) and L-alpha-hydroxyacid oxidase (Hao-1) loci on chromosome 2. |
Volume: |
14 |
Issue: |
11-12 |
Pages: |
981-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sasaki M |
Year: |
1992 |
Journal: |
Biochim Biophys Acta |
Title: |
A single-base-pair substitution abolishes D-amino-acid oxidase activity in the mouse. |
Volume: |
1139 |
Issue: |
4 |
Pages: |
315-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Schweimer JV |
Year: |
2014 |
Journal: |
Eur J Neurosci |
Title: |
Increased burst-firing of ventral tegmental area dopaminergic neurons in D-amino acid oxidase knockout mice in vivo. |
Volume: |
40 |
Issue: |
7 |
Pages: |
2999-3009 |
|
•
•
•
•
•
|
Publication |
First Author: |
Pritchett D |
Year: |
2015 |
Journal: |
Eur J Neurosci |
Title: |
d-amino acid oxidase knockout (Dao(-/-) ) mice show enhanced short-term memory performance and heightened anxiety, but no sleep or circadian rhythm disruption. |
Volume: |
41 |
Issue: |
9 |
Pages: |
1167-79 |
|
•
•
•
•
•
|
Publication |
First Author: |
Labrie V |
Year: |
2009 |
Journal: |
Learn Mem |
Title: |
Genetic inactivation of D-amino acid oxidase enhances extinction and reversal learning in mice. |
Volume: |
16 |
Issue: |
1 |
Pages: |
28-37 |
|
•
•
•
•
•
|
Publication |
First Author: |
Oshima Y |
Year: |
2023 |
Journal: |
Sci Rep |
Title: |
Sodium benzoate attenuates 2,8-dihydroxyadenine nephropathy by inhibiting monocyte/macrophage TNF-α expression. |
Volume: |
13 |
Issue: |
1 |
Pages: |
3331 |
|
•
•
•
•
•
|
Publication |
First Author: |
Nakamura H |
Year: |
2012 |
Journal: |
Infect Immun |
Title: |
Protective role of D-amino acid oxidase against Staphylococcus aureus infection. |
Volume: |
80 |
Issue: |
4 |
Pages: |
1546-53 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hasegawa H |
Year: |
2004 |
Journal: |
Am J Physiol Endocrinol Metab |
Title: |
Role of renal D-amino-acid oxidase in pharmacokinetics of D-leucine. |
Volume: |
287 |
Issue: |
1 |
Pages: |
E160-5 |
|
•
•
•
•
•
|
Publication |
First Author: |
Fukui K |
Year: |
1992 |
Journal: |
J Biol Chem |
Title: |
Molecular cloning and chromosomal localization of a human gene encoding D-amino-acid oxidase. |
Volume: |
267 |
Issue: |
26 |
Pages: |
18631-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Tada M |
Year: |
1990 |
Journal: |
Gene |
Title: |
Cloning and expression of a cDNA encoding mouse kidney D-amino acid oxidase. |
Volume: |
90 |
Issue: |
2 |
Pages: |
293-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sasabe J |
Year: |
2012 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
D-amino acid oxidase controls motoneuron degeneration through D-serine. |
Volume: |
109 |
Issue: |
2 |
Pages: |
627-32 |
|
•
•
•
•
•
|
Publication |
First Author: |
Miyoshi Y |
Year: |
2009 |
Journal: |
J Chromatogr B Analyt Technol Biomed Life Sci |
Title: |
Determination of D-serine and D-alanine in the tissues and physiological fluids of mice with various D-amino-acid oxidase activities using two-dimensional high-performance liquid chromatography with fluorescence detection. |
Volume: |
877 |
Issue: |
24 |
Pages: |
2506-12 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kondori NR |
Year: |
2017 |
Journal: |
PLoS One |
Title: |
Characterisation of the pathogenic effects of the in vivo expression of an ALS-linked mutation in D-amino acid oxidase: Phenotype and loss of spinal cord motor neurons. |
Volume: |
12 |
Issue: |
12 |
Pages: |
e0188912 |
|
•
•
•
•
•
|
Publication |
First Author: |
Dao Thi VL |
Year: |
2011 |
Journal: |
Expert Rev Mol Med |
Title: |
Scavenger receptor class B type I and the hypervariable region-1 of hepatitis C virus in cell entry and neutralisation. |
Volume: |
13 |
|
Pages: |
e13 |
|
•
•
•
•
•
|
Publication |
First Author: |
Katane M |
Year: |
2010 |
Journal: |
Biochimie |
Title: |
Thiolactomycin inhibits D-aspartate oxidase: a novel approach to probing the active site environment. |
Volume: |
92 |
Issue: |
10 |
Pages: |
1371-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Tuinema BR |
Year: |
2014 |
Journal: |
mBio |
Title: |
Salmonella evades D-amino acid oxidase to promote infection in neutrophils. |
Volume: |
5 |
Issue: |
6 |
Pages: |
e01886 |
|
•
•
•
•
•
|
Publication |
First Author: |
Labrie V |
Year: |
2010 |
Journal: |
Genes Brain Behav |
Title: |
Genetic loss of D-amino acid oxidase activity reverses schizophrenia-like phenotypes in mice. |
Volume: |
9 |
Issue: |
1 |
Pages: |
11-25 |
|
•
•
•
•
•
|
Publication |
First Author: |
Miyoshi Y |
Year: |
2012 |
Journal: |
Amino Acids |
Title: |
Alteration of intrinsic amounts of D-serine in the mice lacking serine racemase and D-amino acid oxidase. |
Volume: |
43 |
Issue: |
5 |
Pages: |
1919-31 |
|
•
•
•
•
•
|
Publication |
First Author: |
Katane M |
Year: |
2011 |
Journal: |
Amino Acids |
Title: |
Role of the active site residues arginine-216 and arginine-237 in the substrate specificity of mammalian D-aspartate oxidase. |
Volume: |
40 |
Issue: |
2 |
Pages: |
467-76 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sasabe J |
Year: |
2016 |
Journal: |
Nat Microbiol |
Title: |
Interplay between microbial d-amino acids and host d-amino acid oxidase modifies murine mucosal defence and gut microbiota. |
Volume: |
1 |
Issue: |
10 |
Pages: |
16125 |
|
•
•
•
•
•
|
Publication |
First Author: |
Dao D |
Year: |
2021 |
Journal: |
Cells |
Title: |
High-Fat Diet Alters the Retinal Transcriptome in the Absence of Gut Microbiota. |
Volume: |
10 |
Issue: |
8 |
|
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus caroli |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus pahari |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus spretus |
|
•
•
•
•
•
|
Publication |
First Author: |
Rais R |
Year: |
2012 |
Journal: |
Drug Metab Dispos |
Title: |
Pharmacokinetics of oral D-serine in D-amino acid oxidase knockout mice. |
Volume: |
40 |
Issue: |
11 |
Pages: |
2067-73 |
|
•
•
•
•
•
|
Publication |
First Author: |
Murtas G |
Year: |
2021 |
Journal: |
Cell Mol Life Sci |
Title: |
Antimicrobial D-amino acid oxidase-derived peptides specify gut microbiota. |
Volume: |
78 |
Issue: |
7 |
Pages: |
3607-3620 |
|
•
•
•
•
•
|
Publication |
First Author: |
Konno R |
Year: |
1983 |
Journal: |
Genetics |
Title: |
Mouse mutant deficient in D-amino acid oxidase activity. |
Volume: |
103 |
Issue: |
2 |
Pages: |
277-85 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hamase K |
Year: |
2001 |
Journal: |
Anal Biochem |
Title: |
Determination of free D-proline and D-leucine in the brains of mutant mice lacking D-amino acid oxidase activity. |
Volume: |
298 |
Issue: |
2 |
Pages: |
253-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hashimoto A |
Year: |
2005 |
Journal: |
Brain Res |
Title: |
Mice lacking D-amino acid oxidase activity display marked attenuation of stereotypy and ataxia induced by MK-801. |
Volume: |
1033 |
Issue: |
2 |
Pages: |
210-5 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hashimoto A |
Year: |
2008 |
Journal: |
Eur J Pharmacol |
Title: |
Mice lacking d-amino acid oxidase activity exhibit marked reduction of methamphetamine-induced stereotypy. |
Volume: |
586 |
Issue: |
1-3 |
Pages: |
221-5 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wu M |
Year: |
2006 |
Journal: |
Clin Exp Pharmacol Physiol |
Title: |
D-dopa is unidirectionally converted to L-dopa by D-amino acid oxidase, followed by dopa transaminase. |
Volume: |
33 |
Issue: |
11 |
Pages: |
1042-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Maekawa M |
Year: |
2005 |
Journal: |
Neurosci Res |
Title: |
Spatial learning and long-term potentiation of mutant mice lacking D-amino-acid oxidase. |
Volume: |
53 |
Issue: |
1 |
Pages: |
34-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wake K |
Year: |
2001 |
Journal: |
Neurosci Lett |
Title: |
Exaggerated responses to chronic nociceptive stimuli and enhancement of N-methyl-D-aspartate receptor-mediated synaptic transmission in mutant mice lacking D-amino-acid oxidase. |
Volume: |
297 |
Issue: |
1 |
Pages: |
25-8 |
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Publication |
First Author: |
Konno R |
Year: |
1991 |
Journal: |
Int J Biochem |
Title: |
Presence of D-amino-acid oxidase protein in mutant mice lacking D-amino-acid oxidase activity. |
Volume: |
23 |
Issue: |
11 |
Pages: |
1301-5 |
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Publication |
First Author: |
Konno R |
Year: |
1984 |
Journal: |
J Nutr |
Title: |
Involvement of D-amino-acid oxidase in D-amino acid utilization in the mouse. |
Volume: |
114 |
Issue: |
9 |
Pages: |
1617-21 |
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Publication |
First Author: |
Hamilton GA |
Year: |
1979 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Reactions of cysteamine and other amine metabolites with glyoxylate and oxygen catalyzed by mammalian D-amino acid oxidase. |
Volume: |
76 |
Issue: |
6 |
Pages: |
2625-9 |
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Publication |
First Author: |
Konno R |
Year: |
1984 |
Journal: |
J Neurochem |
Title: |
Brain and kidney D-amino acid oxidases are coded by a single gene in the mouse. |
Volume: |
42 |
Issue: |
2 |
Pages: |
584-6 |
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Publication |
First Author: |
Nagata Y |
Year: |
1992 |
Journal: |
Experientia |
Title: |
Involvement of D-amino acid oxidase in elimination of D-serine in mouse brain. |
Volume: |
48 |
Issue: |
8 |
Pages: |
753-5 |
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Publication |
First Author: |
Konno R |
Year: |
1992 |
Journal: |
Int J Biochem |
Title: |
D-amino-acid oxidase and its physiological function. |
Volume: |
24 |
Issue: |
4 |
Pages: |
519-24 |
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Publication |
First Author: |
Konno R |
Year: |
1993 |
Journal: |
Am J Physiol |
Title: |
Origin of D-alanine present in urine of mutant mice lacking D-amino-acid oxidase activity. |
Volume: |
265 |
Issue: |
4 Pt 1 |
Pages: |
G699-703 |
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Publication |
First Author: |
Nagata Y |
Year: |
1994 |
Journal: |
Metabolism |
Title: |
Amino acid levels in D-alanine-administered mutant mice lacking D-amino acid oxidase. |
Volume: |
43 |
Issue: |
9 |
Pages: |
1153-7 |
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