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Search results 1 to 100 out of 226 for Dapk1

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0.213s
Type Details Score
Gene
Type: gene
Organism: Homo sapiens
Gene
Type: gene
Organism: Rattus norvegicus
Gene
Type: gene
Organism: Danio rerio
Protein Domain
Type: Family
Description: This entry represents death-associated protein kinases 1 (DAPK1). It act as a positive regulator of apoptosis [[cite:PUB00052399], [cite:PUB00052400], [cite:PUB00052401], [cite:PUB00052402], [cite:PUB00052403]]. Protein phosphorylation, which plays a key role in most cellular activities, is a reversible process mediated by protein kinases and phosphoprotein phosphatases. Protein kinases catalyse the transfer of the gamma phosphate from nucleotide triphosphates (often ATP) to one or more amino acid residues in a protein substrate side chain, resulting in a conformational change affecting protein function. Phosphoprotein phosphatases catalyse the reverse process. Protein kinases fall into three broad classes, characterised with respect to substrate specificity [[cite:PUB00005115]]:Serine/threonine-protein kinasesTyrosine-protein kinasesDual specificity protein kinases (e.g. MEK - phosphorylates both Thr and Tyr on target proteins)Protein kinase function is evolutionarily conserved from Escherichia coli to human [[cite:PUB00020114]]. Protein kinases play a role in a multitude of cellular processes, including division, proliferation, apoptosis, and differentiation [[cite:PUB00015362]]. Phosphorylation usually results in a functional change of the target protein by changing enzyme activity, cellular location, or association with other proteins. The catalytic subunits of protein kinases are highly conserved, and several structures have been solved [[cite:PUB00034898]], leading to large screens to develop kinase-specific inhibitors for the treatments of a number of diseases [[cite:PUB00034899]].
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Publication
First Author: Jin Y
Year: 2001
Journal: J Biol Chem
Title: Identification of a new form of death-associated protein kinase that promotes cell survival.
Volume: 276
Issue: 43
Pages: 39667-78
Gene
Type: gene
Organism: Homo sapiens
Publication
First Author: Goodell DJ
Year: 2017
Journal: Cell Rep
Title: DAPK1 Mediates LTD by Making CaMKII/GluN2B Binding LTP Specific.
Volume: 19
Issue: 11
Pages: 2231-2243
Publication
First Author: Pei L
Year: 2015
Journal: Cereb Cortex
Title: A Novel Mechanism of Spine Damages in Stroke via DAPK1 and Tau.
Volume: 25
Issue: 11
Pages: 4559-71
Publication
First Author: Tu W
Year: 2010
Journal: Cell
Title: DAPK1 interaction with NMDA receptor NR2B subunits mediates brain damage in stroke.
Volume: 140
Issue: 2
Pages: 222-34
Protein
Organism: Mus musculus
Length: 1442  
Fragment?: false
Publication
First Author: Kawai T
Year: 1999
Journal: Oncogene
Title: Death-associated protein kinase 2 is a new calcium/calmodulin-dependent protein kinase that signals apoptosis through its catalytic activity.
Volume: 18
Issue: 23
Pages: 3471-80
Publication
First Author: Inbal B
Year: 2000
Journal: Mol Cell Biol
Title: Death-associated protein kinase-related protein 1, a novel serine/threonine kinase involved in apoptosis.
Volume: 20
Issue: 3
Pages: 1044-54
Publication
First Author: Kawai T
Year: 1998
Journal: Mol Cell Biol
Title: ZIP kinase, a novel serine/threonine kinase which mediates apoptosis.
Volume: 18
Issue: 3
Pages: 1642-51
Protein
Organism: Mus musculus
Length: 1430  
Fragment?: false
Publication
First Author: Hanks SK
Year: 1988
Journal: Science
Title: The protein kinase family: conserved features and deduced phylogeny of the catalytic domains.
Volume: 241
Issue: 4861
Pages: 42-52
Publication
First Author: Manning G
Year: 2002
Journal: Trends Biochem Sci
Title: Evolution of protein kinase signaling from yeast to man.
Volume: 27
Issue: 10
Pages: 514-20
Publication
First Author: Manning G
Year: 2002
Journal: Science
Title: The protein kinase complement of the human genome.
Volume: 298
Issue: 5600
Pages: 1912-34
Publication
First Author: Stout TJ
Year: 2004
Journal: Curr Pharm Des
Title: High-throughput structural biology in drug discovery: protein kinases.
Volume: 10
Issue: 10
Pages: 1069-82
Publication
First Author: Li B
Year: 2004
Journal: Comb Chem High Throughput Screen
Title: Creating chemical diversity to target protein kinases.
Volume: 7
Issue: 5
Pages: 453-72
Publication
First Author: Shani G
Year: 2001
Journal: EMBO J
Title: Autophosphorylation restrains the apoptotic activity of DRP-1 kinase by controlling dimerization and calmodulin binding.
Volume: 20
Issue: 5
Pages: 1099-113
Publication    
First Author: McQueen J
Year: 2017
Journal: Elife
Title: Pro-death NMDA receptor signaling is promoted by the GluN2B C-terminus independently of Dapk1.
Volume: 6
Publication
First Author: Martoriati A
Year: 2005
Journal: Oncogene
Title: dapk1, encoding an activator of a p19ARF-p53-mediated apoptotic checkpoint, is a transcription target of p53.
Volume: 24
Issue: 8
Pages: 1461-6
Publication
First Author: You MH
Year: 2017
Journal: Cell Death Differ
Title: Death-associated protein kinase 1 phosphorylates NDRG2 and induces neuronal cell death.
Volume: 24
Issue: 2
Pages: 238-250
Publication
First Author: Shu S
Year: 2016
Journal: J Neurosci
Title: Selective Degeneration of Entorhinal-CA1 Synapses in Alzheimer's Disease via Activation of DAPK1.
Volume: 36
Issue: 42
Pages: 10843-10852
Publication
First Author: Pei L
Year: 2014
Journal: J Neurosci
Title: DAPK1-p53 interaction converges necrotic and apoptotic pathways of ischemic neuronal death.
Volume: 34
Issue: 19
Pages: 6546-56
Publication
First Author: Kim BM
Year: 2016
Journal: Hum Mol Genet
Title: Inhibition of death-associated protein kinase 1 attenuates the phosphorylation and amyloidogenic processing of amyloid precursor protein.
Volume: 25
Issue: 12
Pages: 2498-2513
Publication
First Author: Liu SB
Year: 2012
Journal: J Neurosci
Title: G-protein-coupled receptor 30 mediates rapid neuroprotective effects of estrogen via depression of NR2B-containing NMDA receptors.
Volume: 32
Issue: 14
Pages: 4887-900
Publication
First Author: Gade P
Year: 2008
Journal: Mol Cell Biol
Title: Critical role for transcription factor C/EBP-beta in regulating the expression of death-associated protein kinase 1.
Volume: 28
Issue: 8
Pages: 2528-48
Publication
First Author: Gade P
Year: 2014
Journal: Mol Cell Biol
Title: Regulation of the death-associated protein kinase 1 expression and autophagy via ATF6 requires apoptosis signal-regulating kinase 1.
Volume: 34
Issue: 21
Pages: 4033-48
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Gozuacik D
Year: 2008
Journal: Cell Death Differ
Title: DAP-kinase is a mediator of endoplasmic reticulum stress-induced caspase activation and autophagic cell death.
Volume: 15
Issue: 12
Pages: 1875-86
Publication
First Author: Yukawa K
Year: 2004
Journal: Int J Mol Med
Title: Deletion of the kinase domain in death-associated protein kinase attenuates renal tubular cell apoptosis in chronic obstructive uropathy.
Volume: 13
Issue: 4
Pages: 515-20
Publication
First Author: Kishino M
Year: 2004
Journal: J Am Soc Nephrol
Title: Deletion of the kinase domain in death-associated protein kinase attenuates tubular cell apoptosis in renal ischemia-reperfusion injury.
Volume: 15
Issue: 7
Pages: 1826-34
Publication
First Author: Yukawa K
Year: 2005
Journal: Int J Mol Med
Title: Deletion of the kinase domain from death-associated protein kinase attenuates p53 expression in chronic obstructive uropathy.
Volume: 16
Issue: 3
Pages: 389-93
Publication
First Author: Yukawa K
Year: 2005
Journal: Int J Mol Med
Title: The kinase domain of death-associated protein kinase is inhibitory for tubulointerstitial fibrosis in chronic obstructive nephropathy.
Volume: 15
Issue: 1
Pages: 73-8
Publication
First Author: Yukawa K
Year: 2006
Journal: Int J Mol Med
Title: Deletion of the kinase domain from death-associated protein kinase enhances spatial memory in mice.
Volume: 17
Issue: 5
Pages: 869-73
Publication
First Author: Wu PR
Year: 2011
Journal: Cell Death Differ
Title: DAPK activates MARK1/2 to regulate microtubule assembly, neuronal differentiation, and tau toxicity.
Volume: 18
Issue: 9
Pages: 1507-20
Publication
First Author: Jin Y
Year: 2006
Journal: J Biol Chem
Title: Control of death-associated protein kinase (DAPK) activity by phosphorylation and proteasomal degradation.
Volume: 281
Issue: 51
Pages: 39033-40
Publication
First Author: Chuang YT
Year: 2008
Journal: J Immunol
Title: The tumor suppressor death-associated protein kinase targets to TCR-stimulated NF-kappa B activation.
Volume: 180
Issue: 5
Pages: 3238-49
GXD Expression    
Probe: MGI:3040416
Assay Type: Western blot
Annotation Date: 2004-05-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1672828
Stage: TS28
Assay Id: MGI:3040426
Age: postnatal adult
Image: 3
Detected: true
Specimen Num: 15
GXD Expression    
Probe: MGI:3040412
Assay Type: Northern blot
Annotation Date: 2004-05-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1672828
Stage: TS28
Assay Id: MGI:3040422
Age: postnatal adult
Image: 3
Detected: true
Specimen Num: 15
GXD Expression      
Probe: MGI:3040416
Assay Type: Western blot
Annotation Date: 2004-05-18
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:3040426
Age: postnatal adult
Image: 3
Specimen Num: 5
GXD Expression    
Probe: MGI:3040412
Assay Type: Northern blot
Annotation Date: 2004-05-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:3040422
Age: postnatal adult
Image: 3
Detected: true
Specimen Num: 5
GXD Expression    
Probe: MGI:3040410
Assay Type: RNase protection
Annotation Date: 2004-05-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610523
Stage: TS23
Assay Id: MGI:3040417
Age: embryonic day 15.0
Image: 2
Detected: true
Specimen Num: 7
GXD Expression    
Probe: MGI:3040410
Assay Type: RNase protection
Annotation Date: 2004-05-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610520
Stage: TS20
Assay Id: MGI:3040417
Age: embryonic day 12.0
Image: 2
Detected: true
Specimen Num: 6
GXD Expression      
Probe: MGI:3040416
Assay Type: Western blot
Annotation Date: 2004-05-18
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:1860128
Stage: TS28
Assay Id: MGI:3040426
Age: postnatal adult
Image: 3
Specimen Num: 16
GXD Expression    
Probe: MGI:3040412
Assay Type: Northern blot
Annotation Date: 2004-05-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1860128
Stage: TS28
Assay Id: MGI:3040422
Age: postnatal adult
Image: 3
Detected: true
Specimen Num: 16
GXD Expression    
Probe: MGI:3040416
Assay Type: Western blot
Annotation Date: 2004-05-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603926
Stage: TS26
Assay Id: MGI:3040426
Age: embryonic day 19.0
Image: 3
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:3040416
Assay Type: Western blot
Annotation Date: 2004-05-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603923
Stage: TS23
Assay Id: MGI:3040426
Age: embryonic day 15.0
Image: 3
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:3040416
Assay Type: Western blot
Annotation Date: 2004-05-18
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:1603916
Stage: TS16
Assay Id: MGI:3040426
Age: embryonic day 10.0
Image: 3
Specimen Num: 2
GXD Expression    
Probe: MGI:3040412
Assay Type: Northern blot
Annotation Date: 2004-05-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603926
Stage: TS26
Assay Id: MGI:3040422
Age: embryonic day 19.0
Image: 3
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:3040412
Assay Type: Northern blot
Annotation Date: 2004-05-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603923
Stage: TS23
Assay Id: MGI:3040422
Age: embryonic day 15.0
Image: 3
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:3040412
Assay Type: Northern blot
Annotation Date: 2004-05-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603916
Stage: TS16
Assay Id: MGI:3040422
Age: embryonic day 10.0
Image: 3
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:3040410
Assay Type: RNase protection
Annotation Date: 2004-05-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603926
Stage: TS26
Assay Id: MGI:3040417
Age: embryonic day 19.0
Image: 2
Detected: true
Specimen Num: 5
GXD Expression    
Probe: MGI:3040410
Assay Type: RNase protection
Annotation Date: 2004-05-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603923
Stage: TS23
Assay Id: MGI:3040417
Age: embryonic day 15.0
Image: 2
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:3040410
Assay Type: RNase protection
Annotation Date: 2004-05-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603916
Stage: TS16
Assay Id: MGI:3040417
Age: embryonic day 10.0
Image: 2
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:3040416
Assay Type: Western blot
Annotation Date: 2004-05-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1832128
Stage: TS28
Assay Id: MGI:3040426
Age: postnatal adult
Image: 3
Detected: true
Specimen Num: 7
GXD Expression    
Probe: MGI:3040412
Assay Type: Northern blot
Annotation Date: 2004-05-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1832128
Stage: TS28
Assay Id: MGI:3040422
Age: postnatal adult
Image: 3
Detected: true
Specimen Num: 7
GXD Expression    
Probe: MGI:3040416
Assay Type: Western blot
Annotation Date: 2004-05-18
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1702128
Stage: TS28
Assay Id: MGI:3040426
Age: postnatal adult
Image: 3
Detected: false
Specimen Num: 11
GXD Expression    
Probe: MGI:3040412
Assay Type: Northern blot
Annotation Date: 2004-05-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1702128
Stage: TS28
Assay Id: MGI:3040422
Age: postnatal adult
Image: 3
Detected: true
Specimen Num: 11
GXD Expression    
Probe: MGI:3040416
Assay Type: Western blot
Annotation Date: 2004-05-18
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3276428
Stage: TS28
Assay Id: MGI:3040426
Age: postnatal adult
Image: 3
Detected: false
Specimen Num: 13
GXD Expression    
Probe: MGI:3040412
Assay Type: Northern blot
Annotation Date: 2004-05-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3276428
Stage: TS28
Assay Id: MGI:3040422
Age: postnatal adult
Image: 3
Detected: true
Specimen Num: 13
GXD Expression    
Probe: MGI:3040416
Assay Type: Western blot
Annotation Date: 2004-05-18
Strength: Present
Sex: Female
Emaps: EMAPS:2991528
Stage: TS28
Assay Id: MGI:3040426
Age: postnatal adult
Image: 3
Detected: true
Specimen Num: 8
GXD Expression    
Probe: MGI:3040412
Assay Type: Northern blot
Annotation Date: 2004-05-18
Strength: Present
Sex: Female
Emaps: EMAPS:2991528
Stage: TS28
Assay Id: MGI:3040422
Age: postnatal adult
Image: 3
Detected: true
Specimen Num: 8
GXD Expression    
Probe: MGI:3040416
Assay Type: Western blot
Annotation Date: 2004-05-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1876728
Stage: TS28
Assay Id: MGI:3040426
Age: postnatal adult
Image: 3
Detected: true
Specimen Num: 19
GXD Expression    
Probe: MGI:3040412
Assay Type: Northern blot
Annotation Date: 2004-05-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1876728
Stage: TS28
Assay Id: MGI:3040422
Age: postnatal adult
Image: 3
Detected: true
Specimen Num: 19
GXD Expression    
Probe: MGI:3040416
Assay Type: Western blot
Annotation Date: 2004-05-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:3040426
Age: postnatal adult
Image: 3
Detected: true
Specimen Num: 18
GXD Expression    
Probe: MGI:3040412
Assay Type: Northern blot
Annotation Date: 2004-05-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:3040422
Age: postnatal adult
Image: 3
Detected: true
Specimen Num: 18
GXD Expression    
Probe: MGI:3040416
Assay Type: Western blot
Annotation Date: 2004-05-18
Strength: Present
Sex: Male
Emaps: EMAPS:1868128
Stage: TS28
Assay Id: MGI:3040426
Age: postnatal adult
Image: 3
Detected: true
Specimen Num: 9
GXD Expression    
Probe: MGI:3040412
Assay Type: Northern blot
Annotation Date: 2004-05-18
Strength: Present
Sex: Male
Emaps: EMAPS:1868128
Stage: TS28
Assay Id: MGI:3040422
Age: postnatal adult
Image: 3
Detected: true
Specimen Num: 9
GXD Expression    
Probe: MGI:3040416
Assay Type: Western blot
Annotation Date: 2004-05-18
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3598828
Stage: TS28
Assay Id: MGI:3040426
Age: postnatal adult
Image: 3
Detected: false
Specimen Num: 6
GXD Expression    
Probe: MGI:3040412
Assay Type: Northern blot
Annotation Date: 2004-05-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3598828
Stage: TS28
Assay Id: MGI:3040422
Age: postnatal adult
Image: 3
Detected: true
Specimen Num: 6
GXD Expression    
Probe: MGI:3040416
Assay Type: Western blot
Annotation Date: 2004-05-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1685328
Stage: TS28
Assay Id: MGI:3040426
Age: postnatal adult
Image: 3
Detected: true
Specimen Num: 14
GXD Expression    
Probe: MGI:3040412
Assay Type: Northern blot
Annotation Date: 2004-05-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1685328
Stage: TS28
Assay Id: MGI:3040422
Age: postnatal adult
Image: 3
Detected: true
Specimen Num: 14
GXD Expression    
Probe: MGI:3040416
Assay Type: Western blot
Annotation Date: 2004-05-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:3040426
Age: postnatal adult
Image: 3
Detected: true
Specimen Num: 17
GXD Expression    
Probe: MGI:3040412
Assay Type: Northern blot
Annotation Date: 2004-05-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:3040422
Age: postnatal adult
Image: 3
Detected: true
Specimen Num: 17
GXD Expression    
Probe: MGI:3040410
Assay Type: RNase protection
Annotation Date: 2004-05-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:3040417
Age: postnatal adult
Image: 2
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:3040416
Assay Type: Western blot
Annotation Date: 2004-05-18
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1893928
Stage: TS28
Assay Id: MGI:3040426
Age: postnatal adult
Image: 3
Detected: false
Specimen Num: 12
GXD Expression    
Probe: MGI:3040412
Assay Type: Northern blot
Annotation Date: 2004-05-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1893928
Stage: TS28
Assay Id: MGI:3040422
Age: postnatal adult
Image: 3
Detected: true
Specimen Num: 12
GXD Expression    
Probe: MGI:3040416
Assay Type: Western blot
Annotation Date: 2004-05-18
Strength: Absent
Sex: Male
Emaps: EMAPS:1797228
Stage: TS28
Assay Id: MGI:3040426
Age: postnatal adult
Image: 3
Detected: false
Specimen Num: 10
GXD Expression    
Probe: MGI:3040412
Assay Type: Northern blot
Annotation Date: 2004-05-18
Strength: Present
Sex: Male
Emaps: EMAPS:1797228
Stage: TS28
Assay Id: MGI:3040422
Age: postnatal adult
Image: 3
Detected: true
Specimen Num: 10