Type |
Details |
Score |
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
frog, western clawed |
|
•
•
•
•
•
|
Gene |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
dog, domestic |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chimpanzee |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
cattle |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
zebrafish |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chicken |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Publication |
First Author: |
Kocher BA |
Year: |
2015 |
Journal: |
Mol Cancer Res |
Title: |
DAPK3 suppresses acini morphogenesis and is required for mouse development. |
Volume: |
13 |
Issue: |
2 |
Pages: |
358-67 |
|
•
•
•
•
•
|
Publication |
First Author: |
Takahashi M |
Year: |
2021 |
Journal: |
Nat Immunol |
Title: |
The tumor suppressor kinase DAPK3 drives tumor-intrinsic immunity through the STING-IFN-β pathway. |
Volume: |
22 |
Issue: |
4 |
Pages: |
485-496 |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus caroli |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus pahari |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus spretus |
|
•
•
•
•
•
|
Publication |
First Author: |
Komatsu S |
Year: |
2004 |
Journal: |
J Cell Biol |
Title: |
ZIP kinase is responsible for the phosphorylation of myosin II and necessary for cell motility in mammalian fibroblasts. |
Volume: |
165 |
Issue: |
2 |
Pages: |
243-54 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chang AN |
Year: |
2010 |
Journal: |
J Biol Chem |
Title: |
Cardiac myosin is a substrate for zipper-interacting protein kinase (ZIPK). |
Volume: |
285 |
Issue: |
8 |
Pages: |
5122-6 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4837531 |
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2015-06-17 |
Strength: |
Present |
Sex: |
Female |
Emaps: |
EMAPS:1776028 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:5640956 |
Age: |
postnatal adult |
|
Note: |
Expression is present in the epithelium of the mmamary fat pad. |
Specimen Label: |
7A |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2015-06-17 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:1610513 |
Pattern: |
Not Specified |
Stage: |
TS13 |
Assay Id: |
MGI:5640880 |
Age: |
embryonic day 8.5 |
|
|
Specimen Label: |
6E upper |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2015-06-17 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:1610517 |
Pattern: |
Not Specified |
Stage: |
TS17 |
Assay Id: |
MGI:5640880 |
Age: |
embryonic day 10.5 |
|
|
Specimen Label: |
6E lower |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2015-06-17 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1619117 |
Pattern: |
Not Specified |
Stage: |
TS17 |
Assay Id: |
MGI:5640880 |
Age: |
embryonic day 10.5 |
|
|
Specimen Label: |
6E lower |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kawai T |
Year: |
1998 |
Journal: |
Mol Cell Biol |
Title: |
ZIP kinase, a novel serine/threonine kinase which mediates apoptosis. |
Volume: |
18 |
Issue: |
3 |
Pages: |
1642-51 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sato N |
Year: |
2005 |
Journal: |
Int Immunol |
Title: |
Physical and functional interactions between STAT3 and ZIP kinase. |
Volume: |
17 |
Issue: |
12 |
Pages: |
1543-52 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ohbayashi N |
Year: |
2008 |
Journal: |
Biochem Biophys Res Commun |
Title: |
Physical and functional interactions between ZIP kinase and UbcH5. |
Volume: |
372 |
Issue: |
4 |
Pages: |
708-12 |
|
•
•
•
•
•
|
Publication |
First Author: |
Levy-Strumpf N |
Year: |
1998 |
Journal: |
Oncogene |
Title: |
Death associated proteins (DAPs): from gene identification to the analysis of their apoptotic and tumor suppressive functions. |
Volume: |
17 |
Issue: |
25 |
Pages: |
3331-40 |
|
•
•
•
•
•
|
Publication |
First Author: |
Pike AC |
Year: |
2008 |
Journal: |
EMBO J |
Title: |
Activation segment dimerization: a mechanism for kinase autophosphorylation of non-consensus sites. |
Volume: |
27 |
Issue: |
4 |
Pages: |
704-14 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bomar JM |
Year: |
2003 |
Journal: |
Nat Genet |
Title: |
Mutations in a novel gene encoding a CRAL-TRIO domain cause human Cayman ataxia and ataxia/dystonia in the jittery mouse. |
Volume: |
35 |
Issue: |
3 |
Pages: |
264-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kawai T |
Year: |
2003 |
Journal: |
Mol Cell Biol |
Title: |
ZIP kinase triggers apoptosis from nuclear PML oncogenic domains. |
Volume: |
23 |
Issue: |
17 |
Pages: |
6174-86 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhang Y |
Year: |
2019 |
Journal: |
FASEB J |
Title: |
ZIPK mediates endothelial cell contraction through myosin light chain phosphorylation and is required for ischemic-reperfusion injury. |
Volume: |
33 |
Issue: |
8 |
Pages: |
9062-9074 |
|
•
•
•
•
•
|
Publication |
First Author: |
Arif A |
Year: |
2012 |
Journal: |
Mol Cell Biol |
Title: |
Heterotrimeric GAIT complex drives transcript-selective translation inhibition in murine macrophages. |
Volume: |
32 |
Issue: |
24 |
Pages: |
5046-55 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wooldridge AA |
Year: |
2008 |
Journal: |
J Biol Chem |
Title: |
Deletion of the protein kinase A/protein kinase G target SMTNL1 promotes an exercise-adapted phenotype in vascular smooth muscle. |
Volume: |
283 |
Issue: |
17 |
Pages: |
11850-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Puttagunta R |
Year: |
2000 |
Journal: |
Genome Res |
Title: |
Comparative maps of human 19p13.3 and mouse chromosome 10 allow identification of sequences at evolutionary breakpoints. |
Volume: |
10 |
Issue: |
9 |
Pages: |
1369-80 |
|
•
•
•
•
•
|
Publication |
First Author: |
GO Central curators, GOA curators, Rhea curators |
Year: |
2020 |
|
Title: |
Automatic Gene Ontology annotation based on Rhea mapping |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
GOA curators, MGI curators |
Year: |
2001 |
|
Title: |
Gene Ontology annotation based on Enzyme Commission mapping |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
The Gene Ontology Consortium |
Year: |
2016 |
|
Title: |
Automatic assignment of GO terms using logical inference, based on on inter-ontology links |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
|
Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations for FANTOM2 data |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Stryke D |
Year: |
2003 |
Journal: |
Nucleic Acids Res |
Title: |
BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. |
Volume: |
31 |
Issue: |
1 |
Pages: |
278-81 |
|
•
•
•
•
•
|
Publication |
First Author: |
International Knockout Mouse Consortium |
Year: |
2014 |
Journal: |
Database Download |
Title: |
MGI download of modified allele data from IKMC and creation of new knockout alleles |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Lennon G |
Year: |
1999 |
Journal: |
Database Download |
Title: |
WashU-HHMI Mouse EST Project |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC) |
Year: |
2014 |
Journal: |
Database Release |
Title: |
Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Hansen GM |
Year: |
2008 |
Journal: |
Genome Res |
Title: |
Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. |
Volume: |
18 |
Issue: |
10 |
Pages: |
1670-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Helmholtz Zentrum Muenchen GmbH |
Year: |
2010 |
Journal: |
MGI Direct Data Submission |
Title: |
Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu) |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
The Gene Ontology Consortium |
Year: |
2014 |
|
Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
UniProt-GOA |
Year: |
2012 |
|
Title: |
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Carninci P |
Year: |
2005 |
Journal: |
Science |
Title: |
The transcriptional landscape of the mammalian genome. |
Volume: |
309 |
Issue: |
5740 |
Pages: |
1559-63 |
|
•
•
•
•
•
|
Publication |
First Author: |
Adams DJ |
Year: |
2024 |
Journal: |
Nature |
Title: |
Genetic determinants of micronucleus formation in vivo. |
Volume: |
627 |
Issue: |
8002 |
Pages: |
130-136 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zambrowicz BP |
Year: |
2003 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. |
Volume: |
100 |
Issue: |
24 |
Pages: |
14109-14 |
|
•
•
•
•
•
|
Publication |
First Author: |
GemPharmatech |
Year: |
2020 |
|
Title: |
GemPharmatech Website. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI) |
Year: |
2008 |
Journal: |
Database Download |
Title: |
Mouse Gene Trap Data Load from dbGSS |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators |
Year: |
2011 |
|
Title: |
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
GOA curators |
Year: |
2016 |
|
Title: |
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Okazaki Y |
Year: |
2002 |
Journal: |
Nature |
Title: |
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. |
Volume: |
420 |
Issue: |
6915 |
Pages: |
563-73 |
|
•
•
•
•
•
|
Publication |
First Author: |
The Gene Ontology Consortium |
Year: |
2010 |
|
Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Diez-Roux G |
Year: |
2011 |
Journal: |
PLoS Biol |
Title: |
A high-resolution anatomical atlas of the transcriptome in the mouse embryo. |
Volume: |
9 |
Issue: |
1 |
Pages: |
e1000582 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
|
Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2). |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
Year: |
2010 |
|
Title: |
Annotation inferences using phylogenetic trees |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
Year: |
2000 |
Journal: |
Database Release |
Title: |
Entrez Gene Load |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Allen Institute for Brain Science |
Year: |
2004 |
Journal: |
Allen Institute |
Title: |
Allen Brain Atlas: mouse riboprobes |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Group |
Year: |
2003 |
Journal: |
Database Procedure |
Title: |
Automatic Encodes (AutoE) Reference |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Geering B |
Year: |
2014 |
Journal: |
J Leukoc Biol |
Title: |
DAPK2 positively regulates motility of neutrophils and eosinophils in response to intermediary chemoattractants. |
Volume: |
95 |
Issue: |
2 |
Pages: |
293-303 |
|
•
•
•
•
•
|
Publication |
First Author: |
McNamara LK |
Year: |
2009 |
Journal: |
Acta Crystallogr D Biol Crystallogr |
Title: |
Structural insight into nucleotide recognition by human death-associated protein kinase. |
Volume: |
65 |
Issue: |
Pt 3 |
Pages: |
241-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kögel D |
Year: |
2001 |
Journal: |
Bioessays |
Title: |
The DAP kinase family of pro-apoptotic proteins: novel players in the apoptotic game. |
Volume: |
23 |
Issue: |
4 |
Pages: |
352-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Shiloh R |
Year: |
2014 |
Journal: |
Apoptosis |
Title: |
The DAPK family: a structure-function analysis. |
Volume: |
19 |
Issue: |
2 |
Pages: |
286-97 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Domain |
Description: |
This entry represents the catalytic domain of DAPK3, which is a member of the Ca(2+)/calmodulin-regulated family of serine/threonine protein kinases [, ].STKs (serine/threonine kinases) catalyse the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. DAPKs mediate cell death and act as tumour suppressors. They are necessary to induce cell death and their overexpression leads to death-associated changes including membrane blebbing, cell rounding, and formation of autophagic vesicles []. Vertebrates contain three subfamily members with different domain architecture, localization, and function. DAPK1 is the prototypical member of the DAPK family and is also simply referred to as DAPK. DAPK2 is also called DAPK-related protein 1 (DRP-1), while DAPK3 has also been named DAP-like kinase (DLK) and zipper-interacting protein kinase (ZIPk). These proteins are ubiquitously expressed in adult tissues, are capable of cross talk with each other, and may act synergistically in regulating cell death []. |
|
•
•
•
•
•
|
Publication |
First Author: |
Tereshko V |
Year: |
2001 |
Journal: |
Nat Struct Biol |
Title: |
Crystal structures of the catalytic domain of human protein kinase associated with apoptosis and tumor suppression. |
Volume: |
8 |
Issue: |
10 |
Pages: |
899-907 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
448
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
448
 |
Fragment?: |
false |
|
•
•
•
•
•
|