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Search results 1 to 100 out of 229 for Daxx

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Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: chimpanzee
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: zebrafish
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: frog, western clawed
Gene
Type: gene
Organism: chicken
Protein Domain
Type: Family
Description: Daxx is a ubiquitously expressed protein that functions, in part, as a transcriptional co-repressor through its interaction with a growing numberof nuclear, DNA-associated proteins. Human Daxx contains four structural domains commonly found in transcriptional regulatory proteins: two predicted paired amphipathic helices, an acid-rich domain and a Ser/Pro/Thr (SPT)-rich domain. The post-translational modification status of the SPT-domain of hDaxx regulates its association with transcription factors such as Pax3 and ETS-1, effectively bringing hDaxx to sites of active transcription.Through its presence at the site of active transcription, hDaxx could then be able to associate with acetylated histones present in the nucleosomes andDek that is associated with chromatin. Through its association with the SPT-domain of hDaxx, histone deacetylases may also be brought to the site of active transcription. As a consequence, nucleosomes in the vicinity of the site of active transcription will have the histone tails deacetylated, allowing the deactylated tail to bind to DNA, thereby leading to an inactive chromatin structure and transcriptional repression []. The Daxx protein (also known as the Fas-binding protein or death domain-associated protein 6) is thought to play a role in apoptosis as a component of nuclear promyelocytic leukemia protein (PML) oncogenic domains (PODS). Daxx associates with PODs through a direct interaction withPML, a critical component of PODs. The interaction is a dynamic, cell cycle regulated event and is dependent on the post-translational modification of PML by the small ubiquitin-related modifier SUMO-1.
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: dog, domestic
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein
Organism: Mus musculus/domesticus
Length: 740  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 320  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 651  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 621  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 739  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 715  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 739  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 740  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 739  
Fragment?: false
Publication
First Author: Hollenbach AD
Year: 2002
Journal: J Cell Sci
Title: Daxx and histone deacetylase II associate with chromatin through an interaction with core histones and the chromatin-associated protein Dek.
Volume: 115
Issue: Pt 16
Pages: 3319-30
Protein
Organism: Mus musculus/domesticus
Length: 739  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 152  
Fragment?: true
Publication
First Author: Tang J
Year: 2006
Journal: Nat Cell Biol
Title: Critical role for Daxx in regulating Mdm2.
Volume: 8
Issue: 8
Pages: 855-62
Publication
First Author: Wasylishen AR
Year: 2018
Journal: Mol Cancer Res
Title: Daxx Functions Are p53-Independent In Vivo.
Volume: 16
Issue: 10
Pages: 1523-1529
Publication
First Author: Drané P
Year: 2010
Journal: Genes Dev
Title: The death-associated protein DAXX is a novel histone chaperone involved in the replication-independent deposition of H3.3.
Volume: 24
Issue: 12
Pages: 1253-65
Publication      
First Author: McMenamin J
Year: 2009
Journal: MGI Direct Data Submission
Title: Generation of a Daxx conditional allele
Publication
First Author: Leal-Sanchez J
Year: 2007
Journal: Cell Death Differ
Title: Requirement for Daxx in mature T-cell proliferation and activation.
Volume: 14
Issue: 4
Pages: 795-806
Publication
First Author: Sun C
Year: 2023
Journal: Cell Death Dis
Title: The histone chaperone function of Daxx is dispensable for embryonic development.
Volume: 14
Issue: 8
Pages: 565
Publication
First Author: Muromoto R
Year: 2004
Journal: J Immunol
Title: Physical and functional interactions between Daxx and DNA methyltransferase 1-associated protein, DMAP1.
Volume: 172
Issue: 5
Pages: 2985-93
Publication
First Author: Yang Y
Year: 2019
Journal: Nat Commun
Title: Cytoplasmic DAXX drives SQSTM1/p62 phase condensation to activate Nrf2-mediated stress response.
Volume: 10
Issue: 1
Pages: 3759
Publication
First Author: Pan WW
Year: 2013
Journal: Gene
Title: DAXX silencing suppresses mouse ovarian surface epithelial cell growth by inducing senescence and DNA damage.
Volume: 526
Issue: 2
Pages: 287-94
Publication
First Author: Wasylishen AR
Year: 2020
Journal: Sci Adv
Title: Daxx maintains endogenous retroviral silencing and restricts cellular plasticity in vivo.
Volume: 6
Issue: 32
Pages: eaba8415
Publication
First Author: Puto LA
Year: 2008
Journal: Genes Dev
Title: Daxx represses RelB target promoters via DNA methyltransferase recruitment and DNA hypermethylation.
Volume: 22
Issue: 8
Pages: 998-1010
Publication
First Author: Muromoto R
Year: 2006
Journal: J Immunol
Title: Sumoylation of Daxx regulates IFN-induced growth suppression of B lymphocytes and the hormone receptor-mediated transactivation.
Volume: 177
Issue: 2
Pages: 1160-70
Publication
First Author: Li J
Year: 2017
Journal: PLoS One
Title: Daxx plays a novel role in T cell survival but is dispensable in Fas-induced apoptosis.
Volume: 12
Issue: 3
Pages: e0174011
Publication
First Author: Muromoto R
Year: 2010
Journal: Eur J Immunol
Title: Functional involvement of Daxx in gp130-mediated cell growth and survival in BaF3 cells.
Volume: 40
Issue: 12
Pages: 3570-80
Publication
First Author: Yun HJ
Year: 2011
Journal: EMBO J
Title: Daxx mediates activation-induced cell death in microglia by triggering MST1 signalling.
Volume: 30
Issue: 12
Pages: 2465-76
Publication
First Author: Zhong S
Year: 2000
Journal: J Exp Med
Title: Promyelocytic leukemia protein (PML) and Daxx participate in a novel nuclear pathway for apoptosis.
Volume: 191
Issue: 4
Pages: 631-40
Publication
First Author: Croxton R
Year: 2006
Journal: Cancer Res
Title: Daxx represses expression of a subset of antiapoptotic genes regulated by nuclear factor-kappaB.
Volume: 66
Issue: 18
Pages: 9026-35
Publication
First Author: Feng Z
Year: 2017
Journal: Cancer Res
Title: Menin and Daxx Interact to Suppress Neuroendocrine Tumors through Epigenetic Control of the Membrane Metallo-Endopeptidase.
Volume: 77
Issue: 2
Pages: 401-411
Publication
First Author: Perlman R
Year: 2001
Journal: Nat Cell Biol
Title: TGF-beta-induced apoptosis is mediated by the adapter protein Daxx that facilitates JNK activation.
Volume: 3
Issue: 8
Pages: 708-14
Publication
First Author: Ecsedy JA
Year: 2003
Journal: Mol Cell Biol
Title: Homeodomain-interacting protein kinase 1 modulates Daxx localization, phosphorylation, and transcriptional activity.
Volume: 23
Issue: 3
Pages: 950-60
Publication
First Author: Lin DY
Year: 2006
Journal: Mol Cell
Title: Role of SUMO-interacting motif in Daxx SUMO modification, subnuclear localization, and repression of sumoylated transcription factors.
Volume: 24
Issue: 3
Pages: 341-54
Publication
First Author: Arakawa T
Year: 2015
Journal: Biochem Biophys Res Commun
Title: Stella controls chromocenter formation through regulation of Daxx expression in 2-cell embryos.
Volume: 466
Issue: 1
Pages: 60-5
Publication
First Author: Gerber JP
Year: 2021
Journal: Nat Cell Biol
Title: Aberrant chromatin landscape following loss of the H3.3 chaperone Daxx in haematopoietic precursors leads to Pu.1-mediated neutrophilia and inflammation.
Volume: 23
Issue: 12
Pages: 1224-1239
Publication
First Author: Michod D
Year: 2012
Journal: Neuron
Title: Calcium-dependent dephosphorylation of the histone chaperone DAXX regulates H3.3 loading and transcription upon neuronal activation.
Volume: 74
Issue: 1
Pages: 122-35
Publication
First Author: Bogolyubova IO
Year: 2019
Journal: Acta Histochem
Title: The dynamics of DAXX protein distribution in the nucleus of mouse early embryos.
Volume: 121
Issue: 4
Pages: 522-529
Publication
First Author: Emelyanov AV
Year: 2002
Journal: J Biol Chem
Title: The interaction of Pax5 (BSAP) with Daxx can result in transcriptional activation in B cells.
Volume: 277
Issue: 13
Pages: 11156-64
Publication  
First Author: Sun C
Year: 2022
Journal: Dis Model Mech
Title: Context matters - Daxx and Atrx are not robust tumor suppressors in the murine endocrine pancreas.
Volume: 15
Issue: 8
Publication
First Author: Lee YS
Year: 2013
Journal: FEBS Lett
Title: Daxx is a key downstream component of receptor interacting protein kinase 3 mediating retinal ischemic cell death.
Volume: 587
Issue: 3
Pages: 266-71
Publication
First Author: Lewis PW
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: Daxx is an H3.3-specific histone chaperone and cooperates with ATRX in replication-independent chromatin assembly at telomeres.
Volume: 107
Issue: 32
Pages: 14075-80
Publication
First Author: Salomoni P
Year: 2006
Journal: Cell Death Differ
Title: The PML-nuclear body associated protein Daxx regulates the cellular response to CD40.
Volume: 13
Issue: 4
Pages: 672-5
Publication
First Author: Shimoda K
Year: 2002
Journal: J Immunol
Title: Cutting edge: tyk2 is required for the induction and nuclear translocation of Daxx which regulates IFN-alpha-induced suppression of B lymphocyte formation.
Volume: 169
Issue: 9
Pages: 4707-11
Publication
First Author: Ishov AM
Year: 2004
Journal: J Cell Sci
Title: Heterochromatin and ND10 are cell-cycle regulated and phosphorylation-dependent alternate nuclear sites of the transcription repressor Daxx and SWI/SNF protein ATRX.
Volume: 117
Issue: Pt 17
Pages: 3807-20
Publication
First Author: Roubille F
Year: 2007
Journal: Circulation
Title: Myocardial expression of a dominant-negative form of Daxx decreases infarct size and attenuates apoptosis in an in vivo mouse model of ischemia/reperfusion injury.
Volume: 116
Issue: 23
Pages: 2709-17
Publication
First Author: Ishida N
Year: 2005
Journal: Exp Hematol
Title: Differential effects of a novel IFN-zeta/limitin and IFN-alpha on signals for Daxx induction and Crk phosphorylation that couple with growth control of megakaryocytes.
Volume: 33
Issue: 4
Pages: 495-503
GXD Expression  
Probe: MGI:7384877
Assay Type: Immunohistochemistry
Annotation Date: 2022-11-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:160403
Pattern: Regionally restricted
Stage: TS03
Assay Id: MGI:7384958
Age: embryonic day 3.0
Note: There was no colocalization of Atrx with Daxx immunolabeling at the morula stage.
Specimen Label: 4c
Detected: true
Specimen Num: 9
GXD Expression  
Probe: MGI:7384877
Assay Type: Immunohistochemistry
Annotation Date: 2022-11-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:160362
Pattern: Regionally restricted
Stage: TS02
Assay Id: MGI:7384959
Age: embryonic day 1.0
Note: Daxx gold particles and Atrx gold particles were noted in separate heterochromatin structures.
Specimen Label: 2c
Detected: true
Specimen Num: 3
GXD Expression  
Probe: MGI:7384877
Assay Type: Immunohistochemistry
Annotation Date: 2022-11-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:160362
Pattern: Regionally restricted
Stage: TS02
Assay Id: MGI:7384958
Age: embryonic day 1.0
Note: Daxx and Atrx colocalization in the nucleus of 2-cell mouse embryos.
Specimen Label: 5a
Detected: true
Specimen Num: 10
GXD Expression  
Probe: MGI:7384877
Assay Type: Immunohistochemistry
Annotation Date: 2022-11-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:160331
Pattern: Regionally restricted
Stage: TS01
Assay Id: MGI:7384958
Age: embryonic day 0.5
Note: Daxx accumulated in male and female pronuclei. There was no colocalization of Atrx with Daxx immunolabeling at the late zygote stage.
Specimen Label: 4a
Detected: true
Specimen Num: 7
GXD Expression  
Probe: MGI:7384877
Assay Type: Immunohistochemistry
Annotation Date: 2022-11-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:160362
Pattern: Regionally restricted
Stage: TS02
Assay Id: MGI:7384959
Age: embryonic day 1.0
Note: Daxx gold particles and Atrx gold particles were noted in a single structure in close proximity to the surface of interchromatin granule cluster.
Specimen Label: 2d
Detected: true
Specimen Num: 4
Publication    
First Author: Rowen L
Year: 1998
Journal: GenBank Submission
Title: Mus musculus major histocompatibility locus class II region; Fas-binding protein Daxx (DAXX) gene, partial cds; Bing1 (BING1), tapasin (tapasin), RalGDS-like factor (RLF), KE2 (KE2), BING4 (BING4), betal, 3-galactosyl transferase (beta1,3-galactosyl transferase), ribosomal protein subunit S18 (RPS18), Sacm21 (Sacm21), H2K1(b) (H2-K1(b)), RING1 (RING1), KE6a (KE6a), KE4 (KE4), RXRbeta (RXRbeta), collagen alpha-2 (XI) (COLA11A2), H2-O alpha (H2-Oalpha), RING3 (RING3), H2-M alpha (H2-M alpha), H2-M beta 2 (H
Pages: AF100956
GXD Expression  
Probe: MGI:7384877
Assay Type: Immunohistochemistry
Annotation Date: 2022-11-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:160362
Pattern: Regionally restricted
Stage: TS02
Assay Id: MGI:7384958
Age: embryonic day 1.0
Note: At late two-cell stage, colocalization of Daxx and ATRX was detectable both in the ring-shaped heterochromatin zones associated with the nucleolus precursor body (NPB) periphery and in NPB-unassociated heterochromatin patches. Some zones of Daxx localization did not overlap with ATRX (and vise versa). ATRX was found in 60% Daxx-positive heterochromatin areas associated with NPBs and in 80% Daxx-positive heterochromatin clumps located outside the NPBs.
Specimen Label: 4b
Detected: true
Specimen Num: 8
Publication
First Author: Tang J
Year: 2005
Journal: FEBS Lett
Title: The death domain-associated protein modulates activity of the transcription co-factor Skip/NcoA62.
Volume: 579
Issue: 13
Pages: 2883-90
Publication
First Author: Fisher P
Year: 2007
Journal: Nucleic Acids Res
Title: A systematic strategy for large-scale analysis of genotype phenotype correlations: identification of candidate genes involved in African trypanosomiasis.
Volume: 35
Issue: 16
Pages: 5625-33
Publication
First Author: Liu Z
Year: 2020
Journal: EMBO J
Title: SUMOylated PRC1 controls histone H3.3 deposition and genome integrity of embryonic heterochromatin.
Volume: 39
Issue: 13
Pages: e103697
Publication
First Author: Yang X
Year: 1997
Journal: Cell
Title: Daxx, a novel Fas-binding protein that activates JNK and apoptosis.
Volume: 89
Issue: 7
Pages: 1067-76
Publication
First Author: Michaelson JS
Year: 1999
Journal: Genes Dev
Title: Loss of Daxx, a promiscuously interacting protein, results in extensive apoptosis in early mouse development.
Volume: 13
Issue: 15
Pages: 1918-23
Publication
First Author: Goldberg AD
Year: 2010
Journal: Cell
Title: Distinct factors control histone variant H3.3 localization at specific genomic regions.
Volume: 140
Issue: 5
Pages: 678-91
Publication
First Author: Lovejoy CA
Year: 2020
Journal: PLoS Biol
Title: ATRX affects the repair of telomeric DSBs by promoting cohesion and a DAXX-dependent activity.
Volume: 18
Issue: 1
Pages: e3000594
Publication
First Author: Baker SJ
Year: 1998
Journal: Oncogene
Title: Modulation of life and death by the TNF receptor superfamily.
Volume: 17
Issue: 25
Pages: 3261-70
Publication
First Author: Lopez P
Year: 2002
Journal: Mol Cell Biol
Title: Gene control in germinal differentiation: RNF6, a transcription regulatory protein in the mouse sertoli cell.
Volume: 22
Issue: 10
Pages: 3488-96
Publication
First Author: Aoki K
Year: 2003
Journal: Exp Hematol
Title: Limitin, an interferon-like cytokine, transduces inhibitory signals on B-cell growth through activation of Tyk2, but not Stat1, followed by induction and nuclear translocation of Daxx.
Volume: 31
Issue: 12
Pages: 1317-22
Publication
First Author: Yao Z
Year: 2014
Journal: J Biol Chem
Title: Death domain-associated protein 6 (Daxx) selectively represses IL-6 transcription through histone deacetylase 1 (HDAC1)-mediated histone deacetylation in macrophages.
Volume: 289
Issue: 13
Pages: 9372-9
Publication
First Author: Kawai T
Year: 2003
Journal: Mol Cell Biol
Title: ZIP kinase triggers apoptosis from nuclear PML oncogenic domains.
Volume: 23
Issue: 17
Pages: 6174-86
Publication
First Author: Raoul C
Year: 2006
Journal: Proc Natl Acad Sci U S A
Title: Chronic activation in presymptomatic amyotrophic lateral sclerosis (ALS) mice of a feedback loop involving Fas, Daxx, and FasL.
Volume: 103
Issue: 15
Pages: 6007-12
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
GXD Expression      
Probe: MGI:3055002
Assay Type: RT-PCR
Annotation Date: 2004-10-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:3055061
Age: postnatal adult
Specimen Label: 1
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:3055002
Assay Type: RT-PCR
Annotation Date: 2004-10-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1876728
Stage: TS28
Assay Id: MGI:3055061
Age: postnatal adult
Specimen Label: 2
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:3055002
Assay Type: RT-PCR
Annotation Date: 2004-10-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:3055061
Age: postnatal adult
Specimen Label: 3
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:3055002
Assay Type: RT-PCR
Annotation Date: 2004-10-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:3055061
Age: postnatal adult
Specimen Label: 4
Detected: true
Specimen Num: 5