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Search results 1 to 100 out of 1571 for Dcc

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Type Details Score
Gene
Type: gene
Organism: Homo sapiens
Gene
Type: gene
Organism: Rattus norvegicus
Gene
Type: gene
Organism: Danio rerio
Protein Domain
Type: Family
Description: DCC (deleted in colorectal cancer) is a receptor for netrin required for axon guidance [, ]. It also binds a second axon guidance protein, Draxin []. The interactions between these guidance cues and DCC play a key role in the development of the nervous system.DCC belongs to the immunoglobulin superfamily. The protein consists of four N-terminal Ig-like domains []followed by six fibronectin type III domains (FN), a transmembrane segment and the cytosolic portion []. The deletion of DCC has been linked to the propensity of cancerous cells to metastasise [, ]. DCC indeed functions as a tumour suppressor through its ability to trigger tumour cell apoptosis [].
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Publication
First Author: Castets M
Year: 2011
Journal: Nature
Title: DCC constrains tumour progression via its dependence receptor activity.
Volume: 482
Issue: 7386
Pages: 534-7
Publication
First Author: Krimpenfort P
Year: 2012
Journal: Nature
Title: Deleted in colorectal carcinoma suppresses metastasis in p53-deficient mammary tumours.
Volume: 482
Issue: 7386
Pages: 538-41
Publication
First Author: Ahmed G
Year: 2011
Journal: J Neurosci
Title: Draxin inhibits axonal outgrowth through the netrin receptor DCC.
Volume: 31
Issue: 39
Pages: 14018-23
Protein
Organism: Mus musculus
Length: 1447  
Fragment?: false
Publication
First Author: Stein E
Year: 2001
Journal: Science
Title: Binding of DCC by netrin-1 to mediate axon guidance independent of adenosine A2B receptor activation.
Volume: 291
Issue: 5510
Pages: 1976-82
Publication
First Author: Chen Q
Year: 2013
Journal: J Cell Sci
Title: N-terminal horseshoe conformation of DCC is functionally required for axon guidance and might be shared by other neural receptors.
Volume: 126
Issue: Pt 1
Pages: 186-95
Publication
First Author: Miyake S
Year: 1994
Journal: Cancer Res
Title: Point mutations and allelic deletion of tumor suppressor gene DCC in human esophageal squamous cell carcinomas and their relation to metastasis.
Volume: 54
Issue: 11
Pages: 3007-10
Publication
First Author: Keino-Masu K
Year: 1996
Journal: Cell
Title: Deleted in Colorectal Cancer (DCC) encodes a netrin receptor.
Volume: 87
Issue: 2
Pages: 175-85
Publication
First Author: Jamuar SS
Year: 2017
Journal: Nat Genet
Title: Biallelic mutations in human DCC cause developmental split-brain syndrome.
Volume: 49
Issue: 4
Pages: 606-612
Protein
Organism: Mus musculus
Length: 1140  
Fragment?: true
Publication
First Author: Ly A
Year: 2008
Journal: Cell
Title: DSCAM is a netrin receptor that collaborates with DCC in mediating turning responses to netrin-1.
Volume: 133
Issue: 7
Pages: 1241-54
Publication
First Author: Reynolds LM
Year: 2016
Journal: Behav Brain Res
Title: dcc Haploinsufficiency results in blunted sensitivity to cocaine enhancement of reward seeking.
Volume: 298
Issue: Pt A
Pages: 27-31
Publication
First Author: Manitt C
Year: 2011
Journal: J Neurosci
Title: The netrin receptor DCC is required in the pubertal organization of mesocortical dopamine circuitry.
Volume: 31
Issue: 23
Pages: 8381-94
GXD Expression    
Probe: MGI:3821385
Assay Type: RNA in situ
Annotation Date: 2009-01-15
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1750322
Stage: TS22
Assay Id: MGI:3825941
Age: embryonic day 14.5
Image: Additional file 4 Dcc
Detected: false
Specimen Num: 1
GXD Expression
Probe: MGI:6170971
Assay Type: RNA in situ
Annotation Date: 2018-05-30
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1689419
Pattern: Regionally restricted
Stage: TS19
Assay Id: MGI:6158893
Age: embryonic day 11.5
Image: Dcc - E11.5
Note: There is particularly highly expression at early stages in developing neurons of the cortical plate and brainstem nuclei; expression subsequently tapers off with age.
Detected: true
Specimen Num: 1
GXD Expression
Probe: MGI:6170971
Assay Type: RNA in situ
Annotation Date: 2018-05-30
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1689421
Pattern: Regionally restricted
Stage: TS21
Assay Id: MGI:6158893
Age: embryonic day 13.5
Image: Dcc - E13.5
Note: There is particularly highly expression at early stages in developing neurons of the cortical plate and brainstem nuclei; expression subsequently tapers off with age.
Detected: true
Specimen Num: 2
GXD Expression
Probe: MGI:6170971
Assay Type: RNA in situ
Annotation Date: 2018-05-30
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1689423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:6158893
Age: embryonic day 15.5
Image: Dcc - E15.5
Note: There is particularly highly expression at early stages in developing neurons of the cortical plate and brainstem nuclei; expression subsequently tapers off with age.
Detected: true
Specimen Num: 3
GXD Expression
Probe: MGI:6170971
Assay Type: RNA in situ
Annotation Date: 2018-05-30
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1689426
Pattern: Regionally restricted
Stage: TS26
Assay Id: MGI:6158893
Age: embryonic day 18.5
Image: Dcc - E18.5
Note: There is particularly highly expression at early stages in developing neurons of the cortical plate and brainstem nuclei; expression subsequently tapers off with age.
Detected: true
Specimen Num: 4
Publication
First Author: Rabe Bernhardt N
Year: 2012
Journal: Dev Biol
Title: DCC mediated axon guidance of spinal interneurons is essential for normal locomotor central pattern generator function.
Volume: 366
Issue: 2
Pages: 279-89
Publication  
First Author: Pokinko M
Year: 2017
Journal: Neuroscience
Title: Dcc haploinsufficiency regulates dopamine receptor expression across postnatal lifespan.
Volume: 346
Pages: 182-189
Publication  
First Author: Kim YJ
Year: 2016
Journal: Sci Rep
Title: Dcc Mediates Functional Assembly of Peripheral Auditory Circuits.
Volume: 6
Pages: 23799
Publication
First Author: Jarjour AA
Year: 2008
Journal: J Neurosci
Title: Maintenance of axo-oligodendroglial paranodal junctions requires DCC and netrin-1.
Volume: 28
Issue: 43
Pages: 11003-14
Publication
First Author: Auger ML
Year: 2013
Journal: Eur J Neurosci
Title: unc5c haploinsufficient phenotype: striking similarities with the dcc haploinsufficiency model.
Volume: 38
Issue: 6
Pages: 2853-63
Publication
First Author: Shi M
Year: 2008
Journal: Mol Cell Neurosci
Title: DCC is required for the tangential migration of noradrenergic neurons in locus coeruleus of mouse brain.
Volume: 39
Issue: 4
Pages: 529-38
Publication
First Author: Shi M
Year: 2010
Journal: Dev Biol
Title: DCC is specifically required for the survival of retinal ganglion and displaced amacrine cells in the developing mouse retina.
Volume: 348
Issue: 1
Pages: 87-96
Gene
Type: gene
Organism: Homo sapiens
Gene
Type: gene
Organism: Homo sapiens
Gene
Type: gene
Organism: Homo sapiens
Publication    
First Author: Vigouroux RJ
Year: 2020
Journal: Elife
Title: Revisiting the role of Dcc in visual system development with a novel eye clearing method.
Volume: 9
Publication
First Author: Welniarz Q
Year: 2017
Journal: Sci Rep
Title: Non cell-autonomous role of DCC in the guidance of the corticospinal tract at the midline.
Volume: 7
Issue: 1
Pages: 410
Publication
First Author: Horn KE
Year: 2013
Journal: Cell Rep
Title: DCC expression by neurons regulates synaptic plasticity in the adult brain.
Volume: 3
Issue: 1
Pages: 173-85
Publication
First Author: Finger JH
Year: 2002
Journal: J Neurosci
Title: The netrin 1 receptors Unc5h3 and Dcc are necessary at multiple choice points for the guidance of corticospinal tract axons.
Volume: 22
Issue: 23
Pages: 10346-56
Publication
First Author: Plooster M
Year: 2017
Journal: Mol Biol Cell
Title: TRIM9-dependent ubiquitination of DCC constrains kinase signaling, exocytosis, and axon branching.
Volume: 28
Issue: 18
Pages: 2374-2385
Publication
First Author: Tcherkezian J
Year: 2010
Journal: Cell
Title: Transmembrane receptor DCC associates with protein synthesis machinery and regulates translation.
Volume: 141
Issue: 4
Pages: 632-44
Publication  
First Author: Manitt C
Year: 2013
Journal: Transl Psychiatry
Title: dcc orchestrates the development of the prefrontal cortex during adolescence and is altered in psychiatric patients.
Volume: 3
Pages: e338
Publication
First Author: Bull SJ
Year: 2014
Journal: J Neurosci
Title: Progressive disorganization of paranodal junctions and compact myelin due to loss of DCC expression by oligodendrocytes.
Volume: 34
Issue: 29
Pages: 9768-78
Publication
First Author: Reynolds LM
Year: 2018
Journal: Biol Psychiatry
Title: DCC Receptors Drive Prefrontal Cortex Maturation by Determining Dopamine Axon Targeting in Adolescence.
Volume: 83
Issue: 2
Pages: 181-192
Publication  
First Author: Srivatsa S
Year: 2014
Journal: Nat Commun
Title: Unc5C and DCC act downstream of Ctip2 and Satb2 and contribute to corpus callosum formation.
Volume: 5
Pages: 3708
Publication
First Author: Dalvin S
Year: 2003
Journal: Gene Expr Patterns
Title: Expression of Netrin-1 and its two receptors DCC and UNC5H2 in the developing mouse lung.
Volume: 3
Issue: 3
Pages: 279-83
Publication  
First Author: Liang DY
Year: 2014
Journal: BMC Genomics
Title: The Netrin-1 receptor DCC is a regulator of maladaptive responses to chronic morphine administration.
Volume: 15
Pages: 345
Publication
First Author: Castillo-Paterna M
Year: 2015
Journal: EMBO Rep
Title: DCC functions as an accelerator of thalamocortical axonal growth downstream of spontaneous thalamic activity.
Volume: 16
Issue: 7
Pages: 851-62
Publication
First Author: Liu Y
Year: 2012
Journal: J Cell Sci
Title: Differential regulation of myosin X movements by its cargos, DCC and neogenin.
Volume: 125
Issue: Pt 3
Pages: 751-62
Publication
First Author: da Silva RV
Year: 2018
Journal: Cell Rep
Title: DCC Is Required for the Development of Nociceptive Topognosis in Mice and Humans.
Volume: 22
Issue: 5
Pages: 1105-1114
Publication    
First Author: Leggere JC
Year: 2016
Journal: Elife
Title: NOVA regulates Dcc alternative splicing during neuronal migration and axon guidance in the spinal cord.
Volume: 5
Publication
First Author: Rajasekharan S
Year: 2009
Journal: Development
Title: Netrin 1 and Dcc regulate oligodendrocyte process branching and membrane extension via Fyn and RhoA.
Volume: 136
Issue: 3
Pages: 415-26
Publication
First Author: Marcos S
Year: 2009
Journal: Mol Cell Neurosci
Title: Differential roles of Netrin-1 and its receptor DCC in inferior olivary neuron migration.
Volume: 41
Issue: 4
Pages: 429-39
Publication
First Author: Bouchard JF
Year: 2008
Journal: J Neurochem
Title: Depolarization recruits DCC to the plasma membrane of embryonic cortical neurons and enhances axon extension in response to netrin-1.
Volume: 107
Issue: 2
Pages: 398-417
Publication
First Author: Deiner MS
Year: 1997
Journal: Neuron
Title: Netrin-1 and DCC mediate axon guidance locally at the optic disc: loss of function leads to optic nerve hypoplasia.
Volume: 19
Issue: 3
Pages: 575-89
Publication
First Author: Ding YQ
Year: 2005
Journal: Development
Title: Ventral migration of early-born neurons requires Dcc and is essential for the projections of primary afferents in the spinal cord.
Volume: 132
Issue: 9
Pages: 2047-56
Publication
First Author: Gad JM
Year: 1997
Journal: Dev Biol
Title: The expression patterns of guidance receptors, DCC and Neogenin, are spatially and temporally distinct throughout mouse embryogenesis.
Volume: 192
Issue: 2
Pages: 258-73
Publication
First Author: Gad JM
Year: 2000
Journal: Exp Eye Res
Title: The spatial and temporal expression patterns of netrin receptors, DCC and neogenin, in the developing mouse retina.
Volume: 70
Issue: 6
Pages: 711-22
Publication
First Author: Jiang Y
Year: 2003
Journal: Dev Biol
Title: Netrins and DCC in the guidance of migrating neural crest-derived cells in the developing bowel and pancreas.
Volume: 258
Issue: 2
Pages: 364-84
Publication
First Author: Laumonnerie C
Year: 2014
Journal: Development
Title: Netrin 1 and Dcc signalling are required for confinement of central axons within the central nervous system.
Volume: 141
Issue: 3
Pages: 594-603
Publication
First Author: Cooper HM
Year: 1995
Journal: Oncogene
Title: Cloning of the mouse homologue of the deleted in colorectal cancer gene (mDCC) and its expression in the developing mouse embryo.
Volume: 11
Issue: 11
Pages: 2243-54
Publication
First Author: Peng J
Year: 2018
Journal: Dev Dyn
Title: Loss of Dcc in the spinal cord is sufficient to cause a deficit in lateralized motor control and the switch to a hopping gait.
Volume: 247
Issue: 4
Pages: 620-629
Protein
Organism: Mus musculus
Length: 1363  
Fragment?: false
Protein
Organism: Mus musculus
Length: 1427  
Fragment?: false
Publication
First Author: Zhang JH
Year: 2018
Journal: Cell Rep
Title: DCC-Mediated Dab1 Phosphorylation Participates in the Multipolar-to-Bipolar Transition of Migrating Neurons.
Volume: 22
Issue: 13
Pages: 3598-3611
Publication
First Author: Grant A
Year: 2009
Journal: Eur J Neurosci
Title: Post-pubertal emergence of a dopamine phenotype in netrin-1 receptor-deficient mice.
Volume: 30
Issue: 7
Pages: 1318-28
Publication
First Author: Yetnikoff L
Year: 2010
Journal: Eur J Neurosci
Title: Netrin-1 receptor in the ventral tegmental area is required for sensitization to amphetamine.
Volume: 31
Issue: 7
Pages: 1292-302
Publication
First Author: Vosberg DE
Year: 2018
Journal: J Neurosci
Title: Mesocorticolimbic Connectivity and Volumetric Alterations in DCC Mutation Carriers.
Volume: 38
Issue: 20
Pages: 4655-4665
Author
Publication  
First Author: Rong Y
Year: 2018
Journal: Brain Res
Title: Glycosylation of Cblns attenuates their receptor binding.
Volume: 1694
Pages: 129-139
Publication
First Author: Xie Y
Year: 2005
Journal: Nat Cell Biol
Title: Phosphatidylinositol transfer protein-alpha in netrin-1-induced PLC signalling and neurite outgrowth.
Volume: 7
Issue: 11
Pages: 1124-32
Publication
First Author: Shide K
Year: 2008
Journal: Leukemia
Title: Development of ET, primary myelofibrosis and PV in mice expressing JAK2 V617F.
Volume: 22
Issue: 1
Pages: 87-95
GO Term
Publication  
First Author: Gao R
Year: 2021
Journal: J Clin Invest
Title: Macrophage-derived netrin-1 drives adrenergic nerve-associated lung fibrosis.
Volume: 131
Issue: 1
Publication
First Author: Fothergill T
Year: 2014
Journal: Cereb Cortex
Title: Netrin-DCC signaling regulates corpus callosum formation through attraction of pioneering axons and by modulating Slit2-mediated repulsion.
Volume: 24
Issue: 5
Pages: 1138-51
Publication
First Author: Furne C
Year: 2008
Journal: Proc Natl Acad Sci U S A
Title: Netrin-1 is a survival factor during commissural neuron navigation.
Volume: 105
Issue: 38
Pages: 14465-70
Publication
First Author: Flores C
Year: 2005
Journal: Mol Psychiatry
Title: Netrin receptor deficient mice exhibit functional reorganization of dopaminergic systems and do not sensitize to amphetamine.
Volume: 10
Issue: 6
Pages: 606-12
Publication
First Author: Grant A
Year: 2007
Journal: Eur J Neurosci
Title: Netrin-1 receptor-deficient mice show enhanced mesocortical dopamine transmission and blunted behavioural responses to amphetamine.
Volume: 26
Issue: 11
Pages: 3215-28
Publication
First Author: Fazeli A
Year: 1997
Journal: Nature
Title: Phenotype of mice lacking functional Deleted in colorectal cancer (Dcc) gene.
Volume: 386
Issue: 6627
Pages: 796-804
Publication
First Author: Ren XR
Year: 2004
Journal: Nat Neurosci
Title: Focal adhesion kinase in netrin-1 signaling.
Volume: 7
Issue: 11
Pages: 1204-12
Publication
First Author: Brunet I
Year: 2014
Journal: J Clin Invest
Title: Netrin-1 controls sympathetic arterial innervation.
Volume: 124
Issue: 7
Pages: 3230-40
Publication
First Author: Fearon ER
Year: 1990
Journal: Science
Title: Identification of a chromosome 18q gene that is altered in colorectal cancers.
Volume: 247
Issue: 4938
Pages: 49-56
Publication
First Author: Reale MA
Year: 1994
Journal: Cancer Res
Title: Expression and alternative splicing of the deleted in colorectal cancer (DCC) gene in normal and malignant tissues.
Volume: 54
Issue: 16
Pages: 4493-501
Publication
First Author: Howell DM
Year: 2007
Journal: J Comp Neurol
Title: Molecular guidance cues necessary for axon pathfinding from the ventral cochlear nucleus.
Volume: 504
Issue: 5
Pages: 533-49
Publication
First Author: Barallobre MJ
Year: 2000
Journal: Development
Title: Aberrant development of hippocampal circuits and altered neural activity in netrin 1-deficient mice.
Volume: 127
Issue: 22
Pages: 4797-810
Publication
First Author: Ugai H
Year: 2001
Journal: Biochem Biophys Res Commun
Title: Interaction of Myc-associated zinc finger protein with DCC, the product of a tumor-suppressor gene, during the neural differentiation of P19 EC cells.
Volume: 286
Issue: 5
Pages: 1087-97
Publication
First Author: Xu K
Year: 2014
Journal: Science
Title: Neural migration. Structures of netrin-1 bound to two receptors provide insight into its axon guidance mechanism.
Volume: 344
Issue: 6189
Pages: 1275-9
Publication
First Author: Winkle CC
Year: 2014
Journal: J Cell Biol
Title: A novel Netrin-1-sensitive mechanism promotes local SNARE-mediated exocytosis during axon branching.
Volume: 205
Issue: 2
Pages: 217-32
Publication
First Author: Zelina P
Year: 2014
Journal: Neuron
Title: Signaling switch of the axon guidance receptor Robo3 during vertebrate evolution.
Volume: 84
Issue: 6
Pages: 1258-72
Publication
First Author: Rama N
Year: 2012
Journal: J Biol Chem
Title: Amyloid precursor protein regulates netrin-1-mediated commissural axon outgrowth.
Volume: 287
Issue: 35
Pages: 30014-23
Publication
First Author: Ren T
Year: 2007
Journal: J Neurosci
Title: Diffusion tensor magnetic resonance imaging and tract-tracing analysis of Probst bundle structure in Netrin1- and DCC-deficient mice.
Volume: 27
Issue: 39
Pages: 10345-9
Publication
First Author: Llambi F
Year: 2001
Journal: EMBO J
Title: Netrin-1 acts as a survival factor via its receptors UNC5H and DCC.
Volume: 20
Issue: 11
Pages: 2715-22
Publication
First Author: Argaw A
Year: 2011
Journal: J Neurosci
Title: Concerted action of CB1 cannabinoid receptor and deleted in colorectal cancer in axon guidance.
Volume: 31
Issue: 4
Pages: 1489-99
Publication
First Author: Palmesino E
Year: 2012
Journal: J Neurosci
Title: Genetic analysis of DSCAM's role as a Netrin-1 receptor in vertebrates.
Volume: 32
Issue: 2
Pages: 411-6
Publication
First Author: Bonnin A
Year: 2007
Journal: Nat Neurosci
Title: Serotonin modulates the response of embryonic thalamocortical axons to netrin-1.
Volume: 10
Issue: 5
Pages: 588-97
Publication
First Author: Bouhidel JO
Year: 2015
Journal: Biochim Biophys Acta
Title: Netrin-1 improves post-injury cardiac function in vivo via DCC/NO-dependent preservation of mitochondrial integrity, while attenuating autophagy.
Volume: 1852
Issue: 2
Pages: 277-89
Publication
First Author: Zhu XJ
Year: 2007
Journal: Nat Cell Biol
Title: Myosin X regulates netrin receptors and functions in axonal path-finding.
Volume: 9
Issue: 2
Pages: 184-92
Publication
First Author: Burgess RW
Year: 2006
Journal: J Neurosci
Title: Motor axon guidance of the mammalian trochlear and phrenic nerves: dependence on the netrin receptor Unc5c and modifier loci.
Volume: 26
Issue: 21
Pages: 5756-66
Publication
First Author: Ratcliffe EM
Year: 2006
Journal: J Comp Neurol
Title: Netrin/DCC-mediated attraction of vagal sensory axons to the fetal mouse gut.
Volume: 498
Issue: 5
Pages: 567-80
Publication
First Author: Belle M
Year: 2014
Journal: Cell Rep
Title: A simple method for 3D analysis of immunolabeled axonal tracts in a transparent nervous system.
Volume: 9
Issue: 4
Pages: 1191-201
Publication
First Author: Bin JM
Year: 2015
Journal: Cell Rep
Title: Complete Loss of Netrin-1 Results in Embryonic Lethality and Severe Axon Guidance Defects without Increased Neural Cell Death.
Volume: 12
Issue: 7
Pages: 1099-106
UniProt Feature
Begin: 26
Description: Netrin receptor DCC
Type: chain
End: 1447