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Search results 1 to 100 out of 1439 for Ddb1

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Categories

Hits by Pathway

Hits by Strain

Hits by Category

Type Details Score
Gene
511951 | DDB1
Type: gene
Organism: cattle
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Gene
374050 | DDB1
Type: gene
Organism: chicken
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Gene
393599 | ddb1
Type: gene
Organism: zebrafish
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Gene
694253 | DDB1
Type: gene
Organism: macaque, rhesus
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Gene
100485735 | ddb1
Type: gene
Organism: frog, western clawed
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Gene
1642 | DDB1
Type: gene
Organism: human
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Gene
64470 | Ddb1
Type: gene
Organism: rat
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Gene
476067 | DDB1
Type: gene
Organism: dog, domestic
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Gene
451234 | DDB1
Type: gene
Organism: chimpanzee
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Protein Domain
IPR031297 | DDB1
Type: Family
Description: This entry represents the DNA damage-binding protein 1 (DDB1) family, whose members are involved in DNA repair.The fission yeast members in this family includes Rik1 and Ddb1. Rik1 is a component of the Rik1-associated E3 ubiquitin ligase complex that shows ubiquitin ligase activity and is required for histone H3K9 methylation []. Ddb1 is a component of cullin 4A ubiquitin ligases, which regulates the selective proteolysis of key proteins in DNA repair, replication and transcription [, ].Mammalian Ddb1 is apart of the CUL4-DDB1 ubiquitin E3 ligase that regulates cell-cycle progression, replication and DNA damage response. The CUL4-DDB1 ubiquitin E3 ligase interacts with multiple WD40-repeat proteins and regulates histone methylation []. This complex also regulates the circadian clock function by mediating the ubiquitination and degradation of CRY1 [].The plant Ddb1 is part of the CUL4-DDB1-DDB2 E3 ligase involved in maintaining genome integrity upon UV stress [].
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Protein Coding Gene
MGI:1202384 | Ddb1
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
26431207 | J:243464
First Author: Tong X
Year: 2015
Journal: PLoS One
Title: CUL4-DDB1-CDT2 E3 Ligase Regulates the Molecular Clock Activity by Promoting Ubiquitination-Dependent Degradation of the Mammalian CRY1.
Volume: 10
Issue: 10
Pages: e0139725
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Publication
18794354 | -
First Author: Fukumoto Y
Year: 2008
Journal: Mol Cell Biol
Title: Schizosaccharomyces pombe Ddb1 recruits substrate-specific adaptor proteins through a novel protein motif, the DDB-box.
Volume: 28
Issue: 22
Pages: 6746-56
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Publication
21135245 | J:167296
First Author: Yamaji S
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: Hepatocyte-specific deletion of DDB1 induces liver regeneration and tumorigenesis.
Volume: 107
Issue: 51
Pages: 22237-42
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Publication
10713455 | J:61007
First Author: Zolezzi F
Year: 2000
Journal: Gene
Title: Studies of the murine DDB1 and DDB2 genes.
Volume: 245
Issue: 1
Pages: 151-9
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Publication
32479761 | J:294898
First Author: Zhao L
Year: 2020
Journal: Dev Biol
Title: DDB1 promotes the proliferation and hypertrophy of chondrocytes during mouse skeleton development.
Volume: 465
Issue: 2
Pages: 100-107
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Publication
17301228 | J:125911
First Author: Cang Y
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: DDB1 is essential for genomic stability in developing epidermis.
Volume: 104
Issue: 8
Pages: 2733-7
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Publication
32246987 | J:293502
 
First Author: Tong X
Year: 2020
Journal: Metabolism
Title: DDB1 E3 ligase controls dietary fructose-induced ChREBPα stabilization and liver steatosis via CRY1.
Volume: 107
Pages: 154222
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Publication
18936169 | J:144549
First Author: Alekseev S
Year: 2008
Journal: Mol Cell Biol
Title: Cellular concentrations of DDB2 regulate dynamic binding of DDB1 at UV-induced DNA damage.
Volume: 28
Issue: 24
Pages: 7402-13
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Publication
31779270 | J:291677
 
First Author: Zheng W
Year: 2019
Journal: Genes (Basel)
Title: DDB1 Regulates Sertoli Cell Proliferation and Testis Cord Remodeling by TGFβ Pathway.
Volume: 10
Issue: 12
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Publication
17129780 | J:117820
First Author: Cang Y
Year: 2006
Journal: Cell
Title: Deletion of DDB1 in mouse brain and lens leads to p53-dependent elimination of proliferating cells.
Volume: 127
Issue: 5
Pages: 929-40
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Publication
28623141 | J:250622
First Author: Karim MF
Year: 2017
Journal: Biochem Biophys Res Commun
Title: Sirtuin 7-dependent deacetylation of DDB1 regulates the expression of nuclear receptor TR4.
Volume: 490
Issue: 2
Pages: 423-428
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Publication
34526995 | J:311823
 
First Author: Yang L
Year: 2021
Journal: Front Immunol
Title: Ddb1 Is Essential for the Expansion of CD4+ Helper T Cells by Regulating Cell Cycle Progression and Cell Death.
Volume: 12
Pages: 722273
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Publication
34161765 | J:306626
First Author: Wang X
Year: 2021
Journal: Cell Rep
Title: DDB1 binds histone reader BRWD3 to activate the transcriptional cascade in adipogenesis and promote onset of obesity.
Volume: 35
Issue: 12
Pages: 109281
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Publication
17041588 | -
First Author: Higa LA
Year: 2006
Journal: Nat Cell Biol
Title: CUL4-DDB1 ubiquitin ligase interacts with multiple WD40-repeat proteins and regulates histone methylation.
Volume: 8
Issue: 11
Pages: 1277-83
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Publication
16024659 | -
First Author: Horn PJ
Year: 2005
Journal: Genes Dev
Title: A Rik1-associated, cullin-dependent E3 ubiquitin ligase is essential for heterochromatin formation.
Volume: 19
Issue: 14
Pages: 1705-14
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Publication
21959250 | -
First Author: Iovine B
Year: 2011
Journal: Int J Biochem Cell Biol
Title: Damage-specific DNA binding protein 1 (DDB1): a protein with a wide range of functions.
Volume: 43
Issue: 12
Pages: 1664-7
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Publication
18551167 | -
First Author: Molinier J
Year: 2008
Journal: PLoS Genet
Title: Regulation and role of Arabidopsis CUL4-DDB1A-DDB2 in maintaining genome integrity upon UV stress.
Volume: 4
Issue: 6
Pages: e1000093
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Protein
A0A494BBJ6
Organism: Mus musculus/domesticus
Length: 196  
Fragment?: true
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Protein
A0A494B987
Organism: Mus musculus/domesticus
Length: 451  
Fragment?: false
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Protein
Q3U1J4
Organism: Mus musculus/domesticus
Length: 1140  
Fragment?: false
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Protein
Q3ULS8
Organism: Mus musculus/domesticus
Length: 599  
Fragment?: true
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Protein
Q91YC8
Organism: Mus musculus/domesticus
Length: 994  
Fragment?: false
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Publication
31492966 | J:302674
First Author: Zhang J
Year: 2020
Journal: Cell Mol Life Sci
Title: The CRL4-DCAF13 ubiquitin E3 ligase supports oocyte meiotic resumption by targeting PTEN degradation.
Volume: 77
Issue: 11
Pages: 2181-2197
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Publication
25371539 | J:302872
First Author: Yu C
Year: 2015
Journal: Mol Hum Reprod
Title: CRL4DCAF1 is required in activated oocytes for follicle maintenance and ovulation.
Volume: 21
Issue: 2
Pages: 195-205
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Publication
30111536 | J:266543
 
First Author: Zhang YL
Year: 2018
Journal: EMBO J
Title: DCAF13 promotes pluripotency by negatively regulating SUV39H1 stability during early embryonic development.
Volume: 37
Issue: 18
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Publication
24357321 | J:205485
First Author: Yu C
Year: 2013
Journal: Science
Title: CRL4 complex regulates mammalian oocyte survival and reprogramming by activation of TET proteins.
Volume: 342
Issue: 6165
Pages: 1518-21
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Gene
79016 | DDA1
Type: gene
Organism: human
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Publication
10574459 | J:60115
First Author: Seki N
Year: 1999
Journal: DNA Res
Title: cDNA cloning, tissue expression, and chromosomal assignment of a mouse gene, encoding a 127 kDa UV-damaged DNA binding protein which is defective in XPE cells.
Volume: 6
Issue: 5
Pages: 319-22
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Publication
26281983 | J:224987
 
First Author: Yu C
Year: 2015
Journal: Nat Commun
Title: CRL4-DCAF1 ubiquitin E3 ligase directs protein phosphatase 2A degradation to control oocyte meiotic maturation.
Volume: 6
Pages: 8017
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Publication
22384083 | J:185302
First Author: Endo Y
Year: 2012
Journal: PLoS One
Title: Genetic abolishment of hepatocyte proliferation activates hepatic stem cells.
Volume: 7
Issue: 2
Pages: e31846
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Publication
30442713 | J:331350
First Author: Zhang C
Year: 2019
Journal: J Biol Chem
Title: Proteolysis of methylated SOX2 protein is regulated by L3MBTL3 and CRL4DCAF5 ubiquitin ligase.
Volume: 294
Issue: 2
Pages: 476-489
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Publication
28178526 | J:254519
First Author: Li G
Year: 2017
Journal: Cell Rep
Title: CRL4DCAF8 Ubiquitin Ligase Targets Histone H3K79 and Promotes H3K9 Methylation in the Liver.
Volume: 18
Issue: 6
Pages: 1499-1511
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Publication
28790135 | J:245577
First Author: Tong X
Year: 2017
Journal: Diabetes
Title: DDB1-Mediated CRY1 Degradation Promotes FOXO1-Driven Gluconeogenesis in Liver.
Volume: 66
Issue: 10
Pages: 2571-2582
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Publication
26613412 | J:269486
   
First Author: Gao J
Year: 2015
Journal: Elife
Title: The CUL4-DDB1 ubiquitin ligase complex controls adult and embryonic stem cell differentiation and homeostasis.
Volume: 4
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Publication
29370161 | J:259303
First Author: Song T
Year: 2018
Journal: PLoS Genet
Title: CRL4 antagonizes SCFFbxo7-mediated turnover of cereblon and BK channel to regulate learning and memory.
Volume: 14
Issue: 1
Pages: e1007165
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Publication
26323038 | J:245381
First Author: Tamayo AG
Year: 2015
Journal: Nat Struct Mol Biol
Title: Histone monoubiquitination by Clock-Bmal1 complex marks Per1 and Per2 genes for circadian feedback.
Volume: 22
Issue: 10
Pages: 759-66
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Publication
33524014 | J:305161
First Author: Dar AA
Year: 2021
Journal: PLoS Biol
Title: The E3 ubiquitin ligase Cul4b promotes CD4+ T cell expansion by aiding the repair of damaged DNA.
Volume: 19
Issue: 2
Pages: e3001041
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Gene
50717 | DCAF8
Type: gene
Organism: human
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Gene
80067 | DCAF17
Type: gene
Organism: human
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Gene
10238 | DCAF7
Type: gene
Organism: human
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Gene
80344 | DCAF11
Type: gene
Organism: human
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Gene
8816 | DCAF5
Type: gene
Organism: human
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Gene
26094 | DCAF4
Type: gene
Organism: human
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Gene
79269 | DCAF10
Type: gene
Organism: human
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Gene
90379 | DCAF15
Type: gene
Organism: human
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Gene
139170 | DCAF12L1
Type: gene
Organism: human
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Gene
25853 | DCAF12
Type: gene
Organism: human
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Gene
25879 | DCAF13
Type: gene
Organism: human
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Gene
340578 | DCAF12L2
Type: gene
Organism: human
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Gene
9730 | DCAF1
Type: gene
Organism: human
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Gene
55827 | DCAF6
Type: gene
Organism: human
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Gene
139425 | DCAF8L1
Type: gene
Organism: human
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Gene
285429 | DCAF4L1
Type: gene
Organism: human
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Gene
347442 | DCAF8L2
Type: gene
Organism: human
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Gene
401770 | LOC401770
Type: gene
Organism: human
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Gene
54876 | DCAF16
Type: gene
Organism: human
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Gene
138009 | DCAF4L2
Type: gene
Organism: human
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Gene
100129009 | DCAF13P1
Type: gene
Organism: human
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Gene
100132724 | DCAF13P3
Type: gene
Organism: human
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Gene
100288979 | DCAF13P2
Type: gene
Organism: human
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Gene
100420707 | LOC100420707
Type: gene
Organism: human
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Protein Coding Gene
MGP_CAROLIEiJ_G0022695 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0024852 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0024820 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0024795 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0024820 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0024586 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1202384 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0025268 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0024059 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0024560 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0024687 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0024654 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0024774 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0024681 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0025316 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0023804 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0024121 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0014189 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0023609 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
27471256 | J:302718
First Author: Yu J
Year: 2016
Journal: Development
Title: Protein synthesis and degradation are essential to regulate germline stem cell homeostasis in Drosophila testes.
Volume: 143
Issue: 16
Pages: 2930-45
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GXD Expression
GXD Expression
   
Probe: MGI:6154372
Assay Type: Western blot
Annotation Date: 2018-05-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684625
Stage: TS25
Assay Id: MGI:6154590
Age: embryonic day 17.0
Image: 4
Specimen Label: E17
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:6154372
Assay Type: Western blot
Annotation Date: 2018-05-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684627
Stage: TS27
Assay Id: MGI:6154590
Age: postnatal day 1
Image: 4
Specimen Label: 1 day
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:6154372
Assay Type: Western blot
Annotation Date: 2018-05-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:6154590
Age: postnatal week 1
Image: 4
Specimen Label: 1 wk
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:6154372
Assay Type: Western blot
Annotation Date: 2018-05-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:6154590
Age: postnatal week 2
Image: 4
Specimen Label: 2 wks
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
   
Probe: MGI:6154372
Assay Type: Western blot
Annotation Date: 2018-05-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:6154590
Age: postnatal week 4
Image: 4
Specimen Label: 4 wks
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
   
Probe: MGI:6154372
Assay Type: Western blot
Annotation Date: 2018-05-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:6154590
Age: postnatal week 10
Image: 4
Specimen Label: 10 wks
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
   
Probe: MGI:6154372
Assay Type: Western blot
Annotation Date: 2018-05-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:6154597
Age: postnatal adult
Image: S4
Specimen Label: Li
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:6154372
Assay Type: Western blot
Annotation Date: 2018-05-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:6154597
Age: postnatal adult
Image: S4
Specimen Label: Br
Detected: true
Specimen Num: 2
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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