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Search results 1 to 100 out of 106 for Ddi2

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Hits by Category

Hits by Strain

Type Details Score
Gene
84301 | DDI2
Type: gene
Organism: human
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Gene
619368 | ddi2
Type: gene
Organism: frog, western clawed
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Gene
313668 | Ddi2
Type: gene
Organism: rat
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Gene
739922 | DDI2
Type: gene
Organism: chimpanzee
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Gene
487429 | DDI2
Type: gene
Organism: dog, domestic
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Gene
515551 | DDI2
Type: gene
Organism: cattle
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Gene
425541 | DDI2
Type: gene
Organism: chicken
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Gene
386644 | ddi2
Type: gene
Organism: zebrafish
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Protein Coding Gene
MGI:1917244 | Ddi2
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
39328932 | J:354587
First Author: Nedomova M
Year: 2024
Journal: iScience
Title: DDI2 protease controls embryonic development and inflammation via TCF11/NRF1.
Volume: 27
Issue: 10
Pages: 110893
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Publication
27528193 | J:276391
   
First Author: Koizumi S
Year: 2016
Journal: Elife
Title: The aspartyl protease DDI2 activates Nrf1 to compensate for proteasome dysfunction.
Volume: 5
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Publication
36248746 | J:330405
First Author: Ribeiro ST
Year: 2022
Journal: iScience
Title: The protease DDI2 regulates NRF1 activation in response to cadmium toxicity.
Volume: 25
Issue: 10
Pages: 105227
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Protein Coding Gene
MGP_CAROLIEiJ_G0026750 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0029054 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0029014 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0028966 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0029038 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0028752 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1917244 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0029479 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0028184 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0028716 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0028866 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0028833 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0028965 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0028859 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0029517 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0027905 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0028262 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0029081 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0027729 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
27676298 | J:297195
First Author: Sha Z
Year: 2016
Journal: Curr Biol
Title: Reply to Vangala et al.: Complete inhibition of the proteasome reduces new proteasome production by causing Nrf1 aggregation.
Volume: 26
Issue: 18
Pages: R836-R837
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Publication
28322824 | J:260900
First Author: Liu Y
Year: 2017
Journal: Exp Cell Res
Title: MicroRNA-133 mediates cardiac diseases: Mechanisms and clinical implications.
Volume: 354
Issue: 2
Pages: 65-70
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GXD Expression
GXD Expression
     
Probe: MGI:6192719
Assay Type: RT-PCR
Annotation Date: 2018-08-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689421
Stage: TS21
Assay Id: MGI:6192765
Age: embryonic day 13.5
Specimen Label: E13.5
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:6192719
Assay Type: RT-PCR
Annotation Date: 2018-08-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689423
Stage: TS23
Assay Id: MGI:6192765
Age: embryonic day 15.5
Specimen Label: E15.5
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:6192719
Assay Type: RT-PCR
Annotation Date: 2018-08-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689424
Stage: TS24
Assay Id: MGI:6192765
Age: embryonic day 16.5
Specimen Label: E16.5
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
     
Probe: MGI:6192719
Assay Type: RT-PCR
Annotation Date: 2018-08-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689425
Stage: TS25
Assay Id: MGI:6192765
Age: embryonic day 17.5
Specimen Label: E17.5
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
     
Probe: MGI:6192719
Assay Type: RT-PCR
Annotation Date: 2018-08-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689426
Stage: TS26
Assay Id: MGI:6192765
Age: embryonic day 18.5
Specimen Label: E18.5
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
     
Probe: MGI:6192719
Assay Type: RT-PCR
Annotation Date: 2018-08-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689426
Stage: TS26
Assay Id: MGI:6192765
Age: embryonic day 19.5
Specimen Label: E19.5
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
     
Probe: MGI:6192719
Assay Type: RT-PCR
Annotation Date: 2018-08-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689427
Stage: TS27
Assay Id: MGI:6192765
Age: postnatal day 1
Specimen Label: P1
Detected: true
Specimen Num: 7
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GXD Expression
GXD Expression
     
Probe: MGI:6192719
Assay Type: RT-PCR
Annotation Date: 2018-08-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:6192765
Age: postnatal day 4
Specimen Label: P4
Detected: true
Specimen Num: 8
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GXD Expression
GXD Expression
     
Probe: MGI:6192719
Assay Type: RT-PCR
Annotation Date: 2018-08-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:6192765
Age: postnatal day 8
Specimen Label: P8
Detected: true
Specimen Num: 9
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GXD Expression
GXD Expression
     
Probe: MGI:6192719
Assay Type: RT-PCR
Annotation Date: 2018-08-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:6192765
Age: postnatal day 15
Specimen Label: P15
Detected: true
Specimen Num: 10
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GXD Expression
GXD Expression
     
Probe: MGI:6192719
Assay Type: RT-PCR
Annotation Date: 2018-08-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:6192765
Age: postnatal month 1
Specimen Label: M1
Detected: true
Specimen Num: 11
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GXD Expression
GXD Expression
     
Probe: MGI:6192719
Assay Type: RT-PCR
Annotation Date: 2018-08-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:6192765
Age: postnatal month 3
Specimen Label: M3
Detected: true
Specimen Num: 12
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GXD Expression
GXD Expression
     
Probe: MGI:6192719
Assay Type: RT-PCR
Annotation Date: 2018-08-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:6192765
Age: postnatal month 6
Specimen Label: M6
Detected: true
Specimen Num: 13
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GXD Expression
GXD Expression
     
Probe: MGI:6192719
Assay Type: RT-PCR
Annotation Date: 2018-08-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:6192765
Age: postnatal month 9
Specimen Label: M9
Detected: true
Specimen Num: 14
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Publication
29788202 | J:261900
First Author: Ramirez J
Year: 2018
Journal: Hum Mol Genet
Title: Quantitative proteomics reveals neuronal ubiquitination of Rngo/Ddi1 and several proteasomal subunits by Ube3a, accounting for the complexity of Angelman syndrome.
Volume: 27
Issue: 11
Pages: 1955-1971
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Publication
- | J:193309
       
First Author: Mouse Genome Informatics Scientfic Curators
Year: 2013
Title: Curated associations of genes in MGI and UniProt sequence records
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Publication
- | J:238766
     
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
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Publication
10725249 | J:60984
First Author: Ko MS
Year: 2000
Journal: Development
Title: Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development.
Volume: 127
Issue: 8
Pages: 1737-49
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Publication
17967808 | J:152068
First Author: Friedel RH
Year: 2007
Journal: Brief Funct Genomic Proteomic
Title: EUCOMM--the European conditional mouse mutagenesis program.
Volume: 6
Issue: 3
Pages: 180-5
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Publication
12520002 | J:91812
First Author: Stryke D
Year: 2003
Journal: Nucleic Acids Res
Title: BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Volume: 31
Issue: 1
Pages: 278-81
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Publication
- | J:204739
     
First Author: International Knockout Mouse Consortium
Year: 2014
Journal: Database Download
Title: MGI download of modified allele data from IKMC and creation of new knockout alleles
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Publication
- | J:57656
     
First Author: Lennon G
Year: 1999
Journal: Database Download
Title: WashU-HHMI Mouse EST Project
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Publication
- | J:204812
     
First Author: International Mouse Strain Resource
Year: 2014
Journal: Database Download
Title: MGI download of germline transmission data for alleles from IMSR strain data
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Publication
- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
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Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
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Publication
- | J:157065
     
First Author: Helmholtz Zentrum Muenchen GmbH
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu)
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Publication
- | J:342604
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
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Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
38355793 | J:345621
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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UniProt Feature
UniProt Feature
Begin: 103
Description: Cleavage; by DDI2
Type: site
End: 104
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Allele
Ddi2<em2Smoc> | MGI:7289295
Name: DNA-damage inducible protein 2; endonuclease-mediated mutation 2, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Strain
MGI:6770691 | C57BL/6JSmoc-Ddi2<em2Smoc>/Smoc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Allele
Ddi2<em1Smoc> | MGI:7289294
Name: DNA-damage inducible protein 2; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, No functional change
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Strain
MGI:6770690 | C57BL/6JSmoc-Ddi2<em1Smoc>/Smoc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Publication
10601325 | J:276393
First Author: Kwong M
Year: 1999
Journal: J Biol Chem
Title: The CNC basic leucine zipper factor, Nrf1, is essential for cell survival in response to oxidative stress-inducing agents. Role for Nrf1 in gamma-gcs(l) and gss expression in mouse fibroblasts.
Volume: 274
Issue: 52
Pages: 37491-8
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Publication
23144760 | J:192355
First Author: Kwong EK
Year: 2012
Journal: PLoS One
Title: Characterization of Nrf1b, a novel isoform of the nuclear factor-erythroid-2 related transcription factor-1 that activates antioxidant response element-regulated genes.
Volume: 7
Issue: 10
Pages: e48404
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Publication
29149604 | J:250015
First Author: Widenmaier SB
Year: 2017
Journal: Cell
Title: NRF1 Is an ER Membrane Sensor that Is Central to Cholesterol Homeostasis.
Volume: 171
Issue: 5
Pages: 1094-1109.e15
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Protein
A2A6D0
Organism: Mus musculus/domesticus
Length: 148  
Fragment?: true
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Protein
A2A6D1
Organism: Mus musculus/domesticus
Length: 152  
Fragment?: true
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Publication
19665035 | -
First Author: Biswas M
Year: 2010
Journal: Toxicol Appl Pharmacol
Title: Role of Nrf1 in antioxidant response element-mediated gene expression and beyond.
Volume: 244
Issue: 1
Pages: 16-20
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Protein Domain
IPR029847 | NFE2L1
Type: Family
Description: NFE2L1 is an endoplasmic reticulum membrane sensor which, in response to various stresses, it is released from the ER membrane following cleavage by the protease DDI2 and translocates into the nucleus to form the transcription factor NRF1 []. In conditions of excess cholesterol, the endoplasmic reticulum membrane form of the protein directly binds cholesterol via its CRAC motif, preventing cleavage and release of the transcription factor NRF1, this allows the expression of genes promoting cholesterol removal []. In response to oxidative stress, Nrf1 up-regulates expression of antioxidant genes by binding to the antioxidant response elements (AREs) present in the promoter of these genes []. In humans Nrf1 exists in two forms, p120 and p110. p120 is embedded in the ER membrane, while p110 is soluble and can enter the nucleus [, ].
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Publication
29809168 | J:338283
First Author: Nath SR
Year: 2018
Journal: J Clin Invest
Title: Androgen receptor polyglutamine expansion drives age-dependent quality control defects and muscle dysfunction.
Volume: 128
Issue: 8
Pages: 3630-3641
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Protein
Q61985
Organism: Mus musculus/domesticus
Length: 741  
Fragment?: false
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Protein
Q3U4L3
Organism: Mus musculus/domesticus
Length: 741  
Fragment?: false
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Protein
Q3U5L0
Organism: Mus musculus/domesticus
Length: 741  
Fragment?: false
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Protein
Q3V3M1
Organism: Mus musculus/domesticus
Length: 453  
Fragment?: false
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

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